MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)

Who is this study for? Patients with small cell lung cancer
Status: Recruiting
Location: See all (277) locations...
Intervention Type: Procedure, Radiation
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the actual spread of the cancer) may be at least as good as the combination of PCI with MRI scans.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC)

• Patient must have an MRI of the brain performed within 28 days prior to registration documenting no evidence of brain metastases or leptomeningeal disease. Patient also must not have a history of brain metastases or leptomeningeal disease

• Immunotherapy concurrent with and/or adjuvant to first-line therapy is allowed at the discretion of the treating physician. Patients with limited-stage (LS)-SCLC must have completed platinum-based chemotherapy and either definitive thoracic radiotherapy (including stereotactic body radiation therapy [SBRT] for early-stage T1-2 N0 M0 disease who do not undergo surgery) or definitive surgical resection; thoracic radiation in addition to definitive surgical resection is allowed at the discretion of the treating physician, but is not required. Patients with extensive-stage (ES)-SCLC must have completed platinum-based chemotherapy either with or without thoracic radiotherapy at the discretion of the treating physician

• All adverse events from prior treatment must have resolved to =< grade 2 (Common Terminology Criteria for Adverse Events [CTCAE] version 5.0) prior to randomization

• Patient must have had a response to first-line therapy and no evidence of progression in opinion of the treating investigator. Systemic imaging (computed tomography [CT] or positron emission tomography [PET]/CT including the chest and abdomen) must be performed within 28 days prior to randomization

• No more than 8 weeks may have elapsed between day 1 of the last cycle of chemotherapy and randomization

• Patient must not have received prior radiotherapy to the brain or whole brain radiotherapy. Patients who have undergone prior stereotactic radiosurgery for benign tumors or conditions (e.g., acoustic neuroma, grade I meningioma, trigeminal neuralgia) may be considered on a case-by-case basis

• Patient must have Zubrod performance status of 0-2

• Patient must not have a contraindication to MR imaging, such as implanted metal devices or foreign bodies

• Patient must not have a contraindication to gadolinium contrast administration during MR imaging, such as allergy or insufficient renal function

• Patient must not have other metastatic malignancies requiring current active treatment

• Patient must not have any severe active comorbidities, defined as follows:

• Unstable angina and/or congestive heart failure requiring hospitalization within 6 months prior to randomization

• Transmural myocardial infarction within 6 months prior to randomization

• Acute bacterial or fungal infection requiring intravenous antibiotics at the time of randomization

• Chronic obstructive pulmonary disease exacerbation or other acute respiratory illness precluding study therapy at the time of randomization

• Severe hepatic disease defined as a diagnosis of Child-Pugh class B or C hepatic disease

• Human immunodeficiency virus (HIV) positive with CD4 count < 200 cells/microliter

• Note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 16 weeks prior to randomization

• Note also that HIV testing is not required for eligibility for this protocol

• Patient must not be pregnant because of fetal risks from radiation exposure. Men must have agreed to use an effective contraceptive method during PCI and for six months after completing PCI. Women of reproductive potential must have agreed to use an effective contraceptive method during PCI. A woman is considered to be of reproductive potential if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, effective contraception also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

• Patients who speak and understand English or French must agree to participate in cognitive function testing

• Patient must be offered the opportunity to have specimens submitted for banking

• Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines

• As a part of the Oncology Patient Enrollment Network (OPEN) randomization process the treating institution?s identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Locations
United States
Alabama
University of Alabama at Birmingham Cancer Center
Recruiting
Birmingham
Arizona
University of Arizona Cancer Center-North Campus
Active, not recruiting
Tucson
University of Arizona Cancer Center-Orange Grove Campus
Active, not recruiting
Tucson
California
City of Hope Comprehensive Cancer Center
Recruiting
Duarte
Tibor Rubin VA Medical Center
Recruiting
Long Beach
Los Angeles County-USC Medical Center
Recruiting
Los Angeles
USC / Norris Comprehensive Cancer Center
Recruiting
Los Angeles
University of California Davis Comprehensive Cancer Center
Recruiting
Sacramento
City of Hope South Pasadena
Recruiting
South Pasadena
Colorado
Rocky Mountain Regional VA Medical Center
Recruiting
Aurora
University of Colorado Hospital
Recruiting
Aurora
Memorial Hospital North
Recruiting
Colorado Springs
UCHealth Memorial Hospital Central
Recruiting
Colorado Springs
Cancer Care and Hematology-Fort Collins
Recruiting
Fort Collins
Poudre Valley Hospital
Recruiting
Fort Collins
North Colorado Medical Center
Recruiting
Greeley
UCHealth Greeley Hospital
Recruiting
Greeley
UCHealth Highlands Ranch Hospital
Recruiting
Highlands Ranch
McKee Medical Center
Recruiting
Loveland
Medical Center of the Rockies
Recruiting
Loveland
Connecticut
Smilow Cancer Hospital Care Center at Greenwich
Recruiting
Greenwich
Smilow Cancer Hospital Care Center - Guiford
Recruiting
Guilford
Smilow Cancer Hospital-Hamden Care Center
Recruiting
Hamden
Yale University
Recruiting
New Haven
Smilow Cancer Hospital Care Center-Trumbull
Recruiting
Trumbull
Smilow Cancer Hospital Care Center - Waterford
Recruiting
Waterford
Veterans Affairs Connecticut Healthcare System-West Haven Campus
Recruiting
West Haven
Delaware
Beebe South Coastal Health Campus
Recruiting
Frankford
Christiana Care Health System-Christiana Hospital
Recruiting
Newark
Helen F Graham Cancer Center
Recruiting
Newark
Beebe Health Campus
Recruiting
Rehoboth Beach
Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables
Recruiting
Coral Gables
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Recruiting
Deerfield Beach
University of Florida Health Science Center - Gainesville
Recruiting
Gainesville
University of Miami Miller School of Medicine-Sylvester Cancer Center
Recruiting
Miami
Moffitt Cancer Center
Recruiting
Tampa
Georgia
Northside Hospital-Alpharetta
Recruiting
Alpharetta
Emory University Hospital/Winship Cancer Institute
Not yet recruiting
Atlanta
Northside Hospital
Recruiting
Atlanta
Augusta University Medical Center
Recruiting
Augusta
Northside Hospital-Cherokee
Recruiting
Canton
Northside Hospital-Forsyth
Recruiting
Cumming
Atlanta VA Medical Center
Recruiting
Decatur
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Recruiting
Savannah
Hawaii
Hawaii Cancer Care - Savio
Recruiting
'aiea
Pali Momi Medical Center
Recruiting
'aiea
The Cancer Center of Hawaii-Pali Momi
Recruiting
'aiea
Hawaii Cancer Care Inc - Waterfront Plaza
Recruiting
Honolulu
Kuakini Medical Center
Recruiting
Honolulu
Queen's Cancer Cenrer - POB I
Recruiting
Honolulu
Queen's Cancer Center - Kuakini
Recruiting
Honolulu
Queen's Medical Center
Recruiting
Honolulu
Straub Clinic and Hospital
Recruiting
Honolulu
The Cancer Center of Hawaii-Liliha
Recruiting
Honolulu
Iowa
McFarland Clinic PC - Ames
Recruiting
Ames
Medical Oncology and Hematology Associates-West Des Moines
Recruiting
Clive
Mercy Cancer Center-West Lakes
Recruiting
Clive
Greater Regional Medical Center
Recruiting
Creston
Broadlawns Medical Center
Recruiting
Des Moines
Iowa Lutheran Hospital
Recruiting
Des Moines
Iowa Methodist Medical Center
Recruiting
Des Moines
Medical Oncology and Hematology Associates-Des Moines
