A Phase 3 Trial Investigating Blinatumomab (NSC# 765986) in Combination With Chemotherapy in Patients With Newly Diagnosed Standard Risk or Down Syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients With Localized B-Lymphoblastic Lymphoma (B-LLy)

Who is this study for? Infant to young adult patients with B Cell Acute Lymphoblastic Leukemia
What treatments are being studied? Blinatumomab
Status: Recruiting
Location: See all (222) locations...
Intervention Type: Drug, Biological, Radiation
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. Chemotherapy drugs, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexate, cytarabine, mercaptopurine, doxorubicin, cyclophosphamide, and thioguanine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Leucovorin decreases the toxic effects of methotrexate. Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1
Maximum Age: 31
Healthy Volunteers: No
View:

• All B-ALL patients must be enrolled on APEC14B1 and consented to Eligibility Screening (Part A) prior to treatment and enrollment on AALL1731. APEC 14B1 is not a requirement for B-LLy patients. B-LLy patients may directly enroll on AALL1731.

• Age at diagnosis:

• Patients must be >= 365 days and < 10 years of age (B-ALL patients without DS).

• Patients must be >= 365 days and =< 31 years of age (B-ALL patients with DS).

• Patients must be >= 365 days and =< 31 years of age (B-LLy patients with or without DS).

• B-ALL patients without DS must have an initial white blood cell count < 50,000/uL (performed within 7 days prior to enrollment).

• B-ALL patients with DS are eligible regardless of the presenting white blood cell count (WBC) (performed within 7 days prior to enrollment).

• Patient has newly diagnosed B-cell ALL, with or without Down syndrome: > 25% blasts on a bone marrow (BM) aspirate;

• OR if a BM aspirate is not obtained or is not diagnostic of B-ALL, the diagnosis can be established by a pathologic diagnosis of B-ALL on a BM biopsy;

• OR a complete blood count (CBC) documenting the presence of at least 1,000/uL circulating leukemic cells;

• OR patient has newly diagnosed B-cell LLy Murphy stages I or II, with or without Down syndrome.

• Note: For B-LLy patients with tissue available for flow cytometry, the criterion for diagnosis should be analogous to B-ALL. For tissue processed by other means (i.e., paraffin blocks), the methodology and criteria for immunophenotypic analysis to establish the diagnosis of B-LLy defined by the submitting institution will be accepted (diagnostic biopsy for B-LLy must be performed within 14 days prior to enrollment).

• All patients and/or their parents or legal guardians must sign a written informed consent.

• All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.

