Phase II/III Study of Circulating Tumor DNA as a Predictive Biomarker in Adjuvant Chemotherapy in Patients With Stage IIA Colon Cancer (COBRA)

Who is this study for? Adult patients with Stage IIA Colon Adenocarcinoma
Status: Recruiting
Location: See all (887) locations...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY

This phase II/III trial studies how well circulating tumor deoxyribonucleic acid (ctDNA) testing in the blood works in predicting treatment for patients with stage IIA colon cancer after surgery. ctDNA are circulating tumor cells that are shed by tumors into the blood. Finding ctDNA in the blood means that there is very likely some small amounts of cancer that remain after surgery. However, this cancer, if detected, cannot be found on other tests usually used to find cancer, as it is too small. Testing for ctDNA levels may help identify patients with colon cancer after surgery who do benefit, and those who do not benefit, from receiving chemotherapy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines.

• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

• Histologically/pathologically confirmed stage IIA adenocarcinoma of the colon (T3, N0, M0) with at least 12 lymph nodes examined at the time of surgical resection.

• Appropriate for active surveillance (i.e., no adjuvant chemotherapy) at the discretion of and as documented by the evaluating oncologist based on current practice patterns.

• The distal extent of the tumor must be >= 12 cm from the anal verge on pre-surgical endoscopy (i.e., excluding rectal adenocarcinomas warranting treatment with chemoradiation). If the patient did not undergo a pre-surgical endoscopy, then the distal extent of the tumor must be >= 12 cm from the anal verge as determined by surgical examination or pre-operative imaging.

• The patient must have had an en bloc complete gross resection of tumor (curative resection) as definitive surgical cancer treatment within 14 to 60 days of study randomization. Patients who have had a two-stage surgical procedure to first provide a decompressive colostomy and then, in a later procedure, to have the definitive surgical resection, are eligible.

• Availability and provision of adequate surgical tumor tissue for molecular diagnostics and confirmatory profiling.

• Absolute neutrophil count (ANC) must be >= 1200/mm^3 (within 28 days before randomization).

• Platelet count must be >= 100,000/mm^3 (within 28 days before randomization); and

• Hemoglobin must be >= 9 g/dL (within 28 days before randomization).

• Total bilirubin must be =< ULN (upper limit of normal) for the lab (within 28 days before randomization) unless the patient has a chronic grade 1 bilirubin elevation due to Gilbert?s disease or similar syndrome involving slow conjugation of bilirubin; and

• Alkaline phosphatase must be < 2.5 x ULN for the lab (within 28 days before randomization); and

• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be < 1.5 x ULN for the lab (within 28 days before randomization).

• Serum creatinine =< 1.5 x ULN for the lab or measured or calculated creatinine clearance >= 50 mL/min using the Cockcroft-Gault formula for patients with creatinine levels > 1.5 x ULN for the lab (within 28 days before randomization).

• Pregnancy test (urine or serum according to institutional standard) done within 14 days before randomization must be negative (for women of childbearing potential only).

• Patients receiving a coumarin-derivative anticoagulant must agree to weekly monitoring of international normalized ratio (INR) if they are randomized to Arm 2 and receive capecitabine.

