Randomized Phase III Study of Combination Osimertinib (AZD9291) and Bevacizumab Versus Osimertinib (AZD9291) Alone as First-Line Treatment for Patients With Metastatic EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC)

Who is this study for? Patients with metastatic EGFR-mutant lung cancer
Status: Recruiting
Location: See all (541) locations...
Intervention Type: Drug, Biological
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Patient must have a pathologically-confirmed diagnosis of non-squamous, non-small cell lung cancer (NSCLC)

• Patient must have advanced disease, defined as - either stage IV disease, stage IIIB disease not amenable to definitive multi-modality therapy, or recurrent disease after a prior diagnosis of stage I-III disease. All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 8th edition staging criteria

• Patient must have somatic activating sensitizing mutation in EGFR (e.g. but not limited to Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I). Patients with non-sensitizing mutations in EGFR (EGFR exon 20 insertions) are not eligible. Test results originating from a Clinical Laboratory Improvement Act (CLIA)-certified or similarly accredited laboratory are acceptable; no specific assay is mandated. Plasma, cytology, or tumor tissue can be utilized for mutation testing

• Patients that have received prior radiation therapy are eligible. Radiation (limited field stereotactic radiation or conventional radiation) must have been completed at least one week prior to study drug initiation and more extensive field radiation (i.e., whole-brain radiotherapy [WBRT]) must have been completed at least two weeks prior to drug initiation

• Patient must have measurable disease. Baseline measurements of sites of disease must be obtained within 4 weeks prior to study registration. If a potential target lesion is previously irradiated without subsequent growth and/or is radiated after the imaging from which baseline measurements are obtained, they cannot be included as target lesions, and additional target lesions are required to meet criteria for measurable disease

• Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2

• All females of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out pregnancy

• A female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

• Patient of childbearing potential and sexually active males must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for 2 weeks prior to the start of treatment, while on study treatment, and for

• 6 weeks after the last dose of protocol treatment for female patients on the osimertinib (AZD9291) alone arm

• 4 months after the last dose of protocol treatment for male patients on osimertinib (AZD9291) alone arm

• 6 months after the last dose of protocol treatment for all patients on osimertinib (AZD9291) plus bevacizumab combination arm

• NOTE: Female patients should also not breastfeed while on treatment and for 6 months after the last dose bevacizumab

• Leukocytes >= 3,000/mcL (obtained =< 14 days prior to registration)

• Absolute neutrophil count >= 1,500/mcL (obtained =< 14 days prior to registration)

• Platelets >= 100,000/mcL (obtained =< 14 days prior to registration)

• Hemoglobin >= 9 g/dL (obtained =< 14 days prior to registration)

• Total bilirubin and creatinine =< 1.5 x institutional upper limit of normal (ULN) (obtained =< 14 days prior to registration)

• Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (obtained =< 14 days prior to registration)

• Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial

• For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated

• Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

• Patients with treated brain metastases are eligible if neurologically stable without glucocorticoid therapy after the stated washout period from radiation therapy (RT) or surgery provided the metastatic lesions are non-hemorrhagic

• Patients with untreated brain metastases or leptomeningeal disease are eligible if the treating physician determines that immediate CNS specific treatment is not required provided the metastatic lesions are non-hemorrhagic and are neurologically stable without glucocorticoid therapy

• Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

• Patients with known history or current symptoms of cardiac disease, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better

• Patient must have the ability to understand and the willingness to sign a written informed consent document and comply with study requirements

