A Randomized Phase III Trial for Surgically Resected Early Stage Non-small Cell Lung Cancer: Crizotinib Versus Observation for Patients With Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

Who is this study for? Patients with Non-Small Cell Lung Cancer
What treatments are being studied? Laboratory Biomarker Analysis
Status: Recruiting
Location: See all (1619) locations...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Patients must have undergone complete surgical resection of their stage IB (>= 4 cm), II, or non-squamous IIIA NSCLC per American Joint Committee on Cancer (AJCC) 7th edition and have had negative margins; N3 disease is not allowed

• Baseline chest computed tomography (CT) with or without contrast must be performed within 6 months (180 days) prior to randomization to ensure no evidence of disease; if clinically indicated additional imaging studies must be performed to rule out metastatic disease

• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

• Patients must be registered to the ALCHEMIST-SCREEN (ALLIANCE A151216) trial prior to randomization

• Positive for translocation or inversion events involving the ALK gene locus (e.g. resulting in echinoderm microtubule associated protein like 4 [EML4]-ALK fusion) as determined by the Vysis Break Point fluorescence in situ hybridization (FISH) assay and defined by an increase in the distance between 5? and 3? ALK probes or the loss of the 5? probe; this must have been performed:

• By a local Clinical Laboratory Improvement Amendments (CLIA) certified laboratory: report must indicate the results as well as the CLIA number of the laboratory which performed the assay; tissue must be available for submission for central, retrospective confirmation of the ALK fusion status via ALCHEMIST-SCREEN (ALLIANCE A151216) OR

• Patient registered to and the ALK fusion status performed centrally on the ALCHEMIST-SCREEN (ALLIANCE A151216)

• Women must not be pregnant or breast-feeding

• All females of childbearing potential must have a blood or urine pregnancy test within 72 hours prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

• Women of childbearing potential and sexually active males must be strongly advised to practice abstinence or use an accepted and effective method of contraception

• Patients must NOT have uncontrolled intercurrent illness including, but not limited to, serious ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

• No known interstitial fibrosis or interstitial lung disease

• No prior treatment with crizotinib or another ALK inhibitor

• No ongoing cardiac dysrhythmias of grade >= 2 National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0, uncontrolled atrial fibrillation (any grade), or corrected QT (QTc) interval > 470 msec

• No use of medications, herbals, or foods that are known potent cytochrome P450, subfamily 3A, polypeptide 4 (CYP3A4) inhibitors or inducers, included but not limited to those outlined

• Patients must be adequately recovered from surgery at the time of randomization

• The minimum time requirement between date of surgery and randomization must be at least 4 weeks (28 days)

• The maximum time requirement between surgery and randomization must be:

• 3 months (90 days) if no adjuvant chemotherapy was administered

• 8 months (240 days) if adjuvant chemotherapy was administered

• 10 months (300 days) if adjuvant chemotherapy and radiation therapy were administered

• Patients must have completed any prior adjuvant chemotherapy or radiation therapy 2 or more weeks (6 or more weeks for mitomycin and nitrosoureas) prior to randomization and be adequately recovered at the time of randomization

• NOTE: Patients taking low dose methotrexate for non-malignant conditions and other cytotoxic agents for non-malignant conditions are allowed to continue treatment while on study

• NOTE: Neo-adjuvant chemotherapy or radiation therapy for the resected lung cancer is not permitted

• Serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)

• Total serum bilirubin =< 1.5 x ULN

• Absolute neutrophil count (ANC) >= 1500/mm^3

• Platelets >= 30,000/mm^3

• Hemoglobin >= 8.0 g/dL

• Serum creatinine =< 2 x ULN

• Prior to randomization patients with any non-hematologic toxicity from surgery, chemotherapy, or radiation must have recovered to grade =< 1 with the exception of alopecia and the criteria outlined

• Patients must not have any history of locally advanced or metastatic cancer requiring systemic therapy within 5 years from randomization, with the exception of in-situ carcinomas and non-melanoma skin cancer; patients must have no previous primary lung cancer diagnosed concurrently or within the past 2 years