Locations
United States
Alaska
Providence Alaska Medical Center
Recruiting
Anchorage
Alabama
Children's Hospital of Alabama
Recruiting
Birmingham
USA Health Strada Patient Care Center
Recruiting
Mobile
Arkansas
Arkansas Children's Hospital
Recruiting
Little Rock
Arizona
Banner Children's at Desert
Recruiting
Mesa
Phoenix Childrens Hospital
Recruiting
Phoenix
Banner University Medical Center - Tucson
Recruiting
Tucson
California
Kaiser Permanente Downey Medical Center
Recruiting
Downey
City of Hope Comprehensive Cancer Center
Recruiting
Duarte
Loma Linda University Medical Center
Recruiting
Loma Linda
Miller Children's and Women's Hospital Long Beach
Recruiting
Long Beach
Cedars Sinai Medical Center
Recruiting
Los Angeles
Children's Hospital Los Angeles
Recruiting
Los Angeles
Mattel Children's Hospital UCLA
Recruiting
Los Angeles
Valley Children's Hospital
Recruiting
Madera
Kaiser Permanente-Oakland
Recruiting
Oakland
UCSF Benioff Children's Hospital Oakland
Recruiting
Oakland
Children's Hospital of Orange County
Recruiting
Orange
Lucile Packard Children's Hospital Stanford University
Recruiting
Palo Alto
Sutter Medical Center Sacramento
Recruiting
Sacramento
University of California Davis Comprehensive Cancer Center
Recruiting
Sacramento
Naval Medical Center -San Diego
Recruiting
San Diego
Rady Children's Hospital - San Diego
Recruiting
San Diego
UCSF Medical Center-Mission Bay
Recruiting
San Francisco
Santa Barbara Cottage Hospital
Recruiting
Santa Barbara
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Recruiting
Torrance
Colorado
Children's Hospital Colorado
Recruiting
Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Recruiting
Denver
Connecticut
Connecticut Children's Medical Center
Recruiting
Hartford
Yale University
Recruiting
New Haven
Washington, D.c.
Children's National Medical Center
Recruiting
Washington
MedStar Georgetown University Hospital
Recruiting
Washington
Delaware
Alfred I duPont Hospital for Children
Recruiting
Wilmington
Florida
Broward Health Medical Center
Recruiting
Fort Lauderdale
Golisano Children's Hospital of Southwest Florida
Recruiting
Fort Myers
University of Florida Health Science Center - Gainesville
Recruiting
Gainesville
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Recruiting
Hollywood
Nemours Children's Clinic-Jacksonville
Recruiting
Jacksonville
Palms West Radiation Therapy
Recruiting
Loxahatchee Groves
Miami Cancer Institute
Recruiting
Miami
Nicklaus Children's Hospital
Active, not recruiting
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Recruiting
Miami
AdventHealth Orlando
Suspended
Orlando
Arnold Palmer Hospital for Children
Recruiting
Orlando
Nemours Children's Hospital
Recruiting
Orlando
Sacred Heart Hospital
Recruiting
Pensacola
Johns Hopkins All Children's Hospital
Recruiting
Saint Petersburg
Saint Joseph's Hospital/Children's Hospital-Tampa
Recruiting
Tampa
Tampa General Hospital
Recruiting
Tampa
Saint Mary's Hospital
Recruiting
West Palm Beach
Georgia
Children's Healthcare of Atlanta - Egleston
Recruiting
Atlanta
Augusta University Medical Center
Recruiting
Augusta
Medical Center of Central Georgia
Recruiting
Macon
Memorial Health University Medical Center
Recruiting
Savannah
Hawaii
Kapiolani Medical Center for Women and Children
Recruiting
Honolulu
Tripler Army Medical Center
Recruiting
Honolulu
Iowa
Blank Children's Hospital
Recruiting
Des Moines
University of Iowa/Holden Comprehensive Cancer Center
Recruiting
Iowa City
Idaho
Saint Luke's Cancer Institute - Boise
Recruiting
Boise
Illinois
Lurie Children's Hospital-Chicago
Recruiting
Chicago
University of Chicago Comprehensive Cancer Center
Recruiting
Chicago
University of Illinois
Recruiting
Chicago
Loyola University Medical Center
Recruiting
Maywood
Advocate Children's Hospital-Oak Lawn
Recruiting
Oak Lawn
