Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage

Status: Active, not recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose is, in patients with aneurysmal subarachnoid haemorrhage in the early phase after ictus, to examine the following: The effect of spontaneous and induced changes on the brain's static and dynamic autoregulation calculated by transcranial Doppler (TCD), ICP and MAP (primary purposes) and ICP and PbtO2; The effect of mild hyper- and hypocapnia as well as of mild hyper- and hypoxia on the brain's static and dynamic autoregulation, ICP and PbtO2; The relationship between brain autoregulation, mild hyper- and hypocapnia, as well as of mild hyper- and hypoxia and metabolism in microdialysate on the one hand and the occurrence of DCI during hospitalization and poor neurological outcome one year after ictus on the other.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: Accepts Healthy Volunteers
View:

• Admittance to neurointensive care unit, Rigshospitalet

• Age ≥ 18 years old

• Aneurysmal subarachnoid haemorrhage

• Clinical indication for placement of an external ventricular drain

• Measurements can be done within 3 days of ictus

• Closest relatives understand written and spoken danish

• Age ≥ 18 years old;

• Understands written and spoken danish

• Oral and written consent

• No medication expect hay fever medications

• Alcohol consumption within the limits from the danish health care board

• Healthy without previous or current cerebrovascular diseases

• Insonation is possible from the middle cerebral artery

Locations
Other Locations
Denmark
Department of Neuroanaesthesiology
Copenhagen
Time Frame
Start Date: June 15, 2019
Estimated Completion Date: March 1, 2022
Participants
Target number of participants: 45
Treatments
Other: All patients
Patients included in the study.
Sponsors
Leads: Rigshospitalet, Denmark

This content was sourced from clinicaltrials.gov

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