(CompassHER2-pCR): Preoperative THP and Postoperative HP in Patients Who Achieve a Pathologic Complete Response

Who is this study for? Patients with Breast Cancer
What treatments are being studied? Docetaxel+Lumpectomy+Mastectomy+Nab-Paclitaxel+Paclitaxel+Pertuzumab+Trastuzumab
Status: Recruiting
Location: See all (926) locations...
Intervention Type: Procedure, Biological, Drug, Radiation
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Trastuzumab and pertuzumab are both a form of targeted therapy because they work by attaching themselves to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When these drugs attach to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving paclitaxel, trastuzumab, and pertuzumab may enable fewer chemotherapy drugs to be given without compromising patient outcomes compared to the usual treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

• Patient must have histologically confirmed HER2-positive primary invasive breast carcinoma, determined by local testing. The tumor must have either HER2 IHC result of 3+ or HER2/CEP17 ratio > 2 with > 4.0 HER2 signals per cell by ISH. Tumors with HER2/CEP17 ISH ratio < 2 are ineligible, even if HER2 copy number is > 6, unless HER2 IHC result is 3+.

• Patients hormone receptor (estrogen receptor [ER] and progesterone receptor [PR]) status must be known and will be determined by local testing. Patients with either hormone receptor -positive or hormone receptor- negative HER2-positive breast cancer are eligible

• Patients must have AJCC 8th Edition stage II or IIIa according to anatomic staging table at diagnosis

• Patients without nodal involvement (cN0) are eligible if T size > 2.0 cm (T2-3)

• Patients with nodal involvement (cN1-2) are eligible if T1-3

• Patients with clinical T4 or N3 disease are not eligible

• Patient must be willing and able (i.e., have no contraindication) to receive standard adjuvant therapy, consisting of HER2-directed therapy, radiation (if indicated) and endocrine therapy (if ER+) if achieving pCR at surgery

• Patient with bilateral invasive breast cancers are eligible if both cancers are HER2-positive (as defined in 3.1.3) at least one meets protocol eligibility and neither cancer renders the patient ineligible (i.e. per eligibility 3.1.5)

• Patients with multiple ipsilateral invasive tumors are eligible as long as all tumors are HER2-positive, and at least one tumor focus meets eligibility criteria (per eligibility 3.1.5). Multiple lesions that appear part of the same index tumor do not require additional biopsy/HER2 testing. Multiple lesions that appear part of the same index tumor do not require additional biopsy/HER2 testing. However, even if biopsy is not deemed necessary, consideration should be given to placing a clip in any lesion that is 1 cm or further from the primary tumor to ensure that all tumor is removed at surgery AND that the pathologist can locate all primary sites of tumor to assess pathologic response at surgery.

• Patients with a history of other non-breast malignancies are eligible if they have been disease-free for at least 5 years, and are deemed by the investigator to be at low risk for recurrence of that malignancy.

• Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, basal cell or squamous cell carcinoma of the skin, and localized papillary or follicular thyroid cancer who have completed recommended treatment including surgery. Patients with any other cancers within the last 5 years are ineligible.

• Patents must have a left ventricular ejection fraction (LVEF) within normal institutional parameters (or > 50%)

• Patients must not have > grade 1 peripheral neuropathy of any etiology.

• Patients must have a bilateral mammogram and a diagnostic breast ultrasound [on the side of the cancer(s)] (with or without breast MRI) performed at screening. An axillary ultrasound on the side of the cancer(s) is also required. However, if a patient has a negative axillary physical exam and a baseline MRI without suspicious lymph nodes performed before axillary ultrasound, axillary ultrasound may be omitted. Comprehensive breast and axillary imaging must be performed within 42 days of registration (i.e. the patient's mammogram/ breast ultrasound /axillary ultrasound OR their breast MRI).

• Baseline imaging of the ipsilateral axilla by ultrasound or breast MRI is mandatory. For subjects with axillary lymph node(s) suspicious on clinical exam or imaging, patient must be willing to have a needle aspiration or core biopsy to determine the presence of metastatic disease in the lymph nodes. A clip must be placed in the involved axillary lymph node. (If there are more than 1 suspicious axillary nodes, only one clipped node is required).

• Patient of childbearing potential and sexually active patients must use accepted and effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for 7 months after the last dose of study treatment.

