Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung Cancer

Who is this study for? Patients with small cell lung cancer
Status: Active, not recruiting
Location: See all (283) locations...
Intervention Type: Other, Radiation
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY

This randomized phase II/III trial studies how well whole-brain radiation therapy works and compares it with or without hippocampal avoidance in treating patients with small cell lung cancer that is found in one lung, the tissues between the lungs, and nearby lymph nodes only (limited stage) or has spread outside of the lung in which it began or to other parts of the body (extensive stage). Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. The hippocampus is part of the brain that is important for memory. Avoiding the hippocampus during whole-brain radiation could decrease the chance of side effects on memory and thinking. It is not yet known whether giving whole-brain radiation therapy is more effective with or without hippocampal avoidance in treating patients with small cell lung cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• PRIOR TO STEP 1 REGISTRATION

• Histologic proof or unequivocal cytologic proof (fine needle aspiration, biopsy or two positive sputa) of SCLC within 250 days prior to Step 1 registration

• High-grade neuroendocrine carcinoma or combined SCLC and NSCLC is permitted.

• Patients must have received chemotherapy and be registered to Step 1 registration no earlier than 7 days and no later than 56 days after completing chemotherapy. Note:

• Post-chemotherapy restaging imaging must be completed no more than 56 days prior to Step 1 registration.

• For patients with extensive-stage small cell lung cancer who are being considered for consolidative thoracic radiotherapy after chemotherapy, concomitant administration of consolidative thoracic radiotherapy and protocol-specified prophylactic cranial irradiation with or without hippocampal avoidance is permitted.

• Patients must have a gadolinium contrast-enhanced three-dimensional (3D), spoiled gradient (SPGR), magnetization-prepared rapid gradient echo (MP-RAGE), or turbo field echo (TFE) MRI scan (see section 11.3 regarding axial T2/FLAIR sequence). To yield acceptable image quality, the gadolinium contrast-enhanced three-dimensional SPGR, MP-RAGE or TFE axial MRI scan must use the smallest possible axial slice thickness not exceeding 1.5 mm. Sites may contact the Imaging Co-Chairs for further information or assistance if needed.

• This MRI must be obtained within 56 days prior to Step 1 registration. Note: The MRI study is mandatory irrespective of randomization to the experimental or control arm of this study.

• Prior to chemotherapy +/- thoracic radiotherapy, patients must be defined as limited-stage or extensive-stage SCLC after clinical staging evaluation involving the following:

• History/physical examination;

• CT of the chest and abdomen with contrast (does not have to be done if the patient has had a PET/CT scan prior to initiating chemotherapy or thoracic radiotherapy);

• MRI of the brain with contrast or diagnostic head CT with contrast;

• For patients without evidence of extensive-stage SCLC on chest and abdomen CT and brain MRI or head CT, a PET/CT or bone scan is required to confirm limited-stage SCLC.

• After chemotherapy, patients must be restaged prior to Step 1 registration using the same diagnostic work-up as required pre-chemotherapy. Repeat PET/CT or bone scan is not required. Patients must have:

• History/physical examination within 30 days of Step 1 registration;

• No CNS metastases (Repeat MRI required; see Section 3.2.3 for details) within 56 days prior to Step 1 registration;

• No progression in any site;

• Radiographic partial or complete response to chemotherapy in at least one disease site within 56 days prior to Step 1 registration.

• If PET/CT was obtained prior to chemotherapy, either a repeat PET/CT or CT of the chest and abdomen with contrast can be obtained for response assessment.

• Patients who underwent resection for limited-stage SCLC prior to chemotherapy and have no radiographically evident disease for response assessment remain eligible if post-chemotherapy imaging demonstrates no progression.

