Are SARS-CoV-2 Specific Antibodies a Correlate for Protection?
The objectives of this study are (1) to determine the ex vivo neutralizing capacity and the longevity of SARS-CoV-2-specific Ab responses and (2) to measure the memory B-cell responses in a cohort of health care workers (HCW) recovering from severe, mild or asymptomatic infection. By focusing on HCW, a population that is at risk for re-infection during a second epidemic wave, the correlation between nAb levels and protection is investigated.
• Be diagnosed (PCR+) with COVID-19 between March-May 2020
• Be a permanent employee (HCW: nurse, physician, paramedical) of the study hospital
• Agree to complete a short questionnaire and be sampled 4 tubes of heparin whole blood every 3 months over a one-year period
• Have given their informed consent to participate