• Patient must be willing and able to sign informed consent

• Leukocytes >= 3,000/mcL (obtained =< 28 days prior to protocol registration)

• Absolute neutrophil count >= 1,500/mcL (obtained =< 28 days prior to protocol registration)

• Platelets >= 100,000/mcL (obtained =< 28 days prior to protocol registration)

• Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (obtained =< 28 days prior to protocol registration)

• Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (obtained =< 28 days prior to protocol registration)

• Creatinine =< 1.5 x institutional ULN (obtained =< 28 days prior to protocol registration)

• Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial

• For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated

• Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

Locations
United States
Alaska
Alaska Breast Care and Surgery LLC
Recruiting
Anchorage
Alaska Oncology and Hematology LLC
Recruiting
Anchorage
Alaska Women's Cancer Care
Recruiting
Anchorage
Anchorage Associates in Radiation Medicine
Recruiting
Anchorage
Anchorage Oncology Centre
Recruiting
Anchorage
Anchorage Radiation Therapy Center
Recruiting
Anchorage
Katmai Oncology Group
Recruiting
Anchorage
Providence Alaska Medical Center
Recruiting
Anchorage
Fairbanks Memorial Hospital
Recruiting
Fairbanks
Alabama
University of Alabama at Birmingham Cancer Center
Recruiting
Birmingham
Arkansas
Mercy Hospital Fort Smith
Recruiting
Fort Smith
CHI Saint Vincent Cancer Center Hot Springs
Suspended
Hot Springs
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Recruiting
Jonesboro
Arizona
Kingman Regional Medical Center
Recruiting
Kingman
Cancer Center at Saint Joseph's
Recruiting
Phoenix
Banner University Medical Center - Tucson
Recruiting
Tucson
University of Arizona Cancer Center-North Campus
Recruiting
Tucson
University of Arizona Cancer Center-Orange Grove Campus
Recruiting
Tucson
California
Mission Hope Medical Oncology - Arroyo Grande
Recruiting
Arroyo Grande
PCR Oncology
Recruiting
Arroyo Grande
Sutter Auburn Faith Hospital
Recruiting
Auburn
Sutter Cancer Centers Radiation Oncology Services-Auburn
Recruiting
Auburn
Alta Bates Summit Medical Center-Herrick Campus
Recruiting
Berkeley
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Recruiting
Burbank
Mills-Peninsula Medical Center
Suspended
Burlingame
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Recruiting
Cameron Park
Eden Hospital Medical Center
Recruiting
Castro Valley
Sutter Davis Hospital
Recruiting
Davis
Epic Care-Dublin
Recruiting
Dublin
Bay Area Breast Surgeons Inc
Recruiting
Emeryville
Epic Care Partners in Cancer Care
Recruiting
Emeryville
Palo Alto Medical Foundation-Fremont
Recruiting
Fremont
Washington Hospital
Recruiting
Fremont
Keck Medicine of USC Huntington Beach
Active, not recruiting
Huntington Beach
Los Angeles County-USC Medical Center
Active, not recruiting
Los Angeles
USC / Norris Comprehensive Cancer Center
Active, not recruiting
Los Angeles
Contra Costa Regional Medical Center
Recruiting
Martinez
Fremont - Rideout Cancer Center
Recruiting
Marysville
Memorial Medical Center
Recruiting
Modesto
Palo Alto Medical Foundation-Camino Division
Recruiting
Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology
Recruiting
Mountain View
USC Norris Oncology/Hematology-Newport Beach
Active, not recruiting
Newport Beach
Alta Bates Summit Medical Center - Summit Campus
Suspended
Oakland
Bay Area Tumor Institute
Recruiting
Oakland
Saint Joseph Hospital - Orange
Recruiting
Orange
Desert Regional Medical Center
Recruiting
Palm Springs
Palo Alto Medical Foundation Health Care
Recruiting
Palo Alto
Stanford Cancer Institute Palo Alto
Recruiting
Palo Alto
Keck Medical Center of USC Pasadena
Active, not recruiting
Pasadena
Sutter Cancer Centers Radiation Oncology Services-Roseville
Recruiting
Roseville
Sutter Roseville Medical Center
Recruiting
Roseville
Sutter Medical Center Sacramento
Recruiting
Sacramento
Saint Helena Hospital
Recruiting
Saint Helena
Salinas Valley Memorial
Recruiting
Salinas
California Pacific Medical Center-Pacific Campus
Recruiting