Locations
United States
Alaska
Alaska Breast Care and Surgery LLC
Recruiting
Anchorage
Alaska Oncology and Hematology LLC
Recruiting
Anchorage
Alaska Women's Cancer Care
Recruiting
Anchorage
Anchorage Associates in Radiation Medicine
Recruiting
Anchorage
Anchorage Oncology Centre
Recruiting
Anchorage
Anchorage Radiation Therapy Center
Recruiting
Anchorage
Katmai Oncology Group
Recruiting
Anchorage
Providence Alaska Medical Center
Recruiting
Anchorage
Fairbanks Memorial Hospital
Recruiting
Fairbanks
Alabama
University of Alabama at Birmingham Cancer Center
Active, not recruiting
Birmingham
University of South Alabama Mitchell Cancer Institute
Recruiting
Mobile
Arkansas
Mercy Hospital Fort Smith
Recruiting
Fort Smith
CHI Saint Vincent Cancer Center Hot Springs
Suspended
Hot Springs
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Recruiting
Jonesboro
Arizona
Kingman Regional Medical Center
Recruiting
Kingman
Cancer Center at Saint Joseph's
Recruiting
Phoenix
Banner University Medical Center - Tucson
Recruiting
Tucson
University of Arizona Cancer Center-North Campus
Recruiting
Tucson
California
Kaiser Permanente-Anaheim
Recruiting
Anaheim
Mission Hope Medical Oncology - Arroyo Grande
Recruiting
Arroyo Grande
PCR Oncology
Recruiting
Arroyo Grande
Sutter Auburn Faith Hospital
Recruiting
Auburn
Kaiser Permanente-Baldwin Park
Recruiting
Baldwin Park
Kaiser Permanente-Bellflower
Recruiting
Bellflower
Alta Bates Summit Medical Center-Herrick Campus
Recruiting
Berkeley
UCSF Cancer Center - Berkeley
Recruiting
Berkeley
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Recruiting
Burbank
Mills-Peninsula Medical Center
Suspended
Burlingame
Eden Hospital Medical Center
Recruiting
Castro Valley
Enloe Medical Center
Active, not recruiting
Chico
UC Irvine Health Cancer Center-Newport
Recruiting
Costa Mesa
Sutter Davis Hospital
Recruiting
Davis
City of Hope Comprehensive Cancer Center
Recruiting
Duarte
Epic Care-Dublin
Recruiting
Dublin
Bay Area Breast Surgeons Inc
Recruiting
Emeryville
Epic Care Partners in Cancer Care
Recruiting
Emeryville
Kaiser Permanente-Fontana
Recruiting
Fontana
Palo Alto Medical Foundation-Fremont
Recruiting
Fremont
Kaiser Permanente - Harbor City
Recruiting
Harbor City
Kaiser Permanente-Irvine
Recruiting
Irvine
Kaiser Permanente Los Angeles Medical Center
Recruiting
Los Angeles
Kaiser Permanente West Los Angeles
Recruiting
Los Angeles
Los Angeles County-USC Medical Center
Recruiting
Los Angeles
USC / Norris Comprehensive Cancer Center
Recruiting
Los Angeles
Contra Costa Regional Medical Center
Recruiting
Martinez
Fremont - Rideout Cancer Center
Recruiting
Marysville
Memorial Medical Center
Recruiting
Modesto
Palo Alto Medical Foundation-Camino Division
Recruiting
Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology
Recruiting
Mountain View
Providence Queen of The Valley
Recruiting
Napa
Alta Bates Summit Medical Center - Summit Campus
Suspended
Oakland
Bay Area Tumor Institute
Recruiting
Oakland
Kaiser Permanente-Ontario
Recruiting
Ontario
Saint Joseph Hospital - Orange
Recruiting
Orange
UC Irvine Health/Chao Family Comprehensive Cancer Center
Recruiting
Orange
Palo Alto Medical Foundation Health Care
Recruiting
Palo Alto
Kaiser Permanente - Panorama City
Recruiting
Panorama City
Kaiser Permanente-Riverside
Recruiting
Riverside
Sutter Roseville Medical Center
Recruiting
Roseville
Sutter Medical Center Sacramento
Recruiting
Sacramento
University of California Davis Comprehensive Cancer Center
Active, not recruiting
Sacramento
Salinas Valley Memorial
Recruiting
Salinas
