Inflammatory Mediators as Potential Non-Invasive Biomarkers and Understanding the Mechanism of Remodeling in Tissue Biopsies in Subjects With Eosinophilic Esophagitis: A Pilot Study

Status: Active, not recruiting
Location: See all (2) locations...
Study Type: Observational [Patient Registry]
SUMMARY

The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine the presence of active Eosinophilic Esophagitis. For these purposes, the investigators will correlate esophageal inflammatory mediators measured in blood and urine with histological findings identified on esophageal mucosal biopsies. Additionally, biopsies associated mediators will be assessed relative to clinical phenotype and outcome.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1
Maximum Age: 18
Healthy Volunteers: Accepts Healthy Volunteers
View:

• Patient ages 1-18 undergoing upper endoscopy for suspected esophageal disease or esophageal inflammation or has histologically confirmed esophageal inflammation may be included in this study

Locations
United States
Illinois
Ann & Robert H Lurie Childjren's Hospital of Chicago
Chicago
University of Illinois at Chicago (UIC)
Chicago
Time Frame
Start Date: February 2011
Estimated Completion Date: May 2025
Participants
Target number of participants: 88
Authors
Amir Kagalwalla, Barry Wershil, Joshua Wechsler
Sponsors
Leads: Ann & Robert H Lurie Children's Hospital of Chicago

This content was sourced from clinicaltrials.gov

Similar Clinical Trials