A Phase II/III Trial of Neoadjuvant FOLFOX With Selective Use of Combined Modality Chemoradiation Versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection With Total Mesorectal Excision (PROSPECT)

Status: Active, not recruiting
Location: See all (1073) locations...
Intervention Type: Drug, Procedure, Other
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY

The standard treatment for locally advanced rectal cancer involves chemotherapy and radiation, known as 5FUCMT, (the chemotherapy drugs 5-fluorouracil/capecitabine and radiation therapy) prior to surgery. Although radiation therapy to the pelvis has been a standard and important part of treatment for rectal cancer and has been shown to decrease the risk of the cancer coming back in the same area in the pelvis, some patients experience undesirable side effects from the radiation and there have been important advances in chemotherapy, surgery, and radiation which may be of benefit. The purpose of this study is to compare the effects, both good and bad, of the standard treatment of chemotherapy and radiation to chemotherapy using a combination regimen known as FOLFOX, (the drugs 5-fluorouracil (5-FU), oxaliplatin and leucovorin) and selective use of the standard treatment, depending on response to the FOLFOX. The drugs in the FOLFOX regimen are all FDA (Food and Drug Administration) approved and have been used routinely to treat patients with advanced colorectal cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Age ≥ 18 years at diagnosis

• Diagnosis of rectal adenocarcinoma

• Radiologically measurable or clinically evaluable disease as defined in the protocol

• ECOG Performance Status (PS): 0, 1 or 2

• For this patient, the standard treatment recommendation in the absence of a clinical trial would be combined modality neoadjuvant chemoradiation followed by curative intent surgical resection

• Candidate for sphincter-sparing surgical resection prior to neoadjuvant therapy according to the primary surgeon

• Primary surgeon is credentialed or is willing to be credentialed in Total Mesorectal Excision (TME), which entails submission of photos of a single TME specimen either before enrolling the first patient or by using the surgeon's 1st accrued case.

• Clinical Stage: T2N1, T3N0, T3N1.

• N2 disease is to be estimated as four or more lymph nodes that are ≥ 10 mm.

• Clinical staging should be estimated based on the combination of the following assessments: physical exam by the primary surgeon, CT or PET/CT scan of the chest/abdomen/pelvis and either a pelvic MRI or an ultrasound (ERUS). If a pelvic MRI is peformed, it is acceptable to perform CT of the chest/abdomen, ommitting CT imaging of the pelvis.

• The following laboratory values obtained ≤ 28 days prior to registration:

• Absolute neutrophil count (ANC) ≥ 1500/mm^3

• Platelet count ≥ 100,000/mm^3

• Hemoglobin > 8.0 g/dL

• Total bilirubin ≤ 1.5 x upper limit of normal (ULN)

• SGOT (AST) ≤ 3 x ULN

• SGPT (ALT) ≤ 3 x ULN

• Creatinine ≤1.5 x ULN

• Negative pregnancy test done ≤ 7 days prior to registration, for women of childbearing potential only