Kaiser Permanente-San Diego Mission
Recruiting
San Diego
Kaiser Permanente-San Diego Zion
Recruiting
San Diego
California Pacific Medical Center-Pacific Campus
Recruiting
San Francisco
Kaiser Permanente-San Marcos
Recruiting
San Marcos
UCSF Cancer Center - San Mateo
Recruiting
San Mateo
Palo Alto Medical Foundation-Santa Cruz
Recruiting
Santa Cruz
Mission Hope Medical Oncology - Santa Maria
Recruiting
Santa Maria
Providence Medical Foundation - Santa Rosa
Recruiting
Santa Rosa
Providence Santa Rosa Memorial Hospital
Recruiting
Santa Rosa
Sutter Pacific Medical Foundation
Recruiting
Santa Rosa
City of Hope South Pasadena
Recruiting
South Pasadena
Palo Alto Medical Foundation-Sunnyvale
Recruiting
Sunnyvale
City of Hope South Bay
Recruiting
Torrance
Gene Upshaw Memorial Tahoe Forest Cancer Center
Recruiting
Truckee
City of Hope Upland
Recruiting
Upland
Sutter Solano Medical Center/Cancer Center
Recruiting
Vallejo
Epic Care Cyberknife Center
Recruiting
Walnut Creek
Kaiser Permanente-Woodland Hills
Recruiting
Woodland Hills
Colorado
Rocky Mountain Cancer Centers-Aurora
Recruiting
Aurora
The Medical Center of Aurora
Recruiting
Aurora
University of Colorado Hospital
Recruiting
Aurora
Boulder Community Foothills Hospital
Recruiting
Boulder
Rocky Mountain Cancer Centers-Boulder
Recruiting
Boulder
Rocky Mountain Cancer Centers - Centennial
Recruiting
Centennial
Memorial Hospital North
Recruiting
Colorado Springs
Penrose-Saint Francis Healthcare
Recruiting
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
Recruiting
Colorado Springs
Saint Francis Cancer Center
Recruiting
Colorado Springs
UCHealth Memorial Hospital Central
Recruiting
Colorado Springs
Colorado Blood Cancer Institute
Recruiting
Denver
Porter Adventist Hospital
Recruiting
Denver
Rocky Mountain Cancer Centers-Midtown
Recruiting
Denver
Rocky Mountain Cancer Centers-Rose
Recruiting
Denver
The Women's Imaging Center
Recruiting
Denver
Mercy Medical Center
Recruiting
Durango
Southwest Oncology PC
Recruiting
Durango
Mountain Blue Cancer Care Center - Swedish
Recruiting
Englewood
Rocky Mountain Cancer Centers - Swedish
Recruiting
Englewood
Swedish Medical Center
Recruiting
Englewood
The Melanoma and Skin Cancer Institute
Recruiting
Englewood
Cancer Care and Hematology-Fort Collins
Recruiting
Fort Collins
Poudre Valley Hospital
Recruiting
Fort Collins
North Colorado Medical Center
Suspended
Greeley
UCHealth Greeley Hospital
Recruiting
Greeley
Rocky Mountain Cancer Centers-Lakewood
Recruiting
Lakewood
Saint Anthony Hospital
Recruiting
Lakewood
Littleton Adventist Hospital
Recruiting
Littleton
Rocky Mountain Cancer Centers-Littleton
Recruiting
Littleton
Rocky Mountain Cancer Centers-Sky Ridge
Recruiting
Lone Tree
Sky Ridge Medical Center
Recruiting
Lone Tree
Longmont United Hospital
Recruiting
Longmont
Rocky Mountain Cancer Centers-Longmont
Suspended
Longmont
Medical Center of the Rockies
Recruiting
Loveland
Parker Adventist Hospital
Recruiting
Parker
Saint Mary Corwin Medical Center
Recruiting
Pueblo
Rocky Mountain Cancer Centers-Thornton
Recruiting
Thornton
Connecticut
Danbury Hospital
Active, not recruiting
Danbury
Smilow Cancer Hospital-Derby Care Center
Recruiting
Derby
Smilow Cancer Hospital Care Center-Fairfield
Recruiting
Fairfield
Smilow Cancer Hospital Care Center at Greenwich
Recruiting
Greenwich
Smilow Cancer Hospital Care Center - Guiford
Recruiting
Guilford
Hartford Hospital
Recruiting
Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Recruiting
Hartford
Midstate Medical Center
Recruiting
Meriden
The Hospital of Central Connecticut
Recruiting
New Britain
Smilow Cancer Center/Yale-New Haven Hospital
Recruiting
New Haven
Yale University
Recruiting
New Haven
Yale-New Haven Hospital North Haven Medical Center
Recruiting
North Haven
Norwalk Hospital
Active, not recruiting
Norwalk
Smilow Cancer Hospital-Orange Care Center
Recruiting
Orange
Smilow Cancer Hospital-Torrington Care Center
Recruiting
Torrington
Smilow Cancer Hospital Care Center-Trumbull
Recruiting
Trumbull
Smilow Cancer Hospital-Waterbury Care Center
Recruiting
Waterbury
Smilow Cancer Hospital Care Center - Waterford
Recruiting
Waterford
Washington, D.c.
Kaiser Permanente-Capitol Hill Medical Center
Recruiting
Washington
MedStar Washington Hospital Center
Recruiting
Washington
Delaware
Beebe South Coastal Health Campus
Recruiting
Frankford
Helen F Graham Cancer Center
Recruiting
Newark
Medical Oncology Hematology Consultants PA
Recruiting
Newark
Beebe Health Campus
Recruiting
Rehoboth Beach
Florida
Holy Cross Hospital
Recruiting
Fort Lauderdale
University of Florida Health Science Center - Gainesville
Recruiting
Gainesville
AdventHealth Orlando
Recruiting
Orlando
Orlando Health Cancer Institute
Recruiting
Orlando
Memorial Hospital West
Recruiting
Pembroke Pines
Cleveland Clinic-Weston
Recruiting
Weston
Georgia
Emory Saint Joseph's Hospital
Recruiting
Atlanta
Emory University Hospital Midtown
Recruiting
Atlanta
Emory University Hospital/Winship Cancer Institute
Recruiting
Atlanta
Northeast Georgia Medical Center-Gainesville
Recruiting
Gainesville
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Recruiting
Savannah
Hawaii
Pali Momi Medical Center
Recruiting
'aiea
Queen's Cancer Center - Pearlridge
Recruiting
'aiea
The Cancer Center of Hawaii-Pali Momi
Recruiting
'aiea
Hawaii Cancer Care Inc - Waterfront Plaza
Recruiting
Honolulu
Queen's Cancer Cenrer - POB I
Recruiting
Honolulu
Queen's Cancer Center - Kuakini
Recruiting
Honolulu
Queen's Medical Center
Recruiting
Honolulu
Straub Clinic and Hospital
Recruiting
Honolulu
University of Hawaii Cancer Center
Recruiting
Honolulu
Iowa
Mary Greeley Medical Center
Recruiting
Ames
McFarland Clinic PC - Ames
Recruiting
Ames
University of Iowa Healthcare Cancer Services Quad Cities
Recruiting
Bettendorf
McFarland Clinic PC-Boone
Recruiting
Boone
Mercy Hospital
Recruiting
Cedar Rapids
Oncology Associates at Mercy Medical Center
Recruiting
Cedar Rapids
Physicians' Clinic of Iowa PC
Recruiting
Cedar Rapids
Medical Oncology and Hematology Associates-West Des Moines
Recruiting
Clive
Mercy Cancer Center-West Lakes
Recruiting
Clive
Alegent Health Mercy Hospital
Recruiting
Council Bluffs
Greater Regional Medical Center
Recruiting
Creston
Genesis Cancer Care Institute
Recruiting
Davenport
Genesis Medical Center - East Campus
Recruiting
Davenport
Iowa Cancer Specialists
Recruiting
Davenport
Broadlawns Medical Center
Recruiting
Des Moines
Iowa Lutheran Hospital
Recruiting
Des Moines
Iowa Methodist Medical Center
Recruiting
Des Moines
Medical Oncology and Hematology Associates-Des Moines
Recruiting
Des Moines
Mercy Medical Center - Des Moines
Recruiting
Des Moines
Mission Cancer and Blood - Laurel
Recruiting
Des Moines
McFarland Clinic PC-Trinity Cancer Center
Recruiting
Fort Dodge
Trinity Regional Medical Center
Recruiting
Fort Dodge
University of Iowa/Holden Comprehensive Cancer Center
Recruiting
Iowa City
McFarland Clinic PC-Jefferson
Recruiting
Jefferson
McFarland Clinic PC-Marshalltown
Recruiting
Marshalltown
Mercy Medical Center-West Lakes
Recruiting
West Des Moines
Methodist West Hospital
Recruiting
West Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Recruiting
Boise
Saint Luke's Cancer Institute - Boise
Recruiting
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Recruiting
Caldwell
Kootenai Health - Coeur d'Alene
Recruiting
Coeur D'alene
Walter Knox Memorial Hospital
Recruiting
Emmett
Saint Luke's Cancer Institute - Fruitland
Recruiting
Fruitland
Idaho Urologic Institute-Meridian
Recruiting
Meridian
Saint Luke's Cancer Institute - Meridian
Recruiting
Meridian
Saint Alphonsus Medical Center-Nampa
Recruiting
Nampa
Saint Luke's Cancer Institute - Nampa
Recruiting
Nampa
Kootenai Clinic Cancer Services - Post Falls
Recruiting
Post Falls
Kootenai Cancer Clinic
Recruiting
Sandpoint
Saint Luke's Cancer Institute - Twin Falls
Recruiting
Twin Falls
Illinois
Rush - Copley Medical Center
Recruiting
Aurora
Illinois CancerCare-Bloomington
Recruiting
Bloomington
Illinois CancerCare-Canton
Recruiting
Canton
Memorial Hospital of Carbondale
Recruiting
Carbondale
SIH Cancer Institute
Recruiting
Carterville
Illinois CancerCare-Carthage
Recruiting
Carthage
Centralia Oncology Clinic
Recruiting
Centralia
Northwestern University
Active, not recruiting
Chicago
Rush University Medical Center
Recruiting
Chicago
University of Illinois
Recruiting
Chicago
Carle on Vermilion
Recruiting
Danville
Cancer Care Specialists of Illinois - Decatur
Recruiting
Decatur
Decatur Memorial Hospital
Recruiting
Decatur
Northwestern Medicine Cancer Center Kishwaukee
Recruiting
Dekalb
Illinois CancerCare-Dixon
Recruiting
Dixon
Carle Physician Group-Effingham
Recruiting
Effingham
Crossroads Cancer Center
Recruiting
Effingham
Elmhurst Memorial Hospital
Recruiting
Elmhurst
Illinois CancerCare-Eureka
Recruiting
Eureka
NorthShore University HealthSystem-Evanston Hospital
Recruiting
Evanston
Illinois CancerCare-Galesburg
Recruiting
Galesburg
Western Illinois Cancer Treatment Center
Recruiting
Galesburg
Northwestern Medicine Cancer Center Delnor
Recruiting
Geneva
NorthShore University HealthSystem-Glenbrook Hospital
Recruiting
Glenview
Ingalls Memorial Hospital
Recruiting
Harvey
NorthShore University HealthSystem-Highland Park Hospital
Recruiting
Highland Park
Edward Hines Jr VA Hospital
Recruiting
Hines
Illinois CancerCare-Kewanee Clinic
Recruiting
Kewanee
Illinois CancerCare-Macomb
Recruiting
Macomb
Carle Physician Group-Mattoon/Charleston
Recruiting
Mattoon
Loyola University Medical Center
Recruiting
Maywood
Good Samaritan Regional Health Center
Recruiting
Mount Vernon
Edward Hospital/Cancer Center
Recruiting
Naperville
Cancer Care Center of O'Fallon
Recruiting
O'fallon
Illinois CancerCare-Ottawa Clinic
Recruiting
Ottawa
Illinois CancerCare-Pekin
Recruiting
Pekin
Illinois CancerCare-Peoria
Recruiting
Peoria
Methodist Medical Center of Illinois
Recruiting
Peoria
Illinois CancerCare-Peru
Recruiting
Peru
Valley Radiation Oncology
Recruiting
Peru
Edward Hospital/Cancer Center?Plainfield
Recruiting
Plainfield
Illinois CancerCare-Princeton
Recruiting
Princeton
West Suburban Medical Center
Recruiting
River Forest
Genesis Cancer Center - Silvis
Recruiting
Silvis
Memorial Medical Center
Recruiting
Springfield
Southern Illinois University School of Medicine
Recruiting
Springfield
Springfield Clinic
Recruiting
Springfield
Southwest Illinois Health Services LLP
Suspended
Swansea
Carle Cancer Center
Recruiting
Urbana
The Carle Foundation Hospital
Recruiting
Urbana
Northwestern Medicine Cancer Center Warrenville
Recruiting
Warrenville
Illinois CancerCare - Washington
Recruiting
Washington
Rush-Copley Healthcare Center
Recruiting
Yorkville
Indiana
