Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers

Who is this study for? Patients with non-small cell lung cancers
What treatments are being studied? Nivolumab
Status: Active, not recruiting
Location: See all (892) locations...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This phase III ALCHEMIST treatment trial studies how well nivolumab after surgery and chemotherapy work in treating patients with stage IB-IIIA non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Patients must have undergone complete surgical resection of their stage IB (>= 4 cm), II or IIIA NSCLC according to the American Joint Committee on Cancer (AJCC) 7th edition and have had negative surgical margins

• Baseline chest computed tomography (CT) must be performed within 1 month (30 days) of randomization to ensure no evidence of disease; if clinically indicated, additional imaging studies must be performed to rule out metastatic disease

• Eastern Cooperative Oncology Group (ECOG) performance status 0-1

• Patients must be registered to the ALCHEMIST-SCREEN (ALLIANCE A151216) trial prior to randomization

• Non-squamous tumors must not be positive for epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R mutation (centrally as part of the ALCHEMIST-SCREEN protocol) and anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangement (centrally as part of ALCHEMIST-SCREEN and/or locally)

• NOTE: if the results of the central EGFR testing are negative, but the ALK testing was not able to be completed by the ALCHEMIST central lab, the ALK status will be considered negative (unless locally positive for ALK rearrangement) and the patient may be considered for enrollment onto EA5142, once PD-L1 results are received and all other eligibility requirements are met

• Tumors must have PD-L1 status tested centrally as part of the ALCHEMIST-SCREEN protocol

• Women must not be pregnant or breast-feeding due to unknown and potentially harmful effects of nivolumab on the developing fetus or child

• All females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

• Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse during the treatment period and for 31 weeks after the last nivolumab infusion

• Patients must NOT have uncontrolled intercurrent illness including, but not limited to, serious ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situation that would limit compliance with study requirements

• No prior treatment with an immune checkpoint inhibitor (anti-programmed cell death [PD]-1, anti-PD-L1, anti-cytotoxic T-lymphocyte-associated protein 4 [CTLA4] monoclonal antibody)

• Patients must have adequately recovered from surgery and any administered chemotherapy/radiotherapy at the time of randomization (NOTE: adjuvant chemotherapy and/or radiation is not required)

• Minimum time between date of surgery and randomization is 4 weeks (28 days)

• Maximum time allowed between surgery and randomization:

• 3 months (90 days) if no chemotherapy is administered

• 8 months (240 days) if adjuvant chemotherapy was administered

• 10 months (300 days) if adjuvant chemotherapy and radiation therapy was administered

• Patients must have completed and recovered from any adjuvant chemotherapy 2 or more weeks prior to randomization (6 weeks for mitomycin and nitrosoureas; 4 weeks for post-operative radiation therapy) (NOTE: adjuvant chemotherapy and/or radiation is not required)

• Serum aspartate transaminase (aspartate aminotransferase [AST]) and serum alanine transaminase (alanine aminotransferase [ALT]) =< 2.5 x upper limit normal (within 2 weeks prior to randomization)

• Total bilirubin =< 1.5 x upper limit of normal (ULN) (except in subjects with Gilbert syndrome who must have a total bilirubin < 3.0 x ULN) (within 2 weeks prior to randomization)

• White blood cell (WBC) >= 2000/uL (within 2 weeks prior to randomization)

• Neutrophils >= 1000/uL (within 2 weeks prior to randomization)

• Platelets >= 100 x 10^3/uL (within 2 weeks prior to randomization)

• Hemoglobin >= 8 g/dL (within 2 weeks prior to randomization)

• Serum creatinine =< 2 x ULN (within 2 weeks prior to randomization)

• Prior to randomization patients with any non-hematologic toxicity from surgery, chemotherapy and radiation therapy must have recovered to grade =< 1 with the exception of alopecia, ototoxicity and neuropathy

• Patients must not be receiving any other investigational anti-cancer agents while on study

• Patients must not have known or suspected autoimmune disease; subjects with type I diabetes mellitus, hypothyroidism requiring hormone replacement, or skin disorders not requiring systemic treatment are permitted to enroll

• Patients must not have a condition requiring systemic corticosteroids equivalent to > 10 mg prednisone per day or other immunosuppressive medications within 2 weeks of randomization; inhaled, intra-articular, and epidural steroids are permissible

• Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity

• Patients must not have a known history of human immunodeficiency virus (HIV), hepatitis B, or hepatitis C infection that is untreated and/or with a detectable viral load

• Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab

Locations
United States
Alaska
Katmai Oncology Group
Anchorage
Providence Alaska Medical Center
Anchorage
Alabama
University of Alabama at Birmingham Cancer Center
Birmingham
Southern Cancer Center PC-Daphne
Daphne
Southern Cancer Center PC-Mobile
Mobile
Southern Cancer Center PC-Providence
Mobile
Southern Cancer Center PC-Springhill
Mobile
Arkansas
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro
John L McClellan Memorial Veterans Hospital
Little Rock
Arizona
Mayo Clinic Hospital in Arizona
Phoenix
Mayo Clinic in Arizona
Scottsdale
Banner University Medical Center - Tucson
Tucson
University of Arizona Cancer Center-North Campus
Tucson
California
Kaiser Permanente-Anaheim
Anaheim
PCR Oncology
Arroyo Grande
Sutter Auburn Faith Hospital
Auburn
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield
Kaiser Permanente-Baldwin Park
Baldwin Park
Kaiser Permanente-Bellflower
Bellflower
Alta Bates Summit Medical Center-Herrick Campus
Berkeley
Mills-Peninsula Medical Center
Burlingame
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park
Mercy San Juan Medical Center
Carmichael
Eden Hospital Medical Center
Castro Valley
University Oncology Associates
Clovis
John Muir Medical Center-Concord Campus
Concord
City of Hope Corona
Corona
Sutter Davis Hospital
Davis
City of Hope Comprehensive Cancer Center
Duarte
Mercy Cancer Center - Elk Grove
Elk Grove
Kaiser Permanente-Fontana
Fontana
Palo Alto Medical Foundation-Fremont
Fremont
Saint Jude Medical Center
Fullerton
Kaiser Permanente - Harbor City
Harbor City
Kaiser Permanente-Irvine
Irvine
UC San Diego Moores Cancer Center
La Jolla
Loma Linda University Medical Center
Loma Linda
Kaiser Permanente Los Angeles Medical Center
Los Angeles
Kaiser Permanente West Los Angeles
Los Angeles
Los Angeles County-USC Medical Center
Los Angeles
USC / Norris Comprehensive Cancer Center
Los Angeles
Fremont - Rideout Cancer Center
Marysville
Memorial Medical Center
Modesto
Palo Alto Medical Foundation-Camino Division
Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View
Sutter Cancer Research Consortium
Novato
Saint Joseph Hospital - Orange
Orange
Desert Regional Medical Center
Palm Springs
Palo Alto Medical Foundation Health Care
Palo Alto
Stanford Cancer Institute Palo Alto
Palo Alto
Kaiser Permanente - Panorama City
Panorama City
Eisenhower Medical Center
Rancho Mirage
Mercy Oncology Center
Redding
Mercy Regional Cancer Center
Redding
Kaiser Permanente-Riverside
Riverside
Mercy Cancer Center - Rocklin
Rocklin
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville
Sutter Roseville Medical Center
Roseville
Mercy Cancer Center - Sacramento
Sacramento
Sutter Medical Center Sacramento
Sacramento
University of California Davis Comprehensive Cancer Center
Sacramento
Saint Helena Hospital
Saint Helena
Kaiser Permanente-San Diego Zion
San Diego
Naval Medical Center -San Diego
San Diego
California Pacific Medical Center-Pacific Campus
San Francisco
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo
Kaiser Permanente-San Marcos
San Marcos
Dominican Santa Cruz Hospital
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz
Sutter Pacific Medical Foundation
Santa Rosa
Saint Joseph's Medical Center
Stockton
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Vacaville
Sutter Solano Medical Center/Cancer Center
Vallejo
John Muir Medical Center-Walnut Creek
Walnut Creek
Woodland Memorial Hospital
Woodland
Kaiser Permanente-Woodland Hills
Woodland Hills
Colorado
University of Colorado Hospital
Aurora
Rocky Mountain Cancer Centers-Boulder
Boulder
Penrose-Saint Francis Healthcare
Colorado Springs
UCHealth Memorial Hospital Central
Colorado Springs
Kaiser Permanente-Franklin
Denver
Porter Adventist Hospital
Denver
Mountain Blue Cancer Care Center - Swedish
Englewood
Poudre Valley Hospital
Fort Collins
National Jewish Health-Western Hematology Oncology
Golden
North Colorado Medical Center
Greeley
Kaiser Permanente-Rock Creek
Lafayette
Rocky Mountain Cancer Centers-Lakewood
Lakewood
Kaiser Permanente-Lone Tree
Lone Tree
McKee Medical Center
Loveland
Parker Adventist Hospital
Parker
SCL Health Lutheran Medical Center
Wheat Ridge
Connecticut
Danbury Hospital
Danbury
Smilow Cancer Hospital-Derby Care Center
Derby
Smilow Cancer Hospital Care Center-Fairfield
Fairfield
Greenwich Hospital
Greenwich
Smilow Cancer Hospital Care Center - Guiford
Guilford
Hartford Hospital
Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Hartford
Manchester Memorial Hospital
Manchester
Middlesex Hospital
Middletown
The Hospital of Central Connecticut
New Britain
Smilow Cancer Center/Yale-New Haven Hospital
New Haven
Yale University
New Haven
Yale-New Haven Hospital North Haven Medical Center
North Haven
Smilow Cancer Hospital-Orange Care Center
Orange
Stamford Hospital/Bennett Cancer Center
Stamford
Smilow Cancer Hospital-Torrington Care Center
Torrington
Smilow Cancer Hospital Care Center-Trumbull
Trumbull
Smilow Cancer Hospital-Waterbury Care Center
Waterbury
Smilow Cancer Hospital Care Center - Waterford
Waterford
Veterans Affairs Connecticut Healthcare System-West Haven Campus
West Haven
Washington, D.c.
MedStar Georgetown University Hospital
Washington
MedStar Washington Hospital Center
Washington
Sibley Memorial Hospital
Washington
Delaware
Beebe Medical Center
Lewes
Helen F Graham Cancer Center
Newark
Medical Oncology Hematology Consultants PA
Newark
Beebe Health Campus
Rehoboth Beach
TidalHealth Nanticoke / Allen Cancer Center
Seaford
Florida
Boca Raton Regional Hospital
Boca Raton
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables
Halifax Health Medical Center-Centers for Oncology
Daytona Beach
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood
UM Sylvester Comprehensive Cancer Center at Hollywood
Hollywood
Baptist MD Anderson Cancer Center
Jacksonville
The Watson Clinic
Lakeland
UM Sylvester Comprehensive Cancer Center at Kendall
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami
Mount Sinai Medical Center
Miami Beach
Memorial Hospital West
Pembroke Pines
Sacred Heart Hospital
Pensacola
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation
Moffitt Cancer Center
Tampa
Indian River Medical Center
Vero Beach
Cleveland Clinic-Weston
Weston
Georgia
Phoebe Putney Memorial Hospital
Albany
University Cancer and Blood Center LLC
Athens
Emory Saint Joseph's Hospital
Atlanta
Emory University Hospital Midtown
Atlanta
Emory University Hospital/Winship Cancer Institute
Atlanta
Northside Hospital
Atlanta
John B Amos Cancer Center
Columbus
Atlanta VA Medical Center
Decatur
Dekalb Medical Center
Decatur
Northeast Georgia Medical Center-Gainesville
