Phase 2 Study of Esophageal String Test in Diagnosing Eosinophilic Esophagitis
The overall goal of this study is to develop a novel minimally invasive device, the Esophageal String Test (EST) to monitor esophageal inflammation during treatment of the rare disease Eosinophilic Esophagitis (EoE) in a safe and efficacious manner. This study is broken down into 2 specific aims: Specific Aim 1: Identify the EoE Biomarker Panel (EBP) that will improve the sensitivity and specificity of the EST for documenting esophageal inflammation in a 1-hour time point. Specific Aim 2: Validate the ability of the EST EBP to monitor therapeutic efficacy in a 1-hour sampling time. Funding Source - FDA OOPD
• Patients undergoing esophagogastroduodenoscopy (EGD) at Children's Hospital Colorado, or
• Patients from a participating site in whom an inflammatory GI disease is suspected.
• Patients with symptoms of:
• abdominal pain,
• growth delay, or
• malabsorption for which an etiology has not been determined.
• Patients with chronic eosinophilic esophagitis (EoE) in whom symptoms suggest ongoing inflammation.