Optimization of VIM Targeting in Essential Tremor Surgery

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Deep brain stimulation (DBS) for essential tremor is based on the intermedius ventralis nucleus of the thalamus (VIM) stimulation. This structure is however very difficult to target, as it remains invisible on imaging. The current procedure based on awake surgery with clinical and electrophysiological testings has several limitations that lead us to develop a probabilistic model to locate precisely the target. This study aims to show that asleep DBS surgery based on this new targeting method leads to at least the same clinical results than the classical procedure.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: No
View:

• Severe essential tremor despite the optimal medical management

• Age between 18 and 75 years

• Normal MRI scan

• Mattis Dementia Rating Scale (MDRS) score ≥ 130

• Affiliation to the social security

• Signed informed consent

Locations
Other Locations
France
CHU de Bordeaux
Recruiting
Bordeaux
Hospices Civils de Lyon
Recruiting
Bron
Contact Information
Primary
Julien ENGELHARDT, MD
julien.engelhardt@chu-bordeaux.fr
05 56 79 55 77
Backup
Olivier BRANCHARD
olivier.branchard@chu-bordeaux.fr
05 57 82 06 97
Time Frame
Start Date: March 18, 2018
Estimated Completion Date: March 2023
Participants
Target number of participants: 22
Treatments
Experimental: Severe essential tremor treated by DBS
Sponsors
Leads: University Hospital, Bordeaux

This content was sourced from clinicaltrials.gov

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