• Zubrod performance status 0-2

• Women of childbearing potential and male participants must practice adequate contraception

• Women of childbearing potential must have a negative qualitative serum pregnancy test =< 2 weeks prior to study entry

• Patients who are primary English or French speakers are eligible

• Patients must sign a study-specific informed consent prior to study entry

• PRIOR TO STEP 2 REGISTRATION

• The following baseline neurocognitive assessments must be completed and uploaded within 10 calendar days after or at the time of Step 1 registration: HVLT-R (recall, delayed recall, and recognition), TMT (Parts A and B), and COWA. The neurocognitive assessments will be uploaded into the NRG Oncology RAVE System for evaluation by Dr. Wefel. Once the upload is complete, within 3 business days, a notification email will be sent to the site to proceed to Step 2 registration. At minimum, the HVLT-R delayed recall must be able to be scored (i.e. completed without error) in order to be eligible.

• Patients must have a baseline raw score greater than 2 on the HVLT-R delayed recall

Locations
United States
Alabama
University of Alabama at Birmingham Cancer Center
Birmingham
Lewis and Faye Manderson Cancer Center
Tuscaloosa
Arizona
Banner University Medical Center - Tucson
Tucson
California
Marin General Hospital
Greenbrae
Los Angeles County-USC Medical Center
Los Angeles
USC / Norris Comprehensive Cancer Center
Los Angeles
Mercy UC Davis Cancer Center
Merced
Kaiser Permanente Oakland-Broadway
Oakland
Saint Joseph Hospital - Orange
Orange
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville
The Permanente Medical Group-Roseville Radiation Oncology
Roseville
Sutter Medical Center Sacramento
Sacramento
University of California Davis Comprehensive Cancer Center
Sacramento
California Pacific Medical Center-Pacific Campus
San Francisco
Kaiser Permanente Medical Center - Santa Clara
Santa Clara
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee
Sutter Solano Medical Center/Cancer Center
Vallejo
Colorado
Swedish Medical Center
Englewood
Poudre Valley Hospital
Fort Collins
Connecticut
Hartford HealthCare - Saint Vincent's Medical Center
Bridgeport
Yale University
New Haven
Delaware
Christiana Care Health System-Christiana Hospital
Newark
Helen F Graham Cancer Center
Newark
Florida
Boca Raton Regional Hospital
Boca Raton
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables
Broward Health Medical Center
Fort Lauderdale
Miami Cancer Institute
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami
Orlando Health Cancer Institute
Orlando
Moffitt Cancer Center
Tampa
Georgia
Emory University Hospital Midtown
Atlanta
Emory University Hospital/Winship Cancer Institute
Atlanta
Grady Health System
Atlanta
Northside Hospital
Atlanta
Northside Hospital-Forsyth
Cumming
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah
Memorial Health University Medical Center
Savannah
Hawaii
The Cancer Center of Hawaii-Pali Momi
'aiea
Queen's Medical Center
Honolulu
The Cancer Center of Hawaii-Liliha
Honolulu
Iowa
Mercy Hospital
Cedar Rapids
Saint Luke's Hospital
Cedar Rapids
Iowa Methodist Medical Center
Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Boise
Saint Luke's Cancer Institute - Boise
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell
Saint Luke's Cancer Institute - Meridian
Meridian
Saint Alphonsus Medical Center-Nampa
Nampa
Saint Luke's Cancer Institute - Nampa
Nampa
Saint Luke's Cancer Institute - Twin Falls
Twin Falls
Illinois
John H Stroger Jr Hospital of Cook County