• Patients may not be receiving any other investigational agents while on study

Locations
United States
Alaska
Alaska Breast Care and Surgery LLC
Recruiting
Anchorage
Alaska Oncology and Hematology LLC
Recruiting
Anchorage
Alaska Regional Hospital
Suspended
Anchorage
Alaska Women's Cancer Care
Recruiting
Anchorage
Anchorage Associates in Radiation Medicine
Recruiting
Anchorage
Anchorage Oncology Centre
Recruiting
Anchorage
Anchorage Radiation Therapy Center
Recruiting
Anchorage
Katmai Oncology Group
Recruiting
Anchorage
Providence Alaska Medical Center
Recruiting
Anchorage
Fairbanks Memorial Hospital
Recruiting
Fairbanks
Alabama
University of Alabama at Birmingham Cancer Center
Active, not recruiting
Birmingham
Southern Cancer Center PC-Daphne
Suspended
Daphne
Southern Cancer Center PC-Mobile
Suspended
Mobile
Southern Cancer Center PC-Providence
Suspended
Mobile
Southern Cancer Center PC-Springhill
Suspended
Mobile
Arkansas
Mercy Hospital Fort Smith
Recruiting
Fort Smith
CHI Saint Vincent Cancer Center Hot Springs
Suspended
Hot Springs
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Recruiting
Jonesboro
John L McClellan Memorial Veterans Hospital
Active, not recruiting
Little Rock
Arizona
Banner MD Anderson Cancer Center
Recruiting
Gilbert
Kingman Regional Medical Center
Recruiting
Kingman
Banner-University Medical Center Phoenix
Recruiting
Phoenix
Cancer Center at Saint Joseph's
Recruiting
Phoenix
Mayo Clinic Hospital in Arizona
Recruiting
Phoenix
Mayo Clinic in Arizona
Recruiting
Scottsdale
Banner Boswell Medical Center
Recruiting
Sun City
Banner University Medical Center - Tucson
Recruiting
Tucson
University of Arizona Cancer Center-North Campus
Recruiting
Tucson
California
Kaiser Permanente-Anaheim
Recruiting
Anaheim
Kaiser Permanente-Deer Valley Medical Center
Recruiting
Antioch
Mission Hope Medical Oncology - Arroyo Grande
Recruiting
Arroyo Grande
PCR Oncology
Recruiting
Arroyo Grande
Sutter Auburn Faith Hospital
Recruiting
Auburn
Sutter Cancer Centers Radiation Oncology Services-Auburn
Recruiting
Auburn
AIS Cancer Center at San Joaquin Community Hospital
Suspended
Bakersfield
Kaiser Permanente-Baldwin Park
Recruiting
Baldwin Park
Kaiser Permanente-Bellflower
Recruiting
Bellflower
Alta Bates Summit Medical Center-Herrick Campus
Recruiting
Berkeley
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Recruiting
Burbank
Mills-Peninsula Medical Center
Recruiting
Burlingame
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Recruiting
Cameron Park
Mercy Cancer Center �� Carmichael
Recruiting
Carmichael
Mercy San Juan Medical Center
Recruiting
Carmichael
Eden Hospital Medical Center
Recruiting
Castro Valley
Community Cancer Institute
Recruiting
Clovis
University Oncology Associates
Recruiting
Clovis
John Muir Medical Center-Concord Campus
Recruiting
Concord
City of Hope Corona
Suspended
Corona
Sutter Davis Hospital
Recruiting
Davis
City of Hope Comprehensive Cancer Center
Recruiting
Duarte
Epic Care-Dublin
Recruiting
Dublin
Kaiser Permanente Dublin
Recruiting
Dublin
Mercy Cancer Center - Elk Grove
Recruiting
Elk Grove
Bay Area Breast Surgeons Inc
Recruiting
Emeryville
Epic Care Partners in Cancer Care
Recruiting
Emeryville
Kaiser Permanente-Fontana
Recruiting
Fontana
Kaiser Permanente-Fremont
Recruiting
Fremont
Palo Alto Medical Foundation-Fremont
Recruiting
Fremont
Kaiser Permanente-Fresno
Recruiting
Fresno
Saint Jude Medical Center
Recruiting
Fullerton
Marin Cancer Care Inc
Active, not recruiting
Greenbrae
Marin General Hospital
Active, not recruiting
Greenbrae
Kaiser Permanente - Harbor City
Recruiting
Harbor City
City of Hope at Irvine Lennar
Recruiting
Irvine
Kaiser Permanente-Irvine
Recruiting
Irvine
UC San Diego Moores Cancer Center
Recruiting
La Jolla
City of Hope Antelope Valley
Recruiting
Lancaster
Loma Linda University Medical Center
Recruiting
Loma Linda
Tibor Rubin VA Medical Center
Recruiting
Long Beach
Cedars Sinai Medical Center
Suspended
Los Angeles
Kaiser Permanente Los Angeles Medical Center
Recruiting
Los Angeles
Kaiser Permanente West Los Angeles
Recruiting
Los Angeles
Los Angeles County-USC Medical Center
Active, not recruiting
Los Angeles
USC / Norris Comprehensive Cancer Center
Active, not recruiting
Los Angeles
Contra Costa Regional Medical Center
Recruiting
Martinez
Fremont - Rideout Cancer Center
Recruiting
Marysville
City of Hope Mission Hills
Recruiting
Mission Hills
Kaiser Permanente-Modesto
Recruiting
Modesto
Memorial Medical Center
Recruiting
Modesto
Palo Alto Medical Foundation-Camino Division
Recruiting
Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology
Recruiting
Mountain View
Sutter Cancer Research Consortium
Recruiting
Novato
Alta Bates Summit Medical Center - Summit Campus
Active, not recruiting
Oakland
Bay Area Tumor Institute
Recruiting
Oakland
Hematology and Oncology Associates-Oakland
Suspended
Oakland
Kaiser Permanente Oakland-Broadway
Recruiting
Oakland
Kaiser Permanente-Oakland
Recruiting
Oakland
Kaiser Permanente-Ontario
Recruiting
Ontario
Saint Joseph Hospital - Orange
Recruiting
Orange
Desert Regional Medical Center
Active, not recruiting
Palm Springs
Palo Alto Medical Foundation Health Care
Recruiting
Palo Alto
Stanford Cancer Institute Palo Alto
Recruiting
Palo Alto
Kaiser Permanente - Panorama City
Recruiting
Panorama City
Keck Medical Center of USC Pasadena
Active, not recruiting
Pasadena
Kaiser Permanente-Rancho Cordova Cancer Center
Recruiting
Rancho Cordova
Eisenhower Medical Center
Recruiting
Rancho Mirage
Mercy Oncology Center
Suspended
Redding
Mercy Regional Cancer Center
Suspended
Redding
Kaiser Permanente- Marshall Medical Offices
Recruiting
Redwood City
Kaiser Permanente-Redwood City
Recruiting
Redwood City
Kaiser Permanente-Richmond
Recruiting
Richmond
Kaiser Permanente-Riverside
Recruiting
Riverside
Mercy Cancer Center - Rocklin
Recruiting
Rocklin
Rohnert Park Cancer Center
Recruiting
Rohnert Park
Kaiser Permanente-Roseville
Recruiting
Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Recruiting
Roseville
Sutter Roseville Medical Center
Recruiting
Roseville
The Permanente Medical Group-Roseville Radiation Oncology
Recruiting
Roseville
Kaiser Permanente - Sacramento
Recruiting
Sacramento
Kaiser Permanente Downtown Commons
Recruiting
Sacramento
Kaiser Permanente-South Sacramento
Recruiting
Sacramento
Mercy Cancer Center - Sacramento
Recruiting
Sacramento
South Sacramento Cancer Center
Recruiting
Sacramento
Sutter Medical Center Sacramento
Recruiting
Sacramento
University of California Davis Comprehensive Cancer Center
Recruiting
Sacramento
Saint Helena Hospital
Recruiting
Saint Helena
Kaiser Permanente-San Diego Mission
Recruiting
San Diego
Kaiser Permanente-San Diego Zion
Recruiting
San Diego
Naval Medical Center -San Diego
Active, not recruiting
San Diego
UC San Diego Medical Center - Hillcrest
Recruiting
San Diego
California Pacific Medical Center-Pacific Campus
Recruiting
San Francisco
Kaiser Permanente-San Francisco
Recruiting
San Francisco
Veterans Affairs Medical Center - San Francisco
Recruiting
San Francisco
Kaiser Permanente-Santa Teresa-San Jose
Recruiting
San Jose
Kaiser Permanente San Leandro
Recruiting
San Leandro
Pacific Central Coast Health Center-San Luis Obispo
Recruiting
San Luis Obispo
Kaiser Permanente-San Marcos
Recruiting
San Marcos
Mills Health Center
Recruiting
San Mateo
UCSF Cancer Center - San Mateo
Active, not recruiting
San Mateo
Kaiser Permanente-San Rafael
Recruiting
San Rafael
Kaiser San Rafael-Gallinas
Recruiting
San Rafael
Kaiser Permanente Medical Center - Santa Clara
Recruiting
Santa Clara
City of Hope - Santa Clarita
Recruiting
Santa Clarita
Dominican Santa Cruz Hospital
Recruiting
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Recruiting
Santa Cruz
Mission Hope Medical Oncology - Santa Maria
Recruiting
Santa Maria
Kaiser Permanente-Santa Rosa
Recruiting
Santa Rosa
Sutter Pacific Medical Foundation
Recruiting
Santa Rosa
City of Hope South Pasadena
Recruiting
South Pasadena
Kaiser Permanente Cancer Treatment Center
Recruiting
South San Francisco
Kaiser Permanente-South San Francisco
Recruiting
South San Francisco
Kaiser Permanente-Stockton
Recruiting
Stockton
Saint Joseph's Medical Center
Suspended
Stockton
Palo Alto Medical Foundation-Sunnyvale
Recruiting
Sunnyvale
Gene Upshaw Memorial Tahoe Forest Cancer Center
Recruiting
Truckee
City of Hope Upland
Recruiting
Upland
Kaiser Permanente Medical Center-Vacaville
Recruiting
Vacaville
Northbay Cancer Center
Active, not recruiting
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Recruiting
Vacaville
Kaiser Permanente-Vallejo
Recruiting
Vallejo
Sutter Solano Medical Center/Cancer Center
Recruiting
Vallejo
Epic Care Cyberknife Center
Recruiting
Walnut Creek
John Muir Medical Center-Walnut Creek
Recruiting
Walnut Creek
Kaiser Permanente-Walnut Creek
Recruiting
Walnut Creek
City of Hope West Covina
Recruiting
West Covina
Presbyterian Intercommunity Hospital
Recruiting
Whittier
Woodland Memorial Hospital
Recruiting
Woodland
Kaiser Permanente-Woodland Hills
Recruiting
Woodland Hills
Colorado
Rocky Mountain Cancer Centers-Aurora
Recruiting
Aurora
Rocky Mountain Regional VA Medical Center