Locations
United States
Alaska
Alaska Breast Care and Surgery LLC
Suspended
Anchorage
Alaska Oncology and Hematology LLC
Suspended
Anchorage
Alaska Women's Cancer Care
Suspended
Anchorage
Anchorage Associates in Radiation Medicine
Suspended
Anchorage
Anchorage Oncology Centre
Suspended
Anchorage
Anchorage Radiation Therapy Center
Suspended
Anchorage
Katmai Oncology Group
Suspended
Anchorage
Providence Alaska Medical Center
Suspended
Anchorage
Fairbanks Memorial Hospital
Recruiting
Fairbanks
Arkansas
Mercy Hospital Fort Smith
Suspended
Fort Smith
CHI Saint Vincent Cancer Center Hot Springs
Suspended
Hot Springs
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Recruiting
Jonesboro
Arizona
Cancer Center at Saint Joseph's
Suspended
Phoenix
California
Kaiser Permanente-Deer Valley Medical Center
Recruiting
Antioch
Mission Hope Medical Oncology - Arroyo Grande
Suspended
Arroyo Grande
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Suspended
Burbank
Kaiser Permanente Dublin
Recruiting
Dublin
Kaiser Permanente-Fremont
Recruiting
Fremont
Washington Hospital
Recruiting
Fremont
Kaiser Permanente-Fresno
Recruiting
Fresno
Kaiser Permanente-Modesto
Recruiting
Modesto
Kaiser Permanente-Oakland
Recruiting
Oakland
Stanford Cancer Institute Palo Alto
Recruiting
Palo Alto
Kaiser Permanente-Richmond
Recruiting
Richmond
Kaiser Permanente-Roseville
Recruiting
Roseville
Kaiser Permanente Downtown Commons
Recruiting
Sacramento
Kaiser Permanente-South Sacramento
Recruiting
Sacramento
University of California Davis Comprehensive Cancer Center
Active, not recruiting
Sacramento
Salinas Valley Memorial
Recruiting
Salinas
Kaiser Permanente-San Francisco
Recruiting
San Francisco
Kaiser Permanente-Santa Teresa-San Jose
Recruiting
San Jose
Kaiser Permanente San Leandro
Recruiting
San Leandro
Pacific Central Coast Health Center-San Luis Obispo
Suspended
San Luis Obispo
Kaiser San Rafael-Gallinas
Recruiting
San Rafael
Kaiser Permanente Medical Center - Santa Clara
Recruiting
Santa Clara
Mission Hope Medical Oncology - Santa Maria
Suspended
Santa Maria
Kaiser Permanente-Santa Rosa
Recruiting
Santa Rosa
Kaiser Permanente-South San Francisco
Recruiting
South San Francisco
Kaiser Permanente-Stockton
Recruiting
Stockton
Kaiser Permanente Medical Center-Vacaville
Recruiting
Vacaville
Kaiser Permanente-Vallejo
Recruiting
Vallejo
Kaiser Permanente-Walnut Creek
Recruiting
Walnut Creek
Colorado
Rocky Mountain Cancer Centers-Aurora
Recruiting
Aurora
The Medical Center of Aurora
Suspended
Aurora
Boulder Community Foothills Hospital
Suspended
Boulder
Rocky Mountain Cancer Centers-Boulder
Recruiting
Boulder
Rocky Mountain Cancer Centers - Centennial
Recruiting
Centennial
Penrose-Saint Francis Healthcare
Suspended
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
Suspended
Colorado Springs
Colorado Blood Cancer Institute
Suspended
Denver
Kaiser Permanente-Franklin
Recruiting
Denver
Porter Adventist Hospital
Recruiting
Denver
Presbyterian - Saint Lukes Medical Center - Health One
Suspended
Denver
Rocky Mountain Cancer Centers-Midtown
Recruiting
Denver
Rocky Mountain Cancer Centers-Rose
Recruiting
Denver
Rose Medical Center
Suspended
Denver
The Women's Imaging Center
Suspended
Denver
Western Surgical Care
Suspended
Denver
Mercy Medical Center
Suspended
Durango
Southwest Oncology PC
Suspended
Durango
Mountain Blue Cancer Care Center - Swedish
Recruiting
Englewood
Rocky Mountain Cancer Centers - Swedish
Recruiting
Englewood
Swedish Medical Center
Recruiting
Englewood
The Melanoma and Skin Cancer Institute
Suspended
Englewood
North Colorado Medical Center
Suspended
Greeley
Kaiser Permanente-Rock Creek
Recruiting
Lafayette
Rocky Mountain Cancer Centers-Lakewood
Suspended
Lakewood
Saint Anthony Hospital
Suspended
Lakewood
Littleton Adventist Hospital
Recruiting
Littleton
Rocky Mountain Cancer Centers-Littleton
Recruiting
Littleton
Kaiser Permanente-Lone Tree
Recruiting
Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
Recruiting
Lone Tree
Sky Ridge Medical Center
Suspended
Lone Tree
Longmont United Hospital
Suspended
Longmont
Rocky Mountain Cancer Centers-Longmont
Suspended
Longmont
McKee Medical Center
Suspended
Loveland
Parker Adventist Hospital
Recruiting
Parker
Saint Mary Corwin Medical Center
Suspended
Pueblo
Rocky Mountain Cancer Centers-Thornton
Suspended
Thornton
Delaware
Beebe South Coastal Health Campus