Northwest Cancer Center - Main Campus
Recruiting
Crown Point
Northwest Oncology LLC
Recruiting
Dyer
Goshen Center for Cancer Care
Recruiting
Goshen
Northwest Cancer Center - Hobart
Recruiting
Hobart
Saint Mary Medical Center
Recruiting
Hobart
Franciscan Health Indianapolis
Recruiting
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
Recruiting
Indianapolis
Saint Catherine Hospital
Recruiting
Indianapolis
Franciscan Health Mooresville
Recruiting
Mooresville
The Community Hospital
Recruiting
Munster
Women's Diagnostic Center - Munster
Recruiting
Munster
Reid Health
Recruiting
Richmond
Memorial Hospital of South Bend
Recruiting
South Bend
Union Hospital
Recruiting
Terre Haute
Northwest Cancer Center - Valparaiso
Recruiting
Valparaiso
Kansas
University of Kansas Clinical Research Center
Recruiting
Fairway
HaysMed University of Kansas Health System
Recruiting
Hays
University of Kansas Cancer Center
Recruiting
Kansas City
University of Kansas Cancer Center-West
Recruiting
Kansas City
Lawrence Memorial Hospital
Recruiting
Lawrence
Olathe Health Cancer Center
Recruiting
Olathe
University of Kansas Cancer Center-Overland Park
Recruiting
Overland Park
Ascension Via Christi - Pittsburg
Recruiting
Pittsburg
Salina Regional Health Center
Recruiting
Salina
University of Kansas Health System Saint Francis Campus
Recruiting
Topeka
University of Kansas Hospital-Westwood Cancer Center
Recruiting
Westwood
Ascension Via Christi Hospitals Wichita
Recruiting
Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower
Recruiting
Wichita
Kentucky
Flaget Memorial Hospital
Recruiting
Bardstown
Commonwealth Cancer Center-Corbin
Recruiting
Corbin
Baptist Health Lexington
Recruiting
Lexington
Saint Joseph Hospital East
Recruiting
Lexington
Saint Joseph Radiation Oncology Resource Center
Recruiting
Lexington
Saint Joseph London
Recruiting
London
Baptist Health Louisville
Recruiting
Louisville
Jewish Hospital
Suspended
Louisville
Saints Mary and Elizabeth Hospital
Suspended
Louisville
UofL Health Medical Center Northeast
Suspended
Louisville
Jewish Hospital Medical Center South
Suspended
Shepherdsville
Louisiana
Louisiana Hematology Oncology Associates LLC
Recruiting
Baton Rouge
LSU Health Baton Rouge-North Clinic
Recruiting
Baton Rouge
Mary Bird Perkins Cancer Center
Recruiting
Baton Rouge
Our Lady of The Lake
Recruiting
Baton Rouge
Our Lady of the Lake Physicians Group - Medical Oncology
Recruiting
Baton Rouge
Northshore Oncology Associates-Covington
Recruiting
Covington
Terrebonne General Medical Center
Recruiting
Houma
Ochsner Medical Center Jefferson
Recruiting
New Orleans
Massachusetts
UMass Memorial Medical Center - University Campus
Recruiting
Worcester
Maryland
Greater Baltimore Medical Center
Recruiting
Baltimore
Kaiser Permanente-Woodlawn Medical Center
Recruiting
Baltimore
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Recruiting
Baltimore
MedStar Good Samaritan Hospital
Recruiting
Baltimore
UM Upper Chesapeake Medical Center
Suspended
Bel Air
UPMC Western Maryland
Recruiting
Cumberland
University of Maryland Shore Medical Center at Easton
Suspended
Easton
FMH James M Stockman Cancer Institute
Recruiting
Frederick
Kaiser Permanente-Gaithersburg Medical Center
Recruiting
Gaithersburg
Kaiser Permanente - Largo Medical Center
Recruiting
Largo
Maine
Harold Alfond Center for Cancer Care
Recruiting
Augusta
Waldo County General Hospital
Recruiting
Belfast
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Recruiting
Biddeford
Lafayette Family Cancer Center-EMMC
Recruiting
Brewer
Penobscot Bay Medical Center
