Collaboration on Neuroimmunology: Question, Understand, Educate, Restore - The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders

Status: Recruiting
Location: See location...
Study Type: Observational

This study seeks to determine the biologic causes of inflammation in patients with Transverse Myelitis (TM) Neuromyelitis Optica Spectrum Disorder (NMOSD) and related conditions. While patients will be treated according to decisions with their treating physician, this study will collect data and samples from patients prospectively to gain a better understanding of the disease. We are seeking to understand why some patients respond to medications, while others do not. We also seek to understand what happens biologically, preceding relapses. Gathering these data and samples will allow researchers to identify new ways of diagnosing and treating these diseases. Data and samples will be shared with researchers around the world to support collaborative efforts to treat these conditions.

Participation Requirements
Sex: All
Minimum Age: 6
Healthy Volunteers: Accepts Healthy Volunteers

• Age 6 years or greater

• Male or Female

• Patient or Parent (in the case of a minor) able to give informed consent

• For patients 10 to 17, patient able to assent

• Patient diagnosed with NMO, NMOSD, TM or ON

United States
The University of Texas Southwestern Medical Center
Contact Information
Jan Cameron-Watts, RN
Martha Mann, RN
Time Frame
Start Date: June 2012
Estimated Completion Date: June 2023
Target number of participants: 150
Neuromyelitis Optica Spectrum Disorder
Patients diagnosed with NMOSD based on revised diagnostic criteria. Seronegative, anti-AQP4 seropositive and ant-MOG seropositive patients will be included
Transverse Myelitis and Optic Neuritis
Patients who have had one demyelinating event, not diagnosed with multiple sclerosis and whom are considered at risk for NMO or NMOSD.
Healthy Controls
patients without a history of CNS inflammation
Neuromyelitis Optica
patients diagnosed with NMO
Leads: University of Texas Southwestern Medical Center

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