San Francisco
Zuckerberg San Francisco General Hospital
Recruiting
San Francisco
Stanford Cancer Center South Bay
Recruiting
San Jose
Pacific Central Coast Health Center-San Luis Obispo
Recruiting
San Luis Obispo
Palo Alto Medical Foundation-Santa Cruz
Recruiting
Santa Cruz
Mission Hope Medical Oncology - Santa Maria
Recruiting
Santa Maria
Sutter Pacific Medical Foundation
Recruiting
Santa Rosa
Palo Alto Medical Foundation-Sunnyvale
Recruiting
Sunnyvale
Gene Upshaw Memorial Tahoe Forest Cancer Center
Recruiting
Truckee
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Recruiting
Vacaville
Sutter Solano Medical Center/Cancer Center
Recruiting
Vallejo
Epic Care Cyberknife Center
Recruiting
Walnut Creek
Colorado
Rocky Mountain Cancer Centers-Aurora
Recruiting
Aurora
The Medical Center of Aurora
Recruiting
Aurora
University of Colorado Hospital
Recruiting
Aurora
Boulder Community Foothills Hospital
Recruiting
Boulder
Rocky Mountain Cancer Centers-Boulder
Recruiting
Boulder
Rocky Mountain Cancer Centers - Centennial
Recruiting
Centennial
Memorial Hospital North
Recruiting
Colorado Springs
Penrose-Saint Francis Healthcare
Recruiting
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
Recruiting
Colorado Springs
Saint Francis Cancer Center
Recruiting
Colorado Springs
UCHealth Memorial Hospital Central
Recruiting
Colorado Springs
Colorado Blood Cancer Institute
Recruiting
Denver
Porter Adventist Hospital
Recruiting
Denver
Presbyterian - Saint Lukes Medical Center - Health One
Recruiting
Denver
Rocky Mountain Cancer Centers-Midtown
Recruiting
Denver
Rocky Mountain Cancer Centers-Rose
Recruiting
Denver
Rose Medical Center
Recruiting
Denver
The Women's Imaging Center
Recruiting
Denver
UCHealth - Cherry Creek
Recruiting
Denver
Western Surgical Care
Recruiting
Denver
Mercy Medical Center
Recruiting
Durango
Southwest Oncology PC
Recruiting
Durango
Mountain Blue Cancer Care Center - Swedish
Recruiting
Englewood
Rocky Mountain Cancer Centers - Swedish
Recruiting
Englewood
Swedish Medical Center
Recruiting
Englewood
The Melanoma and Skin Cancer Institute
Recruiting
Englewood
Cancer Care and Hematology-Fort Collins
Recruiting
Fort Collins
Poudre Valley Hospital
Recruiting
Fort Collins
Grand Valley Oncology
Recruiting
Grand Junction
North Colorado Medical Center
Suspended
Greeley
UCHealth Greeley Hospital
Recruiting
Greeley
UCHealth Highlands Ranch Hospital
Recruiting
Highlands Ranch
Rocky Mountain Cancer Centers-Lakewood
Recruiting
Lakewood
Saint Anthony Hospital
Recruiting
Lakewood
Littleton Adventist Hospital
Recruiting
Littleton
Rocky Mountain Cancer Centers-Littleton
Recruiting
Littleton
Rocky Mountain Cancer Centers-Sky Ridge
Recruiting
Lone Tree
Sky Ridge Medical Center
Recruiting
Lone Tree
UCHealth Lone Tree Health Center
Recruiting
Lone Tree
Longmont United Hospital
Recruiting
Longmont
Rocky Mountain Cancer Centers-Longmont
Suspended
Longmont
McKee Medical Center
Suspended
Loveland
Medical Center of the Rockies
Recruiting
Loveland
Parker Adventist Hospital
Recruiting
Parker
Saint Mary Corwin Medical Center
Recruiting
Pueblo
Rocky Mountain Cancer Centers-Thornton
Recruiting
Thornton
Connecticut
Hartford HealthCare - Saint Vincent's Medical Center
Recruiting
Bridgeport
Smilow Cancer Hospital-Derby Care Center
Recruiting
Derby
Smilow Cancer Hospital Care Center-Fairfield
Recruiting
Fairfield
Smilow Cancer Hospital Care Center at Glastonbury
Recruiting
Glastonbury
Smilow Cancer Hospital Care Center at Greenwich
Recruiting
Greenwich
Smilow Cancer Hospital Care Center - Guiford
Recruiting
Guilford
Hartford Hospital
Recruiting
Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Recruiting
Hartford
Midstate Medical Center
Recruiting
Meriden
The Hospital of Central Connecticut
Recruiting
New Britain
Smilow Cancer Center/Yale-New Haven Hospital
Recruiting
New Haven
Yale University
Recruiting
New Haven
Yale-New Haven Hospital North Haven Medical Center
Recruiting
North Haven
Smilow Cancer Hospital-Orange Care Center
Recruiting
Orange
Smilow Cancer Hospital Care Center at Long Ridge
Recruiting
Stamford