Recruiting
Frankford
Beebe Medical Center
Suspended
Lewes
Christiana Care Health System-Christiana Hospital
Suspended
Newark
Delaware Clinical and Laboratory Physicians PA
Suspended
Newark
Helen F Graham Cancer Center
Recruiting
Newark
Medical Oncology Hematology Consultants PA
Recruiting
Newark
Beebe Health Campus
Recruiting
Rehoboth Beach
TidalHealth Nanticoke / Allen Cancer Center
Suspended
Seaford
Christiana Care Health System-Wilmington Hospital
Suspended
Wilmington
Florida
Holy Cross Hospital
Recruiting
Fort Lauderdale
Georgia
Emory University Hospital Midtown
Recruiting
Atlanta
Emory University Hospital/Winship Cancer Institute
Recruiting
Atlanta
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Recruiting
Savannah
Hawaii
Hawaii Cancer Care - Savio
Suspended
'aiea
Pali Momi Medical Center
Suspended
'aiea
Queen's Cancer Center - Pearlridge
Suspended
'aiea
The Cancer Center of Hawaii-Pali Momi
Suspended
'aiea
Hawaii Cancer Care Inc - Waterfront Plaza
Recruiting
Honolulu
Kaiser Permanente Moanalua Medical Center
Recruiting
Honolulu
Kapiolani Medical Center for Women and Children
Suspended
Honolulu
Kuakini Medical Center
Suspended
Honolulu
Queen's Cancer Cenrer - POB I
Recruiting
Honolulu
Queen's Cancer Center - Kuakini
Recruiting
Honolulu
Queen's Medical Center
Recruiting
Honolulu
Straub Clinic and Hospital
Suspended
Honolulu
The Cancer Center of Hawaii-Liliha
Suspended
Honolulu
University of Hawaii Cancer Center
Suspended
Honolulu
Wilcox Memorial Hospital and Kauai Medical Clinic
Suspended
Lihue
Iowa
Mary Greeley Medical Center
Recruiting
Ames
McFarland Clinic PC - Ames
Recruiting
Ames
McFarland Clinic PC-Boone
Recruiting
Boone
Saint Anthony Regional Hospital
Recruiting
Carroll
Medical Oncology and Hematology Associates-West Des Moines
Suspended
Clive
Mercy Cancer Center-West Lakes
Suspended
Clive
Alegent Health Mercy Hospital
Suspended
Council Bluffs
Greater Regional Medical Center
Suspended
Creston
Broadlawns Medical Center
Recruiting
Des Moines
Iowa Lutheran Hospital
Suspended
Des Moines
Iowa Methodist Medical Center
Suspended
Des Moines
Medical Oncology and Hematology Associates-Des Moines
Recruiting
Des Moines
Mercy Medical Center - Des Moines
Suspended
Des Moines
Mission Cancer and Blood - Laurel
Suspended
Des Moines
McFarland Clinic PC-Trinity Cancer Center
Recruiting
Fort Dodge
Trinity Regional Medical Center
Suspended
Fort Dodge
McFarland Clinic PC-Jefferson
Recruiting
Jefferson
McFarland Clinic PC-Marshalltown
Recruiting
Marshalltown
Mercy Medical Center-West Lakes
Suspended
West Des Moines
Methodist West Hospital
Suspended
West Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Recruiting
Boise
Saint Luke's Cancer Institute - Boise
Recruiting
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Recruiting
Caldwell
Kootenai Health - Coeur d'Alene
Recruiting
Coeur D'alene
Walter Knox Memorial Hospital
Suspended
Emmett
Saint Luke's Cancer Institute - Fruitland
Recruiting
Fruitland
Idaho Urologic Institute-Meridian
Suspended
Meridian
Saint Luke's Cancer Institute - Meridian
Recruiting
Meridian
Saint Alphonsus Medical Center-Nampa
Recruiting
Nampa
Saint Luke's Cancer Institute - Nampa
Recruiting
Nampa
Kootenai Clinic Cancer Services - Post Falls
Recruiting
Post Falls
Kootenai Cancer Clinic
Recruiting
Sandpoint
Saint Luke's Cancer Institute - Twin Falls
Recruiting
Twin Falls
Illinois
Saint Anthony's Health
Suspended
Alton
Rush - Copley Medical Center
Suspended
Aurora
Illinois CancerCare-Bloomington
Recruiting
Bloomington
Illinois CancerCare-Canton
Recruiting
Canton
Memorial Hospital of Carbondale
Suspended
Carbondale
SIH Cancer Institute
Suspended
Carterville
Illinois CancerCare-Carthage
Recruiting
Carthage
Centralia Oncology Clinic
Recruiting
Centralia
Jesse Brown Veterans Affairs Medical Center
Suspended
Chicago
Swedish Covenant Hospital
Suspended
Chicago
University of Illinois
Recruiting
Chicago
Carle on Vermilion
Recruiting
Danville
Cancer Care Specialists of Illinois - Decatur
Recruiting
Decatur
Decatur Memorial Hospital
Suspended
Decatur
Illinois CancerCare-Dixon
Recruiting
Dixon
Carle Physician Group-Effingham
Recruiting
Effingham
Crossroads Cancer Center
Recruiting
Effingham
Illinois CancerCare-Eureka
Recruiting
Eureka
Illinois CancerCare-Galesburg
Recruiting
Galesburg
Western Illinois Cancer Treatment Center
Suspended
Galesburg