Active, not recruiting
Aurora
The Medical Center of Aurora
Suspended
Aurora
University of Colorado Hospital
Recruiting
Aurora
Boulder Community Foothills Hospital
Recruiting
Boulder
Boulder Community Hospital
Recruiting
Boulder
Rocky Mountain Cancer Centers-Boulder
Recruiting
Boulder
Rocky Mountain Cancer Centers - Centennial
Recruiting
Centennial
Memorial Hospital North
Recruiting
Colorado Springs
Penrose-Saint Francis Healthcare
Recruiting
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
Recruiting
Colorado Springs
Saint Francis Cancer Center
Recruiting
Colorado Springs
UCHealth Memorial Hospital Central
Recruiting
Colorado Springs
Cancer Center of Colorado at Sloan's Lake
Suspended
Denver
Colorado Blood Cancer Institute
Recruiting
Denver
Denver Health Medical Center
Suspended
Denver
Kaiser Permanente-Franklin
Recruiting
Denver
National Jewish Health-Main Campus
Recruiting
Denver
Porter Adventist Hospital
Recruiting
Denver
Presbyterian - Saint Lukes Medical Center - Health One
Recruiting
Denver
Rocky Mountain Cancer Centers-Midtown
Recruiting
Denver
Rocky Mountain Cancer Centers-Rose
Recruiting
Denver
Rose Medical Center
Recruiting
Denver
SCL Health Saint Joseph Hospital
Suspended
Denver
The Women's Imaging Center
Recruiting
Denver
Mercy Medical Center
Recruiting
Durango
Southwest Oncology PC
Recruiting
Durango
Mountain Blue Cancer Care Center - Swedish
Recruiting
Englewood
Rocky Mountain Cancer Centers - Swedish
Recruiting
Englewood
Swedish Medical Center
Recruiting
Englewood
The Melanoma and Skin Cancer Institute
Recruiting
Englewood
Cancer Care and Hematology-Fort Collins
Recruiting
Fort Collins
Poudre Valley Hospital
Recruiting
Fort Collins
Mountain Blue Cancer Care Center
Suspended
Golden
National Jewish Health-Western Hematology Oncology
Recruiting
Golden
SCL Health Cancer Centers of Colorado - Lutheran Medical Center
Suspended
Golden
Saint Mary's Hospital and Regional Medical Center
Suspended
Grand Junction
North Colorado Medical Center
Suspended
Greeley
UCHealth Greeley Hospital
Recruiting
Greeley
Rocky Mountain Cancer Centers-Greenwood Village
Suspended
Greenwood Village
Good Samaritan Medical Center
Suspended
Lafayette
Kaiser Permanente-Rock Creek
Recruiting
Lafayette
Rocky Mountain Cancer Centers-Lakewood
Recruiting
Lakewood
Saint Anthony Hospital
Recruiting
Lakewood
Littleton Adventist Hospital
Recruiting
Littleton
Rocky Mountain Cancer Centers-Littleton
Recruiting
Littleton
Kaiser Permanente-Lone Tree
Recruiting
Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
Recruiting
Lone Tree
Sky Ridge Medical Center
Suspended
Lone Tree
Longmont United Hospital
Recruiting
Longmont
Rocky Mountain Cancer Centers-Longmont
Suspended
Longmont
McKee Medical Center
Suspended
Loveland
Medical Center of the Rockies
Recruiting
Loveland
Parker Adventist Hospital
Recruiting
Parker
Rocky Mountain Cancer Centers-Parker
Suspended
Parker
Rocky Mountain Cancer Centers - Pueblo
Suspended
Pueblo
Saint Mary Corwin Medical Center
Recruiting
Pueblo
National Jewish Health-Northern Hematology Oncology
Recruiting
Thornton
Rocky Mountain Cancer Centers-Thornton
Recruiting
Thornton
SCL Health Lutheran Medical Center
Suspended
Wheat Ridge
Connecticut
Danbury Hospital
Recruiting
Danbury
Smilow Cancer Hospital-Derby Care Center
Recruiting
Derby
Smilow Cancer Hospital Care Center-Fairfield
Recruiting
Fairfield
Greenwich Hospital
Suspended
Greenwich
Smilow Cancer Hospital Care Center at Greenwich
Recruiting
Greenwich
Smilow Cancer Hospital Care Center - Guiford
Recruiting
Guilford
Smilow Cancer Hospital-Hamden Care Center
Active, not recruiting
Hamden
Hartford Hospital
Active, not recruiting
Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Recruiting
Hartford
Manchester Memorial Hospital
Suspended
Manchester
Middlesex Hospital
Suspended
Middletown
The Hospital of Central Connecticut
Active, not recruiting
New Britain
Smilow Cancer Center/Yale-New Haven Hospital
Recruiting
New Haven
Yale University
Recruiting
New Haven
Yale-New Haven Hospital Saint Raphael Campus
Active, not recruiting
New Haven
Yale-New Haven Hospital North Haven Medical Center
Recruiting
North Haven
Eastern Connecticut Hematology and Oncology Associates
Recruiting
Norwich
Smilow Cancer Hospital-Orange Care Center
Recruiting
Orange
Smilow Cancer Hospital Care Center at Long Ridge
Recruiting
Stamford
Stamford Hospital/Bennett Cancer Center
Recruiting
Stamford
Smilow Cancer Hospital-Torrington Care Center
Recruiting
Torrington
Smilow Cancer Hospital Care Center-Trumbull
Recruiting
Trumbull