Stamford Hospital/Bennett Cancer Center
Recruiting
Stamford
Smilow Cancer Hospital-Torrington Care Center
Recruiting
Torrington
Smilow Cancer Hospital Care Center-Trumbull
Recruiting
Trumbull
Smilow Cancer Hospital-Waterbury Care Center
Recruiting
Waterbury
Smilow Cancer Hospital Care Center - Waterford
Recruiting
Waterford
Washington, D.c.
Kaiser Permanente-Capitol Hill Medical Center
Recruiting
Washington
Sibley Memorial Hospital
Recruiting
Washington
Delaware
Beebe South Coastal Health Campus
Recruiting
Frankford
Beebe Medical Center
Recruiting
Lewes
Christiana Care Health System-Christiana Hospital
Recruiting
Newark
Delaware Clinical and Laboratory Physicians PA
Recruiting
Newark
Helen F Graham Cancer Center
Recruiting
Newark
Medical Oncology Hematology Consultants PA
Recruiting
Newark
Beebe Health Campus
Recruiting
Rehoboth Beach
TidalHealth Nanticoke / Allen Cancer Center
Suspended
Seaford
Christiana Care Health System-Wilmington Hospital
Recruiting
Wilmington
Florida
AdventHealth Altamonte
Recruiting
Altamonte Springs
Mount Sinai Comprehensive Cancer Center at Aventura
Recruiting
Aventura
UM Sylvester Comprehensive Cancer Center at Aventura
Recruiting
Aventura
AdventHealth Celebration
Recruiting
Celebration
Morton Plant Hospital
Recruiting
Clearwater
UM Sylvester Comprehensive Cancer Center at Coral Gables
Recruiting
Coral Gables
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Recruiting
Deerfield Beach
University of Florida Health Science Center - Gainesville
Recruiting
Gainesville
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Recruiting
Hollywood
Mayo Clinic in Florida
Active, not recruiting
Jacksonville
AdventHealth Kissimmee
Suspended
Kissimmee
UM Sylvester Comprehensive Cancer Center at Kendall
Recruiting
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Recruiting
Miami
Mount Sinai Medical Center
Recruiting
Miami Beach
AdventHealth East Orlando
Suspended
Orlando
AdventHealth Medical Group Urology at Orlando
Suspended
Orlando
AdventHealth Orlando
Recruiting
Orlando
Memorial Hospital West
Recruiting
Pembroke Pines
UM Sylvester Comprehensive Cancer Center at Plantation
Recruiting
Plantation
Mease Countryside Hospital
Recruiting
Safety Harbor
Winter Haven Hospital
Recruiting
Winter Haven
AdventHealth Winter Park
Suspended
Winter Park
Georgia
Emory Saint Joseph's Hospital
Recruiting
Atlanta
Emory University Hospital Midtown
Recruiting
Atlanta
Emory University Hospital/Winship Cancer Institute
Recruiting
Atlanta
Grady Health System
Recruiting
Atlanta
Northside Hospital
Recruiting
Atlanta
Hamilton Medical Center - Peeples Cancer Institute
Recruiting
Dalton
Northside Hospital - Duluth
Recruiting
Duluth
Northside Hospital - Gwinnett
Recruiting
Lawrenceville
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Recruiting
Savannah
Suburban Hematology Oncology Associates - Snellville
Recruiting
Snellville
Lewis Hall Singletary Oncology Center
Recruiting
Thomasville
Iowa
Mary Greeley Medical Center
Recruiting
Ames
McFarland Clinic PC - Ames
Recruiting
Ames
McFarland Clinic PC-Boone
Recruiting
Boone
Saint Anthony Regional Hospital
Recruiting
Carroll
Mercy Hospital
Recruiting
Cedar Rapids
Oncology Associates at Mercy Medical Center
Recruiting
Cedar Rapids
Medical Oncology and Hematology Associates-West Des Moines
Recruiting
Clive
Mercy Cancer Center-West Lakes
Recruiting
Clive
Alegent Health Mercy Hospital
Recruiting
Council Bluffs
Greater Regional Medical Center
Recruiting
Creston
Genesis Cancer Care Institute
Recruiting
Davenport
Genesis Medical Center - East Campus
Recruiting
Davenport
Iowa Cancer Specialists
Recruiting
Davenport
Broadlawns Medical Center
Recruiting
Des Moines
Iowa Lutheran Hospital
Recruiting
Des Moines
Iowa Methodist Medical Center
Recruiting
Des Moines
Medical Oncology and Hematology Associates-Des Moines
Recruiting
Des Moines
Medical Oncology and Hematology Associates-Laurel
Recruiting
Des Moines
Mercy Medical Center - Des Moines
Recruiting
Des Moines
McFarland Clinic PC-Trinity Cancer Center
Recruiting
Fort Dodge
Trinity Regional Medical Center
Recruiting
Fort Dodge
McFarland Clinic PC-Jefferson
