A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients With 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer With Recurrence Score (RS) of 25 or Less. RxPONDER: A Clinical Trial Rx for Positive Node, Endocrine Responsive Breast Cancer

Who is this study for? Patients with Breast Cancer
Status: Active, not recruiting
Location: See all (1583) locations...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This randomized phase III clinical trial studies how well tamoxifen citrate, anastrozole, letrozole, or exemestane with or without chemotherapy work in treating patients with breast cancer that has spread from where it began in the breast to surrounding normal tissue (invasive). Estrogen can cause the growth of breast cancer cells. Hormone therapy, using tamoxifen citrate, may fight breast cancer by blocking the use of estrogen by the tumor cells. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, may fight breast cancer by lowering the amount of estrogen the body makes. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving tamoxifen citrate, anastrozole, letrozole, or exemestane is more effective with combination chemotherapy in treating patients with breast cancer.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: No
View:

• Patients must have a histologically confirmed diagnosis of node positive (1-3 nodes) invasive breast carcinoma with positive estrogen and/or progesterone receptor status, and negative HER-2 status; estrogen and progesterone receptor positivity must be assessed according to American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines as either estrogen receptor (ER) or progesterone receptor (PR) >= 1% positive nuclear staining; HER-2 test result negativity must be assessed as per ASCO/CAP 2013 guidelines using immunohistochemistry (IHC), in situ hybridization (ISH) or both; HER-2 is negative if a single test (or all tests) performed in a tumor specimen show: a) IHC negative (0 or 1+) or b) ISH negative using single probe or dual probe (average HER-2 copy number < 4.0 signals per cell by single probe or HER-2/CEP ration < 2.0 with an average copy number < 4.0 signals per cell by dual probe); if HER-2 IHC is 2+, evaluation for gene amplification (ISH) must be performed and the ISH must be negative; ISH is not required if IHC is 0 or 1+; HER-2 equivocal is not eligible

• Patients with multifocal, multicentric and synchronous bilateral breast cancers are allowed

• Multifocal disease is defined as more than one invasive cancer < 2 cm from the largest lesion within the same breast quadrant; (NOTE: the Oncotype DX testing must be completed on the largest lesion)

• Multicentric disease is defined as more than one invasive cancer >= 2 cm from the largest lesion within the same breast quadrant or more than one lesion in different quadrants (NOTE: Oncotype DX testing should be completed on all tumors and the determination for eligibility should be made on the highest recurrence score)

• Synchronous bilateral disease is defined as invasive breast cancer with positive lymph nodes (axillary or intramammary) in at least one breast, diagnosed within 30 days of each other; (NOTE: the Oncotype DX testing should be completed on both tumors and the tumor with the highest recurrence score should be used)

• Patients will have undergone axillary staging by sentinel node biopsy or axillary lymph nodes dissection (ALND); patients must have at least one, but no more than three known positive lymph nodes (pN1a, pN1b or pN1c); patients with micrometastases as the only nodal involvement (pN1mi) are not eligible; patients with positive sentinel node are not required to undergo full axillary lymph node dissection; this is at the discretion of the treating physician; axillary node evaluation is to be performed per the standard of care at each institution

• Patients with a prior diagnosis of contralateral ductal carcinoma in situ (DCIS) are eligible if they underwent a mastectomy or lumpectomy with whole breast radiation; prior partial breast irradiation, including brachytherapy, is not allowed; patients with a prior diagnosis of ipsilateral DCIS or invasive breast cancer who received radiation to that breast are not eligible

• Patients must have had either breast-conserving surgery with planned radiation therapy or total mastectomy (with or without planned postmastectomy radiation); patients must have clear margins from both invasive breast cancer and DCIS (as per local institutional guidelines); lobular carcinoma in situ (LCIS) at the margins is allowed

• Registration of patients who have not yet undergone Oncotype DX screening must occur no later than 56 days after definitive surgery; (for all patients, Step 2 Registration must occur within 84 days after definitive surgery); if the Oncotype DX Breast Cancer Assay has not been performed, patients must be willing to submit tissue samples for testing to determine the Recurrence Score value; a representative block or unstained sections from the representative block are sent directly to Genomic Health for Oncotype DX Breast Cancer Assay which will be performed according to the standard commercial process

• If the Oncotype DX Recurrence Score is already known and is 25 or less, the patient must be registered to Step 2 immediately following Step 1 registration; if the Oncotype DX Recurrence Score is already known and is greater than 25, the patient is ineligible

• Patients must be females >= 18 years of age. As the Oncotype DX recurrence score has not been validated in men with breast cancer, men are not eligible for this study

• Patients must have a complete history and physical examination within 28 days prior to registration

• Patients must have a performance status of 0-2 by Zubrod criteria

• Patients must be able to receive taxane and/or anthracycline based chemotherapy

• Patients must not have received an aromatase inhibitor (AI) or a selective estrogen receptor modulator (SERM) such as tamoxifen or raloxifene within 5 years prior to registration

• No other prior malignancy is allowed except for adequately treated basal cell (or squamous cell) skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for 5 years

• The Quality of Life and Economic Substudy is permanently closed to accrual effective 12/1/12; patients who consented to QOL prior to 12/1/12 should continue to complete QOL forms per their expectation report; patients who are able to complete a questionnaire in English must be offered the opportunity to participate in the Quality of Life and Economic Substudy; (The Quality of Life and Economic Substudy is available to U.S. INSTITUTIONS ONLY); patients who are not able to complete a questionnaire in English are registered to S1007 without participating in the Quality of Life and Economic Substudy

• Patients who consent to participate in the Quality of Life and Economic Substudy and who do not yet know the results of their Oncotype DX screening must agree to complete the S1007 Health-Related Quality of Life Questionnaire: Enrollment between 14 days prior to and 7 days after Step 1 Registration

• Patients who consent to participate in the Quality of Life and Economic Substudy and who do already know their Oncotype DX Recurrence Score (and it is 25 or less) will proceed to Step 2 Registration without completing the S1007 Health-Related Quality of Life Questionnaire Enrollment Form (but will complete the S1007 Health-Related Quality of Life Questionnaire: Randomized Study Form)

• Patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines; for Step 1 registration of patients who have not yet submitted specimens for the Oncotype DX Breast Cancer Assay, the appropriate consent form is the Step 1 Consent Form; for both Step 1 and Step 2 registration of patients whose Recurrence Score is already known and is 25 or less, the appropriate consent form is the Step 2 Consent Form

• As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

• STEP 2 REGISTRATION

• Recurrence score (RS) by Oncotype DX must be =< 25

• Step 2 Registration must take place within 84 days after definitive surgery; patients must not have begun chemotherapy or endocrine therapy for their breast cancer prior to randomization

• Patients randomized to either arm may also co-enroll in phase III trials that compare local therapies, or compare systemic therapies (such as chemotherapy, if randomized to Arm I of S1007)

• The Quality of Life and Economic Substudy is permanently closed to accrual effective 12/1/12; patients at U.S. INSTITUTIONS who consent to participate in the Quality of Life and Economic Substudy must agree to complete the S1007 Health-Related Quality of Life Questionnaire: Randomized Study Form after Recurrence Score results and randomized treatment status are known but before treatment has been initiated

• Patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines; for all patients the appropriate consent form for this registration is the Step 2 Consent

• STEP 3 REGISTRATION CBALR TM Substudy

• Patients must be disease-free, with no prior invasive recurrence at time of registration to Step 3

• Patients must be registered to Step 3 no more than 8 years after randomization (Step 2 Registration) and must agree to have samples drawn within 28 days after registration to Step 3

• Patients must agree to have blood samples collected at up to 3 timepoints: 1) within 28 days after registration to Step 3, 2) 2-3 years after time of registration to Step 3, and 3) At time of invasive recurrence (if applicable). Patients must also agree to have tissue submitted at time of invasive recurrence (if applicable) from the invasive recurrence biopsy (where tissue is available)

