China Cognition and Aging Study: a Multi-center, National-wide, Longitudinal Study in China

Status: Recruiting
Location: See all (65) locations...
Study Type: Observational [Patient Registry]
SUMMARY

The aim of this study is to establish and perfect the China Cognition and Aging Study (China COAST) cohort, to clarify the epidemiology, influencing factors, genetic characteristics, pathogenesis, disease characteristics and diagnosis and treatment status of dementia and its subtypes in China. It is of great significance to establish a relatively comprehensive national database of cognitive disorders, improve the clinical diagnosis and treatment level of cognitive disorders, and formulate prevention and treatment strategies for dementia. The primary aims of China COAST are as follows: To use the prospective cohort to establish a large database research platform, so as to provide comprehensive epidemiological data, clinical and neuropsychological evaluation data, biological samples, and laboratory tests and imaging data. To update the prevalence and incidence rate of dementia and its subtypes every 2-3 years, and clarify the conversion pattern from normal elderly to MCI and from MCI to dementia. To explore the known or unknown protective and risk factors of dementia and its major subtypes (AD, VaD, other dementia). To discover new pathogenic genes and susceptible genes of dementia and its major subtypes (AD and VaD), as well as new mutation sites of known pathogenic genes. To study the genetic variation, mutation and polymorphism of PSEN1, PSEN2, APP and APOE genes in dementia patients, and to understand their distribution and roles in the pathogenesis. To study the biomarkers (body fluid, genetics, imaging) with diagnostic value of MCI, AD (sporadic and familial) and VaD, to define their cut-off values, and to establish prediction models. To study the diagnostic criteria of cognitive normal, MCI, dementia and their subtypes (clinical and molecular subtypes) in the cohort, and to make psychological assessment scales with high sensitivity and specificity, and in line with the characteristics of Chinese people. To find potentially modifiable risk factors for dementia and to study the prevention and intervention effect of non-pharmacological treatment on APOE ε4 carriers, MCI and AD or other dementia patients,which included improvements in education, nutrition, health care, and lifestyle changes. This needs a long time follow-up. To explore the relationship between dementia as well as its major subtype AD and cerebral and systemetic circulatory disorders (for example, mixed dmentia), as well as potential therapeutic strategies. To carry out investigation and researches about dementia related education, improve the awareness of dementia, and strengthen the management of dementia.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: Accepts Healthy Volunteers
View:

• Diagnosis according to 2004 Peterson's MCI criteria.

• CDR = 0.5.

• Memory loss is prominent, and may also be with other cognitive domain dysfunction.

• Insidious onset, slow progress.

• Not reaching the level of dementia.

• Dementia is diagnosed according to the criteria described by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-R). The diagnosis of AD is made using the National Institute of Neurologic and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) or National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

• Subjects and their informed persons can complete relevant and follow- up examinations.

• Subjects or their authorized legal guardians sign the informed consent.

• Written informed consent obtained from participant or legal guardian prior to any study-related procedures.

• Members in FAD pedigree (FAD is defined as at least two first- degree relatives suffer from AD).

• Aged 18 (inclusive) or older.

• At least two persons who can provide reliable information for the study. Note: Dementia is diagnosed according to the criteria described by DSM-IV-R. The diagnosis of AD is made using NINCDS-ADRDA or NIA-AA criteria. A diagnosis of MCI is assigned according to Petersen criteria.

• Diagnosis for probable VaD according to NINDS-AIREN diagnostic criteria.

• MRI inclusion criteria:

• All patients who meet clinical inclusion criteria should accept MRI scans which include an assessment of hippocampal volume.

• multiple (≥3) supratentorial subcortical small infarcts (3-20 mm in diameter) with or without any degree of white matter lesion (WML); or moderate to severe WML (Fazekas score ≥ 2), with or without small infarction; or ≥ 1 subcortical small infarct in key regions, such as caudate nucleus, globus pallidus, or thalamus.

• no cortical and watershed infarction, hemorrhage, hydrocephalus, or WML with specific causes (such as multiple sclerosis).

• no hippocampus or entorhinal cortex atrophy (MTA score = 0 point).

• Aged 18 (inclusive) or above.

• Normal MMSE and MoCA evaluations. MMSE>19 points for illiteracy, >24 points for those educated less than 7 years, >27 points for those educated equal to or more than 7 years. MoCA>13 points for illiteracy, >19 points for those educated less than 7 years, >24 points for those educated equal to or more than 7 years.