Ingalls Memorial Hospital
Active, not recruiting
Harvey
Illinois CancerCare-Kewanee Clinic
Recruiting
Kewanee
Illinois CancerCare-Macomb
Recruiting
Macomb
Carle Physician Group-Mattoon/Charleston
Recruiting
Mattoon
Good Samaritan Regional Health Center
Suspended
Mount Vernon
Cancer Care Center of O'Fallon
Recruiting
O'fallon
Illinois CancerCare-Ottawa Clinic
Recruiting
Ottawa
Illinois CancerCare-Pekin
Recruiting
Pekin
Illinois CancerCare-Peoria
Recruiting
Peoria
Methodist Medical Center of Illinois
Suspended
Peoria
Illinois CancerCare-Peru
Recruiting
Peru
Valley Radiation Oncology
Suspended
Peru
Illinois CancerCare-Princeton
Recruiting
Princeton
Memorial Medical Center
Recruiting
Springfield
Southern Illinois University School of Medicine
Recruiting
Springfield
Springfield Clinic
Recruiting
Springfield
Southwest Illinois Health Services LLP
Suspended
Swansea
Carle Cancer Center
Recruiting
Urbana
The Carle Foundation Hospital
Suspended
Urbana
Illinois CancerCare - Washington
Recruiting
Washington
Rush-Copley Healthcare Center
Suspended
Yorkville
Indiana
Northwest Cancer Center - Main Campus
Recruiting
Crown Point
Northwest Oncology LLC
Recruiting
Dyer
Northwest Cancer Center - Hobart
Recruiting
Hobart
Saint Mary Medical Center
Recruiting
Hobart
Saint Catherine Hospital
Recruiting
Indianapolis
The Community Hospital
Recruiting
Munster
Women's Diagnostic Center - Munster
Recruiting
Munster
Reid Health
Recruiting
Richmond
Northwest Cancer Center - Valparaiso
Recruiting
Valparaiso
Kansas
Central Care Cancer Center - Garden City
Suspended
Garden City
Central Care Cancer Center - Great Bend
Suspended
Great Bend
Ascension Via Christi Hospitals Wichita
Recruiting
Wichita
Cancer Center of Kansas - Wichita
Recruiting
Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower
Recruiting
Wichita
Kentucky
Flaget Memorial Hospital
Suspended
Bardstown
Commonwealth Cancer Center-Corbin
Suspended
Corbin
Saint Joseph Hospital East
Suspended
Lexington
Saint Joseph Radiation Oncology Resource Center
Suspended
Lexington
Saint Joseph London
Suspended
London
Jewish Hospital
Suspended
Louisville
Saints Mary and Elizabeth Hospital
Suspended
Louisville
UofL Health Medical Center Northeast
Suspended
Louisville
Jewish Hospital Medical Center South
Suspended
Shepherdsville
Massachusetts
Beverly Hospital
Recruiting
Beverly
Lahey Hospital and Medical Center
Recruiting
Burlington
Addison Gilbert Hospital
Recruiting
Gloucester
Lahey Medical Center-Peabody
Recruiting
Peabody
Winchester Hospital
Recruiting
Winchester
UMass Memorial Medical Center - University Campus
Recruiting
Worcester
Maryland
Walter Reed National Military Medical Center
Recruiting
Bethesda
Michigan
Hickman Cancer Center
Suspended
Adrian
Saint Joseph Mercy Hospital
Recruiting
Ann Arbor
Saint Joseph Mercy Brighton
Recruiting
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Recruiting
Brighton
Saint Joseph Mercy Canton
Recruiting
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Recruiting
Canton
Caro Cancer Center
Suspended
Caro
Saint Joseph Mercy Chelsea
Recruiting
Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Recruiting
Chelsea
Hematology Oncology Consultants-Clarkston
Suspended
Clarkston
Newland Medical Associates-Clarkston
Suspended
Clarkston
Beaumont Hospital - Dearborn
Recruiting
Dearborn
Ascension Saint John Hospital
Recruiting
Detroit
Great Lakes Cancer Management Specialists-Doctors Park
Recruiting
East China Township
Genesee Cancer and Blood Disease Treatment Center
Recruiting
Flint
Genesee Hematology Oncology PC
Recruiting
Flint
Genesys Hurley Cancer Institute
Recruiting
Flint
Hurley Medical Center
Recruiting
Flint
Academic Hematology Oncology Specialists
Recruiting
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Recruiting
Grosse Pointe Woods
Michigan Breast Specialists-Grosse Pointe Woods
Suspended
Grosse Pointe Woods
Sparrow Hospital
Recruiting
Lansing
Hope Cancer Clinic
Suspended
Livonia
Trinity Health Saint Mary Mercy Livonia Hospital
Recruiting
Livonia
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Recruiting
Macomb
Michigan Breast Specialists-Macomb Township
Suspended
Macomb
Saint Mary's Oncology/Hematology Associates of Marlette
Suspended
Marlette
Toledo Clinic Cancer Centers-Monroe
Suspended
Monroe
21st Century Oncology-Pontiac
Suspended
Pontiac
Hope Cancer Center
Suspended
Pontiac
Newland Medical Associates-Pontiac
