Proton Radiation For Chordomas and Chondrosarcomas

Status: Active, not recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The objectives of this study are 1) To evaluate the feasibility and acute side effects of proton therapy for chordomas and chondrosarcomas and 2) To evaluate clinical outcomes and long term side effects of proton beam radiation for treatment of chordomas and chondrosarcomas.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Histologically confirmed diagnosis of chordoma or chondrosarcoma.

• Patients must have no evidence of metastatic disease based on routine imaging (CT or MRI of the chest/abdomen/pelvis, bone scan, etc.)

• Patients must have an ECOG score equal to or less than 2.

• Age ≥ 18 years.

• Patients must be able to provide informed consent.

• Adequate bone marrow function: WBC ≥ 4000/mm3, platelets ≥ 100, 000mm3

• Women of child-bearing potential as long as she agrees to use a recognized method of birth control (e.g. oral contraceptive , IUD, condoms or other barrier methods etc.) Hysterectomy or menopause must be clinically documented.

• Tumors arising in the skull and spine.

Locations
United States
Pennsylvania
Abramson Cancer Center of the University of Pennsylvania
Philadelphia
Time Frame
Start Date: March 2010
Estimated Completion Date: December 2026
Participants
Target number of participants: 50
Treatments
Experimental: Proton group
Proton radiation total dose 72.00 to 79.2 Gy(RBE) in 40-44 fractions
Sponsors
Leads: Abramson Cancer Center of the University of Pennsylvania

This content was sourced from clinicaltrials.gov

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