Locations
Other Locations
China
Changda Hospital, Anshan
Recruiting
Anshan
Baotou Central Hospital
Recruiting
Baotou
China-Japan friendship Hospital of Jilin university
Recruiting
Changchun
The First Hospital of Jilin University
Recruiting
Changchun
Beijing Geriatric Hospital
Recruiting
Changping
Beijing Chao Yang Hospital
Recruiting
Chaoyang
China-Japan Friendship Hospital
Recruiting
Chaoyang
Affiliated Zhongshan hospital of Dalian university
Recruiting
Dalian
The First Affiliated Hospital of Dalian Medical University
Recruiting
Dalian
Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
Recruiting
Fengtai
Fujian Medical University Union Hospital
Recruiting
Fujian
Guangzhou Psychiatric Hospital
Recruiting
Guangzhou
The Affiliated Hospital Of Guizhou Medical University
Recruiting
Guiyang
First Affiliated Hospital of Harbin Medical University
Recruiting
Haerbin
Chinese PLA General Hospital
Recruiting
Haidian
Fu Xing Hospital, Capital Medical University
Recruiting
Haidian
Peking University Third Hospital
Recruiting
Haidian
Handan Central Hospital
Recruiting
Handan
First Affiliated Hospital of Zhejiang University
Recruiting
Hangzhou
Shao Yifu Hospital of Zhejiang Medical University
Recruiting
Hangzhou
Zhejiang Provincial People's Hospital
Recruiting
Hangzhou
The First Affiliated Hospital of Anhui Medical University
Recruiting
Hefei
Tianjin Medical University General Hospital
Recruiting
Heping
Shanghai Changzheng Hospital
Recruiting
Huangpu
Qilu Hospital of Shandong University
Recruiting
Jinan
Shandong Provincial Hospital
Recruiting
Jining
Tianjin Huanhu Hospital
Recruiting
Jinnan
Kaifeng Central Hospital
Recruiting
Kaifeng
Ruijin Hospital
Recruiting
Luwan
Jiangxi Provincial People's Hospital
Recruiting
Nanchang
Affiliated Hospital of North Sichuan Medical College
Recruiting
Nanchong
First Affiliated Hospital of Guangxi Medical University
Recruiting
Nanning
Nantong University Affiliated Hospital
Recruiting
Nantong
Ningbo City Medical Treatment Center Lihuili Hospital
Recruiting
Ningbo
RenJi Hospital
Recruiting
Putong
Qilu Hospital of Shandong University (Qingdao)
Recruiting
Qingdao
QingDao Municipal Hospital
Recruiting
Qingdao
The Affiliated Hospital of Qingdao University
Recruiting
Qingdao
First Hospital of China Medical University
Recruiting
Shenyang
First Hospital of Shijiazhuang City
Recruiting
Shijiazhuang
Subei People's Hospital of Jiangsu
Recruiting
Subei
The 88th Hospital of PLA
Recruiting
Tai'an
The First Affiliated Hospital of Shanxi Medical University
Recruiting
Taiyuan
Tangshan Worker's Hospital
Recruiting
Tangshan
Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region
Recruiting
Urumqi
First Affiliated Hospital of Wenzhou Medical Univeristy
Recruiting
Wenzhou
People's Hospital Affiliated Hubei Medical University
Recruiting
Wuhan
The Third Xiangya Hospital of Central South University
Recruiting
Wuhan
Tongji Hospital
Recruiting
Wuhan
Wuhan University Zhongnan Hospital
Recruiting
Wuhan
Xiangya Hospital of Central South University
Recruiting
Wuhan
First Affiliated Hospital Xi'an Jiaotong University
Recruiting
Xi'an
Tang-Du Hospital
Recruiting
Xi'an
Peking Union Medical College Hospital
Recruiting
Xicheng
Peking University First Hospital
Recruiting
Xicheng
Mineral General Hospital, Xuzhou
Recruiting
Xuzhou
General Hospital of Ningxia Medical University
Recruiting
Yinchuan
The People's Hospital of Ningxia
Recruiting
Yinchuan
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Recruiting
Yuzhong
The Second Affiliated Hospital of Chongqing Medical University
Recruiting
Yuzhong
Henan Provincial People's Hospital
Recruiting
Zhengzhou
People's Hospital of Zhengzhou
Recruiting
Zhengzhou
Hebei General Hospital
Recruiting
Zhijiazhuang
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Recruiting
Zhongshan
Zigong First People's Hospital
Recruiting
Zigong
Contact Information
Primary
Jianping Jia, Doctor
jiajp@vip.126.com
Time Frame
Start Date: January 10, 2007
Estimated Completion Date: January 1, 2038
Participants
Target number of participants: 100000
Treatments
Mild cognitive impairment (MCI) and its subtypes