Chicago
Northwestern University
Chicago
Rush University Medical Center
Chicago
Decatur Memorial Hospital
Decatur
Crossroads Cancer Center
Effingham
Northwestern Medicine Cancer Center Delnor
Geneva
Edward Hines Jr VA Hospital
Hines
Condell Memorial Hospital
Libertyville
Loyola University Medical Center
Maywood
Illinois CancerCare-Peoria
Peoria
Methodist Medical Center of Illinois
Peoria
OSF Saint Francis Medical Center
Peoria
Memorial Medical Center
Springfield
Carle Cancer Center
Urbana
Northwestern Medicine Cancer Center Warrenville
Warrenville
Indiana
Saint Vincent Anderson Regional Hospital/Cancer Center
Anderson
Parkview Hospital Randallia
Fort Wayne
Parkview Regional Medical Center
Fort Wayne
Goshen Center for Cancer Care
Goshen
IU Health Ball Memorial Hospital
Muncie
Kansas
University of Kansas Cancer Center
Kansas City
Lawrence Memorial Hospital
Lawrence
University of Kansas Cancer Center-Overland Park
Overland Park
Ascension Via Christi Hospitals Wichita
Wichita
Wesley Medical Center
Wichita
Kentucky
University of Kentucky/Markey Cancer Center
Lexington
Louisiana
Tulane University Health Sciences Center
New Orleans
Massachusetts
Lahey Hospital and Medical Center
Burlington
Lowell General Hospital
Lowell
UMass Memorial Medical Center - University Campus
Worcester
Maryland
Anne Arundel Medical Center
Annapolis
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore
MedStar Good Samaritan Hospital
Baltimore
University of Maryland Medical Center
Baltimore
University of Maryland/Greenebaum Cancer Center
Baltimore
UM Upper Chesapeake Medical Center
Bel Air
Central Maryland Radiation Oncology in Howard County
Columbia
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie
TidalHealth Richard A Henson Cancer Institute
Ocean Pines
TidalHealth Peninsula Regional
Salisbury
UM Saint Joseph Medical Center
Towson
Michigan
Saint Joseph Mercy Hospital
Ann Arbor
McLaren Cancer Institute-Bay City
Bay City
Saint Joseph Mercy Brighton
Brighton
Henry Ford Cancer Institute-Downriver
Brownstown
Saint Joseph Mercy Chelsea
Chelsea
GenesisCare USA - Clarkston
Clarkston
McLaren Cancer Institute-Clarkston
Clarkston
Henry Ford Macomb Hospital-Clinton Township
Clinton Township
Beaumont Hospital - Dearborn
Dearborn
Henry Ford Hospital
Detroit
Wayne State University/Karmanos Cancer Institute
Detroit
GenesisCare USA - Farmington Hills
Farmington Hills
Genesys Hurley Cancer Institute
Flint
McLaren Cancer Institute-Flint
Flint
Mercy Health Saint Mary's
Grand Rapids
Spectrum Health at Butterworth Campus
Grand Rapids
West Michigan Cancer Center
Kalamazoo
McLaren Cancer Institute-Lapeer Region
Lapeer
Saint Mary Mercy Hospital
Livonia
GenesisCare USA - Macomb
Macomb
McLaren Cancer Institute-Macomb
Mount Clemens
McLaren Cancer Institute-Central Michigan
Mount Pleasant
Mercy Health Mercy Campus
Muskegon
McLaren Cancer Institute-Owosso
Owosso
McLaren Cancer Institute-Northern Michigan
Petoskey
Saint Joseph Mercy Oakland
Pontiac
McLaren-Port Huron
Port Huron
William Beaumont Hospital-Royal Oak
Royal Oak
Lakeland Medical Center Saint Joseph
Saint Joseph
GenesisCare USA - Troy
Troy
William Beaumont Hospital - Troy
Troy
Henry Ford West Bloomfield Hospital
West Bloomfield
Minnesota
Mayo Clinic Health System in Albert Lea
Albert Lea
Saint Luke's Hospital of Duluth
Duluth
Mayo Clinic Health Systems-Mankato
Mankato
Abbott-Northwestern Hospital
Minneapolis
Mayo Clinic Radiation Therapy-Northfield
Northfield
Mayo Clinic in Rochester
Rochester
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park