• Patient of child-bearing potential is willing to employ adequate contraception

• Provide informed written consent

• Willing to return to enrolling medical site for all study assessments

Locations
United States
Alaska
Alaska Breast Care and Surgery LLC
Anchorage
Alaska Oncology and Hematology LLC
Anchorage
Alaska Regional Hospital
Anchorage
Alaska Women's Cancer Care
Anchorage
Anchorage Associates in Radiation Medicine
Anchorage
Anchorage Oncology Centre
Anchorage
Anchorage Radiation Therapy Center
Anchorage
Katmai Oncology Group
Anchorage
Providence Alaska Medical Center
Anchorage
Fairbanks Memorial Hospital
Fairbanks
Alabama
University of Alabama at Birmingham Cancer Center
Birmingham
Southern Cancer Center PC-Daphne
Daphne
Southern Cancer Center PC-Mobile
Mobile
Southern Cancer Center PC-Providence
Mobile
Southern Cancer Center PC-Springhill
Mobile
University of South Alabama Mitchell Cancer Institute
Mobile
Arkansas
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs
Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro
Highlands Oncology Group-Rogers
Rogers
Arizona
Mayo Clinic Hospital
Phoenix
Mayo Clinic in Arizona
Scottsdale
The University of Arizona Medical Center-University Campus
Tucson
University of Arizona Cancer Center-North Campus
Tucson
University of Arizona Cancer Center-Orange Grove Campus
Tucson
Yuma Cancer Center
Yuma
California
Kaiser Permanente-Anaheim
Anaheim
Kaiser Permanente-Deer Valley Medical Center
Antioch
PCR Oncology
Arroyo Grande
Sutter Auburn Faith Hospital
Auburn
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn
Kaiser Permanente-Baldwin Park
Baldwin Park
Kaiser Permanente-Bellflower
Bellflower
Alta Bates Summit Medical Center-Herrick Campus
Berkeley
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank
Mills-Peninsula Medical Center
Burlingame
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park
East Bay Radiation Oncology Center
Castro Valley
Eden Hospital Medical Center
Castro Valley
Feather River Cancer Center
Chico
Community Cancer Institute
Clovis
University Oncology Associates
Clovis
John Muir Medical Center-Concord Campus
Concord
UC Irvine Health Cancer Center-Newport
Costa Mesa
Sutter Davis Hospital
Davis
Epic Care-Dublin
Dublin
Bay Area Breast Surgeons Inc
Emeryville
Epic Care Partners in Cancer Care
Emeryville
Kaiser Permanente-Fremont
Fremont
Palo Alto Medical Foundation-Fremont
Fremont
Fresno Cancer Center
Fresno
Kaiser Permanente-Fresno
Fresno
Marin Cancer Care Inc
Greenbrae
Marin General Hospital
Greenbrae
UC San Diego Moores Cancer Center
La Jolla
Cedars Sinai Medical Center
Los Angeles
Kaiser Permanente Los Angeles Medical Center
Los Angeles
Los Angeles County-USC Medical Center
Los Angeles
USC / Norris Comprehensive Cancer Center
Los Angeles
Contra Costa Regional Medical Center
Martinez
Kaiser Permanente-Modesto
Modesto
Memorial Medical Center
Modesto
El Camino Hospital
Mountain View
Palo Alto Medical Foundation-Camino Division
Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View
USC Norris Oncology/Hematology-Newport Beach
Newport Beach
Sutter Cancer Research Consortium
Novato
Alta Bates Summit Medical Center - Summit Campus
Oakland
Bay Area Tumor Institute
Oakland
Hematology and Oncology Associates-Oakland
Oakland
Highland General Hospital
Oakland
Kaiser Permanente-Oakland
Oakland
Saint Joseph Hospital - Orange
Orange
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange
Palo Alto Medical Foundation Health Care
Palo Alto
Stanford Cancer Institute Palo Alto
Palo Alto
Keck Medical Center of USC Pasadena
Pasadena
Valley Medical Oncology Consultants
Pleasanton
Kaiser Permanente-Redwood City
Redwood City
Kaiser Permanente-Richmond
Richmond
Kaiser Permanente-Riverside
Riverside
Kaiser Permanente-Roseville
Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville
Sutter Roseville Medical Center
Roseville
Kaiser Permanente - Sacramento
Sacramento
Kaiser Permanente Downtown Commons
Sacramento
Kaiser Permanente-South Sacramento
Sacramento
Sutter Medical Center Sacramento
Sacramento
University of California Davis Comprehensive Cancer Center
Sacramento
Saint Helena Hospital
Saint Helena
Kaiser Permanente-San Diego Mission
San Diego
Kaiser Permanente-San Diego Zion
San Diego
Naval Medical Center -San Diego
San Diego
California Pacific Medical Center-Pacific Campus
San Francisco
Kaiser Permanente-San Francisco
San Francisco
UCSF Medical Center-Mission Bay
San Francisco
UCSF Medical Center-Mount Zion
San Francisco
Kaiser Permanente-Santa Teresa-San Jose
San Jose
Kaiser Permanente San Leandro
San Leandro
Kaiser Permanente-San Marcos
San Marcos
Doctors Medical Center- JC Robinson Regional Cancer Center
San Pablo
Kaiser Permanente-San Rafael
San Rafael
Kaiser San Rafael-Gallinas
San Rafael
Kaiser Permanente Medical Center - Santa Clara
Santa Clara
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz
Kaiser Permanente-Santa Rosa
Santa Rosa
Sutter Pacific Medical Foundation
Santa Rosa
Kaiser Permanente-South San Francisco
South San Francisco
Kaiser Permanente-Stockton
Stockton
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale
Kaiser Permanente Medical Center-Vacaville
Vacaville
Northbay Cancer Center
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Vacaville
Kaiser Permanente-Vallejo
Vallejo
Sutter Solano Medical Center/Cancer Center
Vallejo
Epic Care Cyberknife Center
Walnut Creek
John Muir Medical Center-Walnut Creek
Walnut Creek
Kaiser Permanente-Walnut Creek
Walnut Creek
Colorado
Rocky Mountain Cancer Centers-Aurora
Aurora
The Medical Center of Aurora
Aurora
University of Colorado Hospital
Aurora
Boulder Community Hospital
Boulder
Rocky Mountain Cancer Centers-Boulder
Boulder
Penrose-Saint Francis Healthcare
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
Colorado Springs
UCHealth Memorial Hospital Central
Colorado Springs
Colorado Blood Cancer Institute
Denver
Denver Health Medical Center
Denver
National Jewish Health-Main Campus
Denver
Porter Adventist Hospital
Denver
Presbyterian - Saint Lukes Medical Center - Health One
Denver
Rocky Mountain Cancer Centers-Midtown
Denver
Rocky Mountain Cancer Centers-Rose
Denver
Rose Medical Center
Denver
SCL Health Saint Joseph Hospital
Denver
The Women's Imaging Center
Denver
Mercy Medical Center
Durango
Southwest Oncology PC
Durango
Comprehensive Cancer Care and Research Institute of Colorado LLC
Englewood
Swedish Medical Center
Englewood
Poudre Valley Hospital
Fort Collins
Mountain Blue Cancer Care Center
Golden
National Jewish Health-Western Hematology Oncology
Golden
Saint Mary's Hospital and Regional Medical Center
Grand Junction
North Colorado Medical Center
Greeley
Rocky Mountain Cancer Centers-Greenwood Village
Greenwood Village
Good Samaritan Medical Center
Lafayette
Rocky Mountain Cancer Centers-Lakewood
Lakewood
Saint Anthony Hospital
Lakewood
Littleton Adventist Hospital
Littleton
Rocky Mountain Cancer Centers-Littleton
Littleton
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree
Sky Ridge Medical Center
Lone Tree
Longmont United Hospital
Longmont
Rocky Mountain Cancer Centers-Longmont
Longmont
McKee Medical Center
Loveland
Parker Adventist Hospital
Parker
Rocky Mountain Cancer Centers-Parker
Parker
Rocky Mountain Cancer Centers - Pueblo
Pueblo
Saint Mary Corwin Medical Center
Pueblo
National Jewish Health-Northern Hematology Oncology
Thornton
Rocky Mountain Cancer Centers-Thornton
Thornton
SCL Health Lutheran Medical Center
Wheat Ridge
Connecticut
Yale-New Haven Shoreline Medical Center
Guilford
Hartford Hospital
Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Hartford
Midstate Medical Center
Meriden
The Hospital of Central Connecticut
New Britain
Smilow Cancer Center/Yale-New Haven Hospital
New Haven
Yale University
New Haven
Yale-New Haven Hospital North Haven Medical Center