Gainesville
Northside Hospital - Gwinnett
Lawrenceville
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah
Memorial Health University Medical Center
Savannah
Summit Cancer Care-Memorial
Savannah
South Georgia Medical Center/Pearlman Cancer Center
Valdosta
Hawaii
Pali Momi Medical Center
'aiea
Queen's Cancer Center - Pearlridge
'aiea
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu
Hawaii Cancer Care Inc-Liliha
Honolulu
Kapiolani Medical Center for Women and Children
Honolulu
Kuakini Medical Center
Honolulu
Queen's Cancer Cenrer - POB I
Honolulu
Queen's Cancer Center - Kuakini
Honolulu
Queen's Medical Center
Honolulu
Straub Clinic and Hospital
Honolulu
University of Hawaii Cancer Center
Honolulu
Iowa
Mary Greeley Medical Center
Ames
McFarland Clinic PC - Ames
Ames
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf
McFarland Clinic PC-Boone
Boone
Mercy Hospital
Cedar Rapids
Oncology Associates at Mercy Medical Center
Cedar Rapids
Physicians' Clinic of Iowa PC
Cedar Rapids
Medical Oncology and Hematology Associates-West Des Moines
Clive
Mercy Cancer Center-West Lakes
Clive
Greater Regional Medical Center
Creston
Genesis Cancer Care Institute
Davenport
Genesis Medical Center - East Campus
Davenport
Iowa Cancer Specialists
Davenport
Iowa Lutheran Hospital
Des Moines
Iowa Methodist Medical Center
Des Moines
Medical Oncology and Hematology Associates-Des Moines
Des Moines
Mercy Medical Center - Des Moines
Des Moines
Mission Cancer and Blood - Laurel
Des Moines
McFarland Clinic PC-Trinity Cancer Center
Fort Dodge
Iowa City VA Healthcare System
Iowa City
University of Iowa/Holden Comprehensive Cancer Center
Iowa City
McFarland Clinic PC-Jefferson
Jefferson
McFarland Clinic PC-Marshalltown
Marshalltown
Siouxland Regional Cancer Center
Sioux City
Mercy Medical Center-West Lakes
West Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Boise
Saint Luke's Cancer Institute - Boise
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell
Kootenai Health - Coeur d'Alene
Coeur D'alene
Saint Luke's Cancer Institute - Fruitland
Fruitland
Saint Luke's Cancer Institute - Meridian
Meridian
Saint Alphonsus Medical Center-Nampa
Nampa
Saint Luke's Cancer Institute - Nampa
Nampa
Kootenai Clinic Cancer Services - Post Falls
Post Falls
Kootenai Cancer Clinic
Sandpoint
Saint Luke's Cancer Institute - Twin Falls
Twin Falls
Illinois
Rush - Copley Medical Center
Aurora
Illinois CancerCare-Bloomington
Bloomington
Illinois CancerCare-Canton
Canton
SIH Cancer Institute
Carterville
Illinois CancerCare-Carthage
Carthage
Centralia Oncology Clinic
Centralia
Advocate Illinois Masonic Medical Center
Chicago
John H Stroger Jr Hospital of Cook County
Chicago
Mount Sinai Hospital Medical Center
Chicago
Northwestern University
Chicago
Rush University Medical Center
Chicago
University of Chicago Comprehensive Cancer Center
Chicago
Carle on Vermilion
Danville
Cancer Care Specialists of Illinois - Decatur
Decatur
Decatur Memorial Hospital
Decatur
Northwestern Medicine Cancer Center Kishwaukee
Dekalb
Advocate Good Samaritan Hospital
Downers Grove
Carle Physician Group-Effingham
Effingham
Crossroads Cancer Center
Effingham
Elmhurst Memorial Hospital
Elmhurst
Illinois CancerCare-Eureka
Eureka
NorthShore University HealthSystem-Evanston Hospital
Evanston
Illinois CancerCare-Galesburg
Galesburg
Northwestern Medicine Cancer Center Delnor
Geneva
NorthShore University HealthSystem-Glenbrook Hospital
Glenview
Ingalls Memorial Hospital
Harvey
NorthShore University HealthSystem-Highland Park Hospital
Highland Park
Edward Hines Jr VA Hospital
Hines
Duly Health and Care Joliet
Joliet
Illinois CancerCare-Kewanee Clinic
Kewanee
Illinois CancerCare-Macomb
Macomb
Carle Physician Group-Mattoon/Charleston
Mattoon
Loyola University Medical Center
Maywood
Trinity Medical Center
Moline
Edward Hospital/Cancer Center
Naperville
UC Comprehensive Cancer Center at Silver Cross
New Lenox
Cancer Care Center of O'Fallon
O'fallon
Advocate Christ Medical Center
Oak Lawn
University of Chicago Medicine-Orland Park
Orland Park
Illinois CancerCare-Ottawa Clinic
Ottawa
Illinois CancerCare-Pekin
Pekin
Illinois CancerCare-Peoria
Peoria
Illinois CancerCare-Peru
Peru
Edward Hospital/Cancer Center?Plainfield
Plainfield
Illinois CancerCare-Princeton
Princeton
Quincy Medical Group-Clinic
Quincy
OSF Saint Anthony Medical Center
Rockford
SwedishAmerican Regional Cancer Center/ACT
Rockford
Genesis Cancer Center - Silvis
Silvis
Central Illinois Hematology Oncology Center
Springfield
Memorial Medical Center
Springfield
Southern Illinois University School of Medicine
Springfield
Springfield Clinic
Springfield
Carle Cancer Center
Urbana
The Carle Foundation Hospital
Urbana
Northwestern Medicine Cancer Center Warrenville
Warrenville
Rush-Copley Healthcare Center
Yorkville
Indiana
Parkview Regional Medical Center
Fort Wayne
Goshen Center for Cancer Care
Goshen
Community Cancer Center East
Indianapolis
Community Cancer Center North
Indianapolis
Community Cancer Center South
Indianapolis
Franciscan Health Indianapolis
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis
Richard L. Roudebush Veterans Affairs Medical Center
Indianapolis
Sidney and Lois Eskenazi Hospital
Indianapolis
Community Howard Regional Health
Kokomo
Memorial Regional Cancer Center Day Road
Mishawaka
Franciscan Health Mooresville
Mooresville
The Community Hospital
Munster
Reid Health
Richmond
Memorial Hospital of South Bend
South Bend
Union Hospital
Terre Haute
Kansas
Cancer Center of Kansas - Chanute
Chanute
Cancer Center of Kansas - Dodge City
Dodge City
Cancer Center of Kansas - El Dorado
El Dorado
Cancer Center of Kansas - Fort Scott
Fort Scott
Saint Catherine Hospital
Garden City
Central Care Cancer Center - Great Bend
Great Bend
HaysMed University of Kansas Health System
Hays
Cancer Center of Kansas-Independence
Independence
University of Kansas Cancer Center
Kansas City
University of Kansas Cancer Center-West
Kansas City
Cancer Center of Kansas-Kingman
Kingman
Lawrence Memorial Hospital
Lawrence
Cancer Center of Kansas-Liberal
Liberal
Cancer Center of Kansas - McPherson
Mcpherson
Olathe Health Cancer Center
Olathe
Saint Luke's South Hospital
Overland Park
University of Kansas Cancer Center-Overland Park
Overland Park
Cancer Center of Kansas - Parsons
Parsons
Ascension Via Christi - Pittsburg
Pittsburg
Cancer Center of Kansas - Pratt
Pratt
Cancer Center of Kansas - Salina
Salina
Salina Regional Health Center
Salina
Cotton O'Neil Cancer Center / Stormont Vail Health
Topeka
University of Kansas Health System Saint Francis Campus
Topeka
Cancer Center of Kansas - Wellington
Wellington
University of Kansas Hospital-Westwood Cancer Center