MCI cohort consists of mild cognitive impairment subjects with memory loss as predominant symptom, including amnestic mild cognitive impairment and vascular cognitive impairment no dementia, which recruit from community population and hospital population.
Sporadic Alzheimer's disease (SAD)
SAD cohort consists of mild to moderate sporadic Alzheimer's disease subjects, which recruit from community population and hospital population.
Familial Alzheimer's disease (FAD)
FAD cohort consists of familial Alzheimer disease subjects with known or unknown mutations, which recruit from community population and hospital population.
Vascular dementia(VaD)
VaD cohort consists of cognitive impairment subjects caused by cerebral vessel disease, including vascular dementia and mixes dementia, which recruit from community population and hospital population.
Normal control
Normal control cohort consists of cognitive normal subjects with ApoE ε4 positive or negative, which recruit from community population and hospital population.
Non-Alzheimer degenerative dementia
Frontotemporal dementia (FTD); or Parkinson's disease dementia (PDD); or dementia with Lewy bodies (DLB); or corticobasal degeneration (CBD); or dementia not otherwise specified.
Sponsors
Collaborators: Subei People's Hospital of Jiangsu, First Hospital of Shijiazhuang City, Beijing Geriatric Hospital, Shao Yifu Hospital of Zhejiang Medical University, Wuhan University Zhongnan Hospital, Affiliated Hospital of North Sichuan Medical College, First Hospital of China Medical University, Shandong Provincial Hospital, People's Hospital Affiliated Hubei Medical University, Mineral General Hospital, Xuzhou, People's Hospital of Zhengzhou University, Tianjin Huanhu Hospital, Kaifeng Central Hospital, Tongji Hospital, Beijing Tiantan Hospital, Fujian Medical University Union Hospital, Guangzhou Psychiatric Hospital, China-Japan Union Hospital, Jilin University, Nantong University Affiliated Hospital, Beijing Chao Yang Hospital, Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region, Ruijin Hospital, Hunan Provincial People's Hospital, The First Hospital of Jilin University, The Second Affiliated Hospital of Chongqing Medical University, Xiangya Hospital of Central South University, The First Affiliated Hospital of Anhui Medical University, Zigong No.1 Peoples Hospital, Hebei General Hospital, Handan Central Hospital, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Qilu Hospital of Shandong University, Tang-Du Hospital, General Hospital of Ningxia Medical University, Qilu Hospital of Shandong University (Qingdao), The First Affiliated Hospital of Dalian Medical University, The Third Xiangya Hospital of Central South University, Peking University First Hospital, The 960th Hospital of PLA, Dongfang Hospital Beijing University of Chinese Medicine, Anshan Central Hospital, Baotou Central Hospital, The Affiliated Zhongshan Hospital of Dalian University, Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, Chinese PLA General Hospital, People's Hospital of Chongqing, RenJi Hospital, The First Affiliated Hospital of Shanxi Medical University, First Affiliated Hospital of Zhejiang University, Tangshan Worker's Hospital, Shanghai Changzheng Hospital, Jiangxi Provincial People's Hopital, First Affiliated Hospital Xi'an Jiaotong University, First Affiliated Hospital of Guangxi Medical University, The Affiliated Hospital Of Guizhou Medical University, Ningbo Medical Center Lihuili Hospital, Tianjin Medical University General Hospital, Fu Xing Hospital, Capital Medical University, Zhejiang Provincial People's Hospital, The Affiliated Hospital of Qingdao University, China-Japan Friendship Hospital, Qingdao Municipal Hospital, First Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Ningxia, Peking Union Medical College Hospital, First Affiliated Hospital of Harbin Medical University, Peking University Third Hospital
Leads: Capital Medical University

This content was sourced from clinicaltrials.gov

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