Repetitive Exposure of Intermittent Hypoxia to Enhance Walking Recovery in Persons With Chronic Spinal Cord Injury

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to determine how the nervous system controlling leg muscles is altered following spinal cord injury and how they may be affected by brief periods of low oxygen inhalation over time. The investigators hypothesize: Acute intermittent hypoxia (AIH) exposure will increase maximum voluntary leg strength in persons with incomplete cervical spinal cord injury (SCI) AIH exposure will increase multijoint reflex excitability of leg muscles in persons with incomplete cervical SCI AIH exposure will increase walking performance in persons with incomplete cervical SCI

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: No
View:

• 18 to 75 years old (the latter to reduce likelihood of heart disease);

• medically stable with clearance from physician to participate;

• motor---incomplete SCI at C2---L5 with non---progressive etiology;

• >6 months since SCI to ensure minimal confounds of spontaneous neurological recovery;

• those classified as ambulatory must have the ability to advance one step overground without human assistance.

Locations
United States
Massachusetts
Spaulding Rehabilitation Hospital
Recruiting
Cambridge
Contact Information
Primary
Randy D Trumbower, PT, PhD
randy.trumbower@mgh.harvard.edu
617-952-6951
Backup
Stella Barth, BA
sbarth@partners.org
617-952-6822
Time Frame
Start Date: October 2014
Estimated Completion Date: August 2023
Participants
Target number of participants: 20
Treatments
Active Comparator: Intermittent Hypoxia (AIH)
Subjects with chronic, motor-incomplete SCI will breath mild bouts of low oxygen.~Intervention: AIH - Intermittent Hypoxia - hypoxia air mixture Dosage: 10% oxygen Frequency: 1.5 minutes bouts of low oxygen with 1.0 minute intervals of room air Duration: 38 minutes
Sham Comparator: Intermittent Room Air (SHAM)
Subjects with chronic, motor-incomplete SCI will breath mild bouts of room air.~Intervention: SHAM - Intermittent Room Air - room air mixture Dosage: 21% oxygen Frequency: 1.5 minutes bouts of room air with 1.0 minute intervals also of room air Duration: 38 minutes
Authors
Randy D Trumbower
Related Therapeutic Areas
Sponsors
Collaborators: Foundation Wings For Life
Leads: Spaulding Rehabilitation Hospital

This content was sourced from clinicaltrials.gov

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