North Haven
Norwalk Hospital
Norwalk
Eastern Connecticut Hematology and Oncology Associates
Norwich
Smilow Cancer Hospital Care Center-Trumbull
Trumbull
Lawrence and Memorial Cancer Center
Waterford
Washington, D.c.
MedStar Georgetown University Hospital
Washington
MedStar Washington Hospital Center
Washington
Delaware
Beebe Medical Center
Lewes
Christiana Care Health System-Christiana Hospital
Newark
Christiana Gynecologic Oncology LLC
Newark
Delaware Clinical and Laboratory Physicians PA
Newark
Helen F Graham Cancer Center
Newark
Medical Oncology Hematology Consultants PA
Newark
Regional Hematology and Oncology PA
Newark
Beebe Health Campus
Rehoboth Beach
Nanticoke Memorial Hospital
Seaford
Christiana Care Health System-Wilmington Hospital
Wilmington
Florida
Florida Hospital Cancer Institute Altamonte
Altamonte Springs
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach
Holy Cross Hospital
Fort Lauderdale
University of Florida Health Science Center - Gainesville
Gainesville
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood
Baptist MD Anderson Cancer Center
Jacksonville
Baptist Medical Center South
Jacksonville
Integrated Community Oncology Network-Southside Cancer Center
Jacksonville
Mayo Clinic in Florida
Jacksonville
Integrated Community Oncology Network-Florida Cancer Center Beaches
Jacksonville Beach
Jupiter Medical Center
Jupiter
Florida Hospital Kissimmee
Kissimmee
Lakeland Regional Health Hollis Cancer Center
Lakeland
The Watson Clinic
Lakeland
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami
Mount Sinai Medical Center
Miami Beach
21st Century Oncology-Orange Park
Orange Park
Florida Hospital East Orlando
Orlando
Florida Hospital Orlando
Orlando
Florida Urology Associates-Orlando
Orlando
21st Century Oncology-Palatka
Palatka
Memorial Hospital West
Pembroke Pines
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation
Integrated Community Oncology Network-Flager Cancer Center
Saint Augustine
Tampa General Hospital
Tampa
Florida Hospital Cancer Institute Winter Park
Winter Park
Georgia
Emory Saint Joseph's Hospital
Atlanta
Emory University Hospital Midtown
Atlanta
Emory University Hospital/Winship Cancer Institute
Atlanta
John B Amos Cancer Center
Columbus
Atlanta VA Medical Center
Decatur
Low Country Cancer Care Associates PC
Savannah
Memorial Health University Medical Center
Savannah
Summit Cancer Care-Memorial
Savannah
Lewis Hall Singletary Oncology Center
Thomasville
Hawaii
Hawaii Oncology Inc-Pali Momi
'aiea
Pali Momi Medical Center
'aiea
The Cancer Center of Hawaii-Pali Momi
'aiea
Hawaii Cancer Care Inc-Liliha
Honolulu
Hawaii Cancer Care Inc-POB II
Honolulu
Hawaii Oncology Inc-Kuakini
Honolulu
Hawaii Oncology Inc-POB I
Honolulu
Island Urology
Honolulu
Kaiser Permanente Moanalua Medical Center
Honolulu
Kapiolani Medical Center for Women and Children
Honolulu
Kuakini Medical Center
Honolulu
Queen's Medical Center
Honolulu
Straub Clinic and Hospital
Honolulu
The Cancer Center of Hawaii-Liliha
Honolulu
University of Hawaii Cancer Center
Honolulu
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue
Iowa
Constantinou, Costas L MD (UIA Investigator)
Bettendorf
Mercy Hospital
Cedar Rapids
Oncology Associates at Mercy Medical Center
Cedar Rapids
Medical Oncology and Hematology Associates-West Des Moines
Clive
Mercy Cancer Center-West Lakes
Clive
Alegent Health Mercy Hospital
Council Bluffs
Greater Regional Medical Center
Creston
Broadlawns Medical Center
Des Moines
Iowa Lutheran Hospital
Des Moines
Iowa Methodist Medical Center
Des Moines
Medical Oncology and Hematology Associates-Des Moines
Des Moines
Medical Oncology and Hematology Associates-Laurel
Des Moines
Mercy Medical Center - Des Moines
Des Moines
Trinity Regional Medical Center
Fort Dodge
Mercy Medical Center-West Lakes
West Des Moines
Methodist West Hospital
West Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Boise
Saint Luke's Mountain States Tumor Institute
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell
Kootenai Medical Center
Coeur D'alene
Walter Knox Memorial Hospital
Emmett
Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland
Saint Joseph Regional Medical Center
Lewiston
Idaho Urologic Institute-Meridian
Meridian
Saint Luke's Mountain States Tumor Institute - Meridian
Meridian
Saint Alphonsus Medical Center-Nampa
Nampa
Saint Luke's Mountain States Tumor Institute - Nampa
Nampa
Kootenai Cancer Center
Post Falls
Kootenai Cancer Clinic
Sandpoint
Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls
Illinois
Rush - Copley Medical Center
Aurora
Illinois CancerCare-Bloomington
Bloomington
Saint Joseph Medical Center
Bloomington
Illinois CancerCare-Canton
Canton
Memorial Hospital of Carbondale
Carbondale
SIH Cancer Institute
Carterville
Illinois CancerCare-Carthage
Carthage
Centralia Oncology Clinic
Centralia
Hematology and Oncology Associates
Chicago
John H Stroger Jr Hospital of Cook County
Chicago
Mount Sinai Hospital Medical Center
Chicago
Northwestern University
Chicago
Presence Resurrection Medical Center
Chicago
Presence Saint Joseph Hospital-Chicago
Chicago
Rush University Medical Center
Chicago
Swedish Covenant Hospital
Chicago
University of Chicago Comprehensive Cancer Center
Chicago
University of Illinois
Chicago
Carle on Vermilion
Danville
Cancer Care Specialists of Illinois - Decatur
Decatur
Decatur Memorial Hospital
Decatur
Carle Physician Group-Effingham
Effingham
Crossroads Cancer Center
Effingham
Illinois CancerCare-Eureka
Eureka
NorthShore University HealthSystem-Evanston Hospital
Evanston
Illinois CancerCare-Galesburg
Galesburg
Western Illinois Cancer Treatment Center
Galesburg
Northwestern Medicine Cancer Center Delnor
Geneva
NorthShore University HealthSystem-Glenbrook Hospital
Glenview
Ingalls Memorial Hospital
Harvey
Hematology Oncology Associates of Illinois-Highland Park
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Highland Park
Edward Hines Jr VA Hospital
Hines
Presence Saint Mary's Hospital
Kankakee
Illinois CancerCare-Kewanee Clinic
Kewanee
NorthShore Hematology Oncology-Libertyville
Libertyville
Illinois CancerCare-Macomb
Macomb
Carle Physician Group-Mattoon/Charleston
Mattoon
Loyola University Medical Center
Maywood
Garneau, Stewart C MD (UIA Investigator)
Moline
Porubcin, Michael MD (UIA Investigator)
Moline
Spector, David MD (UIA Investigator)
Moline
Trinity Medical Center
Moline
Good Samaritan Regional Health Center
Mount Vernon
UC Comprehensive Cancer Center at Silver Cross
New Lenox
Illinois Cancer Specialists-Niles
Niles
University of Chicago Medicine-Orland Park
Orland Park
Illinois CancerCare-Ottawa Clinic
Ottawa
Radiation Oncology of Northern Illinois
Ottawa
Advocate Lutheran General Hospital
Park Ridge
Illinois CancerCare-Pekin
Pekin
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin
Illinois CancerCare-Peoria
Peoria
Methodist Medical Center of Illinois
Peoria
OSF Saint Francis Medical Center
Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria
Illinois CancerCare-Peru
Peru
Valley Radiation Oncology
Peru
Illinois CancerCare-Princeton
Princeton
Swedish American Hospital
Rockford
SwedishAmerican Regional Cancer Center/ACT
Rockford
Hematology Oncology Associates of Illinois - Skokie
Skokie
Central Illinois Hematology Oncology Center
Springfield
Memorial Medical Center
Springfield
Southern Illinois University School of Medicine
Springfield
Springfield Clinic
Springfield
Cancer Care Specialists of Illinois-Swansea
Swansea
Southwest Illinois Health Services LLP
Swansea
Carle Cancer Center
Urbana
The Carle Foundation Hospital
Urbana
Northwestern Medicine Cancer Center Warrenville
Warrenville
Rush-Copley Healthcare Center
Yorkville
Indiana
IU Health North Hospital
Carmel
Elkhart Clinic
Elkhart
Elkhart General Hospital
Elkhart