Westwood
Ascension Via Christi Hospitals Wichita
Wichita
Cancer Center of Kansas - Wichita
Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita
Cancer Center of Kansas - Winfield
Winfield
Kentucky
King's Daughter's Medical Center
Ashland
Flaget Memorial Hospital
Bardstown
Baptist Health Corbin
Corbin
Saint Elizabeth Healthcare Edgewood
Edgewood
Baptist Health Hardin
Elizabethtown
Saint Elizabeth Fort Thomas
Fort Thomas
Baptist Health Lexington
Lexington
Saint Joseph Hospital East
Lexington
University of Kentucky/Markey Cancer Center
Lexington
Saint Joseph London
London
Baptist Health Louisville
Louisville
Jewish Hospital
Louisville
Saints Mary and Elizabeth Hospital
Louisville
The James Graham Brown Cancer Center at University of Louisville
Louisville
UofL Health Medical Center Northeast
Louisville
Baptist Health Madisonville/Merle Mahr Cancer Center
Madisonville
Baptist Health Paducah
Paducah
Louisiana
Christus Saint Frances Cabrini Hospital
Alexandria
Louisiana Hematology Oncology Associates LLC
Baton Rouge
LSU Health Baton Rouge-North Clinic
Baton Rouge
Mary Bird Perkins Cancer Center
Baton Rouge
Medical Center of Baton Rouge
Baton Rouge
Ochsner Health Center-Summa
Baton Rouge
Our Lady of the Lake Physicians Group - Medical Oncology
Baton Rouge
Northshore Oncology Associates-Covington
Covington
Ochsner Hematology Oncology North Shore - Covington (West Region)
Covington
Oncology Center of The South Incorporated
Houma
Ochsner Medical Center Kenner
Kenner
CHRISTUS Saint Patrick Hospital
Lake Charles
Ochsner LSU Health Monroe Medical Center
Monroe
Ochsner Medical Center Jefferson
New Orleans
University Medical Center New Orleans
New Orleans
CHRISTUS Highland Medical Center
Shreveport
LSU Health Sciences Center at Shreveport
Shreveport
Ochsner Hematology Oncology North Shore - Slidell (East Region)
Slidell
Massachusetts
Beverly Hospital
Beverly
Beth Israel Deaconess Medical Center
Boston
Boston Medical Center
Boston
Dana-Farber Cancer Institute
Boston
Massachusetts General Hospital Cancer Center
Boston
Steward Saint Elizabeth's Medical Center
Brighton
Lahey Hospital and Medical Center
Burlington
Simonds-Sinon Regional Cancer Center
Fitchburg
Addison Gilbert Hospital
Gloucester
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Milford
Newton-Wellesley Hospital
Newton
Berkshire Medical Center - Cancer Center
Pittsfield
Dana-Farber/Brigham and Women's Cancer Center at South Shore
South Weymouth
Baystate Medical Center
Springfield
Winchester Hospital
Winchester
UMass Memorial Medical Center - University Campus
Worcester
Maryland
Anne Arundel Medical Center
Annapolis
Greater Baltimore Medical Center
Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore
Sinai Hospital of Baltimore
Baltimore
University of Maryland/Greenebaum Cancer Center
Baltimore
UM Upper Chesapeake Medical Center
Bel Air
UPMC Western Maryland
Cumberland
Christiana Care - Union Hospital
Elkton
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie
Northwest Hospital Center
Randallstown
TidalHealth Peninsula Regional
Salisbury
Maine
Harold Alfond Center for Cancer Care
Augusta
Eastern Maine Medical Center
Bangor
Waldo County General Hospital
Belfast
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Biddeford
Lafayette Family Cancer Center-EMMC
Brewer
Maine Center for Cancer Medicine-Kennebunk
Kennebunk
Penobscot Bay Medical Center
Rockport
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Sanford
Maine Center for Cancer Medicine-Scarborough
Scarborough
Maine Medical Partners - South Portland
South Portland
Maine Center for Cancer Medicine-Topsham
Topsham
Michigan
Saint Joseph Mercy Hospital
Ann Arbor
University of Michigan Comprehensive Cancer Center
Ann Arbor
Bronson Battle Creek
Battle Creek
Saint Joseph Mercy Brighton
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton
Henry Ford Cancer Institute-Downriver
Brownstown
Saint Joseph Mercy Canton
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton
Saint Joseph Mercy Chelsea
Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea
Newland Medical Associates-Clarkston
Clarkston
Henry Ford Medical Center-Fairlane
Dearborn
Ascension Saint John Hospital
Detroit
Henry Ford Hospital
Detroit
Green Bay Oncology - Escanaba
Escanaba
Beaumont Hospital - Farmington Hills
Farmington Hills
Genesys Hurley Cancer Institute
Flint
Mercy Health Saint Mary's
Grand Rapids
Spectrum Health at Butterworth Campus
Grand Rapids
Allegiance Health
Jackson
West Michigan Cancer Center
Kalamazoo
Sparrow Hospital
Lansing
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia
UP Health System Hematology Oncology Marquette
Marquette
UP Health System Marquette
Marquette
MyMichigan Medical Center Midland
Midland
Mercy Health Mercy Campus
Muskegon
Ascension Providence Hospitals - Novi
Novi
Henry Ford Medical Center-Columbus
Novi
Saint Joseph Mercy Oakland
Pontiac
Spectrum Health Reed City Hospital
Reed City
William Beaumont Hospital-Royal Oak
Royal Oak
Ascension Saint Mary's Hospital
Saginaw
Marie Yeager Cancer Center
Saint Joseph
Ascension Providence Hospitals - Southfield
Southfield
William Beaumont Hospital - Troy
Troy
Saint John Macomb-Oakland Hospital
Warren
Henry Ford West Bloomfield Hospital
West Bloomfield
Metro Health Hospital
Wyoming
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti
Minnesota
Sanford Joe Lueken Cancer Center
Bemidji
Essentia Health Saint Joseph's Medical Center
Brainerd
Fairview Ridges Hospital
Burnsville
Mercy Hospital
Coon Rapids
Essentia Health Cancer Center
Duluth
Saint Luke's Hospital of Duluth
Duluth
Fairview Southdale Hospital
Edina
Unity Hospital
Fridley
Essentia Health Hibbing Clinic
Hibbing
Minnesota Oncology Hematology PA-Maplewood
Maplewood
Saint John's Hospital - Healtheast
Maplewood
Abbott-Northwestern Hospital
Minneapolis
Health Partners Inc
Minneapolis
Hennepin County Medical Center
Minneapolis
Minneapolis VA Medical Center
Minneapolis
New Ulm Medical Center
New Ulm
North Memorial Medical Health Center
Robbinsdale
Mayo Clinic in Rochester
Rochester
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park
Regions Hospital
Saint Paul
United Hospital
Saint Paul
Saint Francis Regional Medical Center
Shakopee
Lakeview Hospital
Stillwater
Essentia Health Virginia Clinic
Virginia
Ridgeview Medical Center
Waconia
Rice Memorial Hospital
Willmar
Minnesota Oncology Hematology PA-Woodbury
Woodbury
Missouri
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin
Parkland Health Center-Bonne Terre
Bonne Terre
Saint Francis Medical Center
Cape Girardeau
Southeast Cancer Center
Cape Girardeau
Saint Luke's Hospital
Chesterfield
University of Missouri - Ellis Fischel
Columbia
Siteman Cancer Center at West County Hospital