Missouri
Saint Francis Medical Center
Cape Girardeau
Siteman Cancer Center at West County Hospital
Creve Coeur
Freeman Health System
Joplin
North Kansas City Hospital
Kansas City
Saint Luke's Hospital of Kansas City
Kansas City
University of Kansas Cancer Center - North
Kansas City
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City
Mercy Hospital Saint Louis
Saint Louis
Missouri Baptist Medical Center
Saint Louis
Siteman Cancer Center-South County
Saint Louis
Washington University School of Medicine
Saint Louis
Montana
Billings Clinic Cancer Center
Billings
Benefis Healthcare- Sletten Cancer Institute
Great Falls
Community Medical Hospital
Missoula
North Carolina
Atrium Health Pineville/LCI-Pineville
Charlotte
Atrium Health University City/LCI-University
Charlotte
Carolinas Medical Center/Levine Cancer Institute
Charlotte
Atrium Health Cabarrus/LCI-Concord
Concord
Atrium Health Union/LCI-Union
Monroe
Atrium Health Cleveland/LCI-Cleveland
Shelby
North Dakota
Sanford Bismarck Medical Center
Bismarck
Sanford Roger Maris Cancer Center
Fargo
Nebraska
University of Nebraska Medical Center
Omaha
New Hampshire
Wentworth-Douglass Hospital
Dover
Dartmouth Hitchcock Medical Center
Lebanon
New Jersey
Memorial Sloan Kettering Basking Ridge
Basking Ridge
Englewood Hospital and Medical Center
Englewood
Memorial Sloan Kettering Monmouth
Middletown
Virtua Memorial
Mount Holly
Virtua Voorhees
Voorhees
New Mexico
University of New Mexico Cancer Center
Albuquerque
Nevada
Renown Regional Medical Center
Reno
New York
Northwell Health Imbert Cancer Center
Bay Shore
Montefiore Medical Center - Moses Campus
Bronx
Montefiore Medical Center-Einstein Campus
Bronx
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn
Roswell Park Cancer Institute
Buffalo
Memorial Sloan Kettering Commack
Commack
Arnot Ogden Medical Center/Falck Cancer Center
Elmira
Memorial Sloan Kettering Westchester
Harrison
Northwell Health/Center for Advanced Medicine
Lake Success
Lenox Hill Hospital
New York
Memorial Sloan Kettering Cancer Center
New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York
University of Rochester
Rochester
Staten Island University Hospital
Staten Island
State University of New York Upstate Medical University
Syracuse
Memorial Sloan Kettering Nassau
Uniondale
Ohio
Cleveland Clinic Akron General
Akron
Summa Health System - Akron Campus
Akron
Geauga Hospital
Chardon
Adena Regional Medical Center
Chillicothe
Case Western Reserve University
Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland
Cleveland Clinic Foundation
Cleveland
Mount Carmel Health Center West
Columbus
Ohio State University Comprehensive Cancer Center
Columbus
Dayton Physician LLC-Miami Valley Hospital North
Dayton
Mercy Cancer Center-Elyria
Elyria
Cleveland Clinic Cancer Center Independence
Independence
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor
UH Seidman Cancer Center at Southwest General Hospital
Middleburg Heights
University Hospitals Parma Medical Center
Parma
Cleveland Clinic Cancer Center Strongsville
Strongsville
UHHS-Westlake Medical Center
Westlake
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster
Oklahoma
University of Oklahoma Health Sciences Center
Oklahoma City
Oregon
Legacy Mount Hood Medical Center
Gresham
Legacy Good Samaritan Hospital and Medical Center
Portland
Pennsylvania
Jefferson Abington Hospital
Abington
Crozer-Keystone Regional Cancer Center at Broomall
Broomall
Bryn Mawr Hospital
Bryn Mawr
Christiana Care Health System-Concord Health Center
Chadds Ford
Geisinger Medical Center