Michiana Hematology Oncology PC-Elkhart
Elkhart
Deaconess Clinic Downtown
Evansville
Fort Wayne Medical Oncology and Hematology Inc-Parkview
Fort Wayne
Parkview Hospital Randallia
Fort Wayne
Radiation Oncology Associates PC
Fort Wayne
Franciscan Health Indianapolis
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis
Kendrick Colon and Rectal Center-Indianapolis
Indianapolis
Sidney and Lois Eskenazi Hospital
Indianapolis
Springmill Medical Center
Indianapolis
Community Howard Regional Health
Kokomo
IU Health La Porte Hospital
La Porte
Woodland Cancer Care Center
Michigan City
Memorial Regional Cancer Center Day Road
Mishawaka
Michiana Hematology Oncology PC-Mishawaka
Mishawaka
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka
Franciscan Health Mooresville
Mooresville
Chancellor Center for Oncology
Newburgh
Michiana Hematology Oncology PC-Plymouth
Plymouth
Reid Health
Richmond
Memorial Hospital of South Bend
South Bend
Michiana Hematology Oncology PC-South Bend
South Bend
South Bend Clinic
South Bend
Union Hospital
Terre Haute
Michiana Hematology Oncology PC-Westville
Westville
Kansas
Cancer Center of Kansas - Chanute
Chanute
Cancer Center of Kansas - Dodge City
Dodge City
Cancer Center of Kansas - El Dorado
El Dorado
Cancer Center of Kansas - Fort Scott
Fort Scott
Central Care Cancer Center - Garden City
Garden City
Saint Catherine Hospital
Garden City
Central Care Cancer Center - Great Bend
Great Bend
Cancer Center of Kansas-Independence
Independence
University of Kansas Cancer Center
Kansas City
Cancer Center of Kansas-Kingman
Kingman
Lawrence Memorial Hospital
Lawrence
Kansas Institute of Medicine Cancer and Blood Center
Lenexa
Minimally Invasive Surgery Hospital
Lenexa
Cancer Center of Kansas-Liberal
Liberal
Cancer Center of Kansas-Manhattan
Manhattan
Cancer Center of Kansas - McPherson
Mcpherson
Cancer Center of Kansas - Newton
Newton
Olathe Medical Center
Olathe
Menorah Medical Center
Overland Park
Saint Luke's South Hospital
Overland Park
University of Kansas Cancer Center-Overland Park
Overland Park
Cancer Center of Kansas - Parsons
Parsons
Via Christi Hospital-Pittsburg
Pittsburg
Cancer Center of Kansas - Pratt
Pratt
Cancer Center of Kansas - Salina
Salina
Salina Regional Health Center
Salina
Cotton O'Neil Cancer Center / Stormont Vail Health
Topeka
Saint Francis Hospital and Medical Center - Topeka
Topeka
Cancer Center of Kansas - Wellington
Wellington
University of Kansas Hospital-Westwood Cancer Center
Westwood
Associates In Womens Health
Wichita
Cancer Center of Kansas - Wichita
Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita
Via Christi Regional Medical Center
Wichita
Wesley Medical Center
Wichita
Cancer Center of Kansas - Winfield
Winfield
Kentucky
Flaget Memorial Hospital
Bardstown
Baptist Health Corbin
Corbin
Commonwealth Cancer Center-Corbin
Corbin
Oncology Hematology Care Inc-Crestview
Crestview Hills
Baptist Health Lexington
Lexington
Saint Joseph Hospital East
Lexington
Saint Joseph Radiation Oncology Resource Center
Lexington
University of Kentucky/Markey Cancer Center
Lexington
Saint Joseph London
London
Baptist Health Louisville
Louisville
Jewish Hospital
Louisville
Jewish Hospital Medical Center Northeast
Louisville
Saints Mary and Elizabeth Hospital
Louisville
Baptist Health Madisonville/Merle Mahr Cancer Center
Madisonville
Baptist Health Paducah
Paducah
Jewish Hospital Medical Center South
Shepherdsville
Louisiana
Louisiana Hematology Oncology Associates LLC
Baton Rouge
LSU Health Baton Rouge-North Clinic
Baton Rouge
Mary Bird Perkins Cancer Center
Baton Rouge
Our Lady of the Lake Physicians Group - Medical Oncology
Baton Rouge
Louisiana State University Health Science Center
New Orleans
Ochsner Medical Center Jefferson
New Orleans
University Medical Center New Orleans
New Orleans
Massachusetts
Beverly Hospital
Beverly
Beth Israel Deaconess Medical Center
Boston
Boston Medical Center
Boston
Brigham and Women's Hospital
Boston
Dana-Farber Cancer Institute
Boston
Massachusetts General Hospital Cancer Center
Boston
Lahey Hospital and Medical Center
Burlington
Addison Gilbert Hospital
Gloucester
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Milford
Berkshire Hematology Oncology PC
Pittsfield
Dana-Farber/Brigham and Women's Cancer Center at South Shore
South Weymouth
Baystate Medical Center
Springfield
Mercy Medical Center
Springfield
Winchester Hospital
Winchester
Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore
MedStar Good Samaritan Hospital
Baltimore
MedStar Union Memorial Hospital
Baltimore
Sinai Hospital of Baltimore
Baltimore
University of Maryland/Greenebaum Cancer Center
Baltimore
UM Upper Chesapeake Medical Center
Bel Air
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie
Peninsula Regional Medical Center
Salisbury
Maine
Eastern Maine Medical Center
Bangor
Lafayette Family Cancer Center-EMMC
Brewer
Michigan
Saint Joseph Mercy Hospital
Ann Arbor
University of Michigan Comprehensive Cancer Center
Ann Arbor
IHA Hematology Oncology Consultants-Brighton
Brighton
Saint Joseph Mercy Brighton
Brighton
Henry Ford Cancer Institute-Downriver
Brownstown
IHA Hematology Oncology Consultants-Canton
Canton
Saint Joseph Mercy Canton
Canton
Caro Cancer Center
Caro
IHA Hematology Oncology Consultants-Chelsea
Chelsea
Saint Joseph Mercy Chelsea
Chelsea
Hematology Oncology Consultants-Clarkston
Clarkston
Newland Medical Associates-Clarkston
Clarkston
Henry Ford Macomb Hospital-Clinton Township
Clinton Township
Beaumont Hospital-Dearborn
Dearborn
Henry Ford Medical Center-Fairlane
Dearborn
Ascension Saint John Hospital
Detroit
Henry Ford Hospital
Detroit
Wayne State University/Karmanos Cancer Institute
Detroit
Great Lakes Cancer Management Specialists-Doctors Park
East China Township
Beaumont Hospital - Farmington Hills
Farmington Hills
Genesee Cancer and Blood Disease Treatment Center
Flint
Genesee Hematology Oncology PC
Flint
Genesys Hurley Cancer Institute
Flint
Hurley Medical Center
Flint
William Beaumont Hospital-Grosse Point
Grosse Pointe
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods
Lymphoma Clinic of Michigan
Grosse Pointe Woods
Michigan Breast Specialists-Grosse Pointe Woods
Grosse Pointe Woods
Allegiance Health
Jackson
Borgess Medical Center
Kalamazoo
Bronson Methodist Hospital
Kalamazoo
West Michigan Cancer Center
Kalamazoo
Sparrow Hospital
Lansing
Hope Cancer Clinic
Livonia
Saint Mary Mercy Hospital
Livonia
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb
Michigan Breast Specialists-Macomb Township
Macomb
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette
Mid-Michigan Medical Center - Midland
Midland
Monroe Cancer Center
Monroe
Lakeland Hospital Niles
Niles
Henry Ford Medical Center-Columbus
Novi
21st Century Oncology-Pontiac
Pontiac
Hope Cancer Center
Pontiac
Newland Medical Associates-Pontiac
Pontiac
Saint Joseph Mercy Oakland
Pontiac
Huron Medical Center PC
Port Huron
Lake Huron Medical Center
Port Huron
Great Lakes Cancer Management Specialists-Rochester Hills
Rochester Hills
Michigan Cancer Specialists
Roseville
Cancer Care Associates PC
Royal Oak
Comprehensive Medical Center PLLC
Royal Oak
Hematology Oncology Consultants PC
Royal Oak
Oakland Colon and Rectal Association
Royal Oak
Oakland Medical Group
Royal Oak
William Beaumont Hospital-Royal Oak
Royal Oak
Oncology Hematology Associates of Saginaw Valley PC
Saginaw
Saint Mary's of Michigan
Saginaw
Lakeland Medical Center Saint Joseph
Saint Joseph
Marie Yeager Cancer Center
Saint Joseph
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights
Mitchell Folbe MD PC
Sterling Heights
Premier Hematology Oncology Care
Sterling Heights
Saint Joseph Health System-Tawas City
Tawas City
Claudia BR Herke MD PC
Troy
Hematology Oncology Consultants PC-Troy
Troy