Creve Coeur
Capital Region Southwest Campus
Jefferson City
Mercy Hospital Joplin
Joplin
Research Medical Center
Kansas City
Saint Luke's Hospital of Kansas City
Kansas City
The University of Kansas Cancer Center-South
Kansas City
Truman Medical Centers
Kansas City
University of Kansas Cancer Center - North
Kansas City
Saint Luke's East - Lee's Summit
Lee's Summit
University of Kansas Cancer Center - Lee's Summit
Lee's Summit
Mercy Hospital Saint Louis
Saint Louis
Missouri Baptist Medical Center
Saint Louis
Saint Louis Cancer and Breast Institute-South City
Saint Louis
Siteman Cancer Center at Christian Hospital
Saint Louis
Siteman Cancer Center-South County
Saint Louis
Veteran's Affairs Medical Center - Saint Louis
Saint Louis
Washington University School of Medicine
Saint Louis
Siteman Cancer Center at Saint Peters Hospital
Saint Peters
Sainte Genevieve County Memorial Hospital
Sainte Genevieve
CoxHealth South Hospital
Springfield
Missouri Baptist Sullivan Hospital
Sullivan
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills
Mississippi
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus
Baptist Cancer Center-Grenada
Grenada
Forrest General Hospital / Cancer Center
Hattiesburg
Hattiesburg Clinic - Hematology/Oncology Clinic
Hattiesburg
University of Mississippi Medical Center
Jackson
Baptist Memorial Hospital and Cancer Center-Union County
New Albany
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford
Singing River Hospital
Pascagoula
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven
Montana
Community Hospital of Anaconda
Anaconda
Billings Clinic Cancer Center
Billings
Saint Vincent Healthcare
Billings
Bozeman Deaconess Hospital
Bozeman
Saint James Community Hospital and Cancer Treatment Center
Butte
Benefis Healthcare- Sletten Cancer Institute
Great Falls
Great Falls Clinic
Great Falls
Saint Peter's Community Hospital
Helena
Kalispell Regional Medical Center
Kalispell
Community Medical Hospital
Missoula
Saint Patrick Hospital - Community Hospital
Missoula
North Carolina
Randolph Hospital
Asheboro
AdventHealth Infusion Center Asheville
Asheville
Mission Hospital
Asheville
Cone Health Cancer Center at Alamance Regional
Burlington
UNC Lineberger Comprehensive Cancer Center
Chapel Hill
Novant Health Presbyterian Medical Center
Charlotte
Oncology Specialists of Charlotte
Charlotte
Southern Oncology Specialists-Charlotte
Charlotte
Southeastern Medical Oncology Center-Clinton
Clinton
AdventHealth Infusion Center Haywood
Clyde
Duke University Medical Center
Durham
CaroMont Regional Medical Center
Gastonia
Gaston Hematology and Oncology Associates
Gastonia
Southeastern Medical Oncology Center-Goldsboro
Goldsboro
Wayne Memorial Hospital
Goldsboro
Cone Health Cancer Center
Greensboro
East Carolina University
Greenville
Maria Parham Hospital
Henderson
AdventHealth Hendersonville
Hendersonville
Margaret R Pardee Memorial Hospital
Hendersonville
Novant Health Cancer Institute - Huntersville
Huntersville
Southern Oncology Specialists-Huntersville
Huntersville
Southeastern Medical Oncology Center-Jacksonville
Jacksonville
Vidant Oncology-Kenansville
Kenansville
Vidant Oncology-Kinston
Kinston
Scotland Memorial Hospital-Laurinburg Cancer Center
Laurinburg
Southeastern Regional Medical Center
Lumberton
Matthews Radiation Oncology Center
Matthews
Novant Health Cancer Institute - Matthews
Matthews
Novant Health Cancer Institute - Mooresville
Mooresville
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst
Duke Raleigh Hospital
Raleigh
Vidant Oncology-Richlands
Richlands
Johnston Memorial Hospital
Smithfield
Marion L Shepard Cancer Center at Vidant Beaufort Hospital
Washington
Wake Forest University Health Sciences
Winston-salem
North Dakota
Sanford Bismarck Medical Center
Bismarck
Sanford Broadway Medical Center
Fargo
Sanford Roger Maris Cancer Center
Fargo
Altru Cancer Center
Grand Forks
Nebraska
CHI Health Saint Francis
Grand Island
CHI Health Good Samaritan
Kearney
Southeast Nebraska Cancer Center - 68th Street Place
Lincoln
Alegent Health Bergan Mercy Medical Center
Omaha
Alegent Health Immanuel Medical Center
Omaha
Nebraska Methodist Hospital
Omaha
University of Nebraska Medical Center
Omaha
New Hampshire
New Hampshire Oncology Hematology PA-Concord
Concord
Wentworth-Douglass Hospital
Dover
Exeter Hospital
Exeter
Dartmouth Hitchcock Medical Center
Lebanon
The Dana-Farber Cancer Institute at Londonderry
Londonderry
Norris Cotton Cancer Center-Manchester
Manchester
Solinsky Center for Cancer Care
Manchester
Norris Cotton Cancer Center-Nashua
Nashua
Saint Joseph Hospital
Nashua
Portsmouth Regional Hospital
Portsmouth
New Jersey
Memorial Sloan Kettering Basking Ridge
Basking Ridge
Cooper Hospital University Medical Center
Camden
The Cancer Institute of New Jersey Hamilton
Hamilton
Monmouth Medical Center
Long Branch
Memorial Sloan Kettering Monmouth
Middletown
Memorial Sloan Kettering Bergen
Montvale
Morristown Medical Center
Morristown
Virtua Memorial
Mount Holly
Inspira Medical Center Mullica Hill
Mullica Hill
Rutgers Cancer Institute of New Jersey
New Brunswick
Newton Medical Center
Newton
The Valley Hospital-Luckow Pavilion
Paramus
Chilton Medical Center
Pompton
Valley Hospital
Ridgewood
Robert Wood Johnson University Hospital Somerset
Somerville
Overlook Hospital
Summit
Community Medical Center
Toms River
Inspira Medical Center Vineland
Vineland
Virtua Voorhees
Voorhees
Valley Health System-Hematology/Oncology
Westwood
New Mexico
Lovelace Medical Center-Downtown
Albuquerque
Lovelace Medical Center-Saint Joseph Square
Albuquerque
Presbyterian Kaseman Hospital
Albuquerque
University of New Mexico Cancer Center
Albuquerque
Memorial Medical Center - Las Cruces
Las Cruces
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho
Christus Saint Vincent Regional Cancer Center
Santa Fe
Nevada
Cancer and Blood Specialists-Henderson
Henderson
Comprehensive Cancer Centers of Nevada - Henderson
Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson
GenesisCare USA - Henderson
Henderson
Las Vegas Cancer Center-Henderson
Henderson
OptumCare Cancer Care at Seven Hills
Henderson
Cancer and Blood Specialists-Shadow
Las Vegas
Cancer and Blood Specialists-Tenaya
Las Vegas
Cancer Therapy and Integrative Medicine
Las Vegas
Comprehensive Cancer Centers of Nevada
Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas
GenesisCare USA - Fort Apache
Las Vegas
GenesisCare USA - Las Vegas
Las Vegas
GenesisCare USA - Vegas Tenaya
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas
Las Vegas Cancer Center-Medical Center
Las Vegas
OptumCare Cancer Care at Charleston
Las Vegas
OptumCare Cancer Care at Fort Apache
Las Vegas
