An Observational Study Into the Variety of Electrocardiographic Responses to an Ajmaline Provocation in a Healthy Subjects. What Are the Genetic and Structural Variations Dictating This Response ?

Who is this study for? Patients with Brugada Syndrome
What treatments are being studied? Ajmaline
Status: Unknown status
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2

Standard, high lead and sodium channel provoked electrocardiograms of a healthy volunteers will be performed to observe the various ECG changes. Participants will the undergo detailed imaging with cardiac magnetic resonance imaging and deep genotyping to identify structural or genetic variants which might dictate the electrocardiographic patterns at rest and with sodium channel provocation.

Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: Accepts Healthy Volunteers

• Asymptomatic healthy Volunteers

Other Locations
United Kingdom
St George's University Of London
Time Frame
Start Date: October 22, 2017
Completion Date: December 2019
Target number of participants: 100
Experimental: Healthy Volunteers
Once screened by the investigators, the participants will undergo ajmaline provocation, cardiac magnetic resonance imaging and genotype evaluation
Leads: St George's, University of London

This content was sourced from

Similar Clinical Trials