Michigan Institute of Urology-Town Center
Troy
William Beaumont Hospital - Troy
Troy
Advanced Breast Care Center PLLC
Warren
Bhadresh Nayak MD PC-Warren
Warren
Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren
Macomb Hematology Oncology PC
Warren
Michigan Breast Specialists-Warren
Warren
Saint John Macomb-Oakland Hospital
Warren
Henry Ford West Bloomfield Hospital
West Bloomfield
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch
Huron Gastroenterology PC
Ypsilanti
IHA Hematology Oncology Consultants-Ann Arbor
Ypsilanti
Minnesota
Sanford Joe Lueken Cancer Center
Bemidji
Fairview Ridges Hospital
Burnsville
Mercy Hospital
Coon Rapids
Fairview-Southdale Hospital
Edina
Unity Hospital
Fridley
Hutchinson Area Health Care
Hutchinson
Mayo Clinic Health Systems-Mankato
Mankato
Fairview Maple Grove Medical Center
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Maplewood
Saint John's Hospital - Healtheast
Maplewood
Abbott-Northwestern Hospital
Minneapolis
Health Partners Inc
Minneapolis
Hennepin County Medical Center
Minneapolis
Minneapolis VA Medical Center
Minneapolis
Monticello Cancer Center
Monticello
New Ulm Medical Center
New Ulm
North Memorial Medical Health Center
Robbinsdale
Mayo Clinic
Rochester
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud
Saint Cloud Hospital
Saint Cloud
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park
Regions Hospital
Saint Paul
United Hospital
Saint Paul
Saint Francis Regional Medical Center
Shakopee
Lakeview Hospital
Stillwater
Ridgeview Medical Center
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Rice Memorial Hospital
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Minnesota Oncology Hematology PA-Woodbury
Woodbury
Sanford Cancer Center Worthington
Worthington
Fairview Lakes Medical Center
Wyoming
Missouri
Central Care Cancer Center - Bolivar
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Parkland Health Center-Bonne Terre
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Cox Cancer Center Branson
Branson
Saint Francis Medical Center
Cape Girardeau
Southeast Cancer Center
Cape Girardeau
Saint Luke's Hospital
Chesterfield
University of Missouri - Ellis Fischel
Columbia
Siteman Cancer Center at West County Hospital
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Centerpoint Medical Center LLC
Independence
Capital Region Southwest Campus
Jefferson City
Freeman Health System
Joplin
Mercy Hospital Joplin
Joplin
Heartland Hematology and Oncology Associates Incorporated
Kansas City
Research Medical Center
Kansas City
Saint Luke's Hospital of Kansas City
Kansas City
The University of Kansas Cancer Center-North
Kansas City
The University of Kansas Cancer Center-South
Kansas City
Saint Luke's East - Lee's Summit
Lee's Summit
The University of Kansas Cancer Center-Lee's Summit
Lee's Summit
Liberty Radiation Oncology Center
Liberty
Delbert Day Cancer Institute at PCRMC
Rolla
Mercy Clinic-Rolla-Cancer and Hematology
Rolla
Heartland Regional Medical Center
Saint Joseph
Saint Joseph Oncology Inc
Saint Joseph
Mercy Hospital Saint Louis
Saint Louis
Mercy Hospital South
Saint Louis
Missouri Baptist Medical Center
Saint Louis
Saint Louis Cancer and Breast Institute-South City
Saint Louis
Siteman Cancer Center at Christian Hospital
Saint Louis
Siteman Cancer Center-South County
Saint Louis
Washington University School of Medicine
Saint Louis
Siteman Cancer Center at Saint Peters Hospital
Saint Peters
Sainte Genevieve County Memorial Hospital
Sainte Genevieve
CoxHealth South Hospital
Springfield
Mercy Hospital Springfield
Springfield
Missouri Baptist Sullivan Hospital
Sullivan
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills
Mississippi
Gulfport Memorial Hospital
Gulfport
Montana
Community Hospital of Anaconda
Anaconda
Billings Clinic Cancer Center
Billings
Saint Vincent Frontier Cancer Center
Billings
Saint Vincent Healthcare
Billings
Bozeman Deaconess Hospital
Bozeman
Saint James Community Hospital and Cancer Treatment Center
Butte
Benefis Healthcare- Sletten Cancer Institute
Great Falls
Great Falls Clinic
Great Falls
Saint Peter's Community Hospital
Helena
Kalispell Regional Medical Center
Kalispell
Community Medical Hospital
Missoula
Montana Cancer Specialists
Missoula
Saint Patrick Hospital - Community Hospital
Missoula
North Carolina
AdventHealth Infusion Center Asheville
Asheville
UNC Lineberger Comprehensive Cancer Center
Chapel Hill
Carolina Surgical Clinic of Charlotte PA
Charlotte
Novant Health Presbyterian Medical Center
Charlotte
Oncology Specialists of Charlotte
Charlotte
Southern Oncology Specialists-Charlotte
Charlotte
Sampson Radiation Oncology
Clinton
Southeastern Medical Oncology Center-Clinton
Clinton
AdventHealth Infusion Center Haywood
Clyde
Southeastern Medical Oncology Center-Goldsboro
Goldsboro
Wayne Memorial Hospital
Goldsboro
Wayne Radiation Oncology
Goldsboro
East Carolina University
Greenville
AdventHealth Hendersonville
Hendersonville
Lake Norman Hematology Oncology Specialists-Huntersville
Huntersville
Southern Oncology Specialists-Huntersville
Huntersville
Onslow Memorial Hospital
Jacksonville
Southeastern Medical Oncology Center-Jacksonville
Jacksonville
Vidant Oncology-Kenansville
Kenansville
Vidant Oncology-Kinston
Kinston
Matthews Radiation Oncology Center
Matthews
Novant Health Cancer Specialists-Matthews
Matthews
Lake Norman Hematology Oncology Specialists-Mooresville
Mooresville
Vidant Oncology-Richlands
Richlands
Carolina Oncology Associates PA
Salisbury
Southeastern Medical Oncology Center-Wilson
Wilson
Novant Health Forsyth Medical Center
Winston-salem
Wake Forest University Health Sciences
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North Dakota
Roger Maris Cancer Center
Fargo
Sanford Broadway Medical Center
Fargo
Sanford Clinic North-Fargo
Fargo
Altru Cancer Center
Grand Forks
Nebraska
Nebraska Medicine-Bellevue
Bellevue
CHI Health Saint Francis
Grand Island
CHI Health Good Samaritan
Kearney
Heartland Hematology and Oncology
Kearney
Saint Elizabeth Regional Medical Center
Lincoln
Alegent Health Bergan Mercy Medical Center
Omaha
Alegent Health Immanuel Medical Center
Omaha
Alegent Health Lakeside Hospital
Omaha
Creighton University Medical Center
Omaha
Hematology and Oncology Consultants PC
Omaha
Nebraska Medicine-Village Pointe
Omaha
University of Nebraska Medical Center
Omaha
Midlands Community Hospital
Papillion
New Hampshire
Dartmouth Hitchcock Medical Center
Lebanon
Saint Joseph Hospital
Nashua
New Jersey
Memorial Sloan Kettering Basking Ridge
Basking Ridge
Cooper Hospital University Medical Center
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Englewood Hospital and Medical Center
Englewood
Monmouth Medical Center Southern Campus
Lakewood
Monmouth Medical Center
Long Branch
Memorial Sloan Kettering Monmouth
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Morristown Medical Center
Morristown
Virtua Memorial
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Saint Peter's University Hospital
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Overlook Hospital
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Virtua Voorhees
Voorhees
New Mexico
University of New Mexico Cancer Center
Albuquerque
Nevada
Carson Tahoe Regional Medical Center
Carson City
21st Century Oncology-Henderson
Henderson
Cancer and Blood Specialists-Henderson
Henderson
Comprehensive Cancer Centers of Nevada - Henderson
Henderson
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson
Las Vegas Cancer Center-Henderson
Henderson
OptumCare Cancer Care at Seven Hills
Henderson
21st Century Oncology
Las Vegas
21st Century Oncology-Fort Apache
Las Vegas
21st Century Oncology-Vegas Tenaya
Las Vegas
Ann M Wierman MD LTD
Las Vegas
Cancer and Blood Specialists-Shadow
Las Vegas
Cancer and Blood Specialists-Tenaya