Suspended
Pontiac
Saint Joseph Mercy Oakland
Suspended
Pontiac
Great Lakes Cancer Management Specialists-Rochester Hills
Suspended
Rochester Hills
William Beaumont Hospital-Royal Oak
Recruiting
Royal Oak
Ascension Saint Mary's Hospital
Recruiting
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Recruiting
Saginaw
Bhadresh Nayak MD PC-Sterling Heights
Recruiting
Sterling Heights
Ascension Saint Joseph Hospital
Recruiting
Tawas City
William Beaumont Hospital - Troy
Recruiting
Troy
Advanced Breast Care Center PLLC
Suspended
Warren
Great Lakes Cancer Management Specialists-Macomb Professional Building
Recruiting
Warren
Macomb Hematology Oncology PC
Suspended
Warren
Michigan Breast Specialists-Warren
Suspended
Warren
Saint John Macomb-Oakland Hospital
Recruiting
Warren
Saint Mary's Oncology/Hematology Associates of West Branch
Recruiting
West Branch
Huron Gastroenterology PC
Recruiting
Ypsilanti
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Recruiting
Ypsilanti
Minnesota
Sanford Joe Lueken Cancer Center
Recruiting
Bemidji
Fairview Ridges Hospital
Suspended
Burnsville
Minnesota Oncology - Burnsville
Suspended
Burnsville
Cambridge Medical Center
Suspended
Cambridge
Mercy Hospital
Recruiting
Coon Rapids
Fairview Southdale Hospital
Recruiting
Edina
Unity Hospital
Suspended
Fridley
Fairview Clinics and Surgery Center Maple Grove
Suspended
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Suspended
Maplewood
Saint John's Hospital - Healtheast
Suspended
Maplewood
Abbott-Northwestern Hospital
Suspended
Minneapolis
Health Partners Inc
Suspended
Minneapolis
Hennepin County Medical Center
Recruiting
Minneapolis
Monticello Cancer Center
Suspended
Monticello
New Ulm Medical Center
Suspended
New Ulm
Fairview Northland Medical Center
Suspended
Princeton
North Memorial Medical Health Center
Suspended
Robbinsdale
Park Nicollet Clinic - Saint Louis Park
Recruiting
Saint Louis Park
Regions Hospital
Suspended
Saint Paul
United Hospital
Recruiting
Saint Paul
Saint Francis Regional Medical Center
Suspended
Shakopee
Lakeview Hospital
Suspended
Stillwater
Sanford Thief River Falls Medical Center
Suspended
Thief River Falls
Ridgeview Medical Center
Recruiting
Waconia
Rice Memorial Hospital
Suspended
Willmar
Minnesota Oncology Hematology PA-Woodbury
Suspended
Woodbury
Sanford Cancer Center Worthington
Suspended
Worthington
Fairview Lakes Medical Center
Suspended
Wyoming
Missouri
Saint Louis Cancer and Breast Institute-Ballwin
Suspended
Ballwin
Central Care Cancer Center - Bolivar
Suspended
Bolivar
Saint Francis Medical Center
Recruiting
Cape Girardeau
Southeast Cancer Center
Suspended
Cape Girardeau
Parkland Health Center - Farmington
Recruiting
Farmington
Capital Region Southwest Campus
Suspended
Jefferson City
Freeman Health System
Suspended
Joplin
Mercy Hospital Joplin
Suspended
Joplin
Delbert Day Cancer Institute at PCRMC
Suspended
Rolla
Mercy Clinic-Rolla-Cancer and Hematology
Suspended
Rolla
Heartland Regional Medical Center
Suspended
Saint Joseph
Mercy Hospital Saint Louis
Recruiting
Saint Louis
Mercy Hospital South
Suspended
Saint Louis
Missouri Baptist Medical Center
Recruiting
Saint Louis
Saint Louis Cancer and Breast Institute-South City
Suspended
Saint Louis
Sainte Genevieve County Memorial Hospital
Recruiting
Sainte Genevieve
CoxHealth South Hospital
Suspended
Springfield
Mercy Hospital Springfield
Suspended
Springfield
Missouri Baptist Sullivan Hospital
Recruiting
Sullivan
Missouri Baptist Outpatient Center-Sunset Hills
Recruiting
Sunset Hills
Mercy Hospital Washington
Suspended
Washington
Mississippi
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Recruiting
Columbus
Baptist Cancer Center-Grenada
Recruiting
Grenada
Baptist Memorial Hospital and Cancer Center-Union County
Recruiting
New Albany
Baptist Memorial Hospital and Cancer Center-Oxford
Recruiting
Oxford
Baptist Memorial Hospital and Cancer Center-Desoto
Recruiting
Southhaven
Montana
Community Hospital of Anaconda
Recruiting
Anaconda
Billings Clinic Cancer Center
Recruiting
Billings
Bozeman Deaconess Hospital
Recruiting
Bozeman
Benefis Healthcare- Sletten Cancer Institute
Recruiting
Great Falls
Great Falls Clinic
Recruiting
Great Falls
Kalispell Regional Medical Center
Recruiting
Kalispell
Community Medical Hospital
Recruiting
Missoula
Saint Patrick Hospital - Community Hospital
Suspended
Missoula
