Brain-controlled Spinal Cord Stimulation in Patients With Spinal Cord Injury

Status: Enrolling by invitation
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In a current first-in-human study, called Stimulation Movement Overground (STIMO, NCT02936453), Epidural Electrical Stimulation (EES) of the spinal cord is applied to enable individuals with chronic severe spinal cord injury (SCI) to complete intensive locomotor neurorehabilitation training. In this clinical feasibility study, it was demonstrated that EES results in an immediate enhancement of walking function, and that when applied repeatedly as part of a neurorehabilitation program, EES can improve leg motor control and trigger neurological recovery in individuals with severe SCI to a certain extent (Wagner et al. 2018). Preclinical studies showed that linking brain activity to the onset and modulation of spinal cord stimulation protocols not only improves the usability of the stimulation, but also augments neurological recovery. Indeed, rats rapidly learned to modulate their cortical activity in order to adjust the amplitude of spinal cord stimulation protocols. This brain-spine interface allowed them to increase the amplitude of the movement of their otherwise paralyzed legs to climb up a staircase (Bonizzato et al. 2018). Moreover, gait rehabilitation enabled by this brain-spine interface (BSI) augmented plasticity and neurological recovery. When EES was correlated with cortical neuron activity during training, rats showed better recovery than when training was only supported by continuous stimulation (Bonizzato et al. 2018). This concept of brain spine-interface was validated in non-human primates (Capogrosso et al. 2016). Clinatec (Grenoble, France) has developed a fully implantable electrocorticogram (ECoG) recording device with a 64-channel epidural electrode array capable of recording electrical signals from the motor cortex for an extended period of time and with a high signal to noise ratio the electrical signals from the motor cortex. This ECoG-based system allowed tetraplegic patients to control an exoskeleton (ClinicalTrials.gov, NCT02550522) with up to 8 degrees of freedom for the upper limb control (Benabid et al. 2019). This device was implanted in 2 individuals so far; one of them has been using this system both at the hospital and at home for more than 3 years. We hypothesize that ECoG-controlled EES in individuals with SCI will establish a direct bridge between the patient's motor intention and the spinal cord below the lesion, which will not only improve or restore voluntary control of leg movements, but will also boost neuroplasticity and neurological recovery when combined with neurorehabilitation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: No
View:

• Having completed the main phase of the STIMO study (NCT02936453).

• SCI graded as American Spinal Injury Association Impairment Scale (AIS) A, B, C & D

• Level of lesion: T10 and above, based on AIS level determination by the PI, with preservation of conus function

• The intact distance between the cone and the lesion must be at least 60 mm.

• Focal spinal cord disorder caused by either trauma or epidural, subdural or intramedullary bleeding

• Minimum 12 months post-injury

• Completed in-patient rehabilitation program

• Stable medical, physical and psychological condition as considered by Investigators

• Able to understand and interact with the study team in French or English

• Adequate care-giver support and access to appropriate medical care in patient's home community

• Must agree to comply in good faith with all conditions of the study and to attend all required study training and visit

• Must provide and sign the Informed Consent prior to any study related procedures

Locations
Other Locations
Switzerland
CHUV
Lausanne
Time Frame
Start Date: July 4, 2021
Estimated Completion Date: August 2023
Participants
Target number of participants: 3
Treatments
Experimental: All participants
All participants receive the same intervention.
Sponsors
Leads: Ecole Polytechnique Fédérale de Lausanne

This content was sourced from clinicaltrials.gov

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