Las Vegas
Cancer Therapy and Integrative Medicine
Las Vegas
Comprehensive Cancer Centers of Nevada
Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas
Desert West Surgery
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas
Las Vegas Cancer Center-Medical Center
Las Vegas
OptumCare Cancer Care at Fort Apache
Las Vegas
OptumCare Cancer Care at MountainView
Las Vegas
OptumCare Cancer Care at Oakey
Las Vegas
Radiation Oncology Centers of Nevada Central
Las Vegas
Radiation Oncology Centers of Nevada Southeast
Las Vegas
Summerlin Hospital Medical Center
Las Vegas
University Cancer Center
Las Vegas
University Medical Center of Southern Nevada
Las Vegas
Hope Cancer Care of Nevada-Pahrump
Pahrump
Alpine Hematology-Oncology
Reno
Cancer Care Specialists - Reno
Reno
Radiation Oncology Associates
Reno
Renown Regional Medical Center
Reno
Saint Mary's Regional Medical Center
Reno
New York
Hematology Oncology Associates of Central New York-Auburn
Auburn
Southside Hospital
Bay Shore
Montefiore Medical Center - Moses Campus
Bronx
Montefiore Medical Center-Einstein Campus
Bronx
Maimonides Medical Center
Brooklyn
Roswell Park Cancer Institute
Buffalo
Memorial Sloan Kettering Commack
Commack
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse
Arnot Ogden Medical Center/Falck Cancer Center
Elmira
Glens Falls Hospital
Glens Falls
Memorial Sloan Kettering Westchester
Harrison
Huntington Hospital
Huntington
Northwell Health/Center for Advanced Medicine
Lake Success
North Shore University Hospital
Manhasset
Orange Regional Medical Center
Middletown
NYU Winthrop Hospital
Mineola
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York
Memorial Sloan Kettering Cancer Center
New York
Mount Sinai Hospital
New York
Mount Sinai Union Square
New York
Mount Sinai West
New York
Weill Medical College of Cornell University
New York
Vassar Brothers Medical Center
Poughkeepsie
University of Rochester
Rochester
Memorial Sloan Kettering Rockville Centre
Rockville Centre
Memorial Sloan Kettering Sleepy Hollow
Sleepy Hollow
Stony Brook University Medical Center
Stony Brook
Hematology Oncology Associates of Central New York-Onondaga Hill
Syracuse
Ohio
Summa Akron City Hospital/Cooper Cancer Center
Akron
Summa Barberton Hospital
Barberton
UHHS-Chagrin Highlands Medical Center
Beachwood
Indu and Raj Soin Medical Center
Beavercreek
Strecker Cancer Center-Belpre
Belpre
Aultman Health Foundation
Canton
Mercy Medical Center
Canton
Dayton Physicians LLC-Miami Valley South
Centerville
Miami Valley Hospital South
Centerville
Adena Regional Medical Center
Chillicothe
Bethesda North Hospital
Cincinnati
Good Samaritan Hospital - Cincinnati
Cincinnati
Oncology Hematology Care Inc - Anderson
Cincinnati
Oncology Hematology Care Inc-Blue Ash
Cincinnati
Oncology Hematology Care Inc-Eden Park
Cincinnati
Oncology Hematology Care Inc-Kenwood
Cincinnati
Oncology Hematology Care Inc-Mercy West
Cincinnati
TriHealth Cancer Institute-Anderson
Cincinnati
TriHealth Cancer Institute-Westside
Cincinnati
University of Cincinnati/Barrett Cancer Center
Cincinnati
Case Western Reserve University
Cleveland
MetroHealth Medical Center
Cleveland
Columbus Oncology and Hematology Associates Inc
Columbus
Doctors Hospital
Columbus
Grant Medical Center
Columbus
Mount Carmel East Hospital
Columbus
Mount Carmel Health Center West
Columbus
Ohio State University Comprehensive Cancer Center
Columbus
Riverside Methodist Hospital
Columbus
The Mark H Zangmeister Center
Columbus
Dayton Physician LLC-Miami Valley Hospital North
Dayton
Good Samaritan Hospital - Dayton
Dayton
Grandview Hospital
Dayton
Miami Valley Hospital
Dayton
Miami Valley Hospital North
Dayton
Delaware Health Center-Grady Cancer Center
Delaware
Delaware Radiation Oncology
Delaware
Grady Memorial Hospital
Delaware
Oncology Hematology Care Inc-Healthplex
Fairfield
Armes Family Cancer Center
Findlay
Blanchard Valley Hospital
Findlay
Orion Cancer Care
Findlay
Atrium Medical Center-Middletown Regional Hospital
Franklin
Dayton Physicians LLC-Atrium
Franklin
Dayton Physicians LLC-Wayne
Greenville
Wayne Hospital
Greenville
First Dayton Cancer Care
Kettering
Greater Dayton Cancer Center
Kettering
Kettering Medical Center
Kettering
Fairfield Medical Center
Lancaster
Lancaster Radiation Oncology
Lancaster
OhioHealth Mansfield Hospital
Mansfield
Marietta Memorial Hospital
Marietta
OhioHealth Marion General Hospital
Marion
Dayton Physicians LLC-Signal Point
Middletown
Knox Community Hospital
Mount Vernon
Licking Memorial Hospital
Newark
Newark Radiation Oncology
Newark
Southern Ohio Medical Center
Portsmouth
Dayton Physicians LLC-Wilson
Sidney
Springfield Regional Cancer Center
Springfield
Springfield Regional Medical Center
Springfield
ProMedica Flower Hospital
Sylvania
The Toledo Hospital/Toledo Children's Hospital
Toledo
Dayton Physicians LLC-Upper Valley
Troy
Upper Valley Medical Center
Troy
University Pointe
West Chester
Saint Ann's Hospital
Westerville
UHHS-Westlake Medical Center
Westlake
Wright-Patterson Medical Center
Wright-patterson Air Force Base
Greene Memorial Hospital
Xenia
Genesis Healthcare System Cancer Care Center
Zanesville
Oklahoma
Cancer Centers of Southwest Oklahoma Research
Lawton
Integris Cancer Institute of Oklahoma
Oklahoma City
Mercy Hospital Oklahoma City
Oklahoma City
University of Oklahoma Health Sciences Center
Oklahoma City
Oregon
Saint Alphonsus Medical Center-Baker City
Baker City
Saint Charles Health System
Bend
Clackamas Radiation Oncology Center
Clackamas
Providence Oncology and Hematology Care Southeast
Clackamas
Bay Area Hospital
Coos Bay
Providence Milwaukie Hospital
Milwaukie
Providence Newberg Medical Center
Newberg
Saint Alphonsus Medical Center-Ontario
Ontario
Providence Willamette Falls Medical Center
Oregon City
Kaiser Permanente Northwest
Portland
Providence Portland Medical Center
Portland
Providence Saint Vincent Medical Center
Portland
Saint Charles Health System-Redmond
Redmond
Pennsylvania
Abington Memorial Hospital
Abington
Lehigh Valley Hospital-Cedar Crest
Allentown
UPMC-Heritage Valley Health System Beaver
Beaver
Lehigh Valley Hospital - Muhlenberg
Bethlehem
Geisinger Medical Center
Danville
Easton Hospital
Easton
Saint Vincent Hospital
Erie
The Regional Cancer Center
Erie
Fox Chase Cancer Center Buckingham
Furlong
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg
Penn State Milton S Hershey Medical Center
Hershey
Jefferson Hospital
Jefferson Hills
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown
Armstrong Center for Medicine and Health
Kittanning
Geisinger Medical Oncology-Lewisburg
Lewisburg
Lewistown Hospital
Lewistown
UPMC Cancer Center at UPMC McKeesport
Mckeesport
Forbes Hospital
Monroeville
UPMC-Coraopolis/Heritage Valley Radiation Oncology
Moon
Drexel University School of Medicine
Philadelphia
Fox Chase Cancer Center
Philadelphia
Temple University Hospital
Philadelphia
Thomas Jefferson University Hospital
Philadelphia
Allegheny General Hospital
Pittsburgh
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh
UPMC Jefferson Regional Radiation Oncology
Pittsburgh
UPMC-Magee Womens Hospital
Pittsburgh
UPMC-Passavant Hospital
Pittsburgh
UPMC-Presbyterian Hospital
Pittsburgh
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh
UPMC-Saint Margaret
Pittsburgh
UPMC-Shadyside Hospital
Pittsburgh
Pottstown Hospital
Pottstown
UPMC Cancer Center at UPMC Northwest
Seneca
UPMC Uniontown Hospital Radiation Oncology
Uniontown
UPMC Washington Hospital Radiation Oncology
Washington
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-barre
Abington Memorial Hospital-Asplundh Cancer Pavilion
Willow Grove
South Carolina
Greenville Health System Cancer Institute-Laurens
Clinton
Greenville Health System Cancer Institute-Easley
Easley
Greenville Health System Cancer Institute-Butternut