Recruiting
Des Moines
Medical Oncology and Hematology Associates-Laurel
Recruiting
Des Moines
Mercy Medical Center - Des Moines
Recruiting
Des Moines
Mercy Medical Center-West Lakes
Recruiting
West Des Moines
Methodist West Hospital
Recruiting
West Des Moines
Illinois
Alton Memorial Hospital
Recruiting
Alton
Northwestern University
Recruiting
Chicago
Rush University Medical Center
Recruiting
Chicago
University of Illinois
Active, not recruiting
Chicago
Carle on Vermilion
Recruiting
Danville
Cancer Care Specialists of Illinois - Decatur
Recruiting
Decatur
Decatur Memorial Hospital
Recruiting
Decatur
Carle Physician Group-Effingham
Recruiting
Effingham
Edward Hines Jr VA Hospital
Suspended
Hines
Carle Physician Group-Mattoon/Charleston
Recruiting
Mattoon
Loyola University Medical Center
Recruiting
Maywood
Methodist Medical Center of Illinois
Recruiting
Peoria
OSF Saint Francis Medical Center
Recruiting
Peoria
Memorial Medical Center
Recruiting
Springfield
Southern Illinois University School of Medicine
Recruiting
Springfield
Springfield Clinic
Recruiting
Springfield
Carle Cancer Center
Recruiting
Urbana
Kansas
University of Kansas Cancer Center
Recruiting
Kansas City
Lawrence Memorial Hospital
Suspended
Lawrence
University of Kansas Cancer Center-Overland Park
Recruiting
Overland Park
University of Kansas Hospital-Westwood Cancer Center
Recruiting
Westwood
Ascension Via Christi Hospitals Wichita
Recruiting
Wichita
Wesley Medical Center
Recruiting
Wichita
Kentucky
University of Kentucky/Markey Cancer Center
Recruiting
Lexington
The James Graham Brown Cancer Center at University of Louisville
Recruiting
Louisville
Louisiana
East Jefferson General Hospital
Recruiting
Metairie
Louisiana State University Health Science Center
Recruiting
New Orleans
University Medical Center New Orleans
Recruiting
New Orleans
Massachusetts
Boston Medical Center
Recruiting
Boston
Brigham and Women's Hospital
Recruiting
Boston
Dana-Farber Cancer Institute
Recruiting
Boston
Lahey Hospital and Medical Center
Recruiting
Burlington
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Recruiting
Milford
Beth Israel Deaconess Hospital-Plymouth
Recruiting
Plymouth
Dana-Farber/Brigham and Women's Cancer Center at South Shore
Recruiting
South Weymouth
Maryland
Anne Arundel Medical Center
Recruiting
Annapolis
University of Maryland/Greenebaum Cancer Center
Recruiting
Baltimore
Veterans Administration Medical Center-Baltimore
Recruiting
Baltimore
UM Upper Chesapeake Medical Center
Recruiting
Bel Air
Central Maryland Radiation Oncology in Howard County
Recruiting
Columbia
University of Maryland Shore Medical Center at Easton
Recruiting
Easton
UM Baltimore Washington Medical Center/Tate Cancer Center
Recruiting
Glen Burnie
Maine
MaineHealth Coastal Cancer Treatment Center
Recruiting
Bath
Lafayette Family Cancer Center-EMMC
Recruiting
Brewer
Maine Medical Center-Bramhall Campus
Recruiting
Portland
MaineHealth Cancer Care Center of York County
Recruiting
Sanford
Maine Medical Center- Scarborough Campus
Recruiting
Scarborough
Michigan
Saint Joseph Mercy Hospital
Recruiting
Ann Arbor
Saint Joseph Mercy Brighton
Recruiting
Brighton
Henry Ford Cancer Institute-Downriver
Recruiting
Brownstown
Saint Joseph Mercy Canton
Recruiting
Canton
Saint Joseph Mercy Chelsea
Recruiting
Chelsea
Beaumont Hospital - Dearborn
Recruiting
Dearborn
Ascension Saint John Hospital
Recruiting
Detroit
Henry Ford Hospital
Recruiting
Detroit
West Michigan Cancer Center
Recruiting
Kalamazoo
Saint Mary Mercy Hospital
Recruiting
Livonia
21st Century Oncology-Pontiac
Recruiting
Pontiac
Saint Joseph Mercy Oakland
Recruiting
Pontiac
William Beaumont Hospital-Royal Oak
Recruiting
Royal Oak
Ascension Saint Mary's Hospital
Recruiting
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Recruiting
Saginaw
Ascension Saint Joseph Hospital
Recruiting
Tawas City
Munson Medical Center
