Phase II Randomized Trial of Radiotherapy With or Without Cisplatin for Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN) With TP53 Sequencing

Who is this study for? Adult patients with Head and Neck Squamous Cell Carcinoma
What treatments are being studied? Intensity-Modulated Radiotherapy
Status: Recruiting
Location: See all (579) locations...
Intervention Type: Drug, Other, Radiation
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This phase II trial studies how well radiation therapy with or without cisplatin works in treating patients with stage III-IVA squamous cell carcinoma of the head and neck who have undergone surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known if radiation therapy is more effective with or without cisplatin in treating patients with squamous cell carcinoma of the head and neck.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• PRE-REGISTRATION (STEP 0)

• Pathologically proven diagnosis of squamous cell carcinoma (including variants such as verrucous carcinoma, spindle cell carcinoma, carcinoma not otherwise specified [NOS]) of the head/neck (oral cavity, oropharynx, hypopharynx or larynx); pathologic stage III or IVA (American Joint Committee on Cancer [AJCC] 8): T3-T4a, N0-3, M0 or T1-T2, N1-3, M0

• Patient has undergone total resection of the primary tumor with curative intent

• NOTE: Patient is to be pre-registered to screening (Step 0) and tissue submitted to Foundation Medicine as soon as possible after surgery in order to meet the 8 week deadline to register the patient to Step 1 after surgery; full assay minimum turn-around time is 17-24 days

• For oropharynx primary tumors, the patient must have negative human papillomavirus (HPV) status of the tumor as determined by p16 protein expression using immunohistochemistry (IHC)

• Patients with, per the operative and/or pathology report, positive margin(s) (tumor present at the cut or inked edge of the tumor) which is not superceded by an additional margin of tumor-negative tissue, nodal extracapsular extension, and/or gross residual disease after surgery are not eligible

• A paraffin-embedded surgical tumor tissue specimen has been located is available for shipment to Foundation Medicine, Inc. following pre-registration

• NOTE: Complete the EA3132-specific FoundationOne requisition form

• Patients with a history of a curatively treated malignancy must be disease-free for at least two years except for carcinoma in situ of cervix and/or non-melanomatous skin cancer; patients must not have received chemotherapy or investigational therapy within two years of surgical resection of the primary tumor

• Patient must not have had previous irradiation to the head and neck that would result in overlap in radiation fields for the current disease

• Patients with recurrent disease or multiple primaries are ineligible

• RANDOMIZATION (STEP 1)

• NOTE: Patient must meet all eligibility criteria outlined in pre-registration; patient may not be randomized until site has been notified that the central determination of p53 mutation status of the surgical tumor tissue has been completed and site has been notified of assay completion

• Per the operative report, the gross total resection of the primary tumor with curative intent was completed within 8 weeks prior to randomization

• The patient must have the following assessments done =< 8 weeks prior to randomization:

• Examination by a head and neck surgeon

• Chest x-ray (or chest computed tomography [CT] scan or CT/positron emission tomography [PET] of the chest or magnetic resonance imaging [MRI]) to rule out distant metastatic disease

• Patient has Eastern Cooperative Oncology Group (ECOG) performance status 0-1 within 2 weeks prior to randomization

• Women must not be pregnant or breast-feeding; females of childbearing potential must have a blood or urine study within 2 weeks prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

• Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study and until 60 days from the last study treatment

• Absolute neutrophil count >= 1,500/mm^3 within 4 weeks prior to randomization

• Platelets >= 100,000/mm^3 within 4 weeks prior to randomization

• Total bilirubin =< the upper limit of normal (ULN) within 4 weeks prior to randomization

• Calculated creatinine clearance must be > 60 ml/min using the Cockcroft-Gault formula within 4 weeks prior to randomization

• Patient must not have an intercurrent illness likely to interfere with protocol therapy

