SMA Targeted Magnetic Stimulation Against Auditory Verbal Hallucinations

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Auditory verbal hallucinations (AVH) are prevalent among patients with psychiatric disorders. Not only being highly stressful and functionally impairing, AVH often persist despite treatment. Recent attempts to treat AVH with add-on repetitive transcranial magnetic stimulation (rTMS) when targeting the temporoparietal junction (TPJ), a language node in the brain, has gained limited success. The aim of this investigation is to reduce AVH with rTMS using continous theta-burst stimulation over a novel target, the supplementary motor area (SMA), in participants with frequent AVH, while also assessing potential neurophysiological mechanisms underlying the symptom.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 59
Healthy Volunteers: Accepts Healthy Volunteers
View:

• Reported AVH with a minimum frequency of at least daily occurrence, with onset more than one month ago

• Stable psychopharmacological treatment past month

• Reporting no occurrences of AVH for the past year

• Stable psychopharmacological treatment past month

• No life-time occurrence of AVH

• No history of psychiatric disorders as assessed with a Mini-International Neuropsychiatric Interview (M.I.N.I.)

Locations
Other Locations
Sweden
Department of neuroscience, psychiatry, unit for Brain Stimulation and psychiatric clinical trials
Recruiting
Uppsala
Contact Information
Primary
Daniel Larsson
daniel.larsson@akademiska.se
+46186112222
Backup
Persson, PhD
+46186112222
Time Frame
Start Date: November 2, 2020
Estimated Completion Date: January 31, 2023
Participants
Target number of participants: 64
Treatments
Experimental: Open label active cTBS
Four consecutive days with 40s cTBS, 100% MT over the SMA, five times a day with 50 minutes between stimulations
Experimental: active cTBS
One test session with 40s active cTBS, 100% MT, over the SMA in the initial double blind cross-over phase
Sham Comparator: Sham cTBS
One test session with 40s sham cTBS, 100% MT, over the SMA in the initial double blind cross-over phase with a special sham coil that diverts the magnetic field to be only superficial
Authors
Linda Steinholtz, Martin Cernvall, Elin Thörnblom, Robert Boden
Sponsors
Leads: Uppsala University

This content was sourced from clinicaltrials.gov