Greenville
Greenville Health System Cancer Institute-Eastside
Greenville
Greenville Health System Cancer Institute-Faris
Greenville
Greenville Memorial Hospital
Greenville
Greenville Health System Cancer Institute-Greer
Greer
Greenville Health System Cancer Institute-Seneca
Seneca
Greenville Health System Cancer Institute-Spartanburg
Spartanburg
South Dakota
Avera Cancer Institute
Sioux Falls
Tennessee
Memorial Hospital
Chattanooga
Pulmonary Medicine Center of Chattanooga-Hixson
Hixson
Meharry Medical College
Nashville
Memorial GYN Plus
Ooltewah
Texas
The Don and Sybil Harrington Cancer Center
Amarillo
Dell Seton Medical Center at The University of Texas
Austin
Saint Joseph Regional Cancer Center
Bryan
Baylor University Medical Center
Dallas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston
Ben Taub General Hospital
Houston
Lyndon Baines Johnson General Hospital
Houston
M D Anderson Cancer Center
Houston
MD Anderson Regional Care Center-Katy
Houston
Methodist Willowbrook Hospital
Houston
Michael E DeBakey VA Medical Center
Houston
The Methodist Hospital System
Houston
MD Anderson Regional Care Center-Bay Area
Nassau Bay
Houston Methodist Sugar Land Hospital
Sugar Land
MD Anderson Regional Care Center-Sugar Land
Sugar Land
Scott and White Memorial Hospital
Temple
MD Anderson Regional Care Center-The Woodlands
The Woodlands
Utah
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork
Sandra L Maxwell Cancer Center
Cedar City
Logan Regional Hospital
Logan
Intermountain Medical Center
Murray
McKay-Dee Hospital Center
Ogden
Utah Valley Regional Medical Center
Provo
Riverton Hospital
Riverton
Dixie Medical Center Regional Cancer Center
Saint George
Huntsman Cancer Institute/University of Utah
Salt Lake City
LDS Hospital
Salt Lake City
Utah Cancer Specialists-Salt Lake City
Salt Lake City
Virginia
Sentara Martha Jefferson Hospital
Charlottesville
University of Virginia Cancer Center
Charlottesville
Inova Fairfax Hospital
Falls Church
Hematology Oncology Associates of Fredericksburg Inc
Fredericksburg
Sentara Cancer Institute at Sentara CarePlex Hospital
Hampton
Centra Lynchburg Hematology-Oncology Clinic Inc
Lynchburg
Bon Secours Saint Francis Medical Center
Midlothian
Sentara Leigh Hospital
Norfolk
Sentara Norfolk General Hospital
Norfolk
Bon Secours Saint Mary's Hospital
Richmond
Virginia Commonwealth University/Massey Cancer Center
Richmond
VCU Community Memorial Health Center
South Hill
Shenandoah Oncology PC
Winchester
Vermont
Central Vermont Medical Center/National Life Cancer Treatment
Berlin
University of Vermont College of Medicine
Burlington
University of Vermont Medical Center
Burlington
Norris Cotton Cancer Center-North
Saint Johnsbury
Washington
Providence Regional Cancer System-Aberdeen
Aberdeen
Cancer Care Center at Island Hospital
Anacortes
MultiCare Auburn Medical Center
Auburn
Virginia Mason Bainbridge Island Medical Center
Bainbridge Island
Overlake Hospital Medical Center
Bellevue
Swedish Cancer Institute-Eastside Oncology Hematology
Bellevue
PeaceHealth Saint Joseph Medical Center
Bellingham
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton
Harrison Medical Center
Bremerton
Highline Medical Center-Main Campus
Burien
Providence Regional Cancer System-Centralia
Centralia
Swedish Medical Center-Edmonds
Edmonds
Saint Elizabeth Hospital
Enumclaw
Providence Regional Cancer Partnership
Everett
Saint Francis Hospital
Federal Way
Virginia Mason Federal Way Medical Center
Federal Way
MultiCare Gig Harbor Medical Park
Gig Harbor
Tacoma/Valley Radiation Oncology Centers-Gig Harbor
Gig Harbor
Swedish Cancer Institute-Issaquah
Issaquah
Kadlec Clinic Hematology and Oncology
Kennewick
Northwest Cancer Clinic
Kennewick
Tri-Cities Cancer Center
Kennewick
EvergreenHealth Medical Center
Kirkland
Seattle Cancer Care Alliance at EvergreenHealth
Kirkland
Providence Regional Cancer System-Lacey
Lacey
Saint Clare Hospital
Lakewood
PeaceHealth Saint John Medical Center
Longview
Virginia Mason Lynnwood Medical Center
Lynnwood
Skagit Valley Hospital
Mount Vernon
Skagit Valley Hospital Regional Cancer Care Center
Mount Vernon
Jefferson Healthcare
Port Townsend
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo
Peninsula Cancer Center
Poulsbo
MultiCare Good Samaritan Hospital
Puyallup
Tacoma/Valley Radiation Oncology Centers-Puyallup
Puyallup
Valley Medical Center
Renton
Fred Hutchinson Cancer Research Center
Seattle
Kaiser Permanente Washington
Seattle
Minor and James Medical PLLC
Seattle
Pacific Gynecology Specialists
Seattle
Seattle Cancer Care Alliance
Seattle
Seattle Cancer Care Alliance at Northwest Hospital
Seattle
Swedish Medical Center-Ballard Campus
Seattle
Swedish Medical Center-Cherry Hill
Seattle
Swedish Medical Center-First Hill
Seattle
University of Washington Medical Center
Seattle
Virginia Mason Medical Center
Seattle
PeaceHealth United General Medical Center
Sedro-woolley
Providence Regional Cancer System-Shelton
Shelton
Cancer Care Northwest - Spokane South
Spokane
Cancer Care Northwest-North Spokane
Spokane
Cancer Care Northwest-Valley
Spokane
Evergreen Hematology and Oncology PS
Spokane
Rockwood Cancer Treatment Center-DHEC-Downtown
Spokane
Rockwood North Cancer Treatment Center
Spokane
Spokane Valley Cancer Center-Mayfair
Spokane
Spokane Valley Cancer Center-Mission
Spokane
Rockwood Clinic Cancer Treatment Center-Valley
Spokane Valley
Franciscan Research Center-Northwest Medical Plaza
Tacoma
MultiCare Tacoma General Hospital
Tacoma
Northwest Medical Specialties PLLC
Tacoma
Saint Joseph Medical Center
Tacoma
Tacoma/Valley Radiation Oncology Centers-Jackson Hall
Tacoma
Tacoma/Valley Radiation Oncology Centers-Saint Joe's
Tacoma
Compass Oncology Vancouver
Vancouver
PeaceHealth Southwest Medical Center
Vancouver
Providence Saint Mary Regional Cancer Center
Walla Walla
Wenatchee Valley Hospital and Clinics
Wenatchee
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima
Providence Regional Cancer System-Yelm
Yelm
Wisconsin
Langlade Hospital and Cancer Center
Antigo
Aurora Cancer Care-Southern Lakes VLCC
Burlington
Marshfield Clinic-Chippewa Center
Chippewa Falls
HSHS Sacred Heart Hospital
Eau Claire
Marshfield Clinic Cancer Center - Eau Claire
Eau Claire
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire
Mayo Clinic Health System Eau Claire Hospital-Luther Campus
Eau Claire
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire
Aurora Health Center-Fond du Lac
Fond Du Lac
Aurora Health Care Germantown Health Center
Germantown
Aurora Cancer Care-Grafton
Grafton
Aurora BayCare Medical Center
Green Bay
Aurora Cancer Care-Kenosha South
Kenosha
University of Wisconsin Hospital and Clinics
Madison
Aurora Bay Area Medical Group-Marinette
Marinette
Bay Area Medical Center
Marinette
Marshfield Medical Center
Marshfield
Marshfield Medical Center-Marshfield
Marshfield
Aurora Cancer Care-Milwaukee
Milwaukee
Aurora Saint Luke's Medical Center
Milwaukee
Aurora Sinai Medical Center
Milwaukee
Froedtert and the Medical College of Wisconsin
Milwaukee
Marshfield Clinic-Minocqua Center
Minocqua
Cancer Center of Western Wisconsin
New Richmond
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh
Aurora Cancer Care-Racine
Racine
Ascension Saint Mary's Hospital
Rhinelander
Saint Mary's Hospital
Rhinelander
Marshfield Medical Center-Rice Lake
Rice Lake
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan
Ascension Saint Michael's Hospital
Stevens Point
Marshfield Clinic Stevens Point Center
Stevens Point
Saint Michael's Hospital
Stevens Point
Aurora Medical Center in Summit
Summit
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers
Aurora Cancer Care-Waukesha
Waukesha
Aspirus Regional Cancer Center
Wausau
Marshfield Clinic-Wausau Center
Wausau
Aurora Cancer Care-Milwaukee West