Locations
United States
Alaska
Alaska Breast Care and Surgery LLC
Recruiting
Anchorage
Alaska Oncology and Hematology LLC
Recruiting
Anchorage
Alaska Women's Cancer Care
Recruiting
Anchorage
Anchorage Associates in Radiation Medicine
Recruiting
Anchorage
Anchorage Oncology Centre
Recruiting
Anchorage
Anchorage Radiation Therapy Center
Recruiting
Anchorage
Katmai Oncology Group
Recruiting
Anchorage
Providence Alaska Medical Center
Recruiting
Anchorage
Alabama
University of Alabama at Birmingham Cancer Center
Active, not recruiting
Birmingham
Arkansas
Mercy Hospital Fort Smith
Recruiting
Fort Smith
CHI Saint Vincent Cancer Center Hot Springs
Recruiting
Hot Springs
Arizona
Cancer Center at Saint Joseph's
Recruiting
Phoenix
Banner University Medical Center - Tucson
Recruiting
Tucson
University of Arizona Cancer Center-North Campus
Recruiting
Tucson
University of Arizona Cancer Center-Orange Grove Campus
Recruiting
Tucson
California
Mission Hope Medical Oncology - Arroyo Grande
Recruiting
Arroyo Grande
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Recruiting
Burbank
UC San Diego Moores Cancer Center
Active, not recruiting
La Jolla
Desert Regional Medical Center
Recruiting
Palm Springs
Pacific Central Coast Health Center-San Luis Obispo
Recruiting
San Luis Obispo
Mission Hope Medical Oncology - Santa Maria
Recruiting
Santa Maria
Colorado
Penrose-Saint Francis Healthcare
Recruiting
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
Recruiting
Colorado Springs
Saint Francis Cancer Center
Recruiting
Colorado Springs
Porter Adventist Hospital
Recruiting
Denver
Mercy Medical Center
Recruiting
Durango
Southwest Oncology PC
Recruiting
Durango
Mountain Blue Cancer Care Center
Suspended
Golden
Rocky Mountain Cancer Centers-Lakewood
Suspended
Lakewood
Saint Anthony Hospital
Recruiting
Lakewood
Littleton Adventist Hospital
Recruiting
Littleton
Longmont United Hospital
Recruiting
Longmont
Rocky Mountain Cancer Centers-Longmont
Recruiting
Longmont
Parker Adventist Hospital
Recruiting
Parker
Rocky Mountain Cancer Centers-Parker
Suspended
Parker
Rocky Mountain Cancer Centers - Pueblo
Suspended
Pueblo
Saint Mary Corwin Medical Center
Recruiting
Pueblo
Rocky Mountain Cancer Centers-Thornton
Suspended
Thornton
Connecticut
Smilow Cancer Hospital Care Center at Greenwich
Recruiting
Greenwich
Smilow Cancer Hospital Care Center - Guiford
Recruiting
Guilford
Middlesex Hospital
Recruiting
Middletown
Smilow Cancer Center/Yale-New Haven Hospital
Recruiting
New Haven
Yale University
Recruiting
New Haven
Yale-New Haven Hospital North Haven Medical Center
Recruiting
North Haven
Smilow Cancer Hospital Care Center-Trumbull
Recruiting
Trumbull
Smilow Cancer Hospital Care Center - Waterford
Recruiting
Waterford
Washington, D.c.
Sibley Memorial Hospital
Active, not recruiting
Washington
Delaware
Beebe Medical Center
Active, not recruiting
Lewes
Christiana Care Health System-Christiana Hospital
Active, not recruiting
Newark
Delaware Clinical and Laboratory Physicians PA
Active, not recruiting
Newark
Helen F Graham Cancer Center
Active, not recruiting
Newark
Medical Oncology Hematology Consultants PA
Active, not recruiting
Newark
Beebe Health Campus
Active, not recruiting
Rehoboth Beach
TidalHealth Nanticoke / Allen Cancer Center
Active, not recruiting
Seaford
Christiana Care Health System-Wilmington Hospital
Active, not recruiting
Wilmington
Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables
Recruiting
Coral Gables
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Recruiting
Deerfield Beach
Holy Cross Hospital
Recruiting
Fort Lauderdale
University of Florida Health Science Center - Gainesville
Active, not recruiting
Gainesville
Baptist MD Anderson Cancer Center
Active, not recruiting
Jacksonville
University of Miami Miller School of Medicine-Sylvester Cancer Center
Recruiting
Miami
UM Sylvester Comprehensive Cancer Center at Plantation
Recruiting
Plantation
Moffitt Cancer Center
Recruiting
Tampa
Moffitt Cancer Center - McKinley Campus
Recruiting
Tampa
Moffitt Cancer Center-International Plaza
Recruiting
Tampa
Georgia
Emory University Hospital Midtown
Suspended
Atlanta
Emory University Hospital/Winship Cancer Institute
Suspended
Atlanta
Hawaii
Hawaii Cancer Care - Savio
Active, not recruiting
'aiea
Pali Momi Medical Center
Active, not recruiting
'aiea
Queen's Cancer Center - Pearlridge
Active, not recruiting
'aiea
The Cancer Center of Hawaii-Pali Momi
Active, not recruiting
'aiea
Hawaii Cancer Care Inc - Waterfront Plaza
Active, not recruiting
Honolulu
Hawaii Cancer Care Inc-Liliha
Active, not recruiting
Honolulu
Island Urology
Active, not recruiting
Honolulu
Kapiolani Medical Center for Women and Children
Active, not recruiting
Honolulu
Kuakini Medical Center
Active, not recruiting