Advocate Children's Hospital-Park Ridge
Recruiting
Park Ridge
Saint Jude Midwest Affiliate
Recruiting
Peoria
Southern Illinois University School of Medicine
Recruiting
Springfield
Indiana
Ascension Saint Vincent Indianapolis Hospital
Recruiting
Indianapolis
Riley Hospital for Children
Recruiting
Indianapolis
Kentucky
University of Kentucky/Markey Cancer Center
Recruiting
Lexington
Norton Children's Hospital
Recruiting
Louisville
Louisiana
Children's Hospital New Orleans
Suspended
New Orleans
Ochsner Medical Center Jefferson
Recruiting
New Orleans
Massachusetts
Dana-Farber Cancer Institute
Recruiting
Boston
Massachusetts General Hospital Cancer Center
Recruiting
Boston
Tufts Children's Hospital
Active, not recruiting
Boston
Baystate Medical Center
Recruiting
Springfield
UMass Memorial Medical Center - University Campus
Recruiting
Worcester
Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center
Recruiting
Baltimore
Sinai Hospital of Baltimore
Recruiting
Baltimore
University of Maryland/Greenebaum Cancer Center
Recruiting
Baltimore
Walter Reed National Military Medical Center
Recruiting
Bethesda
Maine
Eastern Maine Medical Center
Recruiting
Bangor
Maine Children's Cancer Program
Recruiting
Scarborough
Michigan
C S Mott Children's Hospital
Recruiting
Ann Arbor
Ascension Saint John Hospital
Active, not recruiting
Detroit
Michigan State University Clinical Center
Recruiting
East Lansing
Helen DeVos Children's Hospital at Spectrum Health
Recruiting
Grand Rapids
Bronson Methodist Hospital
Recruiting
Kalamazoo
Beaumont Children's Hospital-Royal Oak
Recruiting
Royal Oak
Minnesota
Children's Hospitals and Clinics of Minnesota - Minneapolis
Recruiting
Minneapolis
University of Minnesota/Masonic Cancer Center
Recruiting
Minneapolis
Mayo Clinic in Rochester
Recruiting
Rochester
Missouri
Columbia Regional
Recruiting
Columbia
Children's Mercy Hospitals and Clinics
Recruiting
Kansas City
Cardinal Glennon Children's Medical Center
Recruiting
Saint Louis
Mercy Hospital Saint Louis
Recruiting
Saint Louis
Washington University School of Medicine
Recruiting
Saint Louis
Mississippi
University of Mississippi Medical Center
Recruiting
Jackson
North Carolina
Mission Hospital
Recruiting
Asheville
UNC Lineberger Comprehensive Cancer Center
Recruiting
Chapel Hill
Carolinas Medical Center/Levine Cancer Institute
Recruiting
Charlotte
Novant Health Presbyterian Medical Center
Recruiting
Charlotte
Duke University Medical Center
Recruiting
Durham
East Carolina University
Recruiting
Greenville
Wake Forest University Health Sciences
Recruiting
Winston-salem
North Dakota
Sanford Broadway Medical Center
Recruiting
Fargo
Nebraska
Children's Hospital and Medical Center of Omaha
Recruiting
Omaha
University of Nebraska Medical Center
Recruiting
Omaha
New Hampshire
Dartmouth Hitchcock Medical Center
Recruiting
Lebanon
New Jersey
Hackensack University Medical Center
Recruiting
Hackensack
Morristown Medical Center
Recruiting
Morristown
Jersey Shore Medical Center
Recruiting
Neptune
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
Recruiting
New Brunswick
Saint Peter's University Hospital
Recruiting
New Brunswick
Newark Beth Israel Medical Center
Recruiting
Newark
Saint Joseph's Regional Medical Center
Recruiting
Paterson
New Mexico
Presbyterian Hospital
Recruiting
Albuquerque
University of New Mexico Cancer Center
Recruiting
Albuquerque
Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Recruiting
Las Vegas
Summerlin Hospital Medical Center
Recruiting
Las Vegas
Sunrise Hospital and Medical Center
Recruiting
Las Vegas
University Medical Center of Southern Nevada
Recruiting
Las Vegas
Renown Regional Medical Center
Recruiting
Reno
New York
Albany Medical Center
Recruiting
Albany
Montefiore Medical Center - Moses Campus
Recruiting
Bronx
Maimonides Medical Center