North Carolina
Novant Health Presbyterian Medical Center
Recruiting
Charlotte
Southeastern Medical Oncology Center-Clinton
Recruiting
Clinton
Southeastern Medical Oncology Center-Goldsboro
Recruiting
Goldsboro
Novant Health Cancer Institute - Huntersville
Recruiting
Huntersville
Southeastern Medical Oncology Center-Jacksonville
Recruiting
Jacksonville
Vidant Oncology-Kenansville
Recruiting
Kenansville
Novant Health Cancer Institute - Kernersville
Recruiting
Kernersville
Vidant Oncology-Kinston
Recruiting
Kinston
Novant Health Cancer Institute - Matthews
Recruiting
Matthews
Novant Health Cancer Institute - Mooresville
Recruiting
Mooresville
Novant Health Cancer Institute - Mount Airy
Suspended
Mount Airy
Vidant Oncology-Richlands
Recruiting
Richlands
Novant Health Cancer Institute - Statesville
Suspended
Statesville
Novant Health Cancer Institute - Thomasville
Suspended
Thomasville
Novant Health Cancer Institute - Wilkesboro
Suspended
Wilkesboro
Novant Health Forsyth Medical Center
Recruiting
Winston-salem
North Dakota
Sanford Bismarck Medical Center
Recruiting
Bismarck
Sanford Broadway Medical Center
Recruiting
Fargo
Sanford Medical Center Fargo
Suspended
Fargo
Sanford Roger Maris Cancer Center
Recruiting
Fargo
Sanford South University Medical Center
Suspended
Fargo
Southpointe-Sanford Medical Center Fargo
Suspended
Fargo
Nebraska
CHI Health Saint Francis
Suspended
Grand Island
CHI Health Good Samaritan
Suspended
Kearney
Cancer Partners of Nebraska - Pine Lake
Recruiting
Lincoln
Saint Elizabeth Regional Medical Center
Suspended
Lincoln
Southeast Nebraska Cancer Center - 68th Street Place
Recruiting
Lincoln
Alegent Health Bergan Mercy Medical Center
Suspended
Omaha
Alegent Health Immanuel Medical Center
Suspended
Omaha
Alegent Health Lakeside Hospital
Suspended
Omaha
Creighton University Medical Center
Suspended
Omaha
Midlands Community Hospital
Suspended
Papillion
New Jersey
Memorial Sloan Kettering Basking Ridge
Recruiting
Basking Ridge
Monmouth Medical Center Southern Campus
Recruiting
Lakewood
Saint Barnabas Medical Center
Recruiting
Livingston
Monmouth Medical Center
Recruiting
Long Branch
Memorial Sloan Kettering Monmouth
Recruiting
Middletown
Memorial Sloan Kettering Bergen
Recruiting
Montvale
Rutgers Cancer Institute of New Jersey
Recruiting
New Brunswick
The Valley Hospital-Luckow Pavilion
Recruiting
Paramus
Neurosurgeons of New Jersey-Ridgewood
Suspended
Ridgewood
Valley Hospital
Recruiting
Ridgewood
Valley Health System-Hematology/Oncology
Recruiting
Westwood
New Mexico
New Mexico Oncology Hematology Consultants
Recruiting
Albuquerque
University of New Mexico Cancer Center
Recruiting
Albuquerque
New York
Montefiore Medical Center - Moses Campus
Recruiting
Bronx
Montefiore Medical Center-Einstein Campus
Recruiting
Bronx
Montefiore Medical Center-Weiler Hospital
Recruiting
Bronx
Roswell Park Cancer Institute
Recruiting
Buffalo
Memorial Sloan Kettering Commack
Recruiting
Commack
Cancer Institute at Saint Francis Hospital
Recruiting
East Hills
Glens Falls Hospital
Recruiting
Glens Falls
Memorial Sloan Kettering Westchester
Recruiting
Harrison
Memorial Sloan Kettering Cancer Center
Recruiting
New York
Upstate Cancer Center at Oneida
Recruiting
Oneida
Upstate Cancer Center at Oswego
Recruiting
Oswego
State University of New York Upstate Medical University
Recruiting
Syracuse
Memorial Sloan Kettering Nassau
Recruiting
Uniondale
Good Samaritan Hospital Medical Center
Recruiting
West Islip
Dickstein Cancer Treatment Center
Recruiting
White Plains
Ohio
UH Seidman Cancer Center at UH Avon Health Center
Recruiting
Avon
UHHS-Chagrin Highlands Medical Center
Recruiting
Beachwood
Indu and Raj Soin Medical Center
Suspended
Beavercreek
Strecker Cancer Center-Belpre
Recruiting
Belpre
Saint Elizabeth Boardman Hospital
Suspended
Boardman
Dayton Physicians LLC-Miami Valley South
Recruiting
Centerville
Miami Valley Hospital South
Recruiting
Centerville
Geauga Hospital
Recruiting
Chardon
Adena Regional Medical Center
Recruiting
Chillicothe
Bethesda North Hospital
Suspended
Cincinnati
Good Samaritan Hospital - Cincinnati
Suspended
Cincinnati
Oncology Hematology Care Inc-Kenwood
Suspended
Cincinnati
TriHealth Cancer Institute-Anderson
Suspended
Cincinnati
TriHealth Cancer Institute-Westside
Suspended
Cincinnati
University of Cincinnati Cancer Center-UC Medical Center
Suspended
Cincinnati