OptumCare Cancer Care at MountainView
Las Vegas
Radiation Oncology Centers of Nevada Central
Las Vegas
Radiation Oncology Centers of Nevada Southeast
Las Vegas
Summerlin Hospital Medical Center
Las Vegas
Renown Regional Medical Center
Reno
Saint Mary's Regional Medical Center
Reno
New York
Northwell Health Imbert Cancer Center
Bay Shore
James J Peters VA Medical Center
Bronx
Montefiore Medical Center - Moses Campus
Bronx
Montefiore Medical Center-Einstein Campus
Bronx
Maimonides Medical Center
Brooklyn
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn
Roswell Park Cancer Institute
Buffalo
Memorial Sloan Kettering Commack
Commack
Mary Imogene Bassett Hospital
Cooperstown
Glens Falls Hospital
Glens Falls
Memorial Sloan Kettering Westchester
Harrison
Northwell Health/Center for Advanced Medicine
Lake Success
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York
Memorial Sloan Kettering Cancer Center
New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York
NYP/Weill Cornell Medical Center
New York
Vassar Brothers Medical Center
Poughkeepsie
Rochester General Hospital
Rochester
University of Rochester
Rochester
Staten Island University Hospital
Staten Island
State University of New York Upstate Medical University
Syracuse
Memorial Sloan Kettering Nassau
Uniondale
Dickstein Cancer Treatment Center
White Plains
Ohio
Cleveland Clinic Akron General
Akron
Aultman Health Foundation
Canton
Dayton Physicians LLC-Miami Valley South
Centerville
Geauga Hospital
Chardon
Adena Regional Medical Center
Chillicothe
Bethesda North Hospital
Cincinnati
Good Samaritan Hospital - Cincinnati
Cincinnati
TriHealth Cancer Institute-Anderson
Cincinnati
TriHealth Cancer Institute-Westside
Cincinnati
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati
Case Western Reserve University
Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland
Cleveland Clinic Foundation
Cleveland
MetroHealth Medical Center
Cleveland
Columbus Oncology and Hematology Associates Inc
Columbus
Doctors Hospital
Columbus
Grant Medical Center
Columbus
Ohio State University Comprehensive Cancer Center
Columbus
The Mark H Zangmeister Center
Columbus
Dayton Veterans Affairs Medical Center
Dayton
Mercy Cancer Center-Elyria
Elyria
Armes Family Cancer Center
Findlay
Blanchard Valley Hospital
Findlay
Cleveland Clinic Cancer Center Independence
Independence
Greater Dayton Cancer Center
Kettering
Kettering Medical Center
Kettering
Saint Rita's Medical Center
Lima
Cleveland Clinic Cancer Center Mansfield
Mansfield
Marietta Memorial Hospital
Marietta
OhioHealth Marion General Hospital
Marion
Toledo Clinic Cancer Centers-Maumee
Maumee
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Maumee
Hillcrest Hospital Cancer Center
Mayfield Heights
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor
UH Seidman Cancer Center at Southwest General Hospital
Middleburg Heights
Knox Community Hospital
Mount Vernon
Licking Memorial Hospital
Newark
Saint Charles Hospital
Oregon
University Hospitals Parma Medical Center
Parma
Mercy Health Perrysburg Cancer Center
Perrysburg
Southern Ohio Medical Center
Portsmouth
North Coast Cancer Care
Sandusky
UH Seidman Cancer Center at Firelands Regional Medical Center
Sandusky
Springfield Regional Cancer Center
Springfield
Springfield Regional Medical Center
Springfield
Cleveland Clinic Cancer Center Strongsville
Strongsville
ProMedica Flower Hospital
Sylvania
Mercy Health - Saint Anne Hospital
Toledo
Toledo Clinic Cancer Centers-Toledo
Toledo
University of Toledo
Toledo
University Hospitals Sharon Health Center
Wadsworth
South Pointe Hospital
Warrensville Heights
UH Seidman Cancer Center at Saint John Medical Center
Westlake
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster
Wright-Patterson Medical Center
Wright-patterson Air Force Base
Genesis Healthcare System Cancer Care Center
Zanesville
Oklahoma
Cancer Centers of Southwest Oklahoma Research
Lawton
Mercy Hospital Oklahoma City
Oklahoma City
University of Oklahoma Health Sciences Center
Oklahoma City
Oregon
Providence Cancer Institute Clackamas Clinic
Clackamas
Bay Area Hospital
Coos Bay
Good Samaritan Hospital
Corvallis
Three Rivers Community Hospital
Grants Pass
Providence Medford Medical Center
Medford
Rogue Valley Medical Center
Medford
Providence Newberg Medical Center
Newberg
Saint Alphonsus Medical Center-Ontario
Ontario
Kaiser Permanente Northwest
Portland
Providence Portland Medical Center
Portland
Providence Saint Vincent Medical Center
Portland
Pennsylvania
Lehigh Valley Hospital-Cedar Crest
Allentown
Lehigh Valley Hospital - Muhlenberg
Bethlehem
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem
Crozer-Keystone Regional Cancer Center at Broomall
Broomall
Bryn Mawr Hospital
Bryn Mawr
Geisinger Medical Center
Danville
Ephrata Cancer Center
Ephrata
Ephrata Community Hospital
Ephrata
UPMC Hillman Cancer Center Erie
Erie
Adams Cancer Center
Gettysburg
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg
Geisinger Medical Center-Cancer Center Hazleton
Hazleton
Penn State Milton S Hershey Medical Center
Hershey
Sechler Family Cancer Center
Lebanon
Geisinger Medical Oncology-Lewisburg
Lewisburg
Lewistown Hospital
Lewistown
Riddle Memorial Hospital
Media
Paoli Memorial Hospital
Paoli
Fox Chase Cancer Center
Philadelphia
Temple University Hospital
Philadelphia
Thomas Jefferson University Hospital
Philadelphia
University of Pennsylvania/Abramson Cancer Center
Philadelphia
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh
Geisinger Cancer Services-Pottsville
Pottsville
Penn State Health Saint Joseph Medical Center
Reading
Guthrie Medical Group PC-Robert Packer Hospital
Sayre
Community Medical Center
Scranton
Geisinger Medical Group
State College
Mount Nittany Medical Center
State College
Chester County Hospital
West Chester
Reading Hospital
West Reading
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-barre
UPMC Susquehanna
Williamsport
Asplundh Cancer Pavilion
Willow Grove
Lankenau Medical Center
Wynnewood
WellSpan Health-York Cancer Center
York
WellSpan Health-York Hospital
York
Rhode Island
Roger Williams Medical Center
Providence
South Carolina
Prisma Health Cancer Institute - Spartanburg
Boiling Springs
Medical University of South Carolina
Charleston
Prisma Health Cancer Institute - Easley
Easley
McLeod Regional Medical Center
Florence
Gibbs Cancer Center-Gaffney
Gaffney
Prisma Health Cancer Institute - Butternut
Greenville
Prisma Health Cancer Institute - Eastside
Greenville
Prisma Health Cancer Institute - Faris
Greenville
Saint Francis Cancer Center
Greenville
Saint Francis Hospital
Greenville
Self Regional Healthcare
Greenwood
Gibbs Cancer Center-Pelham
Greer