Honolulu
Queen's Cancer Cenrer - POB I
Active, not recruiting
Honolulu
Queen's Cancer Center - Kuakini
Active, not recruiting
Honolulu
Queen's Medical Center
Active, not recruiting
Honolulu
Straub Clinic and Hospital
Active, not recruiting
Honolulu
The Cancer Center of Hawaii-Liliha
Active, not recruiting
Honolulu
University of Hawaii Cancer Center
Active, not recruiting
Honolulu
Wilcox Memorial Hospital and Kauai Medical Clinic
Active, not recruiting
Lihue
Iowa
Medical Oncology and Hematology Associates-West Des Moines
Recruiting
Clive
Mercy Cancer Center-West Lakes
Recruiting
Clive
Alegent Health Mercy Hospital
Recruiting
Council Bluffs
Heartland Oncology and Hematology LLP
Recruiting
Council Bluffs
Jennie Edmundson Memorial Hospital
Recruiting
Council Bluffs
Greater Regional Medical Center
Recruiting
Creston
Medical Oncology and Hematology Associates-Laurel
Recruiting
Des Moines
Mercy Medical Center - Des Moines
Recruiting
Des Moines
Mercy Medical Center-West Lakes
Recruiting
West Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Recruiting
Boise
Saint Luke's Cancer Institute - Boise
Recruiting
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Recruiting
Caldwell
Kootenai Health - Coeur d'Alene
Recruiting
Coeur D'alene
Walter Knox Memorial Hospital
Recruiting
Emmett
Saint Luke's Cancer Institute - Fruitland
Recruiting
Fruitland
Idaho Urologic Institute-Meridian
Recruiting
Meridian
Saint Luke's Cancer Institute - Meridian
Recruiting
Meridian
Saint Alphonsus Medical Center-Nampa
Recruiting
Nampa
Saint Luke's Cancer Institute - Nampa
Recruiting
Nampa
Kootenai Clinic Cancer Services - Post Falls
Recruiting
Post Falls
Kootenai Cancer Clinic
Recruiting
Sandpoint
Saint Luke's Cancer Institute - Twin Falls
Recruiting
Twin Falls
Illinois
Saint Anthony's Health
Recruiting
Alton
Rush - Copley Medical Center
Recruiting
Aurora
Illinois CancerCare-Bloomington
Recruiting
Bloomington
Saint Joseph Medical Center
Active, not recruiting
Bloomington
Illinois CancerCare-Canton
Recruiting
Canton
Memorial Hospital of Carbondale
Recruiting
Carbondale
SIH Cancer Institute
Recruiting
Carterville
Illinois CancerCare-Carthage
Recruiting
Carthage
Centralia Oncology Clinic
Recruiting
Centralia
John H Stroger Jr Hospital of Cook County
Recruiting
Chicago
Northwestern University
Active, not recruiting
Chicago
University of Chicago Comprehensive Cancer Center
Recruiting
Chicago
University of Illinois
Active, not recruiting
Chicago
Carle on Vermilion
Recruiting
Danville
Cancer Care Specialists of Illinois - Decatur
Recruiting
Decatur
Decatur Memorial Hospital
Recruiting
Decatur
Illinois CancerCare-Dixon
Recruiting
Dixon
Carle Physician Group-Effingham
Recruiting
Effingham
Crossroads Cancer Center
Recruiting
Effingham
Illinois CancerCare-Eureka
Recruiting
Eureka
NorthShore University HealthSystem-Evanston Hospital
Active, not recruiting
Evanston
Illinois CancerCare-Galesburg
Recruiting
Galesburg
Western Illinois Cancer Treatment Center
Recruiting
Galesburg
NorthShore University HealthSystem-Glenbrook Hospital
Active, not recruiting
Glenview
NorthShore University HealthSystem-Highland Park Hospital
Active, not recruiting
Highland Park
Illinois CancerCare-Kewanee Clinic
Recruiting
Kewanee
Illinois CancerCare-Macomb
Recruiting
Macomb
Carle Physician Group-Mattoon/Charleston
Recruiting
Mattoon
Good Samaritan Regional Health Center
Recruiting
Mount Vernon
UC Comprehensive Cancer Center at Silver Cross
Recruiting
New Lenox
Cancer Care Center of O'Fallon
Recruiting
O'fallon
University of Chicago Medicine-Orland Park
Recruiting
Orland Park
Illinois CancerCare-Ottawa Clinic
Recruiting
Ottawa
Radiation Oncology of Northern Illinois
Suspended
Ottawa
Illinois CancerCare-Pekin
Recruiting
Pekin
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Recruiting
Pekin
Illinois CancerCare-Peoria
Recruiting
Peoria
Methodist Medical Center of Illinois
Recruiting
Peoria
OSF Saint Francis Medical Center
Recruiting
Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Recruiting
Peoria
Illinois CancerCare-Peru
Recruiting
Peru
Valley Radiation Oncology
Recruiting
Peru
Illinois CancerCare-Princeton
Recruiting
Princeton
SwedishAmerican Regional Cancer Center/ACT
Active, not recruiting
Rockford
North Shore Medical Center
Active, not recruiting
Skokie
Central Illinois Hematology Oncology Center
Active, not recruiting
Springfield
Memorial Medical Center
Recruiting
Springfield
Southern Illinois University School of Medicine
Recruiting
Springfield
Springfield Clinic
Recruiting
Springfield
Southwest Illinois Health Services LLP
Suspended
Swansea
Carle Cancer Center
Recruiting
Urbana
The Carle Foundation Hospital
Recruiting
Urbana
Illinois CancerCare - Washington
Recruiting
Washington
Rush-Copley Healthcare Center