Recruiting
Traverse City
William Beaumont Hospital - Troy
Recruiting
Troy
Saint John Macomb-Oakland Hospital
Recruiting
Warren
Henry Ford West Bloomfield Hospital
Recruiting
West Bloomfield
Saint Mary's Oncology/Hematology Associates of West Branch
Recruiting
West Branch
IHA Hematology Oncology Consultants-Ann Arbor
Recruiting
Ypsilanti
Minnesota
Sanford Joe Lueken Cancer Center
Recruiting
Bemidji
Hennepin County Medical Center
Recruiting
Minneapolis
Missouri
Saint Francis Medical Center
Recruiting
Cape Girardeau
University of Missouri - Ellis Fischel
Recruiting
Columbia
Siteman Cancer Center at West County Hospital
Recruiting
Creve Coeur
Parkland Health Center - Farmington
Recruiting
Farmington
University of Kansas Cancer Center - North
Recruiting
Kansas City
University of Kansas Cancer Center at North Kansas City Hospital
Recruiting
North Kansas City
Delbert Day Cancer Institute at PCRMC
Recruiting
Rolla
Missouri Baptist Medical Center
Recruiting
Saint Louis
Siteman Cancer Center at Christian Hospital
Recruiting
Saint Louis
Siteman Cancer Center-South County
Recruiting
Saint Louis
Washington University School of Medicine
Recruiting
Saint Louis
Siteman Cancer Center at Saint Peters Hospital
Recruiting
Saint Peters
Sainte Genevieve County Memorial Hospital
Recruiting
Sainte Genevieve
Missouri Baptist Sullivan Hospital
Recruiting
Sullivan
Mississippi
Baptist Memorial Hospital and Cancer Center-Oxford
Recruiting
Oxford
Baptist Memorial Hospital and Cancer Center-Desoto
Recruiting
Southhaven
Montana
Saint James Community Hospital and Cancer Treatment Center
Recruiting
Butte
Benefis Healthcare- Sletten Cancer Institute
Recruiting
Great Falls
North Carolina
Durham VA Medical Center
Recruiting
Durham
CarolinaEast Medical Center
Recruiting
New Bern
North Dakota
Sanford Bismarck Medical Center
Recruiting
Bismarck
Sanford Broadway Medical Center
Recruiting
Fargo
Sanford Roger Maris Cancer Center
Recruiting
Fargo
Altru Cancer Center
Recruiting
Grand Forks
Nebraska
Alegent Health Bergan Mercy Medical Center
Recruiting
Omaha
Nebraska Methodist Hospital
Recruiting
Omaha
New Jersey
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
Recruiting
Elizabeth
Rutgers Cancer Institute of New Jersey
Recruiting
New Brunswick
Capital Health Medical Center-Hopewell
Recruiting
Pennington
Community Medical Center
Recruiting
Toms River
New Mexico
University of New Mexico Cancer Center
Recruiting
Albuquerque
New York
Montefiore Medical Center - Moses Campus
Recruiting
Bronx
Montefiore Medical Center-Einstein Campus
Recruiting
Bronx
Montefiore Medical Center-Weiler Hospital
Recruiting
Bronx
Roswell Park Cancer Institute
Recruiting
Buffalo
Sands Cancer Center
Recruiting
Canandaigua
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
Recruiting
New York
Highland Hospital
Recruiting
Rochester
University of Rochester
Recruiting
Rochester
Stony Brook University Medical Center
Recruiting
Stony Brook
State University of New York Upstate Medical University
Recruiting
Syracuse
Ohio
Cleveland Clinic Akron General
Recruiting
Akron
UHHS-Chagrin Highlands Medical Center
Recruiting
Beachwood
Cleveland Clinic Mercy Hospital
Recruiting
Canton
University of Cincinnati Cancer Center-UC Medical Center
Recruiting
Cincinnati
Case Western Reserve University
Recruiting
Cleveland
Louis Stokes Cleveland VA Medical Center
Recruiting
Cleveland
Ohio State University Comprehensive Cancer Center
Recruiting
Columbus
Riverside Methodist Hospital
Recruiting
Columbus
Dublin Methodist Hospital
Recruiting
Dublin
Mount Carmel Grove City Hospital
Recruiting
Grove City
UH Seidman Cancer Center at Lake Health Mentor Campus
Recruiting
Mentor
UH Seidman Cancer Center at Southwest General Hospital
Recruiting
Middleburg Heights
Mercy Health Perrysburg Cancer Center
Recruiting
Perrysburg
University Hospitals Portage Medical Center
Recruiting
Ravenna
University of Cincinnati Cancer Center-West Chester