Prisma Health Cancer Institute - Greer
Greer
South Carolina Cancer Specialists PC
Hilton Head Island
Prisma Health Cancer Institute - Seneca
Seneca
Spartanburg Medical Center
Spartanburg
Lexington Medical Center
West Columbia
South Dakota
Avera Cancer Institute
Sioux Falls
Sanford Cancer Center Oncology Clinic
Sioux Falls
Sanford USD Medical Center - Sioux Falls
Sioux Falls
Tennessee
Bristol Regional Medical Center
Bristol
Cookeville Regional Medical Center
Cookeville
Wellmont Medical Associates Oncology and Hematology-Johnson City
Johnson City
Ballad Health Cancer Care - Kingsport
Kingsport
Wellmont Holston Valley Hospital and Medical Center
Kingsport
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis
Baptist Memorial Hospital for Women
Memphis
Family Cancer Center-Memphis
Memphis
Vanderbilt University/Ingram Cancer Center
Nashville
Texas
Hendrick Medical Center
Abilene
The Don and Sybil Harrington Cancer Center
Amarillo
Dell Seton Medical Center at The University of Texas
Austin
Parkland Memorial Hospital
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Dallas
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth
Houston Methodist Hospital
Houston
M D Anderson Cancer Center
Houston
Memorial Hermann Texas Medical Center
Houston
MD Anderson League City
League City
Covenant Medical Center-Lakeside
Lubbock
Houston Methodist Sugar Land Hospital
Sugar Land
Utah
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork
Sandra L Maxwell Cancer Center
Cedar City
Intermountain Medical Center
Murray
McKay-Dee Hospital Center
Ogden
Utah Valley Regional Medical Center
Provo
Saint George Regional Medical Center
Saint George
LDS Hospital
Salt Lake City
Utah Cancer Specialists-Salt Lake City
Salt Lake City
Virginia
Wellmont Medical Associates-Bristol
Bristol
Sentara Martha Jefferson Hospital
Charlottesville
University of Virginia Cancer Center
Charlottesville
Inova Fair Oaks Hospital
Fairfax
Inova Schar Cancer Institute
Fairfax
Inova Fairfax Hospital
Falls Church
Augusta Health Center for Cancer and Blood Disorders
Fishersville
Hematology Oncology Associates of Fredericksburg Inc
Fredericksburg
Mary Washington Hospital
Fredericksburg
Centra Lynchburg Hematology-Oncology Clinic Inc
Lynchburg
Sovah Health Martinsville
Martinsville
Bon Secours Memorial Regional Medical Center
Mechanicsville
Bon Secours Saint Francis Medical Center
Midlothian
Southwest VA Regional Cancer Center
Norton
Bon Secours Saint Mary's Hospital
Richmond
Virginia Cancer Institute
Richmond
Virginia Commonwealth University/Massey Cancer Center
Richmond
VCU Community Memorial Health Center
South Hill
Vermont
Southwestern Vermont Medical Center
Bennington
Central Vermont Medical Center/National Life Cancer Treatment
Berlin
University of Vermont and State Agricultural College
Burlington
University of Vermont Medical Center
Burlington
Washington
Providence Regional Cancer System-Aberdeen
Aberdeen
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton
Providence Regional Cancer System-Centralia
Centralia
Swedish Cancer Institute-Edmonds
Edmonds
Swedish Cancer Institute-Issaquah
Issaquah
Seattle Cancer Care Alliance at EvergreenHealth
Kirkland
Providence Regional Cancer System-Lacey
Lacey
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo
Valley Medical Center
Renton
FHCC South Lake Union
Seattle
Swedish Medical Center-First Hill
Seattle
University of Washington Medical Center - Montlake
Seattle
Virginia Mason Medical Center
Seattle
MultiCare Tacoma General Hospital
Tacoma
PeaceHealth Southwest Medical Center
Vancouver
Providence Saint Mary Regional Cancer Center
Walla Walla
Wisconsin
Langlade Hospital and Cancer Center
Antigo
Ascension Saint Elizabeth Hospital
Appleton
ThedaCare Regional Cancer Center
Appleton
Duluth Clinic Ashland
Ashland
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield
Aurora Cancer Care-Southern Lakes VLCC
Burlington
Marshfield Clinic-Chippewa Center
Chippewa Falls
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire
Marshfield Medical Center-EC Cancer Center
Eau Claire
Aurora Health Center-Fond du Lac
Fond Du Lac
Ascension Saint Francis - Reiman Cancer Center
Franklin
Aurora Health Care Germantown Health Center
Germantown
Aurora Cancer Care-Grafton
Grafton
Aurora BayCare Medical Center
Green Bay
Green Bay Oncology at Saint Vincent Hospital
Green Bay
Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay
Saint Vincent Hospital Cancer Center Green Bay
Green Bay
UW Cancer Center Johnson Creek
Johnson Creek
Aurora Cancer Care-Kenosha South
Kenosha
Gundersen Lutheran Medical Center
La Crosse
Marshfield Clinic - Ladysmith Center
Ladysmith
University of Wisconsin Carbone Cancer Center
Madison
William S Middleton VA Medical Center
Madison
Holy Family Memorial Hospital
Manitowoc
Aurora Bay Area Medical Group-Marinette
Marinette
Saint Vincent Hospital Cancer Center at Marinette
Marinette
Marshfield Medical Center-Marshfield
Marshfield
Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon
Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee
Aurora Cancer Care-Milwaukee
Milwaukee
Aurora Saint Luke's Medical Center
Milwaukee
Aurora Sinai Medical Center
Milwaukee
Medical College of Wisconsin
Milwaukee
Marshfield Clinic-Minocqua Center
Minocqua
ProHealth D N Greenwald Center
Mukwonago
Cancer Center of Western Wisconsin
New Richmond
ProHealth Oconomowoc Memorial Hospital
Oconomowoc
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls
Ascension Mercy Hospital
Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh
Aurora Cancer Care-Racine
Racine
Marshfield Medical Center-Rice Lake
Rice Lake
HSHS Saint Nicholas Hospital
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan
Ascension Saint Michael's Hospital
Stevens Point
Green Bay Oncology - Sturgeon Bay
Sturgeon Bay
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay
Aurora Medical Center in Summit
Summit
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers
UW Cancer Center at ProHealth Care
Waukesha
Aspirus Regional Cancer Center
Wausau
Marshfield Clinic-Wausau Center
Wausau
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa
Aurora Cancer Care-Milwaukee West
Wauwatosa
Aurora West Allis Medical Center
West Allis
Marshfield Medical Center - Weston
Weston
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids
West Virginia
United Hospital Center
Bridgeport
West Virginia University Charleston Division
Charleston
Edwards Comprehensive Cancer Center
Huntington
West Virginia University Healthcare
Morgantown
Wyoming
Big Horn Basin Cancer Center
Cody
Billings Clinic-Cody
Cody
Welch Cancer Center
Sheridan
Time Frame
Start Date: May 6, 2016
Estimated Completion Date: September 1, 2025