Recruiting
Yorkville
Indiana
IU Health North Hospital
Recruiting
Carmel
Community Cancer Center East
Recruiting
Indianapolis
Community Cancer Center North
Recruiting
Indianapolis
Community Cancer Center South
Recruiting
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
Recruiting
Indianapolis
IU Health Methodist Hospital
Recruiting
Indianapolis
Sidney and Lois Eskenazi Hospital
Recruiting
Indianapolis
Community Howard Regional Health
Recruiting
Kokomo
Reid Health
Recruiting
Richmond
Kansas
Central Care Cancer Center - Garden City
Recruiting
Garden City
Central Care Cancer Center - Great Bend
Recruiting
Great Bend
Kentucky
Flaget Memorial Hospital
Recruiting
Bardstown
Commonwealth Cancer Center-Corbin
Recruiting
Corbin
Oncology Hematology Care Inc-Crestview
Suspended
Crestview Hills
Saint Joseph Hospital East
Recruiting
Lexington
Saint Joseph Radiation Oncology Resource Center
Recruiting
Lexington
Saint Joseph London
Recruiting
London
Jewish Hospital
Recruiting
Louisville
Jewish Hospital Medical Center Northeast
Recruiting
Louisville
Saints Mary and Elizabeth Hospital
Recruiting
Louisville
The James Graham Brown Cancer Center at University of Louisville
Recruiting
Louisville
Jewish Hospital Medical Center South
Recruiting
Shepherdsville
Louisiana
Louisiana State University Health Science Center
Recruiting
New Orleans
University Medical Center New Orleans
Recruiting
New Orleans
Massachusetts
Mercy Medical Center
Suspended
Springfield
Maryland
Greater Baltimore Medical Center
Recruiting
Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center
Active, not recruiting
Baltimore
University of Maryland/Greenebaum Cancer Center
Recruiting
Baltimore
UM Upper Chesapeake Medical Center
Recruiting
Bel Air
Suburban Hospital
Active, not recruiting
Bethesda
Central Maryland Radiation Oncology in Howard County
Suspended
Columbia
UM Baltimore Washington Medical Center/Tate Cancer Center
Suspended
Glen Burnie
Michigan
Saint Joseph Mercy Hospital
Recruiting
Ann Arbor
University of Michigan Comprehensive Cancer Center
Recruiting
Ann Arbor
Bronson Battle Creek
Recruiting
Battle Creek
IHA Hematology Oncology Consultants-Brighton
Recruiting
Brighton
Saint Joseph Mercy Brighton
Recruiting
Brighton
Henry Ford Cancer Institute-Downriver
Recruiting
Brownstown
IHA Hematology Oncology Consultants-Canton
Recruiting
Canton
Saint Joseph Mercy Canton
Recruiting
Canton
Caro Cancer Center
Recruiting
Caro
IHA Hematology Oncology Consultants-Chelsea
Recruiting
Chelsea
Saint Joseph Mercy Chelsea
Recruiting
Chelsea
Hematology Oncology Consultants-Clarkston
Recruiting
Clarkston
Newland Medical Associates-Clarkston
Recruiting
Clarkston
Henry Ford Macomb Hospital-Clinton Township
Recruiting
Clinton Township
Beaumont Hospital - Dearborn
Suspended
Dearborn
Henry Ford Medical Center-Fairlane
Recruiting
Dearborn
Ascension Saint John Hospital
Recruiting
Detroit
Henry Ford Hospital
Recruiting
Detroit
Wayne State University/Karmanos Cancer Institute
Recruiting
Detroit
Great Lakes Cancer Management Specialists-Doctors Park
Recruiting
East China Township
Weisberg Cancer Treatment Center
Recruiting
Farmington Hills
Genesee Cancer and Blood Disease Treatment Center
Recruiting
Flint
Genesee Hematology Oncology PC
Recruiting
Flint
Genesys Hurley Cancer Institute
Recruiting
Flint
Hurley Medical Center
Recruiting
Flint
Helen DeVos Children's Hospital at Spectrum Health
Recruiting
Grand Rapids
Mercy Health Saint Mary's
Recruiting
Grand Rapids
Spectrum Health at Butterworth Campus
Recruiting
Grand Rapids
Academic Hematology Oncology Specialists
Recruiting
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Recruiting
Grosse Pointe Woods
Michigan Breast Specialists-Grosse Pointe Woods
Recruiting
Grosse Pointe Woods
Allegiance Health
Recruiting
Jackson
Ascension Borgess Cancer Center
Recruiting
Kalamazoo
Borgess Medical Center
Recruiting
Kalamazoo
Bronson Methodist Hospital
Recruiting
Kalamazoo
West Michigan Cancer Center
Recruiting
Kalamazoo
Sparrow Hospital
Recruiting
Lansing
Hope Cancer Clinic
Recruiting
Livonia
Saint Mary Mercy Hospital
Recruiting
Livonia
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Recruiting
Macomb
Michigan Breast Specialists-Macomb Township
Recruiting
Macomb
Saint Mary's Oncology/Hematology Associates of Marlette
Recruiting
Marlette
Mercy Health Mercy Campus
Recruiting
Muskegon
Lakeland Hospital Niles
Recruiting
Niles
Cancer and Hematology Centers of Western Michigan - Norton Shores
Recruiting
Norton Shores
Henry Ford Medical Center-Columbus
Recruiting
Novi
21st Century Oncology-Pontiac
Recruiting
Pontiac
Hope Cancer Center
Recruiting
Pontiac
Newland Medical Associates-Pontiac
Recruiting
Pontiac
Saint Joseph Mercy Oakland
Recruiting
Pontiac
Spectrum Health Reed City Hospital
Recruiting
