Randomized Phase II/III Study of Nivolumab Plus Ipilimumab Plus Sargramostim Versus Nivolumab Plus Ipilimumab in Patients With Unresectable Stage III or Stage IV Melanoma

Who is this study for? Patients with Metastatic Cutaneous Melanoma
What treatments are being studied? Ipilimumab+Nivolumab
Status: Recruiting
Location: See all (655) locations...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY

This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. It is not yet known whether nivolumab and ipilimumab are more effective with or without sargramostim in treating patients with melanoma.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• All patients must be >= 18 years of age

• Eastern Cooperative Oncology Group (ECOG) performance status: 0 or 1

• Patients must have known BRAF mutational status of tumor; wild-type (WT) or mutated, prior to randomization

• Patients must have unresectable stage III or stage IV melanoma according to American Joint Committee on Cancer (AJCC) version (v)7; patients must have histological or cytological confirmation of melanoma that is metastatic or unresectable and clearly progressive

• Patients must have measