PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes.

Status: Active, not recruiting

Location: See location...

Study Type: Observational

SUMMARY

Central Nervous System (CNS) demyelinating conditions include multiple sclerosis (MS), Acute Disseminated Encephalomyelitis (ADEM), Neuromyelitis Optica Spectrum Disorder (NMOSD), Optic Neuritis (ON) and Transverse Myelitis (TM). The symptoms of these conditions are quite variable from patient to patient, but can include motor, sensory, visual, gait and cognitive changes. Conventional MRI can be used to look for new anatomic changes, but fails to measure underlying biochemical changes in brain tissue. The purposes of this study are to identify the biologic and anatomic correlations between cognitive profiles and disease activity using MRI imaging techniques.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 12

Maximum Age: 21

Healthy Volunteers: Accepts Healthy Volunteers

View:

• Diagnosis of Multiple Sclerosis , ADEM, anti-MOG antibody associated CNS demyelination

• Age 12 to 21 inclusive at time of enrollment

• Ability of parent or legal guardian to provide informed consent if participant is under 18.

• Ability of patients age 12-17 to give assent

• Completion of the signed HIPPA authorization form by a parent or legal guardian or by participants (18 years of age).

Locations

United States

Texas

University Texas Southwestern

Dallas

Time Frame

Start Date: October 22, 2019

Estimated Completion Date: May 31, 2024

Participants

Target number of participants: 160

Treatments

CNS demyelinating diagnosis

Diagnosis of CNS demyelinating disorder: Multiple Sclerosis, Transverse Myelitis, Neuromyelitis Optica, Acute Disseminated Encephalomyelitis, anti-MOG antibody, Optic Neuritis.~3T and 7T MRI~Neuropsychological testing~Optical Coherence Tomography~Questionnaires: Quality of Life and Behavior scales~Non invasive clinical assessment : Walking, hand and eye coordination tests Repeat same research activities one to year and a half year later

Healthy Control

3T and 7T MRI~Neuropsychological testing~Optical Coherence Tomography~Questionnaires: Quality of Life and Behavior scales~Non invasive clinical assessment : Walking, hand and eye coordination tests Repeat same research activities one year to a year and a half later

Authors

Lana Harder, Benjamin Greenberg

Related Therapeutic Areas

Drug Induced Dyskinesia

Transverse Myelitis

Multiple Sclerosis (MS)