Reed City
Great Lakes Cancer Management Specialists-Rochester Hills
Suspended
Rochester Hills
Ascension Saint Mary's Hospital
Recruiting
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Recruiting
Saginaw
Lakeland Medical Center Saint Joseph
Recruiting
Saint Joseph
Marie Yeager Cancer Center
Recruiting
Saint Joseph
Henry Ford Macomb Health Center - Shelby Township
Suspended
Shelby
Bhadresh Nayak MD PC-Sterling Heights
Recruiting
Sterling Heights
Ascension Saint Joseph Hospital
Recruiting
Tawas City
Munson Medical Center
Recruiting
Traverse City
Advanced Breast Care Center PLLC
Recruiting
Warren
Great Lakes Cancer Management Specialists-Macomb Professional Building
Recruiting
Warren
Macomb Hematology Oncology PC
Recruiting
Warren
Michigan Breast Specialists-Warren
Recruiting
Warren
Saint John Macomb-Oakland Hospital
Recruiting
Warren
Henry Ford West Bloomfield Hospital
Recruiting
West Bloomfield
Saint Mary's Oncology/Hematology Associates of West Branch
Recruiting
West Branch
Metro Health Hospital
Recruiting
Wyoming
Huron Gastroenterology PC
Recruiting
Ypsilanti
IHA Hematology Oncology Consultants-Ann Arbor
Recruiting
Ypsilanti
Minnesota
Riverwood Healthcare Center
Recruiting
Aitkin
Mayo Clinic Health System in Albert Lea
Active, not recruiting
Albert Lea
Sanford Joe Lueken Cancer Center
Recruiting
Bemidji
Essentia Health Saint Joseph's Medical Center
Recruiting
Brainerd
Fairview Ridges Hospital
Recruiting
Burnsville
Minnesota Oncology - Burnsville
Recruiting
Burnsville
Cambridge Medical Center
Recruiting
Cambridge
Mercy Hospital
Recruiting
Coon Rapids
Essentia Health - Deer River Clinic
Recruiting
Deer River
Essentia Health Saint Mary's - Detroit Lakes Clinic
Recruiting
Detroit Lakes
Essentia Health Cancer Center
Recruiting
Duluth
Essentia Health Saint Mary's Medical Center
Recruiting
Duluth
Miller-Dwan Hospital
Recruiting
Duluth
Fairview Southdale Hospital
Recruiting
Edina
Lake Region Healthcare Corporation-Cancer Care
Recruiting
Fergus Falls
Essentia Health - Fosston
Recruiting
Fosston
Unity Hospital
Recruiting
Fridley
Essentia Health Hibbing Clinic
Recruiting
Hibbing
Mayo Clinic Health Systems-Mankato
Active, not recruiting
Mankato
Fairview Clinics and Surgery Center Maple Grove
Recruiting
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Recruiting
Maplewood
Saint John's Hospital - Healtheast
Recruiting
Maplewood
Abbott-Northwestern Hospital
Recruiting
Minneapolis
Health Partners Inc
Recruiting
Minneapolis
Hennepin County Medical Center
Recruiting
Minneapolis
Monticello Cancer Center
Recruiting
Monticello
New Ulm Medical Center
Recruiting
New Ulm
Mayo Clinic Radiation Therapy-Northfield
Active, not recruiting
Northfield
Essentia Health - Park Rapids
Recruiting
Park Rapids
Fairview Northland Medical Center
Recruiting
Princeton
North Memorial Medical Health Center
Recruiting
Robbinsdale
Mayo Clinic in Rochester
Active, not recruiting
Rochester
Coborn Cancer Center at Saint Cloud Hospital
Recruiting
Saint Cloud
Saint Cloud Hospital
Suspended
Saint Cloud
Park Nicollet Clinic - Saint Louis Park
Recruiting
Saint Louis Park
Regions Hospital
Recruiting
Saint Paul
United Hospital
Recruiting
Saint Paul
Essentia Health Sandstone
Recruiting
Sandstone
Saint Francis Regional Medical Center
Recruiting
Shakopee
Lakeview Hospital
Recruiting
Stillwater
Sanford Thief River Falls Medical Center
Recruiting
Thief River Falls
Essentia Health Virginia Clinic
Recruiting
Virginia
Ridgeview Medical Center
Recruiting
Waconia
Rice Memorial Hospital
Recruiting
Willmar
Minnesota Oncology Hematology PA-Woodbury
Recruiting
Woodbury
Sanford Cancer Center Worthington
Recruiting
Worthington
Fairview Lakes Medical Center
Recruiting
Wyoming
Missouri
Saint Louis Cancer and Breast Institute-Ballwin
Recruiting
Ballwin
Central Care Cancer Center - Bolivar
Recruiting
Bolivar
Parkland Health Center-Bonne Terre
Suspended
Bonne Terre
Cox Cancer Center Branson
Recruiting
Branson
Saint Francis Medical Center
Recruiting
Cape Girardeau
Southeast Cancer Center
Recruiting
Cape Girardeau
Parkland Health Center - Farmington
Recruiting
Farmington
Capital Region Southwest Campus
Recruiting
Jefferson City
Freeman Health System
Recruiting
Joplin
Mercy Hospital Joplin
Recruiting
Joplin
Delbert Day Cancer Institute at PCRMC
Recruiting
Rolla
Mercy Clinic-Rolla-Cancer and Hematology
Recruiting
Rolla
Heartland Regional Medical Center
Recruiting
Saint Joseph
Mercy Hospital Saint Louis
Recruiting
Saint Louis
Mercy Hospital South
Recruiting
Saint Louis
Missouri Baptist Medical Center
Recruiting
Saint Louis
Saint Louis Cancer and Breast Institute-South City
Recruiting
Saint Louis
Sainte Genevieve County Memorial Hospital
Recruiting
Sainte Genevieve
CoxHealth South Hospital
Recruiting
Springfield
Mercy Hospital Springfield