Participants
Target number of participants: 903
Treatments
Experimental: Arm I (nivolumab)
Patients receive nivolumab IV over 30 minutes on day 1. Cycles repeat every 4 weeks for up to 1 year in the absence of disease progression or unacceptable toxicity.
No Intervention: Arm II (observation)
Patients are followed serially with imaging for 1 year.
Authors
Thomas M. Fynan, Leena Gandhi, Christian A. Thomas, Deborah W. Wilbur, Willard G. Andrews, Eun-mi Yu, Polina Khrizman, Charles S. Kuzma, Kathleen C. Toomey, Yeun-Hee A. Park, Paul J. Hesketh, Kevin M. Sullivan, Chirag M. Shah, Chao H. Huang, Jonathan S. Treisman, John C. Kucharczuk, Umit Tapan, Ticiana B. Leal, Jeffrey P. Letzer, Thomas J. Summers, Syed H. Jafri, Kiran K. Yalamanchili, Robert J. Behrens, Mehul P. Patel, Seth D. Cohen, William E. Lawler, Ralph J. Hauke, Peter R. Graze, Thomas H. Openshaw, Ke Ning, Haiying Cheng, Timothy J. Pluard, Davood Vafai, Peter C. Everett, Philip J. Stella, Connie D. Uzel, Sherman Baker, Thomas J. Spillane, Bryan A. Faller, Mohammed Almubarak, Heather A. Wakelee, Fahd Rahman, Sunitha Vemulapalli, Preston D. Steen, Pablo M. Bedano, Thomas J. Reid, Leonard J. Horwitz, Philip A. Lowry, Justinian R. Ngaiza, Grace K. Dy, Rex B. Mowat, Sreedhar Katragadda, Patrick M. Forde, Joseph W. Leach, Yuhchyau Chen, Bruce J. Averbook, Asheesh Shipstone, Grant R. Seeger, Ashish Saxena, Geoffrey R. Oxnard, Kisa E. Weeman, Joseph F. McLaughlin, Howard M. Gross, Jay W. Carlson, Takefumi Komiya, Basem S. Goueli, Ruby Anne E. Deveras, Chandra P. Belani, Jeffrey L. Berenberg, Amar Hamad, Steven J. Jubelirer, Raja Mudad, Jose M. Pacheco, Maria I. Quejada, Eric H. Bernicker, Eunpi Cho, James R. Egner, Mehmet S. Copur, Joseph J. Merchant, William J. Irvin, David E. Gerber, David M. Spector, Marta Batus, Eric M. Knoche, Robert A. Kloss, William J. Charles, Christine Wasilewski, William V. Walsh, David M. Hufnagel, Glenn M. Mills, Dan P. Zandberg, Michael A. Schwartz, Edward T. Robbins, Elber S. Camacho, Timothy R. Wassenaar, Joel N. Saltzman, Howard A. Zaren, James E. Radford, Donald J. Jurgens, Sarah J. Sinclair, Carroll D. Scroggin, Donald E. Goodin, Susannah P. Friemel, Ewa Mrozek, Qamar U. Zaman, Nadeem Ikhlaque, Jeffrey K. Giguere, Missak Haigentz, Thomas E. Lad, Ranjith B. Dissanayake, James M. Leonardo, Timothy D. Moore, Cheryl M. Czerlanis, George Kovach, John C. McCann, Chul Kim, John M. Schallenkamp, Ding Wang, Jeffrey H. Muler, Wayne B. Harris, Michael L. Maitland, James N. Atkins, Wylie D. Hosmer, Shobha R. Chitneni, Clint D. Kingsley, Homam Alkaied, John J. Inzerillo, Albert S. DeNittis, Ramaswamy Govindan, Abdul H. Mansoor, Lyudmila A. Bazhenova, Gregory A. Masters, Sreekanth C. Reddy, Ashkan Bahrani, Alison D. Savage, Keren Sturtz, Nagesh H. Jayaram, Mebea Aklilu, Giuseppe Giaccone, Abhijit B. Saste, Susannah C. Cooper, Muhammad Furqan, Brian J. Heller, James W. Lee, Gregory P. Kalemkerian, Goetz H. Kloecker, Jyoti D. Patel, Naiyer A. Rizvi, Linda L. Garland, Emrullah Yilmaz, David K. Goebel, David J. Tate, Taofeek K. Owonikoko, J. Mark Prichard, Ashita Talsania, Edmund Folefac, Elena N. Theodosiou, Gigi Q. Chen, Jeffrey Crawford, Lawrence V. Brennan, Adedayo A. Onitilo, Stephen L. Graziano, Robert A. Hirsch, Ritesh Rathore, Steven A. Madden, Kevin Becker, John C. Ruckdeschel, Shahzad Siddique, Raymond Thertulien, Paul R. Walker, Kurt Oettel, Alexander Menter, Timothy E. Byun, Donald F. Busiek, Jamie Chaft, Neil D. Belman, James E. Clarkson, Roland T. Skeel, Puja Nistala, Rajiv Panikkar, Brian L. Burnette, Hamid R. Mirshahidi, Alison K. Conlin, John M. Wrangle, Thomas A. Hensing, Kan Huang, Eric Bravin, Robert D. Siegel, Misbah U. Qadir, Jorge J. Nieva, Ebenezer A. Kio, Elaine Shum, Han A. Koh, Harish G. Ahuja, Donald B. Wender, Andrew W. Pippas, Katy H. Goldsborough, Smitha P. Menon, Harvey C. Lebos, Matthias Weiss, Terrence P. Cescon, Aminder S. Mehdi, Ranveer Nand, Nafisa D. Burhani, Debra M. Prow, Jennifer T. Eubanks, Amaryllis Gil, Andy Y. Huang, Beverly J. Drucker, Aaron S. Mansfield, Joseph Aisner, Harvey Zimbler, Barbara S. Civiello, David R. Gandara, Peter R. Watson, Rajesh Bajaj, Joshua P. Raff, Jason Suh, Shakeeb A. Yunus, Shaker R. Dakhil, Marjory Charlot, Sharon D. Luikart, Douglas J. Weckstein, Steven E. Young, Chandler H. Park, Spencer Bachow, Eric W. Dean, Brian A. DiCarlo, Sally J. York, Ralph G. Zinner, David S. Hanson, Rodolfo E. Bordoni, John C. Morris, Michael J. Kraut, Aaron T. Gerds, Benjamin M. Solomon, Michael Alexander, Mark R. Hancock, Joseph M. Anderson, Ryan D. Gentzler, Sheetal S. Acharya, Nasfat Shehadeh, William E. Nibley, Kelvin B. Raybon, Aldemar Montero, Firas B. Badin, Gregory B. Smith, Uzair B. Chaudhary, Kavitha Beedupalli, Marianna Koczywas, Kamal K. Abbi, Jhanelle E. Gray, John H. Vu, Revati A. Rao, Preston S. Gable, Linda L. Ferris, Jimmy Ruiz, Shadia I. Jalal, James L. Wade, Benjamin T. Marchello, Peter Rubin, Sangeetha Nimmagadda, Boone W. Goodgame, Hamied R. Rezazadeh, David E. Einspahr, Warren L. Robinson, Harvey E. Einhorn, Bret E. Friday, Marc A. Rovito, Paul E. Zorsky, Costas L. Constantinou, Fariborze B. Barhamand, Nisha A. Mohindra, Liza C. Villaruz, Susanna Hong, Raymond P. Smith, Amir Tabatabai, Roberto F. Martinez, Jan M. Rothman, Galina Vugman, Anita Ravipati, Richard L. Deming, James M. Granfortuna, Mark F. Kozloff, Susanne M. Arnold, Vikas Dembla, Omar Al Ustwani, Adam D. Lye, Alexander Bershadskiy, Edmund W. Tai, Deric C. Savior, Joan H. Schiller, David M. King, Mohammad A. Razaq, Brian C. Boulmay, Esther H. Rehmus, Katherine A. Scilla, Amy C. Bessnow, Mohamad Kassar, Robert A. Chapman, Christopher E. Haberman, Samuel N. Ofori, Wilhelmina Cabalona, William P. Fusselman, Panos Fidias, Shylendra B. Sreenivasappa, Salvatore A. Del Prete, Rakesh Gaur, Francisco Robert, Pam G. Khosla, William E. Luginbuhl, Carrie Lee, Charles H. Nash, Rubina Qamar, Maria R. Tria Tirona, James D. Bearden, Sharad A. Ghamande, Chandrikha Chandrasekharan, Michael J. DeLeo, Dyanesh G. Ravindran, Edgardo S. Santos Castillero, Christopher H. Chay, Apar K. Ganti, Herta H. Chao, Claire F. Verschraegen, James M. Grichnik, Kathleen J. Yost, John A. Ellerton, Konstantin H. Dragnev, Justine Yang-Bruce, Abdul Hai Mansoor, Li Li, Vinay K. Gudena, Carl J. Minniti, Janakiraman Subramanian, John A. Keech, Mei Tang, Rafael Santana-Davila, Robert M. Langdon, Suma P. Satti, Raymond U. Osarogiagbon, Don L. Gibbons, Gilberto De Lima Lopes, Hibba Tul Rehman, Ki Wan Kim, Gregory A. Otterson, Rangaswamy Govindarajan
Sponsors
Leads: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov

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