Smilow Cancer Hospital-Waterbury Care Center
Recruiting
Waterbury
Smilow Cancer Hospital Care Center - Waterford
Recruiting
Waterford
Veterans Affairs Connecticut Healthcare System-West Haven Campus
Recruiting
West Haven
Washington, D.c.
Kaiser Permanente-Capitol Hill Medical Center
Recruiting
Washington
MedStar Georgetown University Hospital
Recruiting
Washington
MedStar Washington Hospital Center
Recruiting
Washington
Sibley Memorial Hospital
Recruiting
Washington
Delaware
Beebe South Coastal Health Campus
Recruiting
Frankford
Beebe Medical Center
Recruiting
Lewes
Christiana Care Health System-Christiana Hospital
Recruiting
Newark
Christiana Gynecologic Oncology LLC
Suspended
Newark
Delaware Clinical and Laboratory Physicians PA
Recruiting
Newark
Helen F Graham Cancer Center
Recruiting
Newark
Medical Oncology Hematology Consultants PA
Recruiting
Newark
Beebe Health Campus
Recruiting
Rehoboth Beach
TidalHealth Nanticoke / Allen Cancer Center
Suspended
Seaford
Christiana Care Health System-Wilmington Hospital
Recruiting
Wilmington
Florida
AdventHealth Altamonte
Recruiting
Altamonte Springs
Mount Sinai Comprehensive Cancer Center at Aventura
Suspended
Aventura
Boca Raton Regional Hospital
Active, not recruiting
Boca Raton
AdventHealth Celebration
Recruiting
Celebration
UM Sylvester Comprehensive Cancer Center at Coral Gables
Completed
Coral Gables
Halifax Health Medical Center-Centers for Oncology
Active, not recruiting
Daytona Beach
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Completed
Deerfield Beach
Holy Cross Hospital
Recruiting
Fort Lauderdale
Regional Cancer Center-Lee Memorial Health System
Recruiting
Fort Myers
University of Florida Health Science Center - Gainesville
Suspended
Gainesville
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Recruiting
Hollywood
UM Sylvester Comprehensive Cancer Center at Hollywood
Completed
Hollywood
Baptist MD Anderson Cancer Center
Recruiting
Jacksonville
AdventHealth Kissimmee
Recruiting
Kissimmee
The Watson Clinic
Recruiting
Lakeland
UM Sylvester Comprehensive Cancer Center at Kendall
Completed
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Completed
Miami
Mount Sinai Medical Center
Recruiting
Miami Beach
AdventHealth East Orlando
Recruiting
Orlando
AdventHealth Medical Group Urology at Orlando
Recruiting
Orlando
AdventHealth Orlando
Recruiting
Orlando
Orlando Health Cancer Institute
Active, not recruiting
Orlando
Halifax Health Center for Oncology - Ormond Beach
Active, not recruiting
Ormond Beach
Memorial Hospital West
Recruiting
Pembroke Pines
Sacred Heart Hospital
Recruiting
Pensacola
UM Sylvester Comprehensive Cancer Center at Plantation
Completed
Plantation
Halifax Health Center for Oncology - Port Orange
Active, not recruiting
Port Orange
Moffitt Cancer Center
Recruiting
Tampa
Moffitt Cancer Center - McKinley Campus
Recruiting
Tampa
Moffitt Cancer Center-International Plaza
Recruiting
Tampa
Indian River Medical Center
Active, not recruiting
Vero Beach
Cleveland Clinic-Weston
Recruiting
Weston
AdventHealth Winter Park
Recruiting
Winter Park
Georgia
Phoebe Putney Memorial Hospital
Recruiting
Albany
University Cancer and Blood Center LLC
Recruiting
Athens
Emory Saint Joseph's Hospital
Suspended
Atlanta
Emory University Hospital Midtown
Recruiting
Atlanta
Emory University Hospital/Winship Cancer Institute
Recruiting
Atlanta
Northside Hospital
Recruiting
Atlanta
Augusta University Medical Center
Recruiting
Augusta
Northeast Georgia Medical Center Braselton
Recruiting
Braselton
John B Amos Cancer Center
Active, not recruiting
Columbus
Northside Hospital-Forsyth
Active, not recruiting
Cumming
Atlanta VA Medical Center
Suspended
Decatur
Dekalb Medical Center
Active, not recruiting
Decatur
Northside Hospital - Duluth
Recruiting
Duluth
Northeast Georgia Medical Center-Gainesville
Recruiting
Gainesville
The Longstreet Clinic - Gainesville
Recruiting
Gainesville
Northside Hospital - Gwinnett
Recruiting
Lawrenceville
Central Georgia Gynecologic Oncology
Suspended
Macon
Medical Center of Central Georgia
Suspended
Macon
Northwest Georgia Oncology Centers - Marietta
Active, not recruiting
Marietta
Harbin Clinic Medical Oncology and Clinical Research
Recruiting
Rome
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Recruiting
Savannah
Low Country Cancer Care
Suspended
Savannah
Memorial Health University Medical Center
Active, not recruiting
Savannah
Summit Cancer Care-Candler
Recruiting
Savannah
Summit Cancer Care-Memorial
Active, not recruiting
Savannah
Suburban Hematology Oncology Associates - Snellville
Recruiting
Snellville