Recruiting
Rockport
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Recruiting
Sanford
Maine Medical Partners - South Portland
Recruiting
South Portland
Michigan
Saint Joseph Mercy Hospital
Recruiting
Ann Arbor
University of Michigan Comprehensive Cancer Center
Active, not recruiting
Ann Arbor
Bronson Battle Creek
Recruiting
Battle Creek
McLaren Cancer Institute-Bay City
Recruiting
Bay City
Saint Joseph Mercy Brighton
Recruiting
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Recruiting
Brighton
Saint Joseph Mercy Canton
Recruiting
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Recruiting
Canton
Caro Cancer Center
Recruiting
Caro
Saint Joseph Mercy Chelsea
Recruiting
Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Recruiting
Chelsea
Hematology Oncology Consultants-Clarkston
Recruiting
Clarkston
McLaren Cancer Institute-Clarkston
Recruiting
Clarkston
Newland Medical Associates-Clarkston
Recruiting
Clarkston
Henry Ford Macomb Hospital-Clinton Township
Recruiting
Clinton Township
Beaumont Hospital - Dearborn
Recruiting
Dearborn
Ascension Saint John Hospital
Recruiting
Detroit
Henry Ford Hospital
Recruiting
Detroit
Wayne State University/Karmanos Cancer Institute
Recruiting
Detroit
Great Lakes Cancer Management Specialists-Doctors Park
Recruiting
East China Township
Beaumont Hospital - Farmington Hills
Recruiting
Farmington Hills
Weisberg Cancer Treatment Center
Recruiting
Farmington Hills
Genesee Cancer and Blood Disease Treatment Center
Recruiting
Flint
Genesee Hematology Oncology PC
Recruiting
Flint
Genesys Hurley Cancer Institute
Recruiting
Flint
Hurley Medical Center
Recruiting
Flint
McLaren Cancer Institute-Flint
Recruiting
Flint
Singh and Arora Hematology Oncology PC
Recruiting
Flint
Mercy Health Saint Mary's
Recruiting
Grand Rapids
Spectrum Health at Butterworth Campus
Recruiting
Grand Rapids
Academic Hematology Oncology Specialists
Recruiting
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Recruiting
Grosse Pointe Woods
Michigan Breast Specialists-Grosse Pointe Woods
Recruiting
Grosse Pointe Woods
Allegiance Health
Recruiting
Jackson
Borgess Medical Center
Recruiting
Kalamazoo
Bronson Methodist Hospital
Recruiting
Kalamazoo
West Michigan Cancer Center
Recruiting
Kalamazoo
Karmanos Cancer Institute at McLaren Greater Lansing
Recruiting
Lansing
Mid-Michigan Physicians-Lansing
Recruiting
Lansing
Sparrow Hospital
Recruiting
Lansing
McLaren Cancer Institute-Lapeer Region
Recruiting
Lapeer
Hope Cancer Clinic
Suspended
Livonia
Trinity Health Saint Mary Mercy Livonia Hospital
Recruiting
Livonia
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Recruiting
Macomb
Michigan Breast Specialists-Macomb Township
Recruiting
Macomb
Saint Mary's Oncology/Hematology Associates of Marlette
Recruiting
Marlette
McLaren Cancer Institute-Macomb
Recruiting
Mount Clemens
McLaren Cancer Institute-Central Michigan
Recruiting
Mount Pleasant
Mercy Health Mercy Campus
Recruiting
Muskegon
Lakeland Hospital Niles
Recruiting
Niles
Cancer and Hematology Centers of Western Michigan - Norton Shores
Recruiting
Norton Shores
Henry Ford Medical Center-Columbus
Recruiting
Novi
McLaren Cancer Institute-Northern Michigan
Recruiting
Petoskey
21st Century Oncology-Pontiac
Recruiting
Pontiac
Hope Cancer Center
Recruiting
Pontiac
Newland Medical Associates-Pontiac
Recruiting
Pontiac
Saint Joseph Mercy Oakland
Recruiting
Pontiac
McLaren-Port Huron
Recruiting
Port Huron
Spectrum Health Reed City Hospital
Recruiting
Reed City
Great Lakes Cancer Management Specialists-Rochester Hills
Suspended
Rochester Hills