Recruiting
Brooklyn
NYU Winthrop Hospital
Recruiting
Mineola
The Steven and Alexandra Cohen Children's Medical Center of New York
Recruiting
New Hyde Park
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Recruiting
New York
Memorial Sloan Kettering Cancer Center
Recruiting
New York
Mount Sinai Hospital
Recruiting
New York
NYP/Weill Cornell Medical Center
Recruiting
New York
University of Rochester
Recruiting
Rochester
Stony Brook University Medical Center
Recruiting
Stony Brook
State University of New York Upstate Medical University
Recruiting
Syracuse
New York Medical College
Recruiting
Valhalla
Ohio
Children's Hospital Medical Center of Akron
Recruiting
Akron
Cincinnati Children's Hospital Medical Center
Recruiting
Cincinnati
Cleveland Clinic Foundation
Recruiting
Cleveland
Rainbow Babies and Childrens Hospital
Recruiting
Cleveland
Nationwide Children's Hospital
Recruiting
Columbus
Dayton Children's Hospital
Recruiting
Dayton
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Recruiting
Toledo
Oklahoma
University of Oklahoma Health Sciences Center
Recruiting
Oklahoma City
Natalie Warren Bryant Cancer Center at Saint Francis
Recruiting
Tulsa
Oregon
Legacy Emanuel Children's Hospital
Recruiting
Portland
Oregon Health and Science University
Recruiting
Portland
Pennsylvania
Lehigh Valley Hospital-Cedar Crest
Recruiting
Allentown
Geisinger Medical Center
Recruiting
Danville
Penn State Children's Hospital
Recruiting
Hershey
Children's Hospital of Philadelphia
Recruiting
Philadelphia
Saint Christopher's Hospital for Children
Recruiting
Philadelphia
Children's Hospital of Pittsburgh of UPMC
Recruiting
Pittsburgh
Rhode Island
Rhode Island Hospital
Recruiting
Providence
South Carolina
Medical University of South Carolina
Recruiting
Charleston
Prisma Health Richland Hospital
Recruiting
Columbia
BI-LO Charities Children's Cancer Center
Recruiting
Greenville
South Dakota
Sanford USD Medical Center - Sioux Falls
Recruiting
Sioux Falls
Tennessee
T C Thompson Children's Hospital
Suspended
Chattanooga
East Tennessee Childrens Hospital
Recruiting
Knoxville
The Children's Hospital at TriStar Centennial
Recruiting
Nashville
Vanderbilt University/Ingram Cancer Center
Recruiting
Nashville
Texas
Texas Tech University Health Sciences Center-Amarillo
Recruiting
Amarillo
Dell Children's Medical Center of Central Texas
Recruiting
Austin
Driscoll Children's Hospital
Recruiting
Corpus Christi
Medical City Dallas Hospital
Recruiting
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Recruiting
Dallas
El Paso Children's Hospital
Recruiting
El Paso
Cook Children's Medical Center
Recruiting
Fort Worth
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Recruiting
Houston
M D Anderson Cancer Center
Recruiting
Houston
Covenant Children's Hospital
Recruiting
Lubbock
UMC Cancer Center / UMC Health System
Recruiting
Lubbock
Vannie Cook Children's Clinic
Recruiting
Mcallen
Children's Hospital of San Antonio
Recruiting
San Antonio
Methodist Children's Hospital of South Texas
Recruiting
San Antonio
University of Texas Health Science Center at San Antonio
Recruiting
San Antonio
Scott and White Memorial Hospital
Recruiting
Temple
Utah
Primary Children's Hospital
Recruiting
Salt Lake City
Virginia
University of Virginia Cancer Center
Recruiting
Charlottesville
Inova Fairfax Hospital
Recruiting
Falls Church
Children's Hospital of The King's Daughters
Recruiting
Norfolk
Naval Medical Center - Portsmouth
Recruiting
Portsmouth
Virginia Commonwealth University/Massey Cancer Center
Recruiting
Richmond
Carilion Children's
Recruiting
Roanoke
Vermont
University of Vermont and State Agricultural College
Recruiting
Burlington
Washington
Seattle Children's Hospital
Recruiting
Seattle
Providence Sacred Heart Medical Center and Children's Hospital
Recruiting
Spokane