Recruiting
Springfield
Missouri Baptist Sullivan Hospital
Recruiting
Sullivan
Missouri Baptist Outpatient Center-Sunset Hills
Recruiting
Sunset Hills
Mercy Hospital Washington
Recruiting
Washington
Mississippi
University of Mississippi Medical Center
Recruiting
Jackson
Montana
Community Hospital of Anaconda
Recruiting
Anaconda
Billings Clinic Cancer Center
Recruiting
Billings
Saint Vincent Healthcare
Suspended
Billings
Bozeman Deaconess Hospital
Recruiting
Bozeman
Saint James Community Hospital and Cancer Treatment Center
Active, not recruiting
Butte
Benefis Healthcare- Sletten Cancer Institute
Recruiting
Great Falls
Great Falls Clinic
Recruiting
Great Falls
Saint Peter's Community Hospital
Suspended
Helena
Kalispell Regional Medical Center
Recruiting
Kalispell
Community Medical Hospital
Recruiting
Missoula
Saint Patrick Hospital - Community Hospital
Recruiting
Missoula
North Carolina
Southeastern Medical Oncology Center-Clinton
Active, not recruiting
Clinton
Southeastern Medical Oncology Center-Goldsboro
Active, not recruiting
Goldsboro
Wayne Memorial Hospital
Active, not recruiting
Goldsboro
Onslow Memorial Hospital
Active, not recruiting
Jacksonville
Southeastern Medical Oncology Center-Jacksonville
Active, not recruiting
Jacksonville
North Dakota
Sanford Bismarck Medical Center
Recruiting
Bismarck
Essentia Health Cancer Center-South University Clinic
Recruiting
Fargo
Sanford Broadway Medical Center
Recruiting
Fargo
Sanford Roger Maris Cancer Center
Recruiting
Fargo
Sanford South University Medical Center
Recruiting
Fargo
Essentia Health - Jamestown Clinic
Recruiting
Jamestown
Nebraska
CHI Health Saint Francis
Recruiting
Grand Island
CHI Health Good Samaritan
Recruiting
Kearney
Heartland Hematology and Oncology
Suspended
Kearney
Nebraska Cancer Research Center
Active, not recruiting
Lincoln
Nebraska Hematology and Oncology
Active, not recruiting
Lincoln
Saint Elizabeth Regional Medical Center
Recruiting
Lincoln
Southeast Nebraska Cancer Center - 68th Street Place
Active, not recruiting
Lincoln
Faith Regional Health Services Carson Cancer Center
Active, not recruiting
Norfolk
Great Plains Health Callahan Cancer Center
Active, not recruiting
North Platte
Alegent Health Bergan Mercy Medical Center
Recruiting
Omaha
Alegent Health Immanuel Medical Center
Recruiting
Omaha
Alegent Health Lakeside Hospital
Recruiting
Omaha
Creighton University Medical Center
Recruiting
Omaha
Hematology and Oncology Consultants PC
Suspended
Omaha
Nebraska Cancer Specialists - Omaha
Active, not recruiting
Omaha
Nebraska Methodist Hospital
Recruiting
Omaha
Oncology Hematology West PC
Active, not recruiting
Omaha
Midlands Community Hospital
Recruiting
Papillion
Regional West Medical Center Cancer Center
Active, not recruiting
Scottsbluff
New Jersey
Morristown Medical Center
Recruiting
Morristown
Sparta Cancer Treatment Center
Active, not recruiting
Sparta
Overlook Hospital
Suspended
Summit
New Mexico
New Mexico Oncology Hematology Consultants
Active, not recruiting
Albuquerque
University of New Mexico Cancer Center
Active, not recruiting
Albuquerque
Memorial Medical Center - Las Cruces
Active, not recruiting
Las Cruces
New York
Northwell Health Imbert Cancer Center
Recruiting
Bay Shore
Montefiore Medical Center - Moses Campus
Recruiting
Bronx
Montefiore Medical Center-Einstein Campus
Recruiting
Bronx
Montefiore Medical Center-Weiler Hospital
Recruiting
Bronx
Roswell Park Cancer Institute
Active, not recruiting
Buffalo
Northwell Health/Center for Advanced Medicine
Recruiting
Lake Success
Garnet Health Medical Center
Recruiting
Middletown
Long Island Jewish Medical Center
Recruiting
New Hyde Park
Lenox Hill Hospital
Recruiting
New York
Manhattan Eye Ear and Throat Hospital
Suspended
New York
Highland Hospital
Suspended
Rochester
University of Rochester
Suspended
Rochester
Stony Brook University Medical Center
Suspended
Stony Brook
Ohio
Indu and Raj Soin Medical Center
Recruiting
Beavercreek
Saint Elizabeth Boardman Hospital
Recruiting
Boardman
Dayton Physicians LLC-Miami Valley South
Recruiting
Centerville
Miami Valley Hospital South
Recruiting
Centerville
Geauga Hospital
Recruiting
Chardon
Bethesda North Hospital
Recruiting
Cincinnati
Good Samaritan Hospital - Cincinnati
Recruiting
Cincinnati
Oncology Hematology Care Inc-Anderson
Suspended
Cincinnati
Oncology Hematology Care Inc-Blue Ash
Suspended
Cincinnati
Oncology Hematology Care Inc-Eden Park
Suspended
Cincinnati
Oncology Hematology Care Inc-Kenwood
Recruiting
Cincinnati
Oncology Hematology Care Inc-Mercy West
Suspended
Cincinnati
TriHealth Cancer Institute-Anderson
Recruiting
Cincinnati
TriHealth Cancer Institute-Westside
Recruiting
Cincinnati
University of Cincinnati Cancer Center-UC Medical Center
Recruiting
Cincinnati