Locations
United States
Alaska
Alaska Breast Care and Surgery LLC
Anchorage
Alaska Oncology and Hematology LLC
Anchorage
Alaska Regional Hospital
Anchorage
Alaska Women's Cancer Care
Anchorage
Anchorage Associates in Radiation Medicine
Anchorage
Anchorage Oncology Centre
Anchorage
Anchorage Radiation Therapy Center
Anchorage
Katmai Oncology Group
Anchorage
Providence Alaska Medical Center
Anchorage
Fairbanks Memorial Hospital
Fairbanks
Alabama
Northeast Alabama Regional Medical Center
Anniston
University of Alabama at Birmingham Cancer Center
Birmingham
Providence Hospital
Mobile
University of South Alabama Mitchell Cancer Institute
Mobile
Arkansas
Mercy Hospital Fort Smith
Fort Smith
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs
NEA Baptist Memorial Hospital
Jonesboro
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro
Arizona
Virginia G Piper Cancer Care-Del Camino
Scottsdale
California
Kaiser Permanente-Anaheim
Anaheim
East Bay Medical Oncology Hematology Medical Associates-Antioch
Antioch
Kaiser Permanente-Deer Valley Medical Center
Antioch
PCR Oncology
Arroyo Grande
Sutter Auburn Faith Hospital
Auburn
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn
Kaiser Permanente-Baldwin Park
Baldwin Park
Kaiser Permanente-Bellflower
Bellflower
Alta Bates Summit Medical Center-Herrick Campus
Berkeley
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank
Mills-Peninsula Medical Center
Burlingame
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park
Mercy San Juan Medical Center
Carmichael
East Bay Radiation Oncology Center
Castro Valley
Eden Hospital Medical Center
Castro Valley
Valley Medical Oncology Consultants-Castro Valley
Castro Valley
Community Cancer Institute
Clovis
University Oncology Associates
Clovis
John Muir Medical Center-Concord Campus
Concord
UC Irvine Health Cancer Center-Newport
Costa Mesa
Sutter Davis Hospital
Davis
City of Hope Comprehensive Cancer Center
Duarte
Epic Care-Dublin
Dublin
Bay Area Breast Surgeons Inc
Emeryville
Epic Care Partners in Cancer Care
Emeryville
Kaiser Permanente-Fontana
Fontana
Kaiser Permanente-Fremont
Fremont
Palo Alto Medical Foundation-Fremont
Fremont
Valley Medical Oncology Consultants-Fremont
Fremont
Washington Hospital
Fremont
Kaiser Permanente-Fresno
Fresno
Kaiser Permanente - Harbor City
Harbor City
Kaiser Permanente-Irvine
Irvine
UC San Diego Moores Cancer Center
La Jolla
Loma Linda University Medical Center
Loma Linda
Long Beach Memorial Medical Center-Todd Cancer Institute
Long Beach
Cedars Sinai Medical Center
Los Angeles
Kaiser Permanente Los Angeles Medical Center
Los Angeles
Kaiser Permanente West Los Angeles
Los Angeles
Los Angeles County-USC Medical Center
Los Angeles
USC / Norris Comprehensive Cancer Center
Los Angeles
Contra Costa Regional Medical Center
Martinez
Fremont - Rideout Cancer Center
Marysville
Mercy UC Davis Cancer Center
Merced
Kaiser Permanente-Modesto
Modesto
Memorial Medical Center
Modesto
El Camino Hospital
Mountain View
Palo Alto Medical Foundation-Camino Division
Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View
Northridge Hospital Medical Center
Northridge
Sutter Cancer Research Consortium
Novato
Alta Bates Summit Medical Center - Summit Campus
Oakland
Bay Area Tumor Institute
Oakland
Hematology and Oncology Associates-Oakland
Oakland
Highland General Hospital
Oakland
Kaiser Permanente-Oakland
Oakland
Tom K Lee Inc
Oakland
Saint Joseph Hospital - Orange
Orange
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange
Desert Regional Medical Center
Palm Springs
Palo Alto Medical Foundation Health Care
Palo Alto
Stanford Cancer Institute Palo Alto
Palo Alto
Kaiser Permanente - Panorama City
Panorama City
Keck Medical Center of USC Pasadena
Pasadena
East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill
Pleasant Hill
John Muir Health Cancer Medical Group
Pleasant Hill
Valley Medical Oncology Consultants
Pleasanton
Pomona Valley Hospital Medical Center
Pomona
Kaiser Permanente-Redwood City
Redwood City
Kaiser Permanente-Richmond
Richmond
Kaiser Permanente-Riverside
Riverside
Kaiser Permanente-Roseville
Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville
Sutter Roseville Medical Center
Roseville
Kaiser Permanente - Sacramento
Sacramento
Kaiser Permanente-South Sacramento
Sacramento
Sutter Medical Center Sacramento
Sacramento
University of California Davis Comprehensive Cancer Center
Sacramento
Salinas Valley Memorial
Salinas
Kaiser Permanente-San Diego Mission
San Diego
Kaiser Permanente-San Diego Zion
San Diego
Sharp Memorial Hospital
San Diego
California Pacific Medical Center-Pacific Campus
San Francisco
Kaiser Permanente-San Francisco
San Francisco
Kaiser Permanente-Santa Teresa-San Jose
San Jose
East Bay Medical Oncology Hematology Associates Inc
San Leandro
Kaiser Permanente San Leandro
San Leandro
Kaiser Permanente-San Marcos
San Marcos
Doctors Medical Center- JC Robinson Regional Cancer Center
San Pablo
Kaiser Permanente-San Rafael
San Rafael
Kaiser Permanente Medical Center - Santa Clara
Santa Clara
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz
Kaiser Permanente-Santa Rosa
Santa Rosa
Sutter Pacific Medical Foundation
Santa Rosa
Kaiser Permanente-South San Francisco
South San Francisco
Kaiser Permanente-Stockton
Stockton
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale
Olive View-University of California Los Angeles Medical Center
Sylmar
Kaiser Permanente Medical Center-Vacaville
Vacaville
Northbay Cancer Center
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Vacaville
Kaiser Permanente-Vallejo
Vallejo
Sutter Solano Medical Center/Cancer Center
Vallejo
John Muir Medical Center-Walnut Creek
Walnut Creek
Kaiser Permanente-Walnut Creek
Walnut Creek
Presbyterian Intercommunity Hospital
Whittier
Kaiser Permanente-Woodland Hills
Woodland Hills
Colorado
San Luis Valley Regional Medical Center
Alamosa
Rocky Mountain Cancer Centers-Aurora
Aurora
Rocky Mountain Regional VA Medical Center
Aurora
The Medical Center of Aurora
Aurora
University of Colorado Hospital
Aurora
Boulder Community Hospital
Boulder
Rocky Mountain Cancer Centers-Boulder
Boulder
Penrose-Saint Francis Healthcare
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
Colorado Springs
UCHealth Memorial Hospital Central
Colorado Springs
Colorado Blood Cancer Institute
Denver
Kaiser Permanente-Franklin
Denver
Porter Adventist Hospital
Denver
Presbyterian - Saint Lukes Medical Center - Health One
Denver
Rocky Mountain Cancer Centers-Midtown
Denver
Rocky Mountain Cancer Centers-Rose
Denver
Rose Medical Center
Denver
SCL Health Saint Joseph Hospital
Denver
Western States Cancer Research NCORP
Denver
Mercy Medical Center
Durango
Southwest Oncology PC
Durango
Shaw Cancer Center
Edwards
Mountain Blue Cancer Care Center - Swedish
Englewood
Swedish Medical Center
Englewood
Poudre Valley Hospital
Fort Collins
Valley View Hospital Cancer Center
Glenwood Springs
Mountain Blue Cancer Care Center
Golden
Saint Mary's Hospital and Regional Medical Center
Grand Junction
North Colorado Medical Center
Greeley
Rocky Mountain Cancer Centers-Greenwood Village
Greenwood Village
Kaiser Permanente-Rock Creek
Lafayette
Rocky Mountain Cancer Centers-Lakewood
Lakewood
Saint Anthony Hospital
Lakewood
Littleton Adventist Hospital
Littleton
Rocky Mountain Cancer Centers-Littleton
Littleton
Kaiser Permanente-Lone Tree
Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree
Sky Ridge Medical Center
Lone Tree
Longmont United Hospital
Longmont
Rocky Mountain Cancer Centers-Longmont
Longmont
McKee Medical Center
Loveland
Montrose Memorial Hospital
Montrose
Parker Adventist Hospital
Parker
Rocky Mountain Cancer Centers-Parker
Parker
Rocky Mountain Cancer Centers - Pueblo
Pueblo
Saint Mary Corwin Medical Center
Pueblo
North Suburban Medical Center
Thornton
Rocky Mountain Cancer Centers-Thornton
Thornton
SCL Health Lutheran Medical Center
Wheat Ridge
Connecticut
Bridgeport Hospital
Bridgeport
Danbury Hospital
Danbury
Smilow Cancer Hospital-Derby Care Center
Derby
Smilow Cancer Hospital Care Center-Fairfield
Fairfield
University of Connecticut
Farmington
Greenwich Hospital
Greenwich
Smilow Cancer Hospital Care Center - Guiford
Guilford
Hartford Hospital
Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Hartford
Manchester Memorial Hospital
Manchester
Middlesex Hospital
Middletown
The Hospital of Central Connecticut
New Britain
Yale University
New Haven
Yale-New Haven Hospital Saint Raphael Campus
New Haven
Yale-New Haven Hospital North Haven Medical Center
North Haven
Norwalk Hospital
Norwalk
Eastern Connecticut Hematology and Oncology Associates
Norwich
Smilow Cancer Hospital-Orange Care Center
Orange
Smilow Cancer Hospital-Torrington Care Center
Torrington
Smilow Cancer Hospital Care Center-Trumbull
Trumbull
Harold Leever Regional Cancer Center
Waterbury
Smilow Cancer Hospital-Waterbury Care Center
Waterbury
Smilow Cancer Hospital Care Center - Waterford
Waterford
Washington, D.c.
George Washington University Medical Center
Washington
Kaiser Permanente-Capitol Hill Medical Center
Washington
MedStar Georgetown University Hospital
Washington
MedStar Washington Hospital Center
Washington
Sibley Memorial Hospital
Washington
Delaware
Bayhealth Hospital Kent Campus
Dover
Beebe Medical Center
Lewes
Bayhealth Hospital Sussex Campus
Milford
Christiana Care Health System-Christiana Hospital
Newark
Christiana Gynecologic Oncology LLC
Newark
Delaware Clinical and Laboratory Physicians PA
Newark
Helen F Graham Cancer Center
Newark
Medical Oncology Hematology Consultants PA
Newark
Beebe Health Campus
Rehoboth Beach
TidalHealth Nanticoke / Allen Cancer Center
Seaford
Christiana Care Health System-Wilmington Hospital
Wilmington
Florida
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura
Boca Raton Regional Hospital
Boca Raton
Morton Plant Hospital
Clearwater
Florida Hospital Memorial Medical Center
Daytona Beach
Halifax Health Medical Center-Centers for Oncology
Daytona Beach
Broward Health North
Deerfield Beach
Holy Cross Hospital
Fort Lauderdale
University of Florida Health Science Center - Gainesville
Gainesville
