Genotype-Phenotype Associations in Pediatric Cardiomyopathy

Status: Completed
Location: See all (12) locations...
Study Type: Observational
SUMMARY

Cardiomyopathy in children is a serious disease which can result in death, disability, heart transplantation or serious heart rhythm disorders. Doctors know little about the causes of cardiomyopathy but would like to learn more. In fact, up to 50-75% of cases in children have no known cause. For this reason, the purpose of this study is to identify genes that cause cardiomyopathy or that influence how people with cardiomyopathy do over time. These findings could improve disease prevention, surveillance, early management, and prognosis.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: No
View:

• Patient is alive. (except samples from deceased relatives who have consented for testing).Patients who are status-post heart transplant are eligible if pre-transplant longitudinal data are available.

• Under age 18 years at the time of diagnosis of either primary or idiopathic dilated, hypertropic, or restrictive cardiomyopathy.

• A diagnosis of cardiomyopathy which, at the time of diagnosis, was confirmed by echocardiographic criteria or cardiac MRI

Locations
United States
Colorado
Children's Hospital Colorado
Aurora
Florida
University of Miami, Jackson Memorial Hospital
Miami
Illinois
Ann and Robert H. Lurie Children's Hospital of Chicago
Chicago
Massachusetts
Children's Hospital Boston
Boston
Missouri
Washington University School of Medicine
Saint Louis
New York
Children's Hospital at Montefiore
Bronx
Children's Hospital of New York, Columbia Presbyterian Medical Center
New York
Ohio
Cincinnati Children's Hospital Medical Center
Cincinnati
Pennsylvania
Children's Hospital of Philadelphia
Philadelphia
Tennessee
Monroe Carell Jr. Children's Hospital at Vanderbilt
Nashville
Utah
Primary Children's Medical Center
Salt Lake City
Other Locations
Canada
Stollery Children's Hospital
Edmonton
Time Frame
Start Date: April 2013
Completion Date: March 31, 2018
Participants
Target number of participants: 544
Treatments
Pediatric cardiomyopathy
Diagnosis of primary or idiopathic dilated, hypertrophic or restrictive cardiomyopathy. Diagnosis must have been made before the age of 18 and must be confirmed by established echocardiographic criteria or cardiac MRI (cMRI) at the time of diagnosis.
Authors
Melanie D. Everitt, Charles Canter, Debra Dodd, Joseph Rossano, Ashwin K. Lal, Elfriede Pahl, Steven Webber, Steven Colan, Paolo Rusconi, Paul Kantor, Stephanie Ware, Linda Addonizio, Daphne Hsu, Steven E Lipshultz, John L Jeffries
Sponsors
Collaborators: Children's Hospital Colorado, Primary Children's Hospital, Ann & Robert H Lurie Children's Hospital of Chicago, Washington University School of Medicine, Columbia University, Children's Hospital Medical Center, Cincinnati, HealthCore-NERI, Stollery Children's Hospital, Children's Hospital of Philadelphia, Monroe Carell Jr. Children's Hospital at Vanderbilt, National Heart, Lung, and Blood Institute (NHLBI), Indiana University, Boston Children's Hospital, University of Miami
Leads: Wayne State University

This content was sourced from clinicaltrials.gov

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