Case Western Reserve University
Recruiting
Cleveland
Cleveland Clinic Foundation
Active, not recruiting
Cleveland
Ohio State University Comprehensive Cancer Center
Recruiting
Columbus
Dayton Physician LLC-Miami Valley Hospital North
Recruiting
Dayton
Good Samaritan Hospital - Dayton
Suspended
Dayton
Miami Valley Hospital
Recruiting
Dayton
Miami Valley Hospital North
Recruiting
Dayton
Mercy Cancer Center-Elyria
Suspended
Elyria
Oncology Hematology Care Inc-Healthplex
Suspended
Fairfield
Armes Family Cancer Center
Recruiting
Findlay
Blanchard Valley Hospital
Recruiting
Findlay
Orion Cancer Care
Recruiting
Findlay
Atrium Medical Center-Middletown Regional Hospital
Recruiting
Franklin
Dayton Physicians LLC-Atrium
Recruiting
Franklin
Dayton Physicians LLC-Wayne
Recruiting
Greenville
Wayne Hospital
Recruiting
Greenville
First Dayton Cancer Care
Suspended
Kettering
Greater Dayton Cancer Center
Recruiting
Kettering
Kettering Medical Center
Recruiting
Kettering
UH Seidman Cancer Center at Lake Health Mentor Campus
Recruiting
Mentor
Dayton Physicians LLC-Signal Point
Active, not recruiting
Middletown
Dayton Physicians LLC-Wilson
Active, not recruiting
Sidney
Springfield Regional Cancer Center
Recruiting
Springfield
Springfield Regional Medical Center
Recruiting
Springfield
Dayton Physicians LLC-Upper Valley
Recruiting
Troy
Upper Valley Medical Center
Recruiting
Troy
Saint Joseph Warren Hospital
Recruiting
Warren
University of Cincinnati Cancer Center-West Chester
Recruiting
West Chester
UH Seidman Cancer Center at Saint John Medical Center
Recruiting
Westlake
UHHS-Westlake Medical Center
Recruiting
Westlake
Saint Elizabeth Youngstown Hospital
Recruiting
Youngstown
Oklahoma
Mercy Hospital Oklahoma City
Recruiting
Oklahoma City
University of Oklahoma Health Sciences Center
Recruiting
Oklahoma City
Oregon
Saint Alphonsus Medical Center-Baker City
Recruiting
Baker City
Saint Charles Health System
Recruiting
Bend
Clackamas Radiation Oncology Center
Recruiting
Clackamas
Providence Cancer Institute Clackamas Clinic
Recruiting
Clackamas
Bay Area Hospital
Recruiting
Coos Bay
Legacy Mount Hood Medical Center
Recruiting
Gresham
Providence Newberg Medical Center
Recruiting
Newberg
Saint Alphonsus Medical Center-Ontario
Recruiting
Ontario
Legacy Good Samaritan Hospital and Medical Center
Recruiting
Portland
Providence Portland Medical Center
Recruiting
Portland
Providence Saint Vincent Medical Center
Recruiting
Portland
Saint Charles Health System-Redmond
Recruiting
Redmond
Legacy Meridian Park Hospital
Recruiting
Tualatin
Pennsylvania
Lehigh Valley Hospital-Cedar Crest
Recruiting
Allentown
UPMC-Heritage Valley Health System Beaver
Active, not recruiting
Beaver
Lehigh Valley Hospital - Muhlenberg
Recruiting
Bethlehem
Christiana Care Health System-Concord Health Center
Active, not recruiting
Chadds Ford
Northeast Radiation Oncology Center
Active, not recruiting
Dunmore
Pocono Medical Center
Recruiting
East Stroudsburg
UPMC Hillman Cancer Center Erie
Recruiting
Erie
UPMC Cancer Centers - Arnold Palmer Pavilion
Active, not recruiting
Greensburg
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Recruiting
Harrisburg
Lehigh Valley Hospital-Hazleton
Recruiting
Hazleton
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Active, not recruiting
Johnstown
UPMC Cancer Center at UPMC McKeesport
Active, not recruiting
Mckeesport
UPMC-Coraopolis/Heritage Valley Radiation Oncology
Active, not recruiting
Moon
Fox Chase Cancer Center
Recruiting
Philadelphia
Temple University Hospital
Recruiting
Philadelphia
Thomas Jefferson University Hospital
Active, not recruiting
Philadelphia
University of Pittsburgh Cancer Institute (UPCI)
Recruiting
Pittsburgh
UPMC Jefferson Regional Radiation Oncology
Suspended
Pittsburgh
UPMC-Magee Womens Hospital
Active, not recruiting
Pittsburgh
UPMC-Passavant Hospital
Active, not recruiting
Pittsburgh
UPMC-Presbyterian Hospital
Active, not recruiting
Pittsburgh
UPMC-Saint Clair Hospital Cancer Center
Active, not recruiting
Pittsburgh
UPMC-Saint Margaret
Active, not recruiting
Pittsburgh
UPMC-Shadyside Hospital
Recruiting
Pittsburgh
Pottstown Hospital
Recruiting
Pottstown
UPMC Cancer Center at UPMC Northwest
Active, not recruiting
Seneca
UPMC Uniontown Hospital Radiation Oncology
Active, not recruiting
Uniontown
UPMC Washington Hospital Radiation Oncology
Active, not recruiting
Washington
Reading Hospital
Recruiting
West Reading
Rhode Island
Smilow Cancer Hospital Care Center - Westerly
Recruiting
Westerly
South Carolina
Prisma Health Cancer Institute - Spartanburg
Active, not recruiting
Boiling Springs
Medical University of South Carolina
Active, not recruiting
Charleston
Prisma Health Cancer Institute - Easley
Active, not recruiting
Easley
Prisma Health Cancer Institute - Butternut