Recruiting
West Chester
UH Seidman Cancer Center at Saint John Medical Center
Recruiting
Westlake
UHHS-Westlake Medical Center
Recruiting
Westlake
Genesis Healthcare System Cancer Care Center
Recruiting
Zanesville
Oklahoma
University of Oklahoma Health Sciences Center
Recruiting
Oklahoma City
Pennsylvania
UPMC-Heritage Valley Health System Beaver
Recruiting
Beaver
Crozer-Keystone Regional Cancer Center at Broomall
Recruiting
Broomall
Carlisle Regional Cancer Center
Recruiting
Carlisle
Christiana Care Health System-Concord Health Center
Recruiting
Chadds Ford
Geisinger Medical Center
Recruiting
Danville
Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
Recruiting
East Norriton
Ephrata Cancer Center
Recruiting
Ephrata
UPMC Cancer Center at UPMC Horizon
Recruiting
Farrell
Fox Chase Cancer Center Buckingham
Recruiting
Furlong
Adams Cancer Center
Recruiting
Gettysburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Recruiting
Greensburg
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Recruiting
Harrisburg
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Recruiting
Johnstown
Sechler Family Cancer Center
Recruiting
Lebanon
Geisinger Medical Oncology-Lewisburg
Recruiting
Lewisburg
UPMC Cancer Center at UPMC McKeesport
Recruiting
Mckeesport
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Recruiting
Mechanicsburg
UPMC Cancer Center - Monroeville
Recruiting
Monroeville
UPMC-Coraopolis/Heritage Valley Radiation Oncology
Recruiting
Moon
Fox Chase Cancer Center
Recruiting
Philadelphia
Temple University Hospital
Recruiting
Philadelphia
University of Pittsburgh Cancer Institute (UPCI)
Recruiting
Pittsburgh
UPMC-Magee Womens Hospital
Recruiting
Pittsburgh
UPMC-Passavant Hospital
Recruiting
Pittsburgh
UPMC-Saint Clair Hospital Cancer Center
Recruiting
Pittsburgh
UPMC-Saint Margaret
Recruiting
Pittsburgh
UPMC-Shadyside Hospital
Recruiting
Pittsburgh
Guthrie Medical Group PC-Robert Packer Hospital
Recruiting
Sayre
UPMC Cancer Center at UPMC Northwest
Recruiting
Seneca
UPMC Uniontown Hospital Radiation Oncology
Recruiting
Uniontown
UPMC Washington Hospital Radiation Oncology
Recruiting
Washington
UPMC Memorial
Recruiting
York
WellSpan Health-York Cancer Center
Recruiting
York
South Carolina
Saint Joseph's/Candler - Bluffton Campus
Recruiting
Bluffton
Saint Francis Cancer Center
Recruiting
Greenville
Saint Francis Hospital
Recruiting
Greenville
Self Regional Healthcare
Active, not recruiting
Greenwood
Gibbs Cancer Center-Pelham
Recruiting
Greer
Spartanburg Medical Center
Recruiting
Spartanburg
South Dakota
Avera Cancer Institute at Pierre
Recruiting
Pierre
Avera Cancer Institute
Recruiting
Sioux Falls
Sanford Cancer Center Oncology Clinic
Recruiting
Sioux Falls
Sanford USD Medical Center - Sioux Falls
Recruiting
Sioux Falls
Avera Cancer Institute at Yankton
Recruiting
Yankton
Tennessee
Baptist Memorial Hospital and Cancer Center-Collierville
Recruiting
Collierville
Baptist Memorial Hospital and Cancer Center-Memphis
Recruiting
Memphis
Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Recruiting
Houston
Ben Taub General Hospital
Recruiting
Houston
M D Anderson Cancer Center
Recruiting
Houston
Michael E DeBakey VA Medical Center
Recruiting
Houston
Utah
Farmington Health Center
Recruiting
Farmington
Huntsman Cancer Institute/University of Utah
Recruiting
Salt Lake City
University of Utah Sugarhouse Health Center
Recruiting
Salt Lake City
Virginia
Augusta Health Center for Cancer and Blood Disorders
Recruiting
Fishersville
VCU Massey Cancer Center at Stony Point
Recruiting
Richmond
Virginia Commonwealth University/Massey Cancer Center
Recruiting
Richmond
Wisconsin
ThedaCare Regional Cancer Center
Recruiting
Appleton
Marshfield Medical Center-EC Cancer Center
Recruiting
Eau Claire
Aurora BayCare Medical Center
Recruiting
Green Bay
Gundersen Lutheran Medical Center
Recruiting
La Crosse
