Determination of the Optimal Planning Target Volume for Brain Metastases Treated With Stereotactic Radiosurgery

Status: Completed
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to estimate the rate of local control at the treated site of the metastasis as a function of 1mm versus 3mm expansion about the gross tumor volume (GTV). Each lesion, not each patient will be ranndomized to either the 1mm or 3mm margin with 40 lesions randomized to each arm.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Age >18 years

• Life expectancy of at least 6 months.

• Karnofsky Performance Score greater than 70

• Graded prognostic assessment (GPA score 0.5 or greater

• 1 to 3 brain metastases unresectable

• Maximum tumor diameter no larger than 4cm

Locations
United States
North Carolina
Duke University Medical Center
Durham
Time Frame
Start Date: December 2009
Completion Date: December 2013
Participants
Target number of participants: 49
Treatments
Experimental: 1mm margin
GTV expanded by 1 mm
Experimental: 3mm margin
GTV expanded by 3 mm
Related Therapeutic Areas
Sponsors
Leads: Duke University

This content was sourced from clinicaltrials.gov

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