Manually Controlled Infusion vs Target Controlled Infusion: an Hemodynamic Alterations in StrokeThrombectomy Evaluation (HASTE); a Multi-center Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this randomized controlled trial is to compare manual general anesthesia induction to general anesthesia induction guided by target controlled infusion system in cerebral ischemic stroke The main questions it aims to answer are: Does target controlled infusion has a more favorauble hemodynamic profile than manual general anesthesia induction? Do patients receiving general anesthesia with target controlled infusion system have a more favourable outcome? Participants will receive general anesthesia induction with a target controlled infusion system and will be compared to patients receiving manual general anesthesia induction.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Age ≥ 18 years;

• Anterior Cerebral Circulation Stroke

• Patient eligible for mechanical trombectomy

• mRS ≤ 2;

• Fasting patients (>6 h solid, >2 hours liquids)

• Glashow Coma Scale more than seven.

Locations
Other Locations
Italy
University Hospital of Padova
Recruiting
Padova
Contact Information
Primary
Alessandro De Cassai, MD
alessandro.decassai@aopd.veneto.it
+048213698
Time Frame
Start Date: October 9, 2022
Estimated Completion Date: December 2024
Participants
Target number of participants: 224
Treatments
Active Comparator: Manual induction
General Anesthesia induction: Fentanyl 2 mcg/kg, Propofol 2 mg/kg, Rocuronium 0.6 mg/kg General Anesthesia mainteneance: Propofol 4-6 mg/kg/h to keep an adequate sedation level (BIS between 40-60; entropy between 40-60)
Experimental: Target Controlled Induction
General Anesthesia induction: Fentanyl 2 mcg/kg, Propofol TCI with Schneider site effect model starting from 2 mcg/ml and increasing the dose untile loss of consciousness, Rocuronium 0.6 mg/kg.~General Anesthesia mainteneance: Propofol TCI with Schneider site effect model in order to keep an adequate sedation level (BIS between 40-60; entropy between 40-60)
Related Therapeutic Areas
Sponsors
Leads: University of Padova

This content was sourced from clinicaltrials.gov