Marshfield Medical Center-Marshfield
Recruiting
Marshfield
Aurora Saint Luke's Medical Center
Recruiting
Milwaukee
Aurora Sinai Medical Center
Recruiting
Milwaukee
Zablocki Veterans Administration Medical Center
Recruiting
Milwaukee
Marshfield Clinic-Minocqua Center
Recruiting
Minocqua
ProHealth D N Greenwald Center
Recruiting
Mukwonago
ProHealth Oconomowoc Memorial Hospital
Recruiting
Oconomowoc
Marshfield Medical Center-Rice Lake
Recruiting
Rice Lake
Marshfield Clinic Stevens Point Center
Recruiting
Stevens Point
UW Cancer Center at ProHealth Care
Recruiting
Waukesha
Aurora West Allis Medical Center
Recruiting
West Allis
Marshfield Medical Center - Weston
Recruiting
Weston
Other Locations
Canada
Juravinski Cancer Centre at Hamilton Health Sciences
Recruiting
Hamilton
Lakeridge Health Oshawa
Recruiting
Oshawa
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Recruiting
Quebec City
Allan Blair Cancer Centre
Recruiting
Regina
Atlantic Health Sciences Corporation-Saint John Regional Hospital
Recruiting
Saint John
Doctor H. Bliss Murphy Cancer Centre
Recruiting
St. John's
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Recruiting
Toronto
CancerCare Manitoba
Recruiting
Winnipeg
Time Frame
Start Date: January 10, 2020
Estimated Completion Date: November 15, 2027
Participants
Target number of participants: 668
Treatments
Active Comparator: Arm I (PCI, MRI)
Patients undergo conventional or hippocampal avoidance PCI over 20 minutes 5 days per week for 2 weeks. Patients also undergo MRI scan at 3, 6, 9, 12, 18, and 24 months.
Experimental: Arm II (MRI)
Patients undergo MRI scan at 3, 6, 9, 12, 18, and 24 months.
Authors
James M. Koomey, Jeffrey A. Kittel, Clifford G. Robinson, Inga S. Grills, Sinisa Stanic, Bradford A. Perez, David E. Marinier, Matthew S. Ning, Timothy J. Kruser, Thomas J. Gergel, Simon K. Cheng, Sharon A. Spencer, Robert J. Behrens, Atul Kumar, Scott E. Delacroix, Bryan A. Faller, Richard A. Peterson, Preston D. Steen, Matthew M. Harkenrider, Ashok Ramalingam, Shirnett K. Williamson, Kyle Arneson, Yuhchyau Chen, Grant R. Seeger, Timothy V. Waxweiler, Jay W. Carlson, Jeffrey L. Berenberg, Kartik M. Mani, Gaurav Marwaha, Neal E. Dunlap, Matthew J. Ferris, Jeremy Brownstein, Lawrence E. Feldman, Anand K. Sharma, Timothy R. Wassenaar, Howard A. Zaren, Tithi Biswas, Sarah J. Sinclair, Shailesh R. Satpute, Stephanie E. Weiss, Timothy D. Moore, Drew Moghanaki, John M. Schallenkamp, Ding Wang, Wayne B. Harris, Saif A. Aljabab, Gregory A. Masters, Anamaria R. Yeung, Pankaj Gupta, Mohamed E. Abazeed, David E. Kozono, Matthew D. Cheney, Christine Bang, Joseph K. Salama, Megan E. Daly, Itai M. Pashtan, Joshua Lukenbill, Shaneli A. Fernando, Nitin Ohri, Mitchel L. Fromm, Michael D. Mix, Joshua T. Mckenzie, Puja Nistala, Pavan M. Jhaveri, Samir Narayan, Nicholas DiBella, Charles C. Hsu, Stephanie Macausland, Fiori Alite, Elizabeth M. Gore, Debra M. Prow, Robert M. Kyler, Rachelle M. Lanciano, Aryavarta M. Kumar, Seth M. Miller, Tyler Gunter, Heath D. Skinner, Asa J. Nixon, Chad G. Rusthoven, Shaker R. Dakhil, Arya Amini, Henry S. Park, Amar Rewari, Albert C. Chen, Edward J. Walsh, Rodolfo E. Bordoni, Fen Wang, Jessica D. McDermott, Albert Attia, Bevan Ly, Kristine E. Kokeny, Emily C. Daugherty, James S. Welsh, Dheerendra Prasad, Richard L. Deming, Kimberley S. Mak, Emily S. Kowalski, Joel Broomfield, Elisabeth Weiss, Ian Gallaher, Caroline Lavoie, John G. Phillips, Ronald C. McGarry, Amit B. Shah, Tejan Diwanji, Sharad A. Ghamande, Amarinthia (Amy) Curtis, Tien-Shew W. Huang, Jyoti Malhotra, Jonathan D. Greenland, Alan Libardi Dal Pra, Herta H. Chao, Alexander V. Louie, Anand Swaminath, Kathleen J. Yost, Nelson Leong, Jason C. Ye, Farah Naz, Bashir M. Bashir
Sponsors
Collaborators: National Cancer Institute (NCI)
Leads: Southwest Oncology Group

This content was sourced from clinicaltrials.gov

Similar Clinical Trials