Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage
The purpose is, in patients with aneurysmal subarachnoid haemorrhage in the early phase after ictus, to examine the following: The effect of spontaneous and induced changes on the brain's static and dynamic autoregulation calculated by transcranial Doppler (TCD), ICP and MAP (primary purposes) and ICP and PbtO2; The effect of mild hyper- and hypocapnia as well as of mild hyper- and hypoxia on the brain's static and dynamic autoregulation, ICP and PbtO2; The relationship between brain autoregulation, mild hyper- and hypocapnia, as well as of mild hyper- and hypoxia and metabolism in microdialysate on the one hand and the occurrence of DCI during hospitalization and poor neurological outcome one year after ictus on the other.
• Admittance to neurointensive care unit, Rigshospitalet
• Age ≥ 18 years old
• Aneurysmal subarachnoid haemorrhage
• Clinical indication for placement of an external ventricular drain
• Measurements can be done within 3 days of ictus
• Closest relatives understand written and spoken danish
• Age ≥ 18 years old;
• Understands written and spoken danish
• Oral and written consent
• No medication expect hay fever medications
• Alcohol consumption within the limits from the danish health care board
• Healthy without previous or current cerebrovascular diseases
• Insonation is possible from the middle cerebral artery