Madigan Army Medical Center
Recruiting
Tacoma
Mary Bridge Children's Hospital and Health Center
Recruiting
Tacoma
Wisconsin
Saint Vincent Hospital Cancer Center Green Bay
Recruiting
Green Bay
University of Wisconsin Carbone Cancer Center
Recruiting
Madison
Marshfield Medical Center-Marshfield
Recruiting
Marshfield
Children's Hospital of Wisconsin
Recruiting
Milwaukee
West Virginia
West Virginia University Charleston Division
Recruiting
Charleston
West Virginia University Healthcare
Recruiting
Morgantown
Other Locations
Australia
Monash Medical Center-Clayton Campus
Recruiting
Clayton
John Hunter Children's Hospital
Recruiting
Hunter Regional Mail Centre
Women's and Children's Hospital-Adelaide
Recruiting
North Adelaide
Perth Children's Hospital
Recruiting
Perth
Queensland Children's Hospital
Recruiting
South Brisbane
Canada
Alberta Children's Hospital
Recruiting
Calgary
University of Alberta Hospital
Recruiting
Edmonton
IWK Health Centre
Recruiting
Halifax
McMaster Children's Hospital at Hamilton Health Sciences
Recruiting
Hamilton
Kingston Health Sciences Centre
Recruiting
Kingston
Children's Hospital
Recruiting
London
The Montreal Children's Hospital of the MUHC
Recruiting
Montreal
Children's Hospital of Eastern Ontario
Recruiting
Ottawa
Centre Hospitalier Universitaire de Quebec
Recruiting
Quebec
Janeway Child Health Centre
Recruiting
Saint John's
Jim Pattison Children's Hospital
Recruiting
Saskatoon
Saskatoon Cancer Centre
Suspended
Saskatoon
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Recruiting
Sherbrooke
Hospital for Sick Children
Recruiting
Toronto
British Columbia Children's Hospital
Recruiting
Vancouver
CancerCare Manitoba
Recruiting
Winnipeg
New Zealand
Christchurch Hospital
Recruiting
Christchurch
Starship Children's Hospital
Recruiting
Grafton
Puerto Rico
HIMA San Pablo Oncologic Hospital
Recruiting
Caguas
University Pediatric Hospital
Recruiting
San Juan
Time Frame
Start Date: June 28, 2019
Estimated Completion Date: September 30, 2029
Participants
Target number of participants: 6720
Treatments
Active Comparator: Arm A (SR-Avg control)
Arm A: See detailed description.
Experimental: Arm B (SR-Avg experimental)
Arm B: See detailed description.
Active Comparator: Arm C (SR-High Control)
Arm C: See detailed description.
Experimental: Arm D (SR-High experimental)
Arm D See detailed description.
Experimental: B-LLy
See detailed description.
Experimental: DS B-ALL
See detailed description.
Experimental: NCI SR or HR DS B-ALL
See detailed description.
Authors
Samuel O. Anim, Craig Erker, Lisa L. Hartman, David J. Slomiany, Angela R. Girvin, Lewis B. Silverman, John F. Kuttesch, Hamayun Imran, Carola A. Arndt, Gregory B. Kirkpatrick, Elyssa M. Rubin, Glen Lew, Robin Y. Dulman, Haydar A. Frangoul, Ashley E. Meyer, Michael J. Burke, Alexander Aledo, Nina S. Kadan-Lottick, Alissa Kahn, Eric C. Larsen, Kathryn L. Laurie, Marcio H. Malogolowkin, Jessica C. Hochberg, Anna B. Pawlowska, Douglas S. Hawkins, Mary L. Schmidt, Eduard H. Panosyan, Vinod K. Gidvani-Diaz, Julio C. Barredo, Vlad C. Radulescu, Matthew A. Kutny, Eric J. Lowe, William A. May, Gary D. Crouch, Nadine P. SantaCruz, Mariko Sato, Peter M. Gordon, Ashok B. Raj, Sumit Gupta, Emily B. Walling, Jill A. Salo, Jessica M. Valdez, Peter H. Shaw, Jessica Boklan, Keith J. August, Chana L. Glasser, Kishor M. Bhende, Lisa Gennarini, Stanton C. Goldman, Sushmita Nair, Thomas W. McLean, Michael S. Isakoff, Kayelyn J. Wagner, Mukund G. Dole, David L. Becton, Laura E. Agresta, Adit L. Tal, Lars M. Wagner, Phillip E. Barnette, Rabi Hanna, Erika Friehling, Timothy C. Griffin, Robin D. Hanson, Vonda L. Crouse, Juan F. Rico, Erwood G. Edwards, Ranjan Bista, Kenneth J. Cohen, Doured Daghistani, Jennifer A. Domm, Don E. Eslin, William B. Slayton, Lolie C. Yu, Iftikhar Hanif, Xiaxin Li, Holly