Case Western Reserve University
Recruiting
Cleveland
Cleveland Clinic Foundation
Recruiting
Cleveland
Columbus Oncology and Hematology Associates Inc
Recruiting
Columbus
Doctors Hospital
Recruiting
Columbus
Grant Medical Center
Recruiting
Columbus
Mount Carmel East Hospital
Suspended
Columbus
Mount Carmel Health Center West
Suspended
Columbus
Riverside Methodist Hospital
Recruiting
Columbus
The Mark H Zangmeister Center
Recruiting
Columbus
Dayton Physician LLC-Miami Valley Hospital North
Recruiting
Dayton
Miami Valley Hospital
Recruiting
Dayton
Miami Valley Hospital North
Recruiting
Dayton
Delaware Health Center-Grady Cancer Center
Recruiting
Delaware
Grady Memorial Hospital
Suspended
Delaware
Dublin Methodist Hospital
Suspended
Dublin
Armes Family Cancer Center
Recruiting
Findlay
Blanchard Valley Hospital
Suspended
Findlay
Orion Cancer Care
Suspended
Findlay
Atrium Medical Center-Middletown Regional Hospital
Recruiting
Franklin
Dayton Physicians LLC-Atrium
Recruiting
Franklin
Central Ohio Breast and Endocrine Surgery
Suspended
Gahanna
Dayton Physicians LLC-Wayne
Suspended
Greenville
Wayne Hospital
Suspended
Greenville
Mount Carmel Grove City Hospital
Suspended
Grove City
Greater Dayton Cancer Center
Recruiting
Kettering
Kettering Medical Center
Recruiting
Kettering
Fairfield Medical Center
Suspended
Lancaster
Saint Rita's Medical Center
Suspended
Lima
Cleveland Clinic Cancer Center Mansfield
Recruiting
Mansfield
OhioHealth Mansfield Hospital
Suspended
Mansfield
Marietta Memorial Hospital
Recruiting
Marietta
OhioHealth Marion General Hospital
Recruiting
Marion
Hillcrest Hospital Cancer Center
Recruiting
Mayfield Heights
UH Seidman Cancer Center at Lake Health Mentor Campus
Recruiting
Mentor
UH Seidman Cancer Center at Southwest General Hospital
Recruiting
Middleburg Heights
Knox Community Hospital
Suspended
Mount Vernon
Licking Memorial Hospital
Recruiting
Newark
Newark Radiation Oncology
Suspended
Newark
University Hospitals Parma Medical Center
Recruiting
Parma
Southern Ohio Medical Center
Recruiting
Portsmouth
UH Seidman Cancer Center at Firelands Regional Medical Center
Recruiting
Sandusky
Springfield Regional Cancer Center
Recruiting
Springfield
Springfield Regional Medical Center
Suspended
Springfield
Mercy Health - Saint Anne Hospital
Suspended
Toledo
Saint Vincent Mercy Medical Center
Suspended
Toledo
Toledo Clinic Cancer Centers-Toledo
Recruiting
Toledo
Dayton Physicians LLC-Upper Valley
Suspended
Troy
Upper Valley Medical Center
Recruiting
Troy
University Hospitals Sharon Health Center
Recruiting
Wadsworth
Saint Joseph Warren Hospital
Suspended
Warren
South Pointe Hospital
Recruiting
Warrensville Heights
University of Cincinnati Cancer Center-West Chester
Suspended
West Chester
Saint Ann's Hospital
Suspended
Westerville
UH Seidman Cancer Center at Saint John Medical Center
Recruiting
Westlake
Saint Elizabeth Youngstown Hospital
Suspended
Youngstown
Genesis Healthcare System Cancer Care Center
Recruiting
Zanesville
Oklahoma
Integris Cancer Institute of Oklahoma
Suspended
Oklahoma City
Integris Southwest Medical Center
Suspended
Oklahoma City
Mercy Hospital Oklahoma City
Suspended
Oklahoma City
University of Oklahoma Health Sciences Center
Recruiting
Oklahoma City
Oregon
Saint Alphonsus Medical Center-Baker City
Suspended
Baker City
Saint Charles Health System
Suspended
Bend
Clackamas Radiation Oncology Center
Suspended
Clackamas
Providence Cancer Institute Clackamas Clinic
Suspended
Clackamas
Bay Area Hospital
Suspended
Coos Bay
Providence Newberg Medical Center
Suspended
Newberg
Saint Alphonsus Medical Center-Ontario
Recruiting
Ontario
Providence Portland Medical Center
Suspended
Portland
Providence Saint Vincent Medical Center
Suspended
Portland
Saint Charles Health System-Redmond
Suspended
Redmond
Pennsylvania
Lehigh Valley Hospital-Cedar Crest
Recruiting
Allentown
Lehigh Valley Hospital - Muhlenberg
Recruiting
Bethlehem
Bryn Mawr Hospital
Suspended
Bryn Mawr
Christiana Care Health System-Concord Health Center
Suspended
Chadds Ford
Chambersburg Hospital
Suspended
Chambersburg
WellSpan Medical Oncology and Hematology
Recruiting
Chambersburg
Main Line Health Center-Collegeville
Suspended
Collegeville
Pocono Medical Center
Suspended
East Stroudsburg
Ephrata Cancer Center
Recruiting
Ephrata
Main Line Health Center-Exton
Suspended
Exton
Adams Cancer Center
