Molecular Mechanism Identification in Inherited Arrhythmias and Valvulopathies From Induced Pluripotent Stem Cells

Status: Terminated
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable

The recent developments of research on iPS (induced pluripotent stem) cells lead to the establishment of mature cell lines such as cardiomyocytes or valvular interstitial cells with genetic and cellular characteristics of the donors. These cells represent a biological material more readily available to identify the pathophysiological mechanisms involved in the diseases of BrS or ERS patients, which will lead to the identification of genetic markers.

Participation Requirements
Sex: All
Minimum Age: 22
Maximum Age: 60
Healthy Volunteers: Accepts Healthy Volunteers

• Patient with a family history of inherited arrhythmia or valvulopathy

• Age : 22-60 yo.

• patient no confine to bed

• Male or female

• Written consent

• Patient affiliated to the French social security

Other Locations
Nantes University Hospital
Time Frame
Start Date: November 2011
Completion Date: November 2014
Target number of participants: 20
Other: inherited arrhythmias
6 patient with inherited arrhythmias
Other: valvulopathies
6 patient with valvulopathies
Other: controle
8 healthy people for these pathologies
Leads: Nantes University Hospital

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