Baptist MD Anderson Cancer Center
Jacksonville
Mayo Clinic in Florida
Jacksonville
Saint Vincent's Medical Center
Jacksonville
Jupiter Medical Center
Jupiter
The Watson Clinic
Lakeland
Advanced Medical Specialties -North
Miami
Miami Cancer Institute
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami
Mount Sinai Medical Center
Miami Beach
Orlando Health Cancer Institute
Orlando
Sacred Heart Hospital
Pensacola
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa
Space Coast Cancer Centers-Titusville
Titusville
Cleveland Clinic-Weston
Weston
Georgia
Phoebe Putney Memorial Hospital
Albany
Atlanta Regional CCOP
Atlanta
Emory Saint Joseph's Hospital
Atlanta
Emory University Hospital Midtown
Atlanta
Emory University Hospital/Winship Cancer Institute
Atlanta
Grady Health System
Atlanta
Northside Hospital
Atlanta
Piedmont Hospital
Atlanta
Augusta University Medical Center
Augusta
WellStar Cobb Hospital
Austell
John B Amos Cancer Center
Columbus
Northside Hospital-Forsyth
Cumming
Dekalb Medical Center
Decatur
Dublin Hematology Oncology Care PC
Dublin
Piedmont Fayette Hospital
Fayetteville
Northeast Georgia Medical Center-Gainesville
Gainesville
Northside Hospital - Gwinnett
Lawrenceville
Medical Center of Central Georgia
Macon
Wellstar Kennestone Hospital
Marietta
Southern Regional Medical Center
Riverdale
Harbin Clinic Medical Oncology and Clinical Research
Rome
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah
Low Country Cancer Care
Savannah
Memorial Health University Medical Center
Savannah
Summit Cancer Care-Memorial
Savannah
South Georgia Medical Center/Pearlman Cancer Center
Valdosta
Hawaii
Pali Momi Medical Center
'aiea
Queen's Cancer Center - Pearlridge
'aiea
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu
Kaiser Permanente Moanalua Medical Center
Honolulu
Kapiolani Medical Center for Women and Children
Honolulu
Queen's Cancer Center - Kuakini
Honolulu
Queen's Medical Center
Honolulu
Straub Clinic and Hospital
Honolulu
The Cancer Center of Hawaii-Liliha
Honolulu
Tripler Army Medical Center
Honolulu
University of Hawaii Cancer Center
Honolulu
Castle Medical Center
Kailua
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue
Maui Memorial Medical Center
Wailuku
Pacific Cancer Institute of Maui
Wailuku
Iowa
Mary Greeley Medical Center
Ames
McFarland Clinic PC - Ames
Ames
Constantinou, Costas L MD (UIA Investigator)
Bettendorf
McFarland Clinic PC-Boone
Boone
Mercy Hospital
Cedar Rapids
Oncology Associates at Mercy Medical Center
Cedar Rapids
Physicians' Clinic of Iowa PC
Cedar Rapids
Saint Luke's Hospital
Cedar Rapids
Medical Oncology and Hematology Associates-West Des Moines
Clive
Mercy Cancer Center-West Lakes
Clive
Alegent Health Mercy Hospital
Council Bluffs
Heartland Oncology and Hematology LLP
Council Bluffs
Greater Regional Medical Center
Creston
Genesis Medical Center - East Campus
Davenport
Iowa Lutheran Hospital
Des Moines
Iowa Methodist Medical Center
Des Moines
Medical Oncology and Hematology Associates-Des Moines
Des Moines
Mercy Medical Center - Des Moines
Des Moines
Mission Cancer and Blood - Laurel
Des Moines
JCHC McCreery Cancer Center
Fairfield
McFarland Clinic PC-Trinity Cancer Center
Fort Dodge
McFarland Clinic PC-Jefferson
Jefferson
McFarland Clinic PC-Marshalltown
Marshalltown
Mercy Medical Center - North Iowa
Mason City
Ottumwa Regional Health Center
Ottumwa
Mercy Medical Center-Sioux City
Sioux City
Saint Luke's Regional Medical Center
Sioux City
Siouxland Regional Cancer Center
Sioux City
MercyOne Waterloo Cancer Center
Waterloo
Mercy Medical Center-West Lakes
West Des Moines
Methodist West Hospital
West Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Boise
Saint Luke's Cancer Institute - Boise
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell
Kootenai Health - Coeur d'Alene
Coeur D'alene
Walter Knox Memorial Hospital
Emmett
Saint Luke's Cancer Institute - Fruitland
Fruitland
Saint Joseph Regional Medical Center
Lewiston
Idaho Urologic Institute-Meridian
Meridian
Saint Luke's Cancer Institute - Meridian
Meridian
Saint Alphonsus Medical Center-Nampa
Nampa
Saint Luke's Cancer Institute - Nampa
Nampa
Kootenai Clinic Cancer Services - Post Falls
Post Falls
Kootenai Cancer Clinic
Sandpoint
Saint Luke's Cancer Institute - Twin Falls
Twin Falls
Illinois
Saint Anthony's Health
Alton
Rush - Copley Medical Center
Aurora
Mac Neal Hospital
Berwyn
Illinois CancerCare-Bloomington
Bloomington
Saint Joseph Medical Center
Bloomington
Graham Hospital Association
Canton
Illinois CancerCare-Canton
Canton
Memorial Hospital of Carbondale
Carbondale
Illinois CancerCare-Carthage
Carthage
Memorial Hospital
Carthage
Centralia Oncology Clinic
Centralia
Hematology and Oncology Associates
Chicago
John H Stroger Jr Hospital of Cook County
Chicago
Mount Sinai Hospital Medical Center
Chicago
Northwestern University
Chicago
Presence Resurrection Medical Center
Chicago
University of Chicago Comprehensive Cancer Center
Chicago
University of Illinois
Chicago
Weiss Memorial Hospital
Chicago
Carle on Vermilion
Danville
Cancer Care Specialists of Illinois - Decatur
Decatur
Decatur Memorial Hospital
Decatur
Heartland Cancer Research NCORP
Decatur
Northwestern Medicine Cancer Center Kishwaukee
Dekalb
Advocate Good Samaritan Hospital
Downers Grove
Carle Physician Group-Effingham
Effingham
Crossroads Cancer Center
Effingham
Advocate Sherman Hospital
Elgin
Elmhurst Memorial Hospital
Elmhurst
Eureka Hospital
Eureka
Illinois CancerCare-Eureka
Eureka
Saint Francis Hospital
Evanston
Freeport Memorial Hospital/Leonard C Ferguson Cancer Center
Freeport
Illinois CancerCare-Galesburg
Galesburg
Western Illinois Cancer Treatment Center
Galesburg
Ingalls Memorial Hospital
Harvey
Illinois CancerCare-Havana
Havana
Mason District Hospital
Havana
Hematology Oncology Associates of Illinois-Highland Park
Highland Park
AMITA Health Cancer Institute and Outpatient Center
Hinsdale
Hinsdale Hematology Oncology Associates Incorporated
Hinsdale
Presence Saint Mary's Hospital
Kankakee
Illinois CancerCare-Kewanee Clinic
Kewanee
AMITA Health Adventist Medical Center
La Grange
AMG Libertyville - Oncology
Libertyville
Illinois CancerCare-Macomb
Macomb
Mcdonough District Hospital
Macomb
Carle Physician Group-Mattoon/Charleston
Mattoon
Loyola University Medical Center
Maywood
Garneau, Stewart C MD (UIA Investigator)
Moline
Porubcin, Michael MD (UIA Investigator)
Moline
Spector, David MD (UIA Investigator)
Moline
Trinity Medical Center
Moline
Holy Family Medical Center
Monmouth
Illinois CancerCare-Monmouth
Monmouth
Good Samaritan Regional Health Center
Mount Vernon
Edward Hospital/Cancer Center
Naperville
UC Comprehensive Cancer Center at Silver Cross
New Lenox
Illinois Cancer Specialists-Niles
Niles
Bromenn Regional Medical Center
Normal
Carle Cancer Institute Normal
Normal
Illinois CancerCare-Community Cancer Center
Normal
Mid-Illinois Hematology Oncology Associates Limited
Normal
Cancer Care Center of O'Fallon
O'fallon
Advocate Christ Medical Center
Oak Lawn
Illinois CancerCare-Ottawa Clinic
Ottawa
Ottawa Regional Hospital and Healthcare Center
Ottawa
Radiation Oncology of Northern Illinois
Ottawa
Advocate Lutheran General Hospital
Park Ridge
Illinois CancerCare-Pekin
Pekin
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin
Illinois CancerCare-Peoria
Peoria
Methodist Medical Center of Illinois
Peoria
OSF Saint Francis Medical Center
Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria
Proctor Hospital
Peoria
Illinois CancerCare-Peru
Peru
Illinois Valley Hospital
Peru
Valley Radiation Oncology
Peru
Illinois CancerCare-Princeton
Princeton
Perry Memorial Hospital
Princeton
West Suburban Medical Center
River Forest
Swedish American Hospital
Rockford
SwedishAmerican Regional Cancer Center/ACT
Rockford
Hematology Oncology Associates of Illinois - Skokie
Skokie
Illinois CancerCare-Spring Valley
Spring Valley
Central Illinois Hematology Oncology Center
Springfield
Memorial Medical Center
Springfield
Southern Illinois University School of Medicine
Springfield
Springfield Clinic
Springfield
Carle Cancer Center
Urbana
The Carle Foundation Hospital
Urbana
Rush-Copley Healthcare Center
Yorkville
Indiana
Franciscan Saint Francis Health-Beech Grove
Beech Grove
IU Health North Hospital
Carmel
Michiana Hematology Oncology PC-Crown Point
Crown Point
Elkhart Clinic
Elkhart
Elkhart General Hospital
Elkhart
Michiana Hematology Oncology PC-Elkhart
Elkhart
Deaconess Clinic Downtown
Evansville
Fort Wayne Medical Oncology and Hematology Inc-Parkview
Fort Wayne
Franciscan Health Indianapolis
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis
IU Health Central Indiana Cancer Centers-East
Indianapolis
IU Health Methodist Hospital
Indianapolis
Sidney and Lois Eskenazi Hospital
Indianapolis
Springmill Medical Center
Indianapolis
Community Howard Regional Health
Kokomo
IU Health La Porte Hospital
La Porte
IU Health Arnett Cancer Care
Lafayette
Premier Oncology Hematology Associates
Merrillville
Franciscan Saint Anthony Health-Michigan City
Michigan City
Woodland Cancer Care Center
Michigan City
Memorial Regional Cancer Center Day Road
Mishawaka
Michiana Hematology Oncology PC-Mishawaka
Mishawaka
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka
IU Health Ball Memorial Hospital
Muncie
Chancellor Center for Oncology
Newburgh
Michiana Hematology Oncology PC-Plymouth
Plymouth
Reid Health
Richmond
Memorial Hospital of South Bend
South Bend
Michiana Hematology Oncology PC-South Bend
South Bend
Northern Indiana Cancer Research Consortium
South Bend
South Bend Clinic
South Bend
Porter Memorial Hospital
Valparaiso
Michiana Hematology Oncology PC-Westville
Westville
Kansas
Cancer Center of Kansas - Chanute
Chanute
Cancer Center of Kansas - Dodge City
Dodge City
Cancer Center of Kansas - El Dorado
El Dorado
Newman Regional Health
Emporia
Cancer Center of Kansas - Fort Scott
Fort Scott
Saint Catherine Hospital
Garden City
Saint Rose Ambulatory and Surgery Center
Great Bend
HaysMed University of Kansas Health System
Hays
Hutchinson Regional Medical Center
Hutchinson
Cancer Center of Kansas-Independence
Independence
