Predictive Factors for Therapeutic Response of Subthalamic Stimulation on Quality of Live in Parkinson's Disease

Status: Active, not recruiting
Location: See all (15) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

This study identify preoperative predictors of response to subthalamic stimulation at 1 year, 3 years and 5 years in terms of quality of life, from a broad prospective multicenter study French with standardized collection of clinical data , imaging and genetic . The investigators want to identify factors that predict the improvement of quality of life for one year corresponding to a decrease of PDQ39 score of at least 20 %. They believe that improvement would be less likely to become zero to 3 or 5 years and question the indication of the subthalamic stimulation (risks and costs). This is part of a process of personalization of the therapeutic care that is of any interest to the subthalamic stimulation. It is a therapeutic option that could be dangerous if patient selection is not optimal , and expensive, if the benefit is not large enough to reduce the number of medications and hospitalizations medium term . In addition, it will quantify the improvement of quality of life in the longer term and harmonize national assessments .

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: No
View:

• Patients receiving a pre- therapeutic assessment and therapeutic monitoring for one year , 3 years and 5 years as part of the regular monitoring of the subthalamic stimulation

• Bilateral STN stimulation considered

• Patient able to provide their free and informed consent

• Patient with insurance coverage

Locations
Other Locations
France
CHU Hôpital NORD
Amiens
Hôpital Pierre Wertheimer
Bron
Chu Gabriel-Montpied
Clermont-ferrand
Devos
Lille
Hôpital de la Timone
Marseille
Hôpital Central,
Nancy
CHU hôpital Nord Laennec
Nantes
Hôpital Pasteur
Nice
Fondation Ophtalmologique Adolphe de Rothschild
Paris
Hopital Pitie Salpetriere
Paris
CHU de Poitiers
Poitiers
CHU Hôpital Pontchaillou
Rennes
Chu Ch.Nicolle
Rouen
Hôpital de Hautepierre
Strasbourg
CHU Purpan
Toulouse
Time Frame
Start Date: November 18, 2013
Estimated Completion Date: November 2025
Participants
Target number of participants: 700
Treatments
patients with Parkinson's disease
Large population of Parkinson's patients who benefit from subthalamic stimulation
Sponsors
Collaborators: Ministry of Health, France
Leads: University Hospital, Lille

This content was sourced from clinicaltrials.gov