Effects of Cervical Chiropractic Adjustments on Heart Rate Variability, Quality of Life and Tumor Marker of Colon Cancer Patients

This preliminary clinical trial will examine the effects of vagal nerve activation via cervical chiropractic adjustments on clinical outcomes in patients with colon cancer. Specifically, hypothesize that participants randomly assigned to receive cervical chiropractic adjustments will have higher heart rate variability (HRV), better health-related quality of life (QOL) and lower levels of both pain and a colon cancer tumor marker, than controls. The aim is to recruit 80 participants with advanced colon cáncer (stage III-IV) who will be measured at baseline for QOL, pain, HRV and a colon cancer marker. Thereafter, they will be randomized to receive a high-velocity low amplitude chiropractic intervention or light touch-based intervention for 10 weeks. Follow up will be at specific intervals across 6 months.