Providence Medical Center
Kansas City
University of Kansas Cancer Center
Kansas City
University of Kansas Cancer Center-West
Kansas City
Cancer Center of Kansas-Kingman
Kingman
Lawrence Memorial Hospital
Lawrence
Kansas Institute of Medicine Cancer and Blood Center
Lenexa
Minimally Invasive Surgery Hospital
Lenexa
Cancer Center of Kansas-Liberal
Liberal
Cancer Center of Kansas-Manhattan
Manhattan
Cancer Center of Kansas - McPherson
Mcpherson
Cancer Center of Kansas - Newton
Newton
Olathe Health Cancer Center
Olathe
Menorah Medical Center
Overland Park
Saint Luke's South Hospital
Overland Park
University of Kansas Cancer Center-Overland Park
Overland Park
Cancer Center of Kansas - Parsons
Parsons
Ascension Via Christi - Pittsburg
Pittsburg
Kansas City NCI Community Oncology Research Program
Prairie Village
Cancer Center of Kansas - Pratt
Pratt
Cancer Center of Kansas - Salina
Salina
Salina Regional Health Center
Salina
Cotton O'Neil Cancer Center / Stormont Vail Health
Topeka
University of Kansas Health System Saint Francis Campus
Topeka
Cancer Center of Kansas - Wellington
Wellington
Ascension Via Christi Hospitals Wichita
Wichita
Associates In Womens Health
Wichita
Cancer Center of Kansas - Wichita
Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita
Wesley Medical Center
Wichita
Wichita NCI Community Oncology Research Program
Wichita
Cancer Center of Kansas - Winfield
Winfield
Kentucky
King's Daughter's Medical Center
Ashland
Flaget Memorial Hospital
Bardstown
Baptist Health Corbin
Corbin
Commonwealth Cancer Center-Corbin
Corbin
Oncology Hematology Care Inc-Crestview
Crestview Hills
Saint Elizabeth Healthcare Edgewood
Edgewood
Baptist Health Hardin
Elizabethtown
Saint Elizabeth Fort Thomas
Fort Thomas
Baptist Health Lexington
Lexington
Saint Joseph Hospital East
Lexington
Saint Joseph Radiation Oncology Resource Center
Lexington
University of Kentucky/Markey Cancer Center
Lexington
Saint Joseph London
London
Jewish Hospital
Louisville
Saints Mary and Elizabeth Hospital
Louisville
The James Graham Brown Cancer Center at University of Louisville
Louisville
UofL Health Medical Center Northeast
Louisville
Baptist Health Madisonville/Merle Mahr Cancer Center
Madisonville
Owensboro Health Mitchell Memorial Cancer Center
Owensboro
Baptist Health Paducah
Paducah
Jewish Hospital Medical Center South
Shepherdsville
Louisiana
Christus Saint Frances Cabrini Hospital
Alexandria
Baton Rouge General Medical Center
Baton Rouge
Hematology/Oncology Clinic PLLC
Baton Rouge
Louisiana Hematology Oncology Associates LLC
Baton Rouge
LSU Health Baton Rouge-North Clinic
Baton Rouge
Mary Bird Perkins Cancer Center
Baton Rouge
Ochsner Health Center-Summa
Baton Rouge
Our Lady of the Lake Physicians Group - Medical Oncology
Baton Rouge
Mary Bird Perkins Cancer Center - Covington
Covington
Ochsner Health Center-Covington
Covington
Mary Bird Perkins Cancer Center - Houma
Houma
Ochsner Medical Center Kenner
Kenner
West Jefferson Medical Center
Marrero
East Jefferson General Hospital
Metairie
Robert Veith MD LLC
Metairie
Ochsner LSU Health Monroe Medical Center
Monroe
Louisiana State University Health Science Center
New Orleans
Ochsner Baptist Medical Center
New Orleans
Ochsner Medical Center Jefferson
New Orleans
Tulane University Health Sciences Center
New Orleans
University Medical Center New Orleans
New Orleans
Highland Clinic
Shreveport
LSU Health Sciences Center at Shreveport
Shreveport
Massachusetts
Sturdy Memorial Hospital
Attleboro
Beverly Hospital
Beverly
Beth Israel Deaconess Medical Center
Boston
Brigham and Women's Hospital
Boston
Dana-Farber Cancer Institute
Boston
Steward Saint Elizabeth's Medical Center
Brighton
Lahey Hospital and Medical Center
Burlington
Mass General/North Shore Cancer Center
Danvers
Saint Anne's Hospital
Fall River
Addison Gilbert Hospital
Gloucester
Cape Cod Hospital
Hyannis
Lowell General Hospital
Lowell
Holy Family Hospital
Methuen
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Milford
Newton-Wellesley Hospital
Newton
Berkshire Medical Center - Cancer Center
Pittsfield
Beth Israel Deaconess Hospital-Plymouth
Plymouth
Dana Farber Community Cancer Care-Quincy
Quincy
Dana-Farber/Brigham and Women's Cancer Center at South Shore
South Weymouth
UMass Memorial Medical Center - University Campus
Worcester
Maryland
Greater Baltimore Medical Center
Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore
Kaiser Permanente-Woodlawn Medical Center
Baltimore
MedStar Good Samaritan Hospital
Baltimore
MedStar Union Memorial Hospital
Baltimore
Mercy Medical Center
Baltimore
Sinai Hospital of Baltimore
Baltimore
Suburban Hospital
Bethesda
Walter Reed National Military Medical Center
Bethesda
University of Maryland Shore Medical Center at Easton
Easton
Christiana Care - Union Hospital
Elkton
Frederick Memorial Hospital
Frederick
Kaiser Permanente-Gaithersburg Medical Center
Gaithersburg
Kaiser Permanente - Kensington Medical Center
Kensington
Kaiser Permanente - Largo Medical Center
Largo
MedStar Montgomery Medical Center
Olney
Northwest Hospital Center
Randallstown
TidalHealth Peninsula Regional
Salisbury
William E Kahlert Regional Cancer Center/Sinai Hospital
Westminster
Maine
Harold Alfond Center for Cancer Care
Augusta
Eastern Maine Medical Center
Bangor
Lafayette Family Cancer Center-EMMC
Brewer
Mercy Hospital
Portland
Penobscot Bay Medical Center
Rockport
Maine Center for Cancer Medicine-Scarborough
Scarborough
Michigan
Bixby Medical Center
Adrian
Hickman Cancer Center
Adrian
Michigan Cancer Research Consortium NCORP
Ann Arbor
Saint Joseph Mercy Hospital
Ann Arbor
University of Michigan Comprehensive Cancer Center
Ann Arbor
Bronson Battle Creek
Battle Creek
McLaren Cancer Institute-Bay City
Bay City
Spectrum Health Big Rapids Hospital
Big Rapids
Saint Joseph Mercy Brighton
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton
Henry Ford Cancer Institute-Downriver
Brownstown
Saint Joseph Mercy Canton
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton
Caro Cancer Center
Caro
Saint Joseph Mercy Chelsea
Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea
Hematology Oncology Consultants-Clarkston
Clarkston
McLaren Cancer Institute-Clarkston
Clarkston
Newland Medical Associates-Clarkston
Clarkston
Henry Ford Macomb Hospital-Clinton Township
Clinton Township
Huron Valley-Sinai Hospital
Commerce
Beaumont Hospital - Dearborn
Dearborn
Henry Ford Medical Center-Fairlane
Dearborn
Ascension Saint John Hospital
Detroit
Henry Ford Hospital
Detroit
Wayne State University/Karmanos Cancer Institute
Detroit
Great Lakes Cancer Management Specialists-Doctors Park
East China Township
Green Bay Oncology - Escanaba
Escanaba
Beaumont Hospital - Farmington Hills
Farmington Hills
Weisberg Cancer Treatment Center
Farmington Hills
Genesee Cancer and Blood Disease Treatment Center
Flint
Genesee Hematology Oncology PC
Flint
Genesys Hurley Cancer Institute
Flint
Genesys Regional Medical Center-West Flint Campus
Flint
Hurley Medical Center
Flint
McLaren Cancer Institute-Flint
Flint
Singh and Arora Hematology Oncology PC
Flint
Cancer Research Consortium of West Michigan NCORP
Grand Rapids
Mercy Health Saint Mary's
Grand Rapids
Spectrum Health at Butterworth Campus
Grand Rapids
Academic Hematology Oncology Specialists
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods
Michigan Breast Specialists-Grosse Pointe Woods
Grosse Pointe Woods
Green Bay Oncology - Iron Mountain
Iron Mountain
Allegiance Health
Jackson
Borgess Medical Center
Kalamazoo
Bronson Methodist Hospital
Kalamazoo
West Michigan Cancer Center
Kalamazoo
Karmanos Cancer Institute at McLaren Greater Lansing
Lansing
Sparrow Hospital
Lansing
McLaren Cancer Institute-Lapeer Region
Lapeer
Hope Cancer Clinic
Livonia
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb
Michigan Breast Specialists-Macomb Township
Macomb
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette
UP Health System Marquette
Marquette
MyMichigan Medical Center Midland
Midland
Mercy Memorial Hospital
Monroe
Monroe Cancer Center
Monroe
Toledo Clinic Cancer Centers-Monroe
Monroe
McLaren Cancer Institute-Macomb
Mount Clemens
McLaren Cancer Institute-Central Michigan
Mount Pleasant
Mercy Health Mercy Campus
Muskegon
Lakeland Hospital Niles
Niles
Ascension Providence Hospitals - Novi
Novi
Henry Ford Medical Center-Columbus
Novi
McLaren Cancer Institute-Northern Michigan
Petoskey
21st Century Oncology-Pontiac
Pontiac
Hope Cancer Center
Pontiac
Newland Medical Associates-Pontiac
Pontiac
Saint Joseph Mercy Oakland
Pontiac
Lake Huron Medical Center
Port Huron
Spectrum Health Reed City Hospital
Reed City
Great Lakes Cancer Management Specialists-Rochester Hills
Rochester Hills
William Beaumont Hospital-Royal Oak
Royal Oak
Ascension Saint Mary's Hospital
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Saginaw
Lakeland Medical Center Saint Joseph
Saint Joseph
Marie Yeager Cancer Center
Saint Joseph
Ascension Providence Hospitals - Southfield
Southfield
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights
Ascension Saint Joseph Hospital
Tawas City
Munson Medical Center
Traverse City
William Beaumont Hospital - Troy
Troy
Advanced Breast Care Center PLLC
Warren
Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren
Macomb Hematology Oncology PC
Warren
Michigan Breast Specialists-Warren
Warren
Saint John Macomb-Oakland Hospital
Warren
Henry Ford West Bloomfield Hospital
West Bloomfield
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch
Metro Health Hospital
Wyoming
Huron Gastroenterology PC
Ypsilanti
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti
Minnesota
Medini, Eitan MD (UIA Investigator)
Alexandria
Fairview Ridges Hospital
Burnsville
Mercy Hospital
Coon Rapids
Saint Luke's Hospital of Duluth
Duluth
Fairview Southdale Hospital
Edina
Unity Hospital
Fridley
Hutchinson Area Health Care
Hutchinson
Mayo Clinic Health Systems-Mankato
Mankato
Fairview Clinics and Surgery Center Maple Grove
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Maplewood
Saint John's Hospital - Healtheast
Maplewood
Abbott-Northwestern Hospital
Minneapolis
Health Partners Inc