Danville
Northeast Radiation Oncology Center
Dunmore
Adams Cancer Center
Gettysburg
Crozer Regional Cancer Center at Brinton Lake
Glen Mills
Geisinger Medical Oncology-Lewisburg
Lewisburg
Riddle Memorial Hospital
Media
Fox Chase Cancer Center
Philadelphia
Jefferson Torresdale Hospital
Philadelphia
Temple University Hospital
Philadelphia
Thomas Jefferson University Hospital
Philadelphia
Penn State Health Saint Joseph Medical Center
Reading
Reading Hospital
West Reading
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-barre
Lankenau Medical Center
Wynnewood
WellSpan Health-York Cancer Center
York
South Carolina
AnMed Health Cancer Center
Anderson
Prisma Health Cancer Institute - Spartanburg
Boiling Springs
Prisma Health Cancer Institute - Eastside
Greenville
Prisma Health Cancer Institute - Faris
Greenville
Self Regional Healthcare
Greenwood
The Radiation Oncology Center-Hilton Head/Bluffton
Hilton Head Island
Lancaster Radiation Therapy Center
Lancaster
Rock Hill Radiation Therapy Center
Rock Hill
South Dakota
Rapid City Regional Hospital
Rapid City
Sanford USD Medical Center - Sioux Falls
Sioux Falls
Tennessee
Thompson Cancer Survival Center
Knoxville
Blount Memorial Hospital
Maryville
Vanderbilt University/Ingram Cancer Center
Nashville
Texas
University of Texas Medical Branch
Galveston
M D Anderson Cancer Center
Houston
UTMB Cancer Center at Victory Lakes
League City
Utah
Ogden Regional Medical Center
Ogden
Huntsman Cancer Institute/University of Utah
Salt Lake City
Virginia
Virginia Commonwealth University/Massey Cancer Center
Richmond
Vermont
Central Vermont Medical Center/National Life Cancer Treatment
Berlin
University of Vermont Medical Center
Burlington
Norris Cotton Cancer Center-North
Saint Johnsbury
Wisconsin
Langlade Hospital and Cancer Center
Antigo
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield
Mayo Clinic Health System Eau Claire Hospital-Luther Campus
Eau Claire
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire
Ascension Saint Francis - Reiman Cancer Center
Franklin
Aurora Cancer Care-Grafton
Grafton
Aurora BayCare Medical Center
Green Bay
UW Cancer Center Johnson Creek
Johnson Creek
Aurora Cancer Care-Kenosha South
Kenosha
Gundersen Lutheran Medical Center
La Crosse
Mayo Clinic Health System-Franciscan Healthcare
La Crosse
University of Wisconsin Hospital and Clinics
Madison
Froedtert Menomonee Falls Hospital
Menomonee Falls
Aurora Saint Luke's Medical Center
Milwaukee
Aurora Sinai Medical Center
Milwaukee
Medical College of Wisconsin
Milwaukee
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh
Ascension All Saints Hospital
Racine
Marshfield Clinic Stevens Point Center
Stevens Point
Aurora Medical Center in Summit
Summit
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers
Aspirus Regional Cancer Center
Wausau
Aurora West Allis Medical Center
West Allis
Diagnostic and Treatment Center
Weston
Marshfield Medical Center - Weston
Weston
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids
West Virginia
West Virginia University Healthcare
Morgantown
Wheeling Hospital/Schiffler Cancer Center
Wheeling
Other Locations
Canada
Kingston Health Sciences Centre
Kingston
London Regional Cancer Program
London
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal
CHUM - Hopital Notre-Dame
Montreal
McGill University Department of Oncology
Montreal
The Research Institute of the McGill University Health Centre (MUHC)
Montreal
Stronach Regional Health Centre at Southlake
Newmarket
Ottawa Hospital and Cancer Center-General Campus