Wauwatosa
Aurora West Allis Medical Center
West Allis
Diagnostic and Treatment Center
Weston
Marshfield Clinic - Weston Center
Weston
Saint Clare's Hospital
Weston
Aspirus UW Cancer Center
Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids
West Virginia
United Hospital Center
Bridgeport
Edwards Comprehensive Cancer Center
Huntington
WVUH-Berkely Medical Center
Martinsburg
West Virginia University Healthcare
Morgantown
Camden Clark Medical Center
Parkersburg
Wyoming
Rocky Mountain Oncology
Casper
Cheyenne Regional Medical Center-West
Cheyenne
Big Horn Basin Cancer Center
Cody
Billings Clinic-Cody
Cody
Welch Cancer Center
Sheridan
Other Locations
Canada
Tom Baker Cancer Centre
Calgary
PEI Cancer Treatment Centre-Queen Elizabeth Hospital
Charlottetown
Cross Cancer Institute
Edmonton
BCCA-Cancer Centre for the Southern Interior
Kelowna
London Regional Cancer Program
London
McGill University Department of Oncology
Montreal
The Research Institute of the McGill University Health Centre (MUHC)
Montreal
Lakeridge Health Oshawa
Oshawa
Ottawa Hospital and Cancer Center-General Campus
Ottawa
Allan Blair Cancer Centre
Regina
Niagara Health System-Saint Catharines General
Saint Catharines
Atlantic Health Sciences Corporation-Saint John Regional Hospital
Saint John
Saskatoon Cancer Centre
Saskatoon
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto
BCCA-Vancouver Cancer Centre
Vancouver
CancerCare Manitoba
Winnipeg
Israel
Shaare Zedek Medical Center
Jerusalem
Switzerland
Kantonsspital Aarau
Aarau
University Hospital Basel
Basel
Oncology Institute of Southern Switzerland
Bellinzona
Kantonsspital Graubunden
Chur
University Hospital of Lausanne
Lausanne
Kantonsspital Winterthur
Winterthur
Zurich Hirslanden Klinik
Zurich
Zurich Im Park
Zurich
Time Frame
Start Date: January 2012
Estimated Completion Date: June 30, 2023
Participants
Target number of participants: 1194
Treatments
Experimental: Group 1
Patients will receive FOLFOX chemotherapy once every two weeks for 6 cycles total over a period of 12 weeks. After completing FOLFOX chemotherapy, the patient will have an MRI scan or endorectal ultrasound (ERUS) to examine the tumor. If the tumor has not decreased in size by at least 20%, the patient will receive 5FUCMT (radiation with chemotherapy). If the tumor has decreased in size by 20%, then the patient will proceed directly to surgery.~If all borders of the tumor are normal post surgery, then the patient receives six additional cycles of FOLFOX chemotherapy. If all borders of the tumor are not normal then the patient receives chemoradiation therapy for 5.5 weeks after surgery. After chemoradiation, additional cycles of FOLFOX or similar chemotherapy will be recommended for 4 cycles or 8 weeks. Patient observation with follow up evaluations and event monitoring will occur up to 8 years post randomization.
Active Comparator: Group 2
Patients receive 5FUCMT including chemotherapy and radiation therapy for 5.5 weeks. Patients will be given either 5-fluorouracil or capecitabine and radiation therapy. After the chemoradiation therapy is completed, patients will proceed directly to surgery. Post-surgery, patients will receive FOLFOX chemotherapy once every two weeks for 8 cycles total over a period of 16 weeks. Patient observation with follow up evaluations and event monitoring will occur up to 8 years post randomization.
Authors
Sophie D. Morse, Dennis E. Slater, William T. Muuse, Deborah W. Wilbur, Willard G. Andrews, Kevan L. Hartshorn, Desiree E. Doncals, Alfred D. Christie, Peter S. Tate, Minaxi Jhawer, Umit Tapan, Stephen E. Rubenstein, Jeffrey P. Letzer, Jonathan A. Polikoff, Ira A. Oliff, Robert J. Behrens, Shahid Ahmed, Seth D. Cohen, Minsig Choi, Thomas H. Openshaw, Hagen F. Kennecke, Janine M. Davies, Miroslaw A. Mazurczak, Connie D. Uzel, Patrick J. Loehrer, Bryan A. Faller, James W. Fleshman, Thomas J. Reid, Milana V. Dolezal, Emad Elquza, Wei Song, Yujie Zhao, Bruce J. Averbook, Grant R. Seeger, Vikram Attaluri, Howard M. Gross, Jay W. Carlson, Mohammad J. Ranginwala, Jeffrey L. Berenberg, Jeffrey J. Kirshner, Steven Ades, Hitendra Patel, James R. Nitzkorski, Mehmet S. Copur, Peter D. Eisenberg, William J. Irvin, Jean L. Grem, Brian G. Vikstrom, David M. Spector, Angus P. McIntyre, Meghana Raghavendra, Madhavi L. Venigalla, Michael A. Schwartz, Traci L. Hedrick, Alan P. Venook, Suresh G. Nair, Donald J. Jurgens, Carroll D. Scroggin, Stewart A. Sharp, Jeffrey K. Giguere, Edward S. James, Thomas E. Lad, Robin T. Zon, Timothy D. Moore, Joseph P. Muldoon, Deirdre J. Cohen, Paul M. Barr, Abdul M. Choudhury, Ding Wang, Jeffrey H. Muler, James N. Atkins, Afsaneh Barzi, Patrick S. Sullivan, Clint D. Kingsley, Sam Mazj, Elena G. Chiorean, Keren Sturtz, Jeffrey M. Stewart, Abhijit B. Saste, Brian K. Chang, Heidi Bahna, Kevin Dawravoo, Om N. Pandey, Brian J. Heller, J. M. Prichard, Carlos A. Alemany, Dustin A. Deming, Celina S. Ang, Benjamin R. Tan, Ashwani Rajput, Gary L. Buchschacher, Raymond Thertulien, Paul R. Walker, Sakti Chakrabarti, Jack J. Hong, R. J. Lee, Timothy E. Byun, Oleg I. Krijanovski, Nadim F. Nimeh, Puja Nistala, Alison K. Conlin, Hassan Hatoum, Tony Philip, Misbah U. Qadir, Alessio Pigazzi, Malcolm D. Mattes, Ross A. Abrams, Allyson J. Ocean, Kenneth C. Micetich, Neal B. Goldberg, Harish G. Ahuja, Mikhail Vinogradov, Justin P. Favaro, Harvey C. Lebos, Jongming Li, Jyotsna Fuloria, Muhammad I. Moid, Harvey Zimbler, Charles A. Kunos, Peter R. Watson, Philip E. Lammers, Jeremy S. Kortmansky, Shaker R. Dakhil, Bernadine Donahue, Sharon D. Luikart, Leonard B. Saltz, Jeffrey M. Farma, Stefan D. Holubar, Harold L. Kennedy, Carl R. Schmidt, Timothy L. Cannon, Keith S. Lanier, George J. Chang, Neeta K. Venepalli, Nasfat Shehadeh, Amy L. Halverson, Srinivas J. Ivatury, Blase N. Polite, Gregory B. Smith, Uzair B. Chaudhary, Keith E. Stuart, Lee G. Hicks, Tatjana Kolevska, Daniel M. Anderson, John C. Krauss, Preston S. Gable, Eric C. Feliberti, Pablo H. Ferraro, James L. Wade, Benjamin T. Marchello, Nelson S. Yee, Deborah Schrag, Tracey E. Schefter, Augusto C. Ochoa, Courtney L. Scaife, Sandeep H. Mashru, Anna Serur, Harvey E. Einhorn, Sameer P. Desai, Richard C. Frank, Benjamin L. Musher, Peter S. Kozuch, Kirk A. Ludwig, Cherif N. Boutros, Josh D. Simmons, John L. Marshall, Lucas Wong, Mark F. Kozloff, Rebecca A. Levine, Thomas J. George, Steven Nurkin, Rezwan Islam, James T. McCormick, Robert A. Chapman, Christopher R. Marsh, Daniel E. Lehane, Philip E. Champion, Amiel Segal, Stephen A. Welch, Cynthia G. Leichman, Brian P. Findlay, James A. Posey, Katharine J. Shim, Lucas A. Widmer, Peter R. Moosmann, Rakesh Gaur, Pam G. Khosla, Mitchell Haut, William R. Taylor, Haji I. Chalchal, Dieter Hahnloser, Rubina Qamar, Patricia Tang, Jamil Asselah, Piercarlo Saletti, Christopher Lominska, Roger A. von Moos, Daniel Helbling, Vallerie L. Gordon, Maria R. Tria Tirona, Karyn B. Stitzenberg, Andreas Wicki, Grant M. Schofield, Samantha L. Gray, Melanie Loffler, Suhasini (Sue) Nadesan, George A. Fisher, Olugbenga Olowokure (Gbenga), Mohmmad J. Ranginwala, Rebecca C. Auer, Robert R. McWilliams, Richard Tuli, Scott Berry, Kathleen J. Yost, Maneesh Jain, Sabina Schacher, John A. Ellerton, James H. Feusner, Christopher M. Reynolds, Sanjay C. Rao, Rebecca Ann C. Auer, John A. Keech, Suma P. Satti, Luis A. Rojas-Espaillat, Sabina Schacher-Kaufmann, John L. Hays, Ravi K. Paluri, Jonathan W. Friedberg, Christopher G. Peterson, Prashanti Atluri, Moh'd Khushman
Related Therapeutic Areas
Sponsors
Collaborators: Canadian Cancer Trials Group, National Cancer Institute (NCI)
Leads: Alliance for Clinical Trials in Oncology

This content was sourced from clinicaltrials.gov

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