Minneapolis
Hennepin County Medical Center
Minneapolis
New Ulm Medical Center
New Ulm
North Memorial Medical Health Center
Robbinsdale
Mayo Clinic in Rochester
Rochester
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud
Saint Cloud Hospital
Saint Cloud
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park
Regions Hospital
Saint Paul
United Hospital
Saint Paul
Saint Francis Regional Medical Center
Shakopee
Lakeview Hospital
Stillwater
Ridgeview Medical Center
Waconia
Rice Memorial Hospital
Willmar
Minnesota Oncology Hematology PA-Woodbury
Woodbury
Fairview Lakes Medical Center
Wyoming
Missouri
Central Care Cancer Center - Bolivar
Bolivar
Parkland Health Center-Bonne Terre
Bonne Terre
Cox Cancer Center Branson
Branson
Saint Francis Medical Center
Cape Girardeau
Southeast Cancer Center
Cape Girardeau
Saint Luke's Hospital
Chesterfield
University of Missouri - Ellis Fischel
Columbia
Siteman Cancer Center at West County Hospital
Creve Coeur
Centerpoint Medical Center LLC
Independence
Capital Region Southwest Campus
Jefferson City
Freeman Health System
Joplin
Mercy Hospital Joplin
Joplin
Heartland Hematology and Oncology Associates Incorporated
Kansas City
North Kansas City Hospital
Kansas City
Research Medical Center
Kansas City
Saint Joseph Health Center
Kansas City
Saint Luke's Hospital of Kansas City
Kansas City
The University of Kansas Cancer Center-South
Kansas City
Truman Medical Centers
Kansas City
University of Kansas Cancer Center - North
Kansas City
Saint Luke's East - Lee's Summit
Lee's Summit
University of Kansas Cancer Center - Lee's Summit
Lee's Summit
Liberty Radiation Oncology Center
Liberty
Delbert Day Cancer Institute at PCRMC
Rolla
Mercy Clinic-Rolla-Cancer and Hematology
Rolla
Heartland Regional Medical Center
Saint Joseph
Saint Joseph Oncology Inc
Saint Joseph
Comprehensive Cancer Care PC
Saint Louis
Mercy Hospital Saint Louis
Saint Louis
Missouri Baptist Medical Center
Saint Louis
Saint Louis Cancer and Breast Institute-South City
Saint Louis
Saint Louis-Cape Girardeau CCOP
Saint Louis
Siteman Cancer Center at Christian Hospital
Saint Louis
SSM Health Saint Louis University Hospital
Saint Louis
Washington University School of Medicine
Saint Louis
Siteman Cancer Center at Saint Peters Hospital
Saint Peters
Sainte Genevieve County Memorial Hospital
Sainte Genevieve
Cancer Research for the Ozarks NCORP
Springfield
CoxHealth South Hospital
Springfield
Mercy Hospital Springfield
Springfield
Missouri Baptist Sullivan Hospital
Sullivan
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills
Mississippi
Gulfport Memorial Hospital
Gulfport
Forrest General Hospital / Cancer Center
Hattiesburg
Hattiesburg Clinic - Hematology/Oncology Clinic
Hattiesburg
University of Mississippi Medical Center
Jackson
Singing River Hospital
Pascagoula
Montana
Community Hospital of Anaconda
Anaconda
Billings Clinic Cancer Center
Billings
Montana Cancer Consortium NCORP
Billings
Saint Vincent Frontier Cancer Center
Billings
Saint Vincent Healthcare
Billings
Bozeman Deaconess Hospital
Bozeman
Saint James Community Hospital and Cancer Treatment Center
Butte
Benefis Healthcare- Sletten Cancer Institute
Great Falls
Great Falls Clinic
Great Falls
Northern Montana Hospital
Havre
Saint Peter's Community Hospital
Helena
Glacier Oncology PLLC
Kalispell
Kalispell Medical Oncology
Kalispell
Kalispell Regional Medical Center
Kalispell
Community Medical Hospital
Missoula
Montana Cancer Specialists
Missoula
Saint Patrick Hospital - Community Hospital
Missoula
North Carolina
Atrium Health Stanly/LCI-Albemarle
Albemarle
Randolph Hospital
Asheboro
AdventHealth Infusion Center Asheville
Asheville
Hope Women's Cancer Centers-Asheville
Asheville
Messino Cancer Centers
Asheville
Mission Hospital
Asheville
Mountain Radiation Oncology PA
Asheville
Gaston Hematology and Oncology Associates-Belmont
Belmont
Transylvania Regional Hospital
Brevard
Cone Health Cancer Center at Alamance Regional
Burlington
Waverly Hematology Oncology
Cary
Atrium Health Pineville/LCI-Pineville
Charlotte
Atrium Health University City/LCI-University
Charlotte
Carolinas Medical Center/Levine Cancer Institute
Charlotte
Levine Cancer Institute-Ballantyne
Charlotte
Levine Cancer Institute-SouthPark
Charlotte
Novant Health Carolina Surgical - Randolph
Charlotte
Novant Health Presbyterian Medical Center
Charlotte
Oncology Specialists of Charlotte
Charlotte
Southern Oncology Specialists-Charlotte
Charlotte
Sampson Radiation Oncology
Clinton
Southeastern Medical Oncology Center-Clinton
Clinton
Atrium Health Cabarrus/LCI-Concord
Concord
Duke University Medical Center
Durham
Cape Fear Valley Health System
Fayetteville
Angel Medical Center
Franklin
CaroMont Regional Medical Center
Gastonia
Gaston Hematology and Oncology Associates
Gastonia
Southeastern Medical Oncology Center-Goldsboro
Goldsboro
Wayne Memorial Hospital
Goldsboro
Wayne Radiation Oncology
Goldsboro
Cone Health Cancer Center
Greensboro
Maria Parham Hospital
Henderson
AdventHealth Hendersonville
Hendersonville
Margaret R Pardee Memorial Hospital
Hendersonville
Hayworth Cancer Center
High Point
High Point Regional Hospital
High Point
Novant Health Cancer Institute - Huntersville
Huntersville
Southern Oncology Specialists-Huntersville
Huntersville
Onslow Memorial Hospital
Jacksonville
Southeastern Medical Oncology Center-Jacksonville
Jacksonville
Vidant Oncology-Kinston
Kinston
Scotland Memorial Hospital-Laurinburg Cancer Center
Laurinburg
Cape Fear Cancer Specialists-Leland
Leland
Southeastern Regional Medical Center
Lumberton
Mission Hospital McDowell
Marion
Matthews Radiation Oncology Center
Matthews
Novant Health Cancer Institute - Matthews
Matthews
Cone Heath Cancer Center at Mebane
Mebane
Atrium Health Union/LCI-Union
Monroe
Novant Health Cancer Institute - Mooresville
Mooresville
Granville Medical Center
Oxford
Duke Raleigh Hospital
Raleigh
UNC Rex Cancer Center of Wakefield
Raleigh
UNC Rex Healthcare
Raleigh
Annie Penn Memorial Hospital
Reidsville
Person Memorial Hospital
Roxboro
Rutherford Hospital
Rutherfordton
Atrium Health Cleveland/LCI-Cleveland
Shelby
Cleveland Hematology and Oncology Associates PC
Shelby
Johnston Memorial Hospital
Smithfield
Blue Ridge Regional Hospital
Spruce Pine
Iredell Memorial Hospital
Statesville
Marion L Shepard Cancer Center at Vidant Beaufort Hospital
Washington
Cape Fear Cancer Specialists
Wilmington
Novant Health New Hanover Regional Medical Center
Wilmington
Southeast Clinical Oncology Research Consortium NCORP
Winston-salem
Wake Forest University Health Sciences
Winston-salem
North Dakota
Mid Dakota Clinic
Bismarck
Saint Alexius Medical Center
Bismarck
Sanford Bismarck Medical Center
Bismarck
Altru Cancer Center
Grand Forks
Trinity Cancer Care Center
Minot
Nebraska
CHI Health Saint Francis
Grand Island
CHI Health Good Samaritan
Kearney
Heartland Hematology and Oncology
Kearney
Nebraska Cancer Research Center
Lincoln
Nebraska Hematology and Oncology
Lincoln
Saint Elizabeth Regional Medical Center
Lincoln
Southeast Nebraska Cancer Center - 68th Street Place
Lincoln
Faith Regional Health Services Carson Cancer Center
Norfolk
Great Plains Health Callahan Cancer Center
North Platte
Alegent Health Bergan Mercy Medical Center
Omaha
Alegent Health Immanuel Medical Center
Omaha
Alegent Health Lakeside Hospital
Omaha
Creighton University Medical Center
Omaha
Hematology and Oncology Consultants PC
Omaha
Missouri Valley Cancer Consortium
Omaha
Nebraska Cancer Specialists - Omaha
Omaha
Nebraska Methodist Hospital
Omaha
Oncology Hematology West PC
Omaha
University of Nebraska Medical Center
Omaha
Urology Cancer Center PC
Omaha
Midlands Community Hospital
Papillion
Regional West Medical Center Cancer Center
Scottsbluff
New Hampshire
Parkland Medical Center
Derry
Wentworth-Douglass Hospital
Dover
Cheshire Medical Center-Dartmouth-Hitchcock Keene
Keene
Dartmouth Hitchcock Medical Center
Lebanon
The Dana-Farber Cancer Institute at Londonderry
Londonderry
Norris Cotton Cancer Center-Manchester
Manchester
Foundation Medical Partners
Nashua
Norris Cotton Cancer Center-Nashua
Nashua
Portsmouth Regional Hospital
Portsmouth
New Jersey
Memorial Sloan Kettering Basking Ridge
Basking Ridge
Cooper Hospital University Medical Center
Camden
AtlantiCare Health Park-Cape May Court House
Cape May Court House
AtlantiCare Surgery Center
Egg Harbor Township
Englewood Hospital and Medical Center
Englewood
Hackensack University Medical Center
Hackensack
The Cancer Institute of New Jersey Hamilton
Hamilton
Saint Barnabas Medical Center
Livingston
Monmouth Medical Center
Long Branch
Morristown Medical Center
Morristown
Virtua Memorial
Mount Holly
Inspira Medical Center Mullica Hill
Mullica Hill
Rutgers Cancer Institute of New Jersey
New Brunswick
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick
Saint Peter's University Hospital
New Brunswick
Newark Beth Israel Medical Center
Newark
Rutgers New Jersey Medical School
Newark
The Valley Hospital-Luckow Pavilion
Paramus
Saint Joseph's Regional Medical Center
Paterson
Capital Health Medical Center-Hopewell
Pennington
AtlantiCare Regional Medical Center -Main Campus
Pomona
Neurosurgeons of New Jersey-Ridgewood
Ridgewood
Valley Hospital
Ridgewood
Sidney Kimmel Cancer Center Washington Township
Sewell
Robert Wood Johnson University Hospital Somerset
Somerville
Sparta Cancer Treatment Center
Sparta
Overlook Hospital
Summit
Inspira Medical Center Vineland
Vineland
Virtua Voorhees
Voorhees
Valley Health System-Hematology/Oncology
Westwood
New Mexico
Lovelace Medical Center-Saint Joseph Square
Albuquerque
Presbyterian Kaseman Hospital
Albuquerque
University of New Mexico Cancer Center
Albuquerque
Memorial Medical Center - Las Cruces
Las Cruces
Christus Saint Vincent Regional Cancer Center
Santa Fe
Nevada
Cancer and Blood Specialists-Henderson
Henderson
Comprehensive Cancer Centers of Nevada - Henderson
Henderson
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson
GenesisCare USA - Henderson
Henderson
Las Vegas Cancer Center-Henderson
Henderson
OptumCare Cancer Care at Seven Hills
Henderson
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas
Ann M Wierman MD LTD
Las Vegas
Cancer and Blood Specialists-Shadow
Las Vegas
Cancer and Blood Specialists-Tenaya
Las Vegas
Cancer Therapy and Integrative Medicine
Las Vegas
Comprehensive Cancer Centers of Nevada
Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas
Desert West Surgery
Las Vegas
GenesisCare USA - Fort Apache
Las Vegas
GenesisCare USA - Las Vegas
Las Vegas
GenesisCare USA - Vegas Tenaya
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas
Las Vegas Cancer Center-Medical Center
Las Vegas
Nevada Cancer Research Foundation NCORP
Las Vegas
OptumCare Cancer Care at Charleston
Las Vegas
OptumCare Cancer Care at Fort Apache
Las Vegas
OptumCare Cancer Care at MountainView
Las Vegas
Radiation Oncology Centers of Nevada Central
Las Vegas
Radiation Oncology Centers of Nevada Southeast
Las Vegas
Summerlin Hospital Medical Center
Las Vegas
University Medical Center of Southern Nevada
Las Vegas
Hope Cancer Care of Nevada-Pahrump
Pahrump
Radiation Oncology Associates
Reno
Renown Regional Medical Center
Reno
Saint Mary's Regional Medical Center
Reno
New York
Lincoln Medical and Mental Health Center
Bronx
Montefiore Medical Center - Moses Campus
Bronx
Montefiore Medical Center-Weiler Hospital
Bronx
Maimonides Medical Center
Brooklyn
Roswell Park Cancer Institute
Buffalo
Memorial Sloan Kettering Commack
Commack
Mary Imogene Bassett Hospital
Cooperstown
Elmhurst Hospital Center
Elmhurst
Arnot Ogden Medical Center/Falck Cancer Center
Elmira
Glens Falls Hospital
Glens Falls
Memorial Sloan Kettering Westchester
Harrison
Queens Hospital Center
Jamaica
Northwell Health NCORP
Lake Success
Northwell Health/Center for Advanced Medicine
Lake Success
North Shore University Hospital
Manhasset
Garnet Health Medical Center
Middletown
NYU Winthrop Hospital
Mineola
Long Island Jewish Medical Center
New Hyde Park
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York
Memorial Sloan Kettering Cancer Center
New York
Mount Sinai Union Square
New York
Mount Sinai West
New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York
NYP/Weill Cornell Medical Center
New York
Nyack Hospital
Nyack
MidHudson Regional Hospital of Westchester Medical Center
Poughkeepsie
Rochester General Hospital
Rochester
University of Rochester
Rochester
Memorial Sloan Kettering Sleepy Hollow
Sleepy Hollow
Staten Island University Hospital
Staten Island
Stony Brook University Medical Center
Stony Brook
State University of New York Upstate Medical University
Syracuse
Memorial Sloan Kettering Nassau
Uniondale
Faxton-Saint Luke's Healthcare
Utica
Dickstein Cancer Treatment Center
White Plains
Ohio
Cleveland Clinic Akron General
Akron
Summa Health System - Akron Campus
Akron
Summa Health System - Barberton Campus
Barberton
Cleveland Clinic Cancer Center Beachwood
Beachwood
UHHS-Chagrin Highlands Medical Center
Beachwood
Indu and Raj Soin Medical Center
Beavercreek
Mary Rutan Hospital
Bellefontaine
Strecker Cancer Center-Belpre
Belpre
Toledo Clinic Cancer Centers-Bowling Green
Bowling Green
Aultman Health Foundation
Canton
Miami Valley Hospital South
Centerville
Geauga Hospital
Chardon
Adena Regional Medical Center
Chillicothe
Bethesda North Hospital
Cincinnati
Good Samaritan Hospital - Cincinnati
Cincinnati
Oncology Hematology Care Inc-Anderson
Cincinnati
Oncology Hematology Care Inc-Blue Ash
Cincinnati
Oncology Hematology Care Inc-Eden Park
Cincinnati
Oncology Hematology Care Inc-Kenwood
Cincinnati
Oncology Hematology Care Inc-Mercy West
Cincinnati
The Christ Hospital
Cincinnati
TriHealth Cancer Institute-Anderson
Cincinnati
TriHealth Cancer Institute-Westside
Cincinnati
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati
Case Western Reserve University
Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland
Cleveland Clinic Foundation
Cleveland
MetroHealth Medical Center
Cleveland
North Coast Cancer Care-Clyde
Clyde
Columbus NCI Community Oncology Research Program
Columbus
Columbus Oncology and Hematology Associates Inc
Columbus
Doctors Hospital
Columbus
Grant Medical Center
Columbus
Mount Carmel East Hospital
Columbus
Mount Carmel Health Center West
Columbus
Ohio State University Comprehensive Cancer Center
Columbus
Riverside Methodist Hospital
Columbus
The Mark H Zangmeister Center
Columbus
Dayton NCI Community Oncology Research Program
Dayton
Good Samaritan Hospital - Dayton
Dayton
Grandview Hospital
Dayton
Miami Valley Hospital
Dayton
Miami Valley Hospital North
Dayton
Delaware Health Center-Grady Cancer Center
Delaware
Delaware Radiation Oncology
Delaware
Grady Memorial Hospital
Delaware
Hematology Oncology Center Incorporated
Elyria
Mercy Cancer Center-Elyria
Elyria
Oncology Hematology Care Inc-Healthplex
Fairfield
Blanchard Valley Hospital
Findlay
Atrium Medical Center-Middletown Regional Hospital
Franklin
Wayne Hospital
Greenville
Cleveland Clinic Cancer Center Independence
Independence
First Dayton Cancer Care
Kettering
Kettering Medical Center
Kettering
Fairfield Medical Center
Lancaster
Lancaster Radiation Oncology
Lancaster
Lima Memorial Hospital
Lima
Saint Rita's Medical Center
Lima
Cleveland Clinic Cancer Center Mansfield
Mansfield
OhioHealth Mansfield Hospital
Mansfield
Marietta Memorial Hospital
Marietta
Toledo Clinic Cancer Centers-Maumee
Maumee
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Maumee
Hillcrest Hospital Cancer Center
Mayfield Heights
UH Seidman Cancer Center at Landerbrook Health Center
Mayfield Heights
Summa Health Medina Medical Center
Medina
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor
UH Seidman Cancer Center at Southwest General Hospital
Middleburg Heights
Knox Community Hospital
Mount Vernon
Licking Memorial Hospital
Newark
Newark Radiation Oncology
Newark
Fisher-Titus Medical Center
Norwalk
Saint Charles Hospital
Oregon
Toledo Clinic Cancer Centers-Oregon
Oregon
University Hospitals Parma Medical Center
Parma
Mercy Health Perrysburg Cancer Center
Perrysburg
Southern Ohio Medical Center
Portsmouth
North Coast Cancer Care
Sandusky
Springfield Regional Cancer Center
Springfield
Springfield Regional Medical Center
Springfield
Cleveland Clinic Cancer Center Strongsville
Strongsville
ProMedica Flower Hospital
Sylvania
Mercy Hospital of Tiffin
Tiffin
Mercy Health - Saint Anne Hospital
Toledo
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo
Saint Vincent Mercy Medical Center
Toledo
Toledo Clinic Cancer Centers-Toledo
Toledo
Toledo Community Hospital Oncology Program CCOP
Toledo
University of Toledo
Toledo
Upper Valley Medical Center
Troy
University Hospitals Sharon Health Center
Wadsworth
South Pointe Hospital
Warrensville Heights
Fulton County Health Center
Wauseon
University of Cincinnati Cancer Center-West Chester
West Chester
Saint Ann's Hospital
Westerville
UH Seidman Cancer Center at Saint John Medical Center
Westlake
UHHS-Westlake Medical Center
Westlake
Clinton Memorial Hospital
Wilmington
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster
Wright-Patterson Medical Center
Wright-patterson Air Force Base
Greene Memorial Hospital
Xenia
Genesis Healthcare System Cancer Care Center
Zanesville
Oklahoma
Mercy Clinic Oncology and Hematology-Ardmore
Ardmore
Cancer Centers of Southwest Oklahoma Research
Lawton
Cancer Care Associates-Norman
Norman
Mercy Hospital Oklahoma City
Oklahoma City
Mercy Physicians of Oklahoma-Lakeside
Oklahoma City
University of Oklahoma Health Sciences Center
Oklahoma City
Natalie Warren Bryant Cancer Center at Saint Francis
Tulsa
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa
Surgical Associates Inc
Tulsa
Warren Clinic Oncology-Tulsa
Tulsa
Oregon
Saint Alphonsus Medical Center-Baker City
Baker City
Saint Charles Health System
Bend
Clackamas Radiation Oncology Center
Clackamas
Providence Cancer Institute Clackamas Clinic
Clackamas
Bay Area Hospital
Coos Bay
Good Samaritan Hospital
Corvallis
Three Rivers Community Hospital
Grants Pass
Legacy Mount Hood Medical Center
Gresham
Asante Health System
Medford
Providence Medford Medical Center
Medford
Rogue Valley Medical Center
Medford
Providence Milwaukie Hospital
Milwaukie
Providence Newberg Medical Center
Newberg
Saint Alphonsus Medical Center-Ontario
Ontario
Providence Willamette Falls Medical Center
Oregon City
Kaiser Permanente Northwest
Portland
Legacy Emanuel Hospital and Health Center
Portland
Legacy Good Samaritan Hospital and Medical Center
Portland
Oregon Health and Science University
Portland
Providence Portland Medical Center
Portland
Providence Saint Vincent Medical Center
Portland
Legacy Meridian Park Hospital
Tualatin
Pennsylvania
Jefferson Abington Hospital
Abington
Lehigh Valley Hospital-Cedar Crest
Allentown
UPMC-Heritage Valley Health System Beaver
Beaver
Lehigh Valley Hospital - Muhlenberg
Bethlehem
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem
Bryn Mawr Hospital
Bryn Mawr
Butler Memorial Hospital
Butler
Carlisle Regional Cancer Center
Carlisle
Geisinger Medical Center
Danville
Doylestown Hospital
Doylestown
Delaware County Memorial Hospital
Drexel Hill
Pocono Medical Center
East Stroudsburg
Easton Hospital
Easton
Ephrata Cancer Center
Ephrata
Ephrata Community Hospital
Ephrata
Adams Cancer Center
Gettysburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg
Cherry Tree Cancer Center
Hanover
Geisinger Medical Center-Cancer Center Hazleton
Hazleton
Penn State Milton S Hershey Medical Center
Hershey
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown
Lancaster General Hospital
Lancaster
Sechler Family Cancer Center
Lebanon
Geisinger Medical Oncology-Lewisburg
Lewisburg
Lewistown Hospital
Lewistown
UPMC Cancer Center at UPMC McKeesport
Mckeesport
Riddle Memorial Hospital
Media
UPMC-Coraopolis/Heritage Valley Radiation Oncology
Moon
Suburban Community Hospital and Cancer Center
Norristown
Paoli Memorial Hospital
Paoli
Einstein Medical Center Philadelphia
Philadelphia
Fox Chase Cancer Center
Philadelphia
Pennsylvania Hospital
Philadelphia
Temple University Hospital
Philadelphia
Thomas Jefferson University Hospital
Philadelphia
Phoenixville Hospital
Phoenixville
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh
UPMC Jefferson Regional Radiation Oncology
Pittsburgh
UPMC-Magee Womens Hospital
Pittsburgh
UPMC-Passavant Hospital
Pittsburgh
UPMC-Presbyterian Hospital
Pittsburgh
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh
UPMC-Saint Margaret
Pittsburgh
UPMC-Shadyside Hospital
Pittsburgh
Pottstown Hospital
Pottstown
Geisinger Cancer Services-Pottsville
Pottsville
Penn State Health Saint Joseph Medical Center
Reading
Guthrie Medical Group PC-Robert Packer Hospital
Sayre
Hematology and Oncology Associates of North East Pennsylvania
Scranton
Mercy Hospital
Scranton
Scranton Hematology Oncology
Scranton
Grand View Hospital
Sellersville
UPMC Cancer Center at UPMC Northwest
Seneca
Geisinger Medical Group
State College
Mount Nittany Medical Center
State College
UPMC Uniontown Hospital Radiation Oncology
Uniontown
Associates In Hematology Oncology PC-Upland
Upland
UPMC Washington Hospital Radiation Oncology
Washington
Chester County Hospital
West Chester
Reading Hospital
West Reading
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-barre
UPMC Susquehanna
Williamsport
Lankenau Medical Center
Wynnewood
WellSpan Health-York Cancer Center
York
WellSpan Health-York Hospital
York
Rhode Island
Miriam Hospital
Providence
Rhode Island Hospital
Providence
Roger Williams Medical Center
Providence
Women and Infants Hospital
Providence
Kent Hospital
Warwick
South Carolina
AnMed Health Cancer Center
Anderson
AnMed Health Hospital
Anderson
Prisma Health Cancer Institute - Spartanburg
Boiling Springs
Bon Secours Saint Francis Hospital
Charleston
Charleston Oncology - Roper
Charleston
Charleston Oncology - Saint Francis
Charleston
Lowcountry Hematology Oncology PA-North Charleston
Charleston
Lowcountry Hematology Oncology PA-West Ashley
Charleston
Medical University of South Carolina
Charleston
Roper Hospital
Charleston
Prisma Health Cancer Institute - Laurens
Clinton
Prisma Health Cancer Institute - Easley
Easley
McLeod Regional Medical Center
Florence
Gibbs Cancer Center-Gaffney
Gaffney
Tidelands Georgetown Memorial Hospital
Georgetown
Greenville Health System Cancer Institute-Andrews
Greenville
Prisma Health Cancer Institute - Butternut
Greenville
Prisma Health Cancer Institute - Eastside
Greenville
Prisma Health Cancer Institute - Faris
Greenville
Prisma Health Greenville Memorial Hospital
Greenville
Saint Francis Cancer Center
Greenville
Saint Francis Hospital
Greenville
Self Regional Healthcare
Greenwood
Gibbs Cancer Center-Pelham
Greer
Prisma Health Cancer Institute - Greer
Greer
Carolina Blood and Cancer Care Associates PA-Lancaster
Lancaster
Lowcountry Hematology Oncology PA-Mount Pleasant
Mount Pleasant
Carolina Blood and Cancer Care Associates PA
Rock Hill
Levine Cancer Institute-Rock Hill
Rock Hill
Prisma Health Cancer Institute - Seneca
Seneca
Spartanburg Medical Center
Spartanburg
MGC Hematology Oncology-Union
Union
Lexington Medical Center
West Columbia
South Dakota
Avera Cancer Institute-Aberdeen
Aberdeen
Rapid City Regional Hospital
Rapid City
Avera Cancer Institute
Sioux Falls
Avera McKennan Hospital and University Health Center
Sioux Falls
Medical X-Ray Center
Sioux Falls
Sanford Cancer Center Oncology Clinic
Sioux Falls
Sanford USD Medical Center - Sioux Falls
Sioux Falls
Tennessee
Bristol Regional Medical Center
Bristol
Wellmont Medical Associates Oncology and Hematology-Bristol
Bristol
Erlanger Medical Center
Chattanooga
Memorial Hospital
Chattanooga
Cookeville Regional Medical Center
Cookeville
Vanderbilt-Ingram Cancer Center Cool Springs
Franklin
Pulmonary Medicine Center of Chattanooga-Hixson
Hixson
Wellmont Medical Associates Oncology and Hematology-Johnson City
Johnson City
Ballad Health Cancer Care - Kingsport
Kingsport
Wellmont Holston Valley Hospital and Medical Center
Kingsport
Thompson Cancer Survival Center
Knoxville
University of Tennessee - Knoxville
Knoxville
University of Tennessee Health Science Center
Memphis
Meharry Medical College
Nashville
Nashville Breast Center
Nashville
Vanderbilt Breast Center at One Hundred Oaks
Nashville
Vanderbilt University/Ingram Cancer Center
Nashville
Memorial GYN Plus
Ooltewah
Texas
The Don and Sybil Harrington Cancer Center
Amarillo
Dell Seton Medical Center at The University of Texas
Austin
Saint Joseph Regional Cancer Center
Bryan
MD Anderson in The Woodlands
Conroe
Dallas VA Medical Center
Dallas
Parkland Memorial Hospital
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Dallas
Texas Tech University Health Sciences Center-El Paso
El Paso
Baylor All Saints Medical Center at Fort Worth
Fort Worth
University of Texas Medical Branch
Galveston
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston
Houston Methodist Hospital
Houston
Lyndon Baines Johnson General Hospital
Houston
M D Anderson Cancer Center
Houston
MD Anderson West Houston
Houston
Baylor Medical Center at Irving
Irving
Doctor's Hospital of Laredo
Laredo
MD Anderson League City
League City
Covenant Medical Center-Lakeside
Lubbock
Texas Tech University Health Sciences Center-Lubbock
Lubbock
UMC Cancer Center / UMC Health System
Lubbock
Audie L Murphy VA Hospital
San Antonio
Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
San Antonio
University Hospital
San Antonio
University of Texas Health Science Center at San Antonio
San Antonio
MD Anderson in Sugar Land
Sugar Land
Scott and White Memorial Hospital
Temple
Blood and Cancer Center of East Texas
Tyler
Utah
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork
Sandra L Maxwell Cancer Center
Cedar City
Logan Regional Hospital
Logan
Intermountain Medical Center
Murray
McKay-Dee Hospital Center
Ogden
Utah Valley Regional Medical Center
Provo
Riverton Hospital
Riverton
Saint George Regional Medical Center
Saint George
Huntsman Cancer Institute/University of Utah
Salt Lake City
LDS Hospital
Salt Lake City
Utah Cancer Specialists-Salt Lake City
Salt Lake City
Virginia
Wellmont Medical Associates-Bristol
Bristol
Kaiser Permanente-Burke Medical Center
Burke
Sentara Martha Jefferson Hospital
Charlottesville
University of Virginia Cancer Center
Charlottesville
Danville Regional Medical Center
Danville
Fredericksburg Oncology Inc
Fredericksburg
Hematology Oncology Associates of Fredericksburg Inc
Fredericksburg
Peninsula Cancer Institute-Gloucester
Gloucester
Centra Lynchburg Hematology-Oncology Clinic Inc
Lynchburg
Kaiser Permanente Tysons Corner Medical Center
Mclean
Peninsula Cancer Institute-Newport News
Newport News
Southwest VA Regional Cancer Center
Norton
Virginia Commonwealth University/Massey Cancer Center
Richmond
VCU Community Memorial Health Center
South Hill
Peninsula Cancer Institute-Cancer Specialists of Tidewater
Virginia Beach
Peninsula Cancer Institute-Williamsburg
Williamsburg
Vermont
Southwestern Vermont Medical Center
Bennington
Central Vermont Medical Center/National Life Cancer Treatment
Berlin
University of Vermont and State Agricultural College
Burlington
Rutland Regional Medical Center
Rutland
Washington
Providence Regional Cancer System-Aberdeen
Aberdeen
Cancer Care Center at Island Hospital
Anacortes
MultiCare Auburn Medical Center
Auburn
Virginia Mason Bainbridge Island Medical Center
Bainbridge Island
Overlake Medical Center
Bellevue
PeaceHealth Saint Joseph Medical Center
Bellingham
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton
Harrison Medical Center
Bremerton
Highline Medical Center-Main Campus
Burien
Providence Regional Cancer System-Centralia
Centralia
Swedish Cancer Institute-Edmonds
Edmonds
Saint Elizabeth Hospital
Enumclaw
Providence Regional Cancer Partnership
Everett
Saint Francis Hospital
Federal Way
Virginia Mason Federal Way Medical Center
Federal Way
MultiCare Gig Harbor Medical Park
Gig Harbor
Tacoma/Valley Radiation Oncology Centers-Gig Harbor
Gig Harbor
Swedish Cancer Institute-Issaquah
Issaquah
Kadlec Clinic Hematology and Oncology
Kennewick
Northwest Cancer Clinic
Kennewick
EvergreenHealth Medical Center
Kirkland
Seattle Cancer Care Alliance at EvergreenHealth
Kirkland
Providence Regional Cancer System-Lacey
Lacey
Saint Clare Hospital
Lakewood
PeaceHealth Saint John Medical Center
Longview
Virginia Mason Lynnwood Medical Center
Lynnwood
Skagit Regional Health Cancer Care Center
Mount Vernon
Skagit Valley Hospital
Mount Vernon
Capital Medical Center
Olympia
Providence - Saint Peter Hospital
Olympia
Olympic Medical Center
Port Angeles
Jefferson Healthcare
Port Townsend
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo
Peninsula Cancer Center
Poulsbo
MultiCare Good Samaritan Hospital
Puyallup
Tacoma/Valley Radiation Oncology Centers-Puyallup
Puyallup
FHCC South Lake Union
Seattle
Fred Hutchinson Cancer Research Center
Seattle
Harborview Medical Center
Seattle
Kaiser Permanente Washington
Seattle
Minor and James Medical PLLC
Seattle
Pacific Gynecology Specialists
Seattle
Pacific Medical Center-First Hill
Seattle
Swedish Medical Center-Ballard Campus
Seattle
Swedish Medical Center-Cherry Hill
Seattle
Swedish Medical Center-First Hill
Seattle
University of Washington Medical Center - Montlake
Seattle
Virginia Mason Medical Center
Seattle
PeaceHealth United General Medical Center
Sedro-woolley
Olympic Medical Cancer Care Center
Sequim
Providence Regional Cancer System-Shelton
Shelton
Cancer Care Northwest - Spokane South
Spokane
Cancer Care Northwest-North Spokane
Spokane
Cancer Care Northwest-Valley
Spokane
Evergreen Hematology and Oncology PS
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - North
Spokane
Rockwood Clinic
Spokane
Spokane Valley Cancer Center-Mayfair
Spokane
Spokane Valley Cancer Center-Mission
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
Spokane Valley
Franciscan Research Center-Northwest Medical Plaza
Tacoma
Madigan Army Medical Center
Tacoma
MultiCare Allenmore Hospital
Tacoma
MultiCare Tacoma General Hospital
Tacoma
Northwest Medical Specialties PLLC
Tacoma
Northwest NCI Community Oncology Research Program
Tacoma
Saint Joseph Medical Center
Tacoma
Tacoma/Valley Radiation Oncology Centers-Jackson Hall
Tacoma
Tacoma/Valley Radiation Oncology Centers-Saint Joe's
Tacoma
Compass Oncology Vancouver
Vancouver
Legacy Salmon Creek Hospital