South Georgia Medical Center/Pearlman Cancer Center
Recruiting
Valdosta
Hawaii
Hawaii Cancer Care - Savio
Recruiting
'aiea
Pali Momi Medical Center
Recruiting
'aiea
Queen's Cancer Center - Pearlridge
Recruiting
'aiea
Straub Pearlridge Clinic
Recruiting
'aiea
The Cancer Center of Hawaii-Pali Momi
Recruiting
'aiea
The Queen's Medical Center - West Oahu
Recruiting
'ewa Beach
Hawaii Cancer Care Inc - Waterfront Plaza
Recruiting
Honolulu
Hawaii Cancer Care Inc-Liliha
Recruiting
Honolulu
Hawaii Diagnostic Radiology Services LLC
Recruiting
Honolulu
Island Urology
Suspended
Honolulu
Kaiser Permanente Moanalua Medical Center
Recruiting
Honolulu
Kapiolani Medical Center for Women and Children
Recruiting
Honolulu
Kuakini Medical Center
Recruiting
Honolulu
Queen's Cancer Cenrer - POB I
Recruiting
Honolulu
Queen's Cancer Center - Kuakini
Recruiting
Honolulu
Queen's Medical Center
Recruiting
Honolulu
Straub Clinic and Hospital
Recruiting
Honolulu
The Cancer Center of Hawaii-Liliha
Recruiting
Honolulu
University of Hawaii Cancer Center
Recruiting
Honolulu
Straub Medical Center - Kahului Clinic
Recruiting
Kahului
Castle Medical Center
Recruiting
Kailua
Wilcox Memorial Hospital and Kauai Medical Clinic
Recruiting
Lihue
Iowa
Mary Greeley Medical Center
Recruiting
Ames
McFarland Clinic PC - Ames
Recruiting
Ames
University of Iowa Healthcare Cancer Services Quad Cities
Suspended
Bettendorf
McFarland Clinic PC-Boone
Recruiting
Boone
Saint Anthony Regional Hospital
Recruiting
Carroll
Mercy Hospital
Recruiting
Cedar Rapids
Oncology Associates at Mercy Medical Center
Recruiting
Cedar Rapids
Physicians' Clinic of Iowa PC
Recruiting
Cedar Rapids
Medical Oncology and Hematology Associates-West Des Moines
Recruiting
Clive
Mercy Cancer Center-West Lakes
Recruiting
Clive
Alegent Health Mercy Hospital
Recruiting
Council Bluffs
Heartland Oncology and Hematology LLP
Recruiting
Council Bluffs
Jennie Edmundson Memorial Hospital
Recruiting
Council Bluffs
Greater Regional Medical Center
Recruiting
Creston
Genesis Cancer Care Institute
Recruiting
Davenport
Genesis Medical Center - East Campus
Recruiting
Davenport
Iowa Cancer Specialists
Recruiting
Davenport
Broadlawns Medical Center
Recruiting
Des Moines
Iowa Lutheran Hospital
Recruiting
Des Moines
Iowa Methodist Medical Center
Recruiting
Des Moines
Medical Oncology and Hematology Associates-Des Moines
Recruiting
Des Moines
Mercy Medical Center - Des Moines
Recruiting
Des Moines
Mission Cancer and Blood - Laurel
Recruiting
Des Moines
JCHC McCreery Cancer Center
Active, not recruiting
Fairfield
McFarland Clinic PC-Trinity Cancer Center
Recruiting
Fort Dodge
Trinity Regional Medical Center
Recruiting
Fort Dodge
Iowa City VA Healthcare System
Recruiting
Iowa City
University of Iowa/Holden Comprehensive Cancer Center
Recruiting
Iowa City
McFarland Clinic PC-Jefferson
Recruiting
Jefferson
McFarland Clinic PC-Marshalltown
Recruiting
Marshalltown
Ottumwa Regional Health Center
Active, not recruiting
Ottumwa
Siouxland Regional Cancer Center
Recruiting
Sioux City
Mercy Medical Center-West Lakes
Recruiting
West Des Moines
Methodist West Hospital
Recruiting
West Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Recruiting
Boise
Saint Luke's Cancer Institute - Boise
Recruiting
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Recruiting
Caldwell
Kootenai Health - Coeur d'Alene
Recruiting
Coeur D'alene
Walter Knox Memorial Hospital
Recruiting
Emmett
Saint Luke's Cancer Institute - Fruitland
Recruiting
Fruitland
Idaho Urologic Institute-Meridian
Recruiting
Meridian
Saint Luke's Cancer Institute - Meridian
Recruiting
Meridian
Saint Alphonsus Medical Center-Nampa
Recruiting
Nampa
Saint Luke's Cancer Institute - Nampa
Recruiting
Nampa
Kootenai Clinic Cancer Services - Post Falls
Recruiting
Post Falls
Kootenai Cancer Clinic
Recruiting
Sandpoint
Saint Luke's Cancer Institute - Twin Falls
Recruiting
Twin Falls
Illinois
Saint Anthony's Health
Recruiting
Alton
Rush - Copley Medical Center
Recruiting
Aurora
Advocate Good Shepherd Hospital
Recruiting
Barrington
Illinois CancerCare-Bloomington
Recruiting
Bloomington
Saint Joseph Medical Center
Active, not recruiting
Bloomington
Illinois CancerCare-Canton
Recruiting
Canton
Memorial Hospital of Carbondale
Recruiting
Carbondale
SIH Cancer Institute
Recruiting
Carterville
Illinois CancerCare-Carthage
Recruiting
Carthage
Centralia Oncology Clinic
Recruiting
Centralia
Advocate Illinois Masonic Medical Center
Recruiting
Chicago
John H Stroger Jr Hospital of Cook County
Recruiting
Chicago
Mount Sinai Hospital Medical Center
Recruiting
