PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes.

Status: Active, not recruiting
Location: See location...
Study Type: Observational
SUMMARY

Central Nervous System (CNS) demyelinating conditions include multiple sclerosis (MS), Acute Disseminated Encephalomyelitis (ADEM), Neuromyelitis Optica Spectrum Disorder (NMOSD), Optic Neuritis (ON) and Transverse Myelitis (TM). The symptoms of these conditions are quite variable from patient to patient, but can include motor, sensory, visual, gait and cognitive changes. Conventional MRI can be used to look for new anatomic changes, but fails to measure underlying biochemical changes in brain tissue. The purposes of this study are to identify the biologic and anatomic correlations between cognitive profiles and disease activity using MRI imaging techniques.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Maximum Age: 21
Healthy Volunteers: Accepts Healthy Volunteers
View:

• Diagnosis of Multiple Sclerosis , ADEM, anti-MOG antibody associated CNS demyelination

• Age 12 to 21 inclusive at time of enrollment

• Ability of parent or legal guardian to provide informed consent if participant is under 18.

• Ability of patients age 12-17 to give assent

• Completion of the signed HIPPA authorization form by a parent or legal guardian or by participants (18 years of age).

Locations
United States
Texas
University Texas Southwestern
Dallas
Time Frame
Start Date: October 22, 2019
Estimated Completion Date: May 31, 2024
Participants
Target number of participants: 160
Treatments
CNS demyelinating diagnosis
Diagnosis of CNS demyelinating disorder: Multiple Sclerosis, Transverse Myelitis, Neuromyelitis Optica, Acute Disseminated Encephalomyelitis, anti-MOG antibody, Optic Neuritis.~3T and 7T MRI~Neuropsychological testing~Optical Coherence Tomography~Questionnaires: Quality of Life and Behavior scales~Non invasive clinical assessment : Walking, hand and eye coordination tests Repeat same research activities one to year and a half year later
Healthy Control
3T and 7T MRI~Neuropsychological testing~Optical Coherence Tomography~Questionnaires: Quality of Life and Behavior scales~Non invasive clinical assessment : Walking, hand and eye coordination tests Repeat same research activities one year to a year and a half later
Authors
Lana Harder, Benjamin Greenberg
Sponsors
Leads: University of Texas Southwestern Medical Center

This content was sourced from clinicaltrials.gov

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