Spasticity After Spinal Cord Injury

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Very often, people who have a SCI have difficulty doing things with their arms or hands as a result of muscle stiffness , or spasticity. Spastacity can cause problems performing even the simplest of everyday tasks. This research will help us understand how the body recovers and changes neurologically after SCI.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: Accepts Healthy Volunteers
View:

⁃ Chronic SCI (≥1 year of injury)

⁃ Incomplete spinal cord injury at T12 or above

⁃ Males and Females

⁃ Ages 18-75 years

• MAS scores of 0 and 1

⁃ MAS scores of 2, 3 and 4

⁃ The ability to perform a voluntary flexion and extension of the elbow and/or knee or ankle

⁃ The ability to reach and grasp an object

⁃ Males and females

⁃ Ages 18-75 years

⁃ Right-handed

⁃ Able to perform elbow and/or knee or ankle flexion and extension

Locations
United States
Illinois
Shirley Ryan AbilityLab
Recruiting
Chicago
Contact Information
Primary
Sina Sangari, PhD
ssangari@rsralab.org
312.238.1365
Time Frame
Start Date: May 13, 2020
Estimated Completion Date: May 18, 2024
Participants
Target number of participants: 120
Treatments
Experimental: Aim 1
To accomplish this aim, we will conduct one experiment in two sessions separated by 2- 3 days using a crossover design. Participants will be assigned into one of three groups: spastic SCI, non-spastic SCI, and controls. We expect that people enrolled in Aim 1 will complete 2 visits within 1 week.~Visit 1 Measurements:~MVCs~MEP Recruitment Curves~iMEPs~StartReact~Visit 2 Measurements:~Participant Reported Spasticity~MAS~PSAD~KINARM~MRI of brain and spinal cord
Experimental: Aim 2
To accomplish this aim, we will use a randomized crossover design study with spastic SCI participants receiving a single intervention combining non-invasive acoustic stimuli (Startle) or sham-Startle with motor training to enhance cortico- and reticulo-spinal contribution, separated by ~2 weeks.~Visit 1 and Visit 2~Single intervention of:~Startle + exercise training OR sham-Startle + exercise training~Pre and post measurements:~MVCs~MEP recruitment curves~iMEPs~StartReact~Participant reported spasticity~MAS~PSAD~KINARM~Neuromechanical hand and/or leg testing~GRASSP~TRI-HFT~10-meter walk test~Pendulum Test
Related Therapeutic Areas
Sponsors
Leads: Shirley Ryan AbilityLab

This content was sourced from clinicaltrials.gov

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