Chicago
Northwestern University
Suspended
Chicago
Presence Resurrection Medical Center
Active, not recruiting
Chicago
Rush University Medical Center
Active, not recruiting
Chicago
Swedish Covenant Hospital
Recruiting
Chicago
University of Chicago Comprehensive Cancer Center
Recruiting
Chicago
University of Illinois
Recruiting
Chicago
AMG Crystal Lake - Oncology
Recruiting
Crystal Lake
Carle on Vermilion
Recruiting
Danville
Cancer Care Specialists of Illinois - Decatur
Recruiting
Decatur
Decatur Memorial Hospital
Recruiting
Decatur
Northwestern Medicine Cancer Center Kishwaukee
Recruiting
Dekalb
Illinois CancerCare-Dixon
Recruiting
Dixon
Advocate Good Samaritan Hospital
Recruiting
Downers Grove
Carle Physician Group-Effingham
Recruiting
Effingham
Crossroads Cancer Center
Recruiting
Effingham
Advocate Sherman Hospital
Recruiting
Elgin
Elmhurst Memorial Hospital
Active, not recruiting
Elmhurst
Illinois CancerCare-Eureka
Recruiting
Eureka
NorthShore University HealthSystem-Evanston Hospital
Recruiting
Evanston
Saint Francis Hospital
Active, not recruiting
Evanston
Illinois CancerCare-Galesburg
Recruiting
Galesburg
Western Illinois Cancer Treatment Center
Recruiting
Galesburg
Northwestern Medicine Cancer Center Delnor
Recruiting
Geneva
NorthShore University HealthSystem-Glenbrook Hospital
Recruiting
Glenview
Ingalls Memorial Hospital
Recruiting
Harvey
Advocate South Suburban Hospital
Recruiting
Hazel Crest
NorthShore University HealthSystem-Highland Park Hospital
Recruiting
Highland Park
Edward Hines Jr VA Hospital
Recruiting
Hines
Duly Health and Care Joliet
Recruiting
Joliet
Presence Saint Mary's Hospital
Active, not recruiting
Kankakee
Illinois CancerCare-Kewanee Clinic
Recruiting
Kewanee
AMG Libertyville - Oncology
Recruiting
Libertyville
Condell Memorial Hospital
Recruiting
Libertyville
Illinois CancerCare-Macomb
Recruiting
Macomb
Carle Physician Group-Mattoon/Charleston
Recruiting
Mattoon
Loyola University Medical Center
Recruiting
Maywood
Trinity Medical Center
Recruiting
Moline
Good Samaritan Regional Health Center
Recruiting
Mount Vernon
Edward Hospital/Cancer Center
Active, not recruiting
Naperville
UC Comprehensive Cancer Center at Silver Cross
Recruiting
New Lenox
Cancer Care Center of O'Fallon
Recruiting
O'fallon
Advocate Christ Medical Center
Recruiting
Oak Lawn
University of Chicago Medicine-Orland Park
Recruiting
Orland Park
Illinois CancerCare-Ottawa Clinic
Recruiting
Ottawa
Radiation Oncology of Northern Illinois
Suspended
Ottawa
Advocate Lutheran General Hospital
Recruiting
Park Ridge
Illinois CancerCare-Pekin
Recruiting
Pekin
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Recruiting
Pekin
Illinois CancerCare-Peoria
Recruiting
Peoria
Methodist Medical Center of Illinois
Recruiting
Peoria
OSF Saint Francis Medical Center
Recruiting
Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Recruiting
Peoria
Illinois CancerCare-Peru
Recruiting
Peru
Valley Radiation Oncology
Recruiting
Peru
Edward Hospital/Cancer Center?Plainfield
Active, not recruiting
Plainfield
Illinois CancerCare-Princeton
Recruiting
Princeton
Quincy Medical Group-Clinic
Active, not recruiting
Quincy
OSF Saint Anthony Medical Center
Recruiting
Rockford
SwedishAmerican Regional Cancer Center/ACT
Recruiting
Rockford
Genesis Cancer Center - Silvis
Recruiting
Silvis
North Shore Medical Center
Suspended
Skokie
Central Illinois Hematology Oncology Center
Active, not recruiting
Springfield
Memorial Medical Center
Recruiting
Springfield
Southern Illinois University School of Medicine
Recruiting
Springfield
Springfield Clinic
Recruiting
Springfield
Southwest Illinois Health Services LLP
Suspended
Swansea
Carle Cancer Center
Recruiting
Urbana
The Carle Foundation Hospital
Recruiting
Urbana
Northwestern Medicine Cancer Center Warrenville
Recruiting
Warrenville
Illinois CancerCare - Washington
Recruiting
Washington
Rush-Copley Healthcare Center
Recruiting
Yorkville
Indiana
Michiana Hematology Oncology PC-Crown Point
Active, not recruiting
Crown Point
Northwest Cancer Center - Main Campus
Recruiting
Crown Point
Northwest Oncology LLC
Recruiting
Dyer
Michiana Hematology Oncology PC-Elkhart
Active, not recruiting
Elkhart
Deaconess Clinic Downtown
Recruiting
Evansville
Parkview Hospital Randallia
Active, not recruiting
Fort Wayne
Parkview Regional Medical Center
Recruiting
Fort Wayne
Radiation Oncology Associates PC
Suspended
Fort Wayne
Goshen Center for Cancer Care
Recruiting
Goshen
Northwest Cancer Center - Hobart
Recruiting
Hobart
Saint Mary Medical Center
Recruiting
Hobart
Ascension Saint Vincent Indianapolis Hospital