William Beaumont Hospital-Royal Oak
Recruiting
Royal Oak
Ascension Saint Mary's Hospital
Recruiting
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Recruiting
Saginaw
Lakeland Medical Center Saint Joseph
Recruiting
Saint Joseph
Marie Yeager Cancer Center
Recruiting
Saint Joseph
Henry Ford Macomb Health Center - Shelby Township
Suspended
Shelby
Ascension Providence Hospitals - Southfield
Recruiting
Southfield
Bhadresh Nayak MD PC-Sterling Heights
Recruiting
Sterling Heights
Ascension Saint Joseph Hospital
Recruiting
Tawas City
Munson Medical Center
Recruiting
Traverse City
William Beaumont Hospital - Troy
Recruiting
Troy
Advanced Breast Care Center PLLC
Recruiting
Warren
Great Lakes Cancer Management Specialists-Macomb Professional Building
Recruiting
Warren
Macomb Hematology Oncology PC
Recruiting
Warren
Michigan Breast Specialists-Warren
Recruiting
Warren
Saint John Macomb-Oakland Hospital
Recruiting
Warren
Henry Ford West Bloomfield Hospital
Recruiting
West Bloomfield
Saint Mary's Oncology/Hematology Associates of West Branch
Recruiting
West Branch
Metro Health Hospital
Recruiting
Wyoming
Huron Gastroenterology PC
Recruiting
Ypsilanti
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Recruiting
Ypsilanti
Minnesota
Sanford Joe Lueken Cancer Center
Recruiting
Bemidji
Fairview Ridges Hospital
Recruiting
Burnsville
Cambridge Medical Center
Recruiting
Cambridge
Mercy Hospital
Recruiting
Coon Rapids
Fairview Southdale Hospital
Recruiting
Edina
Unity Hospital
Recruiting
Fridley
Fairview Clinics and Surgery Center Maple Grove
Recruiting
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Recruiting
Maplewood
Saint John's Hospital - Healtheast
Recruiting
Maplewood
Abbott-Northwestern Hospital
Recruiting
Minneapolis
Health Partners Inc
Recruiting
Minneapolis
Hennepin County Medical Center
Recruiting
Minneapolis
Monticello Cancer Center
Recruiting
Monticello
New Ulm Medical Center
Recruiting
New Ulm
Fairview Northland Medical Center
Recruiting
Princeton
North Memorial Medical Health Center
Recruiting
Robbinsdale
Coborn Cancer Center at Saint Cloud Hospital
Recruiting
Saint Cloud
Park Nicollet Clinic - Saint Louis Park
Recruiting
Saint Louis Park
Regions Hospital
Recruiting
Saint Paul
United Hospital
Recruiting
Saint Paul
Saint Francis Regional Medical Center
Recruiting
Shakopee
Lakeview Hospital
Recruiting
Stillwater
Ridgeview Medical Center
Recruiting
Waconia
Rice Memorial Hospital
Recruiting
Willmar
Minnesota Oncology Hematology PA-Woodbury
Recruiting
Woodbury
Fairview Lakes Medical Center
Recruiting
Wyoming
Missouri
Saint Louis Cancer and Breast Institute-Ballwin
Recruiting
Ballwin
Cox Cancer Center Branson
Recruiting
Branson
Saint Francis Medical Center
Recruiting
Cape Girardeau
Southeast Cancer Center
Recruiting
Cape Girardeau
Siteman Cancer Center at West County Hospital
Recruiting
Creve Coeur
Parkland Health Center - Farmington
Recruiting
Farmington
Capital Region Southwest Campus
Recruiting
Jefferson City
Freeman Health System
Recruiting
Joplin
Mercy Hospital Joplin
Recruiting
Joplin
Truman Medical Centers
Recruiting
Kansas City
University of Kansas Cancer Center - North
Recruiting
Kansas City
University of Kansas Cancer Center - Lee's Summit
Recruiting
Lee's Summit
University of Kansas Cancer Center at North Kansas City Hospital
Recruiting
North Kansas City
Delbert Day Cancer Institute at PCRMC
Recruiting
Rolla
Mercy Clinic-Rolla-Cancer and Hematology
Recruiting
Rolla
Heartland Regional Medical Center
Recruiting
Saint Joseph
Mercy Hospital Saint Louis
Recruiting
Saint Louis