E. Pariury, Catherine A. Long, Mark A. Ranalli, David S. Dickens, Pooja Hingorani, Erin K. Barr, William C. Petersen, Leo Mascarenhas, Erin Wright, Ray C. Pais, Laura E. Hogan, Jamie L. Dargart, Nibal A. Zaghloul, Theodore B. Moore, Adonis N. Lorenzana, Jason Law, Kenneth M. Heym, Duncan S. Stearns, Andrew L. Pendleton, Barbara A. Gruner, Yoko T. Udaka, Craig A. Mullen, Jose M. Esquilin, Manoo G. Bhakta, Kavitha Ramaswamy, Rajen Mody, Aarati V. Rao, Joseph C. Torkildson, Michelle A. Manalang, Craig Lotterman, Erlyn C. Smith, Aniket Saha, Burton E. Appel, Maria E. Echevarria, Colleen H. McDonough, Eugenia Chang, Sandeep Batra, Benjamin J. Huang, Aghiad Chamdin, Asmaa Ferdjallah, Thomas B. Russell, Arlene S. Redner, Victor A. Lewis, Alexander J. Chou, Meghann P. McManus, Richard A. Drachtman, Kenneth Caldwell, Luke D. Maese, Nicholas W. McGregor, James T. Badgett, Robert G. Irwin, Carla B. Golden, Susan E. Spiller, Shivani Upadhyay, Douglas J. Scothorn, Eugene Suh, Jennifer M. Levine, Joanna G. Luty, Fouad M. Hajjar, Alison M. Friedmann, Judy L. Felgenhauer, Jacob A. Troutman, Ryan J. Summers, Mira Kohorst, Minnie Abromowitch, Kelly W. Maloney, Wade T. Kyono, Amy A. Smith, Emi H. Caywood, Kara-Marie H. Delaney, William D. Roberts, Bethany M. Mikles, Mahmut Y. Celiker, Gregory P. Brandt, William S. Ferguson, Marshall A. Schorin, Scott M. Bradfield, Lisa M. McGregor, Juan C. Bernini, Robert M. Cooper, Nichole L. Bryant, Santosh S. Hanmod, Kira O. Bona, Laura A. Campbell, Jennifer J. Welch, Jagadeesh Ramdas, Philip M. Monteleone, Stuart L. Cramer, Andrea R. Whitfield, Jeffrey A. Toretsky, Jay Michael S. Balagtas, Lauren M. Vasta, Joel A. Kaplan, Jean M. Tersak, Gregory E. Halligan, Bassem I. Razzouk, Brenda J. Wittman, Robert J. Hayashi, Tamra L. Slone, Yung S. Yim, Samuel J. Milanovich, India Y. Sisler, Alan K. Ikeda, Samantha L. Mallory, Enrique A. Escalon, Dana A. Obzut, Nkechi I. Mba, Janice F. Olson, Laura K. Gowans, Rebecca E. McFall, Narayana Gowda, Michael K. Richards, Steven J. Kuerbitz, Joanna L. Weinstein, Lauren R. Weintraub, Mark E. Weinblatt, Jennifer B. Dean, Jeffrey H. Schwartz, Jason M. Fixler, Sharon L. Gardner, Jill C. Beck, Jennifer J. Clark, Julie Kim, Jessica A. Bell, Teena Bhatla, Teresa A. York, Jessica L. Heath, Albert Kheradpour, Jeffrey S. Dome, Melissa A. Forouhar, Mohamad H. Badawi, Pillai Pallavi Madhusoodhan, Maureen M. O'Brien, Stefanie R. Lowas, Melissa S. Singer, Susan R. Rheingold, Farzana Pashankar, John J. Gregory, Dana B. Salzberg, Emad K. Salman, Stuart H. Gold, Amy C. Fowler, Christopher J. Fraser, Luis A. Clavell, Douglas R. Strother, Jhon A. Guerra, Kenneth B. De Santes, Felipe S. Bautista-Otanez, Christopher P. Keuker, Tanya R. Brown, Stephan R. Paul, Christopher Mpofu, Elizabeth L. Hesketh, Karen S. Fernandez, Patrick A. Brown, Rebecca O. Clark, Jacqueline N. Casillas, Kathleen Felton, Paul J. Wood, Ashley Chopek, Lisa A. Goodyear, Sharon B. Abish, Laura Wheaton, Ayman A. El-Sheikh, Lochie R. Teague, Maria L. Kirby, Anne-Marie R. Langevin, Donna L. Johnston, David B. Dix, Shannon M. Cohn, Najat C. Daw, Josee Brossard, Kenneth B. DeSantes, Uma H. Athale, Jacqueline M. Kraveka, Rachel E. Rau, Siobhan F. Cross, Fataneh (Fae) Majlessipour, Shayna M. Zelcer, Rene Y. McNall-Knapp, Sara Zarnegar-Lumley, Vilmarie Rodriguez, David E. Kram, Kathleen J. Yost, Jaime M. Libes, Marianne B. Phillips, Mignon L. Loh, Samer Zaid Kaylani, Mohamad M. Al-Rahawan, Hector M. Rodriguez-Cortes, Mariana P. Silva, Amber M. D'Souza, Bill H. Chang, Sarah J. McKillop, Sarah E. Leary, Geoff D. Cuvelier, Anderson (Andy) B. Collier, Jennifer L. McNeer, Bruno Michon, Conrad V. Fernandez, Kenneth Lieuw
Sponsors
Leads: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov

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