Recruiting
Gettysburg
Cherry Tree Cancer Center
Recruiting
Hanover
Lehigh Valley Hospital-Hazleton
Suspended
Hazleton
Sechler Family Cancer Center
Recruiting
Lebanon
Riddle Memorial Hospital
Suspended
Media
Paoli Memorial Hospital
Suspended
Paoli
Fox Chase Cancer Center
Recruiting
Philadelphia
Lankenau Medical Center
Recruiting
Wynnewood
Cancer Care Associates of York
Recruiting
York
WellSpan Health-York Cancer Center
Recruiting
York
WellSpan Health-York Hospital
Recruiting
York
South Carolina
Medical University of South Carolina
Active, not recruiting
Charleston
South Dakota
Sanford Cancer Center Oncology Clinic
Recruiting
Sioux Falls
Sanford USD Medical Center - Sioux Falls
Recruiting
Sioux Falls
Tennessee
Baptist Memorial Hospital and Cancer Center-Collierville
Recruiting
Collierville
Baptist Memorial Hospital and Cancer Center-Memphis
Recruiting
Memphis
Vanderbilt University/Ingram Cancer Center
Recruiting
Nashville
Texas
Saint Joseph Regional Cancer Center
Suspended
Bryan
Parkland Memorial Hospital
Recruiting
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Recruiting
Dallas
UT Southwestern/Simmons Cancer Center-Fort Worth
Recruiting
Fort Worth
UT Southwestern Clinical Center at Richardson/Plano
Recruiting
Richardson
Washington
Providence Regional Cancer System-Aberdeen
Suspended
Aberdeen
PeaceHealth Saint Joseph Medical Center
Suspended
Bellingham
Harrison HealthPartners Hematology and Oncology-Bremerton
Recruiting
Bremerton
Harrison Medical Center
Suspended
Bremerton
Highline Medical Center-Main Campus
Suspended
Burien
Providence Regional Cancer System-Centralia
Suspended
Centralia
Swedish Cancer Institute-Edmonds
Suspended
Edmonds
Saint Elizabeth Hospital
Suspended
Enumclaw
Providence Regional Cancer Partnership
Suspended
Everett
Saint Francis Hospital
Suspended
Federal Way
Swedish Cancer Institute-Issaquah
Suspended
Issaquah
Kadlec Clinic Hematology and Oncology
Recruiting
Kennewick
Providence Regional Cancer System-Lacey
Suspended
Lacey
Saint Clare Hospital
Suspended
Lakewood
PeaceHealth Saint John Medical Center
Recruiting
Longview
Jefferson Healthcare
Recruiting
Port Townsend
Harrison HealthPartners Hematology and Oncology-Poulsbo
Active, not recruiting
Poulsbo
Pacific Gynecology Specialists
Suspended
Seattle
Swedish Medical Center-Ballard Campus
Suspended
Seattle
Swedish Medical Center-Cherry Hill
Suspended
Seattle
Swedish Medical Center-First Hill
Suspended
Seattle
PeaceHealth United General Medical Center
Suspended
Sedro-woolley
Providence Regional Cancer System-Shelton
Suspended
Shelton
Franciscan Research Center-Northwest Medical Plaza
Suspended
Tacoma
Northwest Medical Specialties PLLC
Suspended
Tacoma
PeaceHealth Southwest Medical Center
Recruiting
Vancouver
Providence Saint Mary Regional Cancer Center
Suspended
Walla Walla
Providence Regional Cancer System-Yelm
Suspended
Yelm
Wisconsin
Gundersen Lutheran Medical Center
Recruiting
La Crosse
Marshfield Medical Center-Marshfield
Recruiting
Marshfield
Medical College of Wisconsin
Recruiting
Milwaukee
Marshfield Clinic-Minocqua Center
Recruiting
Minocqua
ProHealth D N Greenwald Center
Recruiting
Mukwonago
Cancer Center of Western Wisconsin
Suspended
New Richmond
ProHealth Oconomowoc Memorial Hospital
Recruiting
Oconomowoc
Marshfield Medical Center-Rice Lake
Recruiting
Rice Lake
Marshfield Medical Center-River Region at Stevens Point
Recruiting
Stevens Point
ProHealth Waukesha Memorial Hospital
Recruiting
Waukesha
UW Cancer Center at ProHealth Care
Recruiting
Waukesha
Marshfield Medical Center - Weston
Recruiting
Weston
West Virginia
West Virginia University Charleston Division
Recruiting
Charleston
Wyoming
Cheyenne Regional Medical Center-West
Suspended
Cheyenne
Billings Clinic-Cody
Suspended
Cody
Welch Cancer Center
Suspended
Sheridan
Time Frame
Start Date: October 22, 2020
Estimated Completion Date: September 1, 2025
Participants
Target number of participants: 300
Treatments
Active Comparator: Arm A (osimertinib)
Patients receive osimertinib PO QD on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Experimental: Arm B (osimertinib, bevacizumab)
Patients receive osimertinib PO QD on days 1-21 and bevacizumab IV over 30-90 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Sponsors
Leads: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov

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