Ottawa
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Quebec City
Allan Blair Cancer Centre
Regina
Saskatoon Cancer Centre
Saskatoon
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke
University Health Network-Princess Margaret Hospital
Toronto
Time Frame
Start Date: December 7, 2015
Estimated Completion Date: April 2027
Participants
Target number of participants: 418
Treatments
Active Comparator: Arm I (PCI using 3DCRT)
Patients undergo PCI using 3DCRT daily for 2 weeks.
Experimental: Arm II (PCI with HA using IMRT)
Patients undergo PCI with HA using IMRT daily for 2 weeks.
Authors
Steven J. Feigenberg, Nicholas A. Blondin, John L. Mikell, Clifford G. Robinson, Inga S. Grills, Sinisa Stanic, Bradford A. Perez, Desiree E. Doncals, Grant M. Clark, Timothy J. Kruser, Vinai Gondi, David T. Marshall, Mitchell Machtay, Brian K. Yeh, Simon K. Cheng, Roy H. Decker, David M. Dubin, Jason R. Citron, Robert J. Behrens, Chi K. Tsang, Ruben C. Fragoso, Paul G. Montgomery, Bryan A. Faller, Matthew S. Katz, Richard A. Peterson, Amit K. Bhatt, Preston D. Steen, Matthew M. Harkenrider, Ashok Ramalingam, Justin M. Rineer, Navesh K. Sharma, Yuhchyau Chen, Andrew Y. Kee, Howard M. Gross, Jay W. Carlson, Gaurav Marwaha, Rajiv Sharma, Anand Mahadevan, Arul Mahadevan, William V. Walsh, Sajeel A. Chowdhary, Wayne H. Pinover, Howard A. Zaren, Aaron W. Pederson, Tithi Biswas, Minesh P. Mehta, Thomas E. Lad, Stephanie E. Weiss, Robert B. Ash, Alexander M. Yeh, Timothy D. Moore, Cheryl M. Czerlanis, Christopher U. Jones, Emory McTyre, Krishna C. Alluri, John M. Schallenkamp, Evan M. Landau, Patricia K. Lillis, Albert S. DeNittis, Gregory A. Masters, Keren Sturtz, Frank A. Vicini, Brian K. Chang, Luqman Dad, Thomas M. Schroeder, Kiran Devisetty, Andrew M. Baschnagel, Joseph A. Bovi, Eleanor M. Walker, Weining Zhen, Joshua Lukenbill, Todd A. Swanson, Jack J. Hong, Mitchel L. Fromm, Michael D. Zurenko, Michael D. Mix, Eric A. Mellon, Steven R. Bonin, Malcolm D. Mattes, Wenyin Shi, Klaudia U. Hunter, Ellen L. Ziaja, Samir Narayan, Yolanda I. Garces, Charles C. Hsu, David L. Grisell, Parvez M. Shaikh, Michael J. Swartz, Hani L. Ashamalla, Leander I. Cannick, Terrence P. Cescon, Gregory A. Russo, Rachelle M. Lanciano, Michael C. Dobelbower, Collin D. Driscoll, Richard L. Jennelle, John H. Heinzerling, Shaker R. Dakhil, Yunjie X. Lin, Abraham J. Wu, Kristin A. Higgins, Dean J. Conterato, Ying J. Hitchcock, Phillip M. Vigneri, Samantha A. Seaward, Dan S. Zuckerman, Henry S. Park, Kristin J. Redmond, James A. Wheeler, Fen Wang, John R. Mansueti, James C. Tucker, Jondavid Pollock, Pranshu Mohindra, Albert Attia, Rupesh R. Kotecha, James L. Wade, Benjamin T. Marchello, James H. Taylor, Robert J. Isaak, Bevan Ly, Mark V. Mishra, Brandon J. Fisher, Edmund L. Simon, Dheerendra Prasad, Paul B. Fowler, William E. Richards, Christopher S. Platta, Sameer Rafla-Demetrious, Zishan Allibhai, J. S. Thompson, Tony J. Wang, Alexander Y. Sun, Timothy J. Harris, Caroline Lavoie, Ronald C. McGarry, Richard Y. Lee, Rakesh Gaur, Isabelle Thibault, Karl E. Haglund, Shannon Offerman, Amit B. Shah, Gregory M. M. Videtic, Vijayananda Kundapur, Christopher J. Anker, Kathleen J. Yost, John A. Ellerton, Sergio L. Faria, Robert M. MacRae, Michelle J. Ferguson, William R. Bodner, John M. Varlotto, Anne Dagnault
Sponsors
Leads: NRG Oncology
Collaborators: National Cancer Institute (NCI), Radiation Therapy Oncology Group

This content was sourced from clinicaltrials.gov

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