Recruiting
Jefferson
McFarland Clinic PC-Marshalltown
Recruiting
Marshalltown
Mercy Medical Center-West Lakes
Recruiting
West Des Moines
Methodist West Hospital
Recruiting
West Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Recruiting
Boise
Saint Luke's Cancer Institute - Boise
Recruiting
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Recruiting
Caldwell
Kootenai Health - Coeur d'Alene
Recruiting
Coeur D'alene
Walter Knox Memorial Hospital
Recruiting
Emmett
Saint Luke's Cancer Institute - Fruitland
Recruiting
Fruitland
Idaho Urologic Institute-Meridian
Recruiting
Meridian
Saint Luke's Cancer Institute - Meridian
Recruiting
Meridian
Saint Alphonsus Medical Center-Nampa
Recruiting
Nampa
Saint Luke's Cancer Institute - Nampa
Recruiting
Nampa
Kootenai Clinic Cancer Services - Post Falls
Recruiting
Post Falls
Kootenai Cancer Clinic
Recruiting
Sandpoint
Saint Luke's Cancer Institute - Twin Falls
Recruiting
Twin Falls
Illinois
Saint Anthony's Health
Recruiting
Alton
Rush - Copley Medical Center
Recruiting
Aurora
Illinois CancerCare-Bloomington
Recruiting
Bloomington
Illinois CancerCare-Canton
Recruiting
Canton
Memorial Hospital of Carbondale
Recruiting
Carbondale
SIH Cancer Institute
Recruiting
Carterville
Illinois CancerCare-Carthage
Recruiting
Carthage
Centralia Oncology Clinic
Recruiting
Centralia
Mount Sinai Hospital Medical Center
Recruiting
Chicago
Northwestern University
Recruiting
Chicago
Rush University Medical Center
Recruiting
Chicago
Swedish Covenant Hospital
Suspended
Chicago
University of Chicago Comprehensive Cancer Center
Recruiting
Chicago
University of Illinois
Recruiting
Chicago
Carle on Vermilion
Recruiting
Danville
Cancer Care Specialists of Illinois - Decatur
Recruiting
Decatur
Decatur Memorial Hospital
Recruiting
Decatur
Illinois CancerCare-Dixon
Recruiting
Dixon
Carle Physician Group-Effingham
Recruiting
Effingham
Crossroads Cancer Center
Recruiting
Effingham
Illinois CancerCare-Eureka
Recruiting
Eureka
NorthShore University HealthSystem-Evanston Hospital
Recruiting
Evanston
Illinois CancerCare-Galesburg
Recruiting
Galesburg
Western Illinois Cancer Treatment Center
Recruiting
Galesburg
NorthShore University HealthSystem-Glenbrook Hospital
Recruiting
Glenview
NorthShore University HealthSystem-Highland Park Hospital
Recruiting
Highland Park
Duly Health and Care Joliet
Recruiting
Joliet
Illinois CancerCare-Kewanee Clinic
Recruiting
Kewanee
Northwestern Medicine Lake Forest Hospital
Recruiting
Lake Forest
Illinois CancerCare-Macomb
Recruiting
Macomb
Carle Physician Group-Mattoon/Charleston
Recruiting
Mattoon
Good Samaritan Regional Health Center
Recruiting
Mount Vernon
UC Comprehensive Cancer Center at Silver Cross
Recruiting
New Lenox
Cancer Care Center of O'Fallon
Recruiting
O'fallon
University of Chicago Medicine-Orland Park
Recruiting
Orland Park
Illinois CancerCare-Ottawa Clinic
Recruiting
Ottawa
Advocate Lutheran General Hospital
Recruiting
Park Ridge
Illinois CancerCare-Pekin
Recruiting
Pekin
Illinois CancerCare-Peoria
Recruiting
Peoria
Methodist Medical Center of Illinois
Recruiting
Peoria
Illinois CancerCare-Peru
Recruiting
Peru
Valley Radiation Oncology
Recruiting
Peru
Illinois CancerCare-Princeton
Recruiting
Princeton
SwedishAmerican Regional Cancer Center/ACT
Recruiting
Rockford
Genesis Cancer Center - Silvis
Recruiting
Silvis
North Shore Medical Center
Recruiting
Skokie
Memorial Medical Center
Recruiting
Springfield
Southern Illinois University School of Medicine
Recruiting
Springfield
Springfield Clinic
Recruiting
Springfield
Southwest Illinois Health Services LLP
Suspended
Swansea
Carle Cancer Center
Recruiting
Urbana
The Carle Foundation Hospital
Recruiting
Urbana
Illinois CancerCare - Washington
Recruiting
Washington
Rush-Copley Healthcare Center
Recruiting
Yorkville
Indiana
IU Health North Hospital
Recruiting
Carmel
Community Cancer Center East
Recruiting
Indianapolis
Community Cancer Center North
Recruiting
Indianapolis
Community Cancer Center South
Recruiting
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
Recruiting
Indianapolis