Active, not recruiting
Indianapolis
Community Cancer Center East
Active, not recruiting
Indianapolis
Community Cancer Center North
Active, not recruiting
Indianapolis
Community Cancer Center South
Active, not recruiting
Indianapolis
Franciscan Health Indianapolis
Recruiting
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
Recruiting
Indianapolis
Richard L. Roudebush Veterans Affairs Medical Center
Recruiting
Indianapolis
Saint Catherine Hospital
Recruiting
Indianapolis
Sidney and Lois Eskenazi Hospital
Recruiting
Indianapolis
Community Howard Regional Health
Active, not recruiting
Kokomo
Franciscan Saint Elizabeth Health - Lafayette East
Recruiting
Lafayette
Franciscan Saint Anthony Health-Michigan City
Suspended
Michigan City
Woodland Cancer Care Center
Recruiting
Michigan City
Memorial Regional Cancer Center Day Road
Suspended
Mishawaka
Michiana Hematology Oncology PC-Mishawaka
Active, not recruiting
Mishawaka
Franciscan Health Mooresville
Recruiting
Mooresville
The Community Hospital
Recruiting
Munster
Women's Diagnostic Center - Munster
Recruiting
Munster
Baptist Health Floyd
Recruiting
New Albany
Chancellor Center for Oncology
Recruiting
Newburgh
Michiana Hematology Oncology PC-Plymouth
Active, not recruiting
Plymouth
Reid Health
Recruiting
Richmond
Memorial Hospital of South Bend
Recruiting
South Bend
Michiana Hematology Oncology PC-South Bend
Withdrawn
South Bend
Union Hospital
Recruiting
Terre Haute
Northwest Cancer Center - Valparaiso
Recruiting
Valparaiso
Michiana Hematology Oncology PC-Westville
Active, not recruiting
Westville
Kansas
Cancer Center of Kansas - Chanute
Recruiting
Chanute
Cancer Center of Kansas - Dodge City
Recruiting
Dodge City
Cancer Center of Kansas - El Dorado
Recruiting
El Dorado
Newman Regional Health
Suspended
Emporia
Cancer Center of Kansas - Fort Scott
Suspended
Fort Scott
Central Care Cancer Center - Garden City
Suspended
Garden City
Saint Catherine Hospital
Suspended
Garden City
Central Care Cancer Center - Great Bend
Recruiting
Great Bend
Saint Rose Ambulatory and Surgery Center
Suspended
Great Bend
HaysMed University of Kansas Health System
Recruiting
Hays
Cancer Center of Kansas-Independence
Recruiting
Independence
University of Kansas Cancer Center
Recruiting
Kansas City
University of Kansas Cancer Center-West
Recruiting
Kansas City
Cancer Center of Kansas-Kingman
Recruiting
Kingman
Lawrence Memorial Hospital
Recruiting
Lawrence
Kansas Institute of Medicine Cancer and Blood Center
Active, not recruiting
Lenexa
Minimally Invasive Surgery Hospital
Active, not recruiting
Lenexa
Cancer Center of Kansas-Liberal
Recruiting
Liberal
Cancer Center of Kansas-Manhattan
Recruiting
Manhattan
Cancer Center of Kansas - McPherson
Recruiting
Mcpherson
Cancer Center of Kansas - Newton
Recruiting
Newton
Olathe Health Cancer Center
Recruiting
Olathe
Menorah Medical Center
Active, not recruiting
Overland Park
Saint Luke's South Hospital
Recruiting
Overland Park
University of Kansas Cancer Center-Overland Park
Recruiting
Overland Park
Cancer Center of Kansas - Parsons
Recruiting
Parsons
Ascension Via Christi - Pittsburg
Recruiting
Pittsburg
Cancer Center of Kansas - Pratt
Recruiting
Pratt
Cancer Center of Kansas - Salina
Recruiting
Salina
Salina Regional Health Center
Recruiting
Salina
Cotton O'Neil Cancer Center / Stormont Vail Health
Recruiting
Topeka
University of Kansas Health System Saint Francis Campus
Recruiting
Topeka
Cancer Center of Kansas - Wellington
Recruiting
Wellington
University of Kansas Hospital-Westwood Cancer Center
Recruiting
Westwood
Ascension Via Christi Hospitals Wichita
Recruiting
Wichita
Associates In Womens Health
Suspended
Wichita
Cancer Center of Kansas - Wichita
Recruiting
Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower
Recruiting
Wichita
Cancer Center of Kansas - Winfield
Recruiting
Winfield
Kentucky
King's Daughter's Medical Center
Recruiting
Ashland
Flaget Memorial Hospital
Recruiting
Bardstown
Baptist Health Corbin
Recruiting
Corbin
Commonwealth Cancer Center-Corbin
Recruiting
Corbin
Oncology Hematology Care Inc-Crestview
Suspended
Crestview Hills
Saint Elizabeth Healthcare Edgewood
Active, not recruiting
Edgewood
Baptist Health Hardin
Recruiting
Elizabethtown
Saint Elizabeth Fort Thomas
Active, not recruiting
Fort Thomas
Baptist Health Lexington
Recruiting
Lexington
Saint Joseph Hospital East
Recruiting
Lexington
Saint Joseph Radiation Oncology Resource Center
Recruiting
Lexington
University of Kentucky/Markey Cancer Center
Recruiting
Lexington
Saint Joseph London
Recruiting
London