The Down Syndrome Clinical Trials Network (DS-CTN) Study of Alzheimer's Disease in Down Syndrome

Status: Recruiting
Location: See all (14) locations...
Study Type: Observational
SUMMARY

This is an observational, multi-center, longitudinal cohort study to characterize adults with DS ages 25 years and above enrolled at specialized care centers. The aim is to assess changes in cognition, behavior, function and health over approximately 32 months. Blood will be collected for the development of plasma AD biomarkers useful in the DS population.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Healthy Volunteers: No
View:

• Age 25 years or older

• Diagnosis of DS, typically supported by karyotype analysis documenting full trisomy for chromosome 21 or complete unbalanced translocation of chromosome 21. Karyotype analysis is not required for study entry

• Participants, or Legal Authorized Representative, and their study partner if applicable, in the opinion of the investigator, are able to understand and willing to sign written informed consent.

• Participants must have a study partner who has frequent interaction with the participant on a regular basis, will agree to participate in annual clinic visits, can provide accurate responses to questions about the participant, and facilitate participation in the study visits, in the opinion of site PI or study coordinator.

• Participant and study partner must be capable of reliably completing study assessments.

Locations
United States
Arizona
Barrow Neurological Institute
Recruiting
Phoenix
California
University California Irvine
Recruiting
Irvine
University of California, San Diego
Recruiting
La Jolla
Georgia
Emory University
Recruiting
Atlanta
Illinois
Rush University Medical Center
Recruiting
Chicago
Advocate Health
Recruiting
Park Ridge
Kansas
Kansas University Medical Center
Recruiting
Fairway
Kentucky
University Of Kentucky
Recruiting
Lexington
Massachusetts
Massachusetts General Hospital
Recruiting
Boston
Massachusetts General Hospital
Recruiting
Charlestown
Maryland
Kennedy Krieger Institute
Recruiting
Baltimore
North Carolina
Duke University Medical Center
Recruiting
Durham
Ohio
Cincinnatti Children's Hospital Medical Center
Recruiting
Cincinnati
Case Western Reserve University
Recruiting
Cleveland
Contact Information
Primary
Angela L Britton, MA
abritton@lumindidsc.org
301-758-0468
Backup
Administrator LuMind IDSC
lifedsr@lumindidsc.org
Time Frame
Start Date: June 30, 2019
Estimated Completion Date: December 30, 2023
Participants
Target number of participants: 270
Authors
Stephanie Santoro, Brian Chicoine, Jose Soria Lopez, Amy Talboy, Ira Lott, Anna Burke, Frederick Schmitt, Priya Kishnani, Anna Esbensen, Cesar Ochoa-Lubinoff, George Capone, Moya Peterson, Diana Rosas, Elizabeth Bevins-Murphy, Alberto Costa
Sponsors
Leads: LuMind IDSC Foundation
Collaborators: Alzheimer's Disease Cooperative Study (ADCS)

This content was sourced from clinicaltrials.gov

Similar Clinical Trials