Sidney and Lois Eskenazi Hospital
Recruiting
Indianapolis
Community Howard Regional Health
Recruiting
Kokomo
Reid Health
Recruiting
Richmond
Kansas
Cancer Center of Kansas - Chanute
Recruiting
Chanute
Cancer Center of Kansas - Dodge City
Recruiting
Dodge City
Cancer Center of Kansas - El Dorado
Recruiting
El Dorado
Central Care Cancer Center - Garden City
Recruiting
Garden City
Central Care Cancer Center - Great Bend
Recruiting
Great Bend
Cancer Center of Kansas-Independence
Recruiting
Independence
Cancer Center of Kansas-Kingman
Recruiting
Kingman
Cancer Center of Kansas-Liberal
Recruiting
Liberal
Cancer Center of Kansas-Manhattan
Recruiting
Manhattan
Cancer Center of Kansas - McPherson
Recruiting
Mcpherson
Cancer Center of Kansas - Newton
Recruiting
Newton
Cancer Center of Kansas - Parsons
Recruiting
Parsons
Cancer Center of Kansas - Pratt
Recruiting
Pratt
Cancer Center of Kansas - Salina
Recruiting
Salina
Cancer Center of Kansas - Wellington
Recruiting
Wellington
Ascension Via Christi Hospitals Wichita
Recruiting
Wichita
Cancer Center of Kansas - Wichita
Recruiting
Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower
Recruiting
Wichita
Cancer Center of Kansas - Winfield
Recruiting
Winfield
Kentucky
King's Daughter's Medical Center
Recruiting
Ashland
Flaget Memorial Hospital
Recruiting
Bardstown
Baptist Health Corbin
Recruiting
Corbin
Commonwealth Cancer Center-Corbin
Recruiting
Corbin
Baptist Health Lexington
Recruiting
Lexington
Saint Joseph Hospital East
Recruiting
Lexington
Saint Joseph Radiation Oncology Resource Center
Recruiting
Lexington
University of Kentucky/Markey Cancer Center
Recruiting
Lexington
Saint Joseph London
Recruiting
London
Baptist Health Louisville
Recruiting
Louisville
Jewish Hospital
Suspended
Louisville
Saints Mary and Elizabeth Hospital
Suspended
Louisville
UofL Health Medical Center Northeast
Suspended
Louisville
Baptist Health Madisonville/Merle Mahr Cancer Center
Recruiting
Madisonville
Baptist Health Paducah
Recruiting
Paducah
Jewish Hospital Medical Center South
Suspended
Shepherdsville
Louisiana
Ochsner Hematology Oncology North Shore - Covington (West Region)
Recruiting
Covington
Louisiana State University Health Science Center
Recruiting
New Orleans
Ochsner Medical Center Jefferson
Recruiting
New Orleans
University Medical Center New Orleans
Recruiting
New Orleans
LSU Health Sciences Center at Shreveport
Recruiting
Shreveport
Massachusetts
Beverly Hospital
Recruiting
Beverly
Beth Israel Deaconess Medical Center
Recruiting
Boston
Boston Medical Center
Recruiting
Boston
Dana-Farber Cancer Institute
Recruiting
Boston
Tufts Medical Center
Recruiting
Boston
Lahey Hospital and Medical Center
Recruiting
Burlington
Addison Gilbert Hospital
Recruiting
Gloucester
Lowell General Hospital
Recruiting
Lowell
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Recruiting
Milford
Lahey Medical Center-Peabody
Recruiting
Peabody
Dana-Farber/Brigham and Women's Cancer Center at South Shore
Recruiting
South Weymouth
Baystate Medical Center
Recruiting
Springfield
Winchester Hospital
Recruiting
Winchester
UMass Memorial Medical Center - University Campus
Recruiting
Worcester
Maryland
Anne Arundel Medical Center
Recruiting
Annapolis
Johns Hopkins University/Sidney Kimmel Cancer Center
Recruiting
Baltimore
Kaiser Permanente-Woodlawn Medical Center
Recruiting
Baltimore
Sinai Hospital of Baltimore
Recruiting
Baltimore
Kaiser Permanente-Gaithersburg Medical Center
Recruiting
Gaithersburg
Kaiser Permanente - Kensington Medical Center
Recruiting
Kensington
Kaiser Permanente - Largo Medical Center
Recruiting
Largo
Northwest Hospital Center
Suspended
Randallstown
William E Kahlert Regional Cancer Center/Sinai Hospital
Suspended
Westminster
Maine
Harold Alfond Center for Cancer Care
Recruiting
Augusta
Waldo County General Hospital
Recruiting
Belfast
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Recruiting
Biddeford
Lafayette Family Cancer Center-EMMC
Recruiting
Brewer
Maine Center for Cancer Medicine-Kennebunk
Recruiting
Kennebunk
Penobscot Bay Medical Center
Recruiting
Rockport