Active, not recruiting
Greenville
Prisma Health Cancer Institute - Eastside
Active, not recruiting
Greenville
Prisma Health Cancer Institute - Faris
Active, not recruiting
Greenville
Prisma Health Greenville Memorial Hospital
Active, not recruiting
Greenville
Prisma Health Cancer Institute - Greer
Active, not recruiting
Greer
Prisma Health Cancer Institute - Seneca
Active, not recruiting
Seneca
South Dakota
Avera Cancer Institute
Active, not recruiting
Sioux Falls
Sanford Cancer Center Oncology Clinic
Recruiting
Sioux Falls
Sanford USD Medical Center - Sioux Falls
Recruiting
Sioux Falls
Tennessee
Memorial Hospital
Suspended
Chattanooga
Pulmonary Medicine Center of Chattanooga-Hixson
Suspended
Hixson
Memorial GYN Plus
Suspended
Ooltewah
Texas
Saint Joseph Regional Cancer Center
Recruiting
Bryan
Parkland Memorial Hospital
Active, not recruiting
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Active, not recruiting
Dallas
University of Texas Medical Branch
Active, not recruiting
Galveston
UTMB Cancer Center at Victory Lakes
Active, not recruiting
League City
UT Southwestern Clinical Center at Richardson/Plano
Active, not recruiting
Richardson
Utah
Farmington Health Center
Recruiting
Farmington
Huntsman Cancer Institute/University of Utah
Recruiting
Salt Lake City
South Jordan Health Center
Recruiting
South Jordan
Virginia
University of Virginia Cancer Center
Active, not recruiting
Charlottesville
Inova Schar Cancer Institute
Recruiting
Fairfax
Inova Fairfax Hospital
Recruiting
Falls Church
VCU Massey Cancer Center at Stony Point
Recruiting
Richmond
Virginia Commonwealth University/Massey Cancer Center
Recruiting
Richmond
Washington
Providence Regional Cancer System-Aberdeen
Recruiting
Aberdeen
PeaceHealth Saint Joseph Medical Center
Recruiting
Bellingham
Harrison HealthPartners Hematology and Oncology-Bremerton
Recruiting
Bremerton
Harrison Medical Center
Recruiting
Bremerton
Highline Medical Center-Main Campus
Recruiting
Burien
Providence Regional Cancer System-Centralia
Recruiting
Centralia
Swedish Cancer Institute-Edmonds
Recruiting
Edmonds
Saint Elizabeth Hospital
Recruiting
Enumclaw
Providence Regional Cancer Partnership
Recruiting
Everett
Saint Francis Hospital
Recruiting
Federal Way
Swedish Cancer Institute-Issaquah
Recruiting
Issaquah
Kadlec Clinic Hematology and Oncology
Recruiting
Kennewick
Providence Regional Cancer System-Lacey
Recruiting
Lacey
Saint Clare Hospital
Recruiting
Lakewood
PeaceHealth Saint John Medical Center
Recruiting
Longview
Harrison HealthPartners Hematology and Oncology-Poulsbo
Suspended
Poulsbo
Pacific Gynecology Specialists
Suspended
Seattle
Swedish Medical Center-Ballard Campus
Recruiting
Seattle
Swedish Medical Center-Cherry Hill
Recruiting
Seattle
Swedish Medical Center-First Hill
Recruiting
Seattle
PeaceHealth United General Medical Center
Recruiting
Sedro-woolley
Providence Regional Cancer System-Shelton
Recruiting
Shelton
Franciscan Research Center-Northwest Medical Plaza
Recruiting
Tacoma
Northwest Medical Specialties PLLC
Suspended
Tacoma
Legacy Cancer Institute Medical Oncology and Day Treatment
Recruiting
Vancouver
Legacy Salmon Creek Hospital
Recruiting
Vancouver
PeaceHealth Southwest Medical Center
Recruiting
Vancouver
Providence Saint Mary Regional Cancer Center
Recruiting
Walla Walla
Providence Regional Cancer System-Yelm
Recruiting
Yelm
Wisconsin
ThedaCare Regional Cancer Center
Recruiting
Appleton
Duluth Clinic Ashland
Recruiting
Ashland
Northwest Wisconsin Cancer Center
Recruiting
Ashland
Aurora Cancer Care-Southern Lakes VLCC
Recruiting
Burlington
HSHS Sacred Heart Hospital
Suspended
Eau Claire
Marshfield Clinic Cancer Center at Sacred Heart
Suspended
Eau Claire
Marshfield Medical Center-EC Cancer Center
Recruiting
Eau Claire
Aurora Health Center-Fond du Lac
Recruiting
Fond Du Lac
Aurora Health Care Germantown Health Center
Recruiting
Germantown
Aurora Cancer Care-Grafton
Recruiting
Grafton
Aurora BayCare Medical Center
Recruiting
Green Bay
Aurora Cancer Care-Kenosha South
Recruiting
Kenosha
University of Wisconsin Hospital and Clinics
Completed
Madison
Aurora Bay Area Medical Group-Marinette
Recruiting
Marinette
Bay Area Medical Center
Active, not recruiting
Marinette
Marshfield Medical Center
Suspended
Marshfield
Marshfield Medical Center-Marshfield
Recruiting
Marshfield
Aurora Cancer Care-Milwaukee
Recruiting
Milwaukee
Aurora Saint Luke's Medical Center
Recruiting
Milwaukee
Aurora Sinai Medical Center
Recruiting
Milwaukee
Marshfield Clinic-Minocqua Center
Recruiting
Minocqua
Cancer Center of Western Wisconsin
Recruiting
New Richmond
Vince Lombardi Cancer Clinic - Oshkosh
Recruiting
Oshkosh
Aurora Cancer Care-Racine
Recruiting
Racine
Marshfield Medical Center-Rice Lake
Recruiting
Rice Lake