Vancouver
PeaceHealth Southwest Medical Center
Vancouver
Providence Saint Mary Regional Cancer Center
Walla Walla
Wenatchee Valley Hospital and Clinics
Wenatchee
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima
Providence Regional Cancer System-Yelm
Yelm
Wisconsin
Langlade Hospital and Cancer Center
Antigo
ThedaCare Regional Cancer Center
Appleton
ThedaCare Regional Medical Center - Appleton
Appleton
Aurora Cancer Care-Southern Lakes VLCC
Burlington
Marshfield Clinic-Chippewa Center
Chippewa Falls
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire
Marshfield Medical Center-EC Cancer Center
Eau Claire
Aurora Health Center-Fond du Lac
Fond Du Lac
Ascension Saint Francis - Reiman Cancer Center
Franklin
Aurora Health Care Germantown Health Center
Germantown
Aurora Cancer Care-Grafton
Grafton
Aurora BayCare Medical Center
Green Bay
Green Bay Oncology at Saint Vincent Hospital
Green Bay
Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay
Saint Vincent Hospital Cancer Center Green Bay
Green Bay
Mercyhealth Hospital and Cancer Center - Janesville
Janesville
UW Cancer Center Johnson Creek
Johnson Creek
Aurora Cancer Care-Kenosha South
Kenosha
Gundersen Lutheran Medical Center
La Crosse
Mayo Clinic Health System-Franciscan Healthcare
La Crosse
University of Wisconsin Carbone Cancer Center
Madison
Holy Family Memorial Hospital
Manitowoc
Aurora Bay Area Medical Group-Marinette
Marinette
Bay Area Medical Center
Marinette
Marshfield Medical Center-Marshfield
Marshfield
Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon
Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
Milwaukee
Aurora Cancer Care-Milwaukee
Milwaukee
Aurora Saint Luke's Medical Center
Milwaukee
Aurora Sinai Medical Center
Milwaukee
Medical College of Wisconsin
Milwaukee
Marshfield Clinic-Minocqua Center
Minocqua
ProHealth D N Greenwald Center
Mukwonago
Cancer Center of Western Wisconsin
New Richmond
ProHealth Oconomowoc Memorial Hospital
Oconomowoc
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh
Ascension All Saints Hospital
Racine
Aurora Cancer Care-Racine
Racine
Ascension Saint Mary's Hospital
Rhinelander
Marshfield Medical Center-Rice Lake
Rice Lake
HSHS Saint Nicholas Hospital
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan
Ascension Saint Michael's Hospital
Stevens Point
Marshfield Medical Center-River Region at Stevens Point
Stevens Point
Green Bay Oncology - Sturgeon Bay
Sturgeon Bay
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay
Aurora Medical Center in Summit
Summit
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers
Aurora Cancer Care-Waukesha
Waukesha
ProHealth Waukesha Memorial Hospital
Waukesha
UW Cancer Center at ProHealth Care
Waukesha
Aspirus Regional Cancer Center
Wausau
Marshfield Clinic-Wausau Center
Wausau
Aurora Cancer Care-Milwaukee West
Wauwatosa
Aurora West Allis Medical Center
West Allis
Marshfield Medical Center - Weston
Weston
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids
West Virginia
United Hospital Center
Bridgeport
West Virginia University Charleston Division
Charleston
Edwards Comprehensive Cancer Center
Huntington
WVUH-Berkely Medical Center
Martinsburg
Monongalia Hospital
Morgantown
West Virginia University Healthcare
Morgantown
Camden Clark Medical Center
Parkersburg
Princeton Community Hospital
Princeton
Wyoming
Rocky Mountain Oncology
Casper
Cheyenne Regional Medical Center-West
Cheyenne
Big Horn Basin Cancer Center
Cody
Billings Clinic-Cody
Cody
Welch Cancer Center
Sheridan
Other Locations
Canada
BCCA-Abbotsford Cancer Centre
Abbotsford
Royal Victoria Regional Health Centre
Barrie
PEI Cancer Treatment Centre-Queen Elizabeth Hospital
Charlottetown
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton
BCCA-Cancer Centre for the Southern Interior
Kelowna
Grand River Regional Cancer Centre at Grand River Hospital
Kitchener
Trillium Health Partners - Credit Valley Hospital
Mississauga
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal
CHUM-Hotel Dieu de Montreal
Montreal
CIUSSSEMTL-Hopital Maisonneuve-Rosemont
Montreal
Jewish General Hospital
Montreal
McGill University Department of Oncology
Montreal
The Research Institute of the McGill University Health Centre (MUHC)
Montreal
CHU de Quebec-Hopital du Saint-Sacrement (HSS)
Quebec City
Allan Blair Cancer Centre
Regina
Atlantic Health Sciences Corporation-Saint John Regional Hospital
Saint John
Saskatoon Cancer Centre
Saskatoon
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke
Doctor H. Bliss Murphy Cancer Centre
St. John's
Health Sciences North
Sudbury
BCCA-Fraser Valley Cancer Centre
Surrey
Thunder Bay Regional Health Science Centre
Thunder Bay
Michael Garron Hospital
Toronto
Mount Sinai Hospital
Toronto
Trillium Health Partners - Queensway Health Centre
Toronto
University Health Network-Princess Margaret Hospital
Toronto
BCCA-Vancouver Cancer Centre
Vancouver
CancerCare Manitoba
Winnipeg
Colombia
Instituto Nacional De Cancerologia
Bogota
France
Institut de Cancerologie de l'Ouest- Angers
Angers
Centre Hospitalier d'Auch
Auch
Institut Sainte Catherine
Avignon
Centre d'Oncologie et de Radiotherapie Pays Basque
Bayonne
Centre Hospitalier de la Cote Basque
Bayonne
Centre Hospitalier de Beauvais
Beauvais
Centre Hospitalier de Blois
Blois
Clinique Tivoli Ducos
Bordeaux
Institut Bergonie Cancer Center
Bordeaux
Polyclinic Bordeaux Nord Aquitaine
Bordeaux
CHU de Brest-Hopital Morvan
Brest
Centre Francois Baclesse
Caen
Centre Jean Perrin
Clermont-ferrand
Centre Hospitlier Intercommunal de Creteil
Creteil
Centre Hospitalier de Douai
Dechy
Centre Georges-Francois Leclerc
Dijon
Hopital Prive Drome Ardeche-Clinique Pasteur
Guilherand-granges
Departemental Hospitalier Roche-sur-Yon (Les Oudairies)
La Roche Sur Yon
Hopital Prive de l'Estuaire
Le Havre
Clinique Victor Hugo-Centre Jean Bernard
Le Mans
Centre Oscar Lambert
Lille
CHU Limoges - Hopital Dupuytren
Limoges
Clinique Chenieux
Limoges
Centre Leon Berard
Lyon
Hopital Prive Jean Mermoz
Lyon
Hopital Prive Clairval
Marseile
Centre Hospitalier de Montelimar
Montelimar
Centre Catherine de Sienne
Nantes
Clinique Hartmann
Neuilly-sur-seine
Centre Antoine Lacassagne
Nice
Hospital De La Source
Orleans
Hôpital La Pitié-Salpétrière
Paris
Hopital Prive des Peupliers
Paris
Hopital Saint Louis
Paris
Institut Curie Paris
Paris
Centre Hopitalier
Pau
Polyclinique Francheville
Perigueux
Centre Hospitalier de Perpignan
Perpignan
Clinical Saint-Pierre/Centre Catalan d?Oncologie
Perpignan
Centre hospitalier Rene Dubos Pontoise
Pontoise
Institut Jean Godinot
Reims
Centre Henri Becquerel
Rouen
Institut Curie-Centre Rene Huguenin Saint Cloud
Saint Cloud
Centre Hospitalier Prive Saint-Gregoire
Saint Gregoire
Institut de Cancerologie de l'Ouest-Rene Gauducheau
Saint Herblain
Clinique Mutualiste de l'Estuaire
Saint-nazaire
Centre de Cancerologie Paris Nord
Sarcelles
Groupe Hospitalier Public du Sud de l'Oise Senlis
Senlis
Centre Paul Strauss
Strasbourg
CHRU Strasbourg - Hospital Civil
Strasbourg
Polyclinique de l'Ormeau
Tarbes
Hopitaux du Leman
Thonon Les Bains
Center Claudius Regaud
Toulouse
Clinique Pasteur
Toulouse
Clinique Saint-Jean Languedoc
Toulouse
Hospital Bretonneau
Tours
Centre Alexis Vautrin
Vandoeuvre-les-nancy
Gustave Roussy
Villejuif
Hopital Prive de Villeneuve d'Ascq
Villeneuve
Ireland
Bon Secours Hospital
Cork
Cork University Hospital
Cork
Beaumont Hospital
Dublin
Mater Misericordiae University Hospital
Dublin
Mater Private Hospital
Dublin
Saint James Hospital
Dublin
Saint Vincent's University Hospital
Dublin
Tallaght University Hospital
Dublin
University College Hospital Galway
Galway
Letterkenny General Hospital
Letterkenny
Mid-Western Regional Hospital
Limerick
Saint Vincent's Private Hospital
Merrion
Sligo University Hospital
Sligo
University Hospital Waterford
Waterford
Mexico
Instituto Nacional De Cancerologia de Mexico
Mexico City
Puerto Rico
Cancer Center-Metro Medical Center Bayamon
Bayamon
Doctors Cancer Center
Manati
San Juan City Hospital
San Juan
San Juan Community Oncology Group
San Juan
Republic of Korea
National Cancer Center-Korea
Goyang-si
Seoul National University Bundang Hospital
Seongnam City
Asan Medical Center
Seoul
Saudi Arabia
King Faisal Specialist Hospital and Research Centre
Riyadh
Spain
Complejo Hospitalario Universitario de Albacete
Albacete
Hospital Clinic De Barcelona
Barcelona
Hospital De La Santa Creu I Sant Pau
Barcelona
Hospital Universitari Germans Trias i Pujol
Barcelona
Hospital San Pedro de Alcantara
Caceres
Hospital Provincial de Castellon
Castellon
Centro Oncologico de Galicia
Coruna
Hospital Universitari de Girona Doctor Josep Trueta
Girona
Institut Catalad'Oncologia
Girona
Hospital Infanta Cristina de Parla
Madrid
Hospital Universitario Gregorio Maranon
Madrid
Hospital Universitario Ramon y Cajal
Madrid
Hospital Clinico Universitario Virgen de la Victoria
Malaga
Grupo Espanol de Investigacion en Cancer de Mama
San Sebastian
Hospital Nuestra Senora de Aranzazu
San Sebastian
Onkologikoa
San Sebastian
Hospital Universitario Virgen del Rocio
Sevilla
Hospital Virgen de la Salud
Toledo
Hospital Clinico Universitario de Valencia
Valencia
Instituto Valenciano de Oncologia
Valencia
Hospital Clinico Universitario Lozano Blesa
Zaragoza
Hospital Universitario Miguel Servet
Zaragoza
Time Frame
Start Date: January 15, 2011
Estimated Completion Date: February 1, 2023
Participants
Target number of participants: 10000
Treatments
Experimental: Arm I (chemotherapy and endocrine therapy)
Patients receive a protocol-approved chemotherapy regimen based on the patient and/or physician preference. Patients then receive a protocol-approved adjuvant endocrine therapy comprising tamoxifen citrate, an aromatase inhibitor (anastrozole, letrozole, or exemestane), or both for 5-10 years in the absence of disease progression or unacceptable toxicity.
Experimental: Arm II (endocrine therapy)
Patients receive a protocol-approved endocrine therapy comprising tamoxifen citrate, an aromatase inhibitor (anastrozole, letrozole, or exemestane), or both for 5-10 years in the absence of disease progression or unacceptable toxicity.