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Recruiting
Sanford
Maine Center for Cancer Medicine-Scarborough
Recruiting
Scarborough
Maine Medical Center- Scarborough Campus
Recruiting
Scarborough
Maine Medical Partners - South Portland
Recruiting
South Portland
Maine Center for Cancer Medicine-Topsham
Recruiting
Topsham
Michigan
University of Michigan Comprehensive Cancer Center
Recruiting
Ann Arbor
Bronson Battle Creek
Recruiting
Battle Creek
University of Michigan - Brighton Center for Specialty Care
Recruiting
Brighton
Wayne State University/Karmanos Cancer Institute
Recruiting
Detroit
Weisberg Cancer Treatment Center
Recruiting
Farmington Hills
Helen DeVos Children's Hospital at Spectrum Health
Recruiting
Grand Rapids
Mercy Health Saint Mary's
Recruiting
Grand Rapids
Spectrum Health at Butterworth Campus
Recruiting
Grand Rapids
Ascension Borgess Cancer Center
Recruiting
Kalamazoo
Borgess Medical Center
Recruiting
Kalamazoo
Bronson Methodist Hospital
Recruiting
Kalamazoo
West Michigan Cancer Center
Recruiting
Kalamazoo
Mercy Health Mercy Campus
Recruiting
Muskegon
Lakeland Hospital Niles
Recruiting
Niles
Cancer and Hematology Centers of Western Michigan - Norton Shores
Recruiting
Norton Shores
Ascension Providence Hospitals - Novi
Recruiting
Novi
Spectrum Health Reed City Hospital
Recruiting
Reed City
Lakeland Medical Center Saint Joseph
Recruiting
Saint Joseph
Marie Yeager Cancer Center
Recruiting
Saint Joseph
Ascension Providence Hospitals - Southfield
Recruiting
Southfield
Munson Medical Center
Recruiting
Traverse City
Metro Health Hospital
Recruiting
Wyoming
Minnesota
Riverwood Healthcare Center
Recruiting
Aitkin
Essentia Health - Baxter Clinic
Recruiting
Baxter
Sanford Joe Lueken Cancer Center
Recruiting
Bemidji
Essentia Health Saint Joseph's Medical Center
Recruiting
Brainerd
Fairview Ridges Hospital
Recruiting
Burnsville
Minnesota Oncology - Burnsville
Recruiting
Burnsville
Cambridge Medical Center
Recruiting
Cambridge
Mercy Hospital
Recruiting
Coon Rapids
Essentia Health - Deer River Clinic
Recruiting
Deer River
Essentia Health Saint Mary's - Detroit Lakes Clinic
Recruiting
Detroit Lakes
Essentia Health Cancer Center
Recruiting
Duluth
Essentia Health Saint Mary's Medical Center
Recruiting
Duluth
Miller-Dwan Hospital
Recruiting
Duluth
Fairview Southdale Hospital
Recruiting
Edina
Essentia Health - Ely Clinic
Recruiting
Ely
Lake Region Healthcare Corporation-Cancer Care
Suspended
Fergus Falls
Essentia Health - Fosston
Recruiting
Fosston
Unity Hospital
Recruiting
Fridley
Essentia Health Hibbing Clinic
Recruiting
Hibbing
Essentia Health - International Falls Clinic
Recruiting
International Falls
Fairview Clinics and Surgery Center Maple Grove
Recruiting
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Recruiting
Maplewood
Saint John's Hospital - Healtheast
Recruiting
Maplewood
Abbott-Northwestern Hospital
Recruiting
Minneapolis
Health Partners Inc
Recruiting
Minneapolis
Hennepin County Medical Center
Recruiting
Minneapolis
Monticello Cancer Center
Recruiting
Monticello
Essentia Health - Moose Lake Clinic
Recruiting
Moose Lake
New Ulm Medical Center
Recruiting
New Ulm
Essentia Health - Park Rapids
Recruiting
Park Rapids
Fairview Northland Medical Center
Recruiting
Princeton
North Memorial Medical Health Center
Recruiting
Robbinsdale
Mayo Clinic in Rochester
Recruiting
Rochester
Coborn Cancer Center at Saint Cloud Hospital
Recruiting
Saint Cloud
Park Nicollet Clinic - Saint Louis Park
Recruiting
Saint Louis Park
Regions Hospital
Recruiting
Saint Paul
United Hospital
Recruiting
Saint Paul
Essentia Health Sandstone
Recruiting
Sandstone
Saint Francis Regional Medical Center
Recruiting
Shakopee
Lakeview Hospital
Recruiting
Stillwater
Sanford Thief River Falls Medical Center
Recruiting
Thief River Falls
Essentia Health Virginia Clinic
Recruiting
Virginia
Ridgeview Medical Center
Recruiting
Waconia
Rice Memorial Hospital
Recruiting
Willmar
Minnesota Oncology Hematology PA-Woodbury
Recruiting
Woodbury
Fairview Lakes Medical Center
Recruiting
Wyoming
Missouri
Saint Louis Cancer and Breast Institute-Ballwin
Recruiting
Ballwin
Central Care Cancer Center - Bolivar
Recruiting
Bolivar
Cox Cancer Center Branson
Recruiting
Branson
Saint Francis Medical Center
Recruiting
Cape Girardeau
Southeast Cancer Center
Recruiting
Cape Girardeau
Saint Luke's Hospital
Recruiting
Chesterfield
University of Missouri - Ellis Fischel
Recruiting
Columbia
Siteman Cancer Center at West County Hospital
Recruiting
Creve Coeur
Parkland Health Center - Farmington
Recruiting
Farmington
Capital Region Southwest Campus
Recruiting
Jefferson City
Freeman Health System
Recruiting
Joplin
Mercy Hospital Joplin
Recruiting
Joplin
Delbert Day Cancer Institute at PCRMC
Recruiting
Rolla
Mercy Clinic-Rolla-Cancer and Hematology
Recruiting
Rolla
Heartland Regional Medical Center
Recruiting
Saint Joseph
Mercy Hospital Saint Louis
Recruiting
Saint Louis
Mercy Hospital South
Recruiting
Saint Louis
Missouri Baptist Medical Center
Recruiting
Saint Louis
Saint Louis Cancer and Breast Institute-South City
Recruiting
Saint Louis
Siteman Cancer Center at Christian Hospital
Recruiting
Saint Louis
Siteman Cancer Center-South County
Recruiting
Saint Louis
Washington University School of Medicine
Recruiting
Saint Louis
Siteman Cancer Center at Saint Peters Hospital
Recruiting
Saint Peters
Sainte Genevieve County Memorial Hospital
Recruiting
Sainte Genevieve
CoxHealth South Hospital
Recruiting
Springfield
Mercy Hospital Springfield
Recruiting
Springfield
Missouri Baptist Sullivan Hospital
Recruiting
Sullivan
Missouri Baptist Outpatient Center-Sunset Hills
Recruiting
Sunset Hills
Mercy Hospital Washington
Recruiting
Washington
Mississippi
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Recruiting
Columbus
Baptist Cancer Center-Grenada
Recruiting
Grenada
University of Mississippi Medical Center
Recruiting
Jackson
Baptist Memorial Hospital and Cancer Center-Union County
Recruiting
New Albany
Baptist Memorial Hospital and Cancer Center-Oxford
Recruiting
Oxford
Singing River Hospital
Active, not recruiting
Pascagoula
Baptist Memorial Hospital and Cancer Center-Desoto
Recruiting
Southhaven
Montana
Community Hospital of Anaconda
Recruiting
Anaconda
Billings Clinic Cancer Center
Recruiting
Billings
Bozeman Deaconess Hospital
Recruiting
Bozeman
Benefis Healthcare- Sletten Cancer Institute
Recruiting
Great Falls
Great Falls Clinic
Recruiting
Great Falls
Kalispell Regional Medical Center
Recruiting
Kalispell
Community Medical Hospital
Recruiting
Missoula
Saint Patrick Hospital - Community Hospital
Recruiting
Missoula
North Carolina
Atrium Health Stanly/LCI-Albemarle
Recruiting
Albemarle
Rex Hematology Oncology Associates-Cary
Recruiting
Cary
UNC Lineberger Comprehensive Cancer Center
Recruiting
Chapel Hill
Atrium Health Pineville/LCI-Pineville
Recruiting
Charlotte
Atrium Health University City/LCI-University
Recruiting
Charlotte
Carolinas Medical Center/Levine Cancer Institute
Recruiting
Charlotte
Novant Health Carolina Surgical - Randolph
Recruiting
Charlotte
Novant Health Presbyterian Medical Center
Recruiting
Charlotte
Southeastern Medical Oncology Center-Clinton
Recruiting
Clinton
Atrium Health Cabarrus/LCI-Concord
Recruiting
Concord
Levine Cancer Institute - Rutherford
Recruiting
Forest City
Rex Hematology Oncology Associates-Garner
Recruiting
Garner
Southeastern Medical Oncology Center-Goldsboro
Recruiting
Goldsboro
Novant Health Breast Surgery - Greensboro
Recruiting
Greensboro
Margaret R Pardee Memorial Hospital
Recruiting
Hendersonville
University of North Carolina-Hillsborough Campus
Recruiting
Hillsborough
Novant Health Cancer Institute - Huntersville
Recruiting
Huntersville
Novant Health Presbyterian Medical Center Huntersville
Recruiting
Huntersville
Southeastern Medical Oncology Center-Jacksonville
Recruiting
Jacksonville
Novant Health Cancer Institute - Kernersville
Recruiting
Kernersville
Atrium Health Lincoln/LCI-Lincolnton
Recruiting
Lincolnton
Levine Cancer Institute - Union West
Recruiting
Matthews
Matthews Radiation Oncology Center
Recruiting
Matthews
Novant Health Cancer Institute - Matthews
Recruiting
Matthews
Atrium Health Union/LCI-Union
Recruiting
Monroe