Hypoxia-PET and IMPT Dose Painting in Patients With Chordomas: A Pilot Study

Status: Completed
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Before radiation treatment is given to treat chordomas, CT and MRI scans are used to create a three dimensional picture of the tumor using x-rays. The CT and MRI scans are used to determine the size and location of the area that will receive radiation treatment. The purpose of this research study is to see if combining the images from the FMISO-PET scan and the CT and MRI scans in radiation treatment planning changes the size and location of the area that will receive radiation treatment when compared to planning the radiation treatment with CT and MRI scans alone.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Skull base and spinal chordomas diagnosis based on pathology review by Department of Pathology at Massachusetts General Hospital

• Patient to be treated with proton or combined photon RT for primary CD or recurrent CD after surgery

• 18 years of age or older

• Karnofsky Score of 60% or greater

• Gross tumor mass larger than 1cm (maximal diameter on MRI)

Locations
United States
Massachusetts
Massachusetts General Hospital
Boston
Time Frame
Start Date: June 2008
Completion Date: June 2016
Participants
Target number of participants: 20
Treatments
Experimental: (18F)-FMISO/CT
The study utilizes PET/CT scanning with (18F)-FMISO/CT in addition to standard used CT and MRI. Patients enrolled in this trial completed 2 PET/CT investigations, the first before proton radiation therapy and the second at a dose of approximately 30 Gy (24-36 Gy).
Related Therapeutic Areas
Sponsors
Collaborators: National Cancer Institute (NCI)
Leads: Massachusetts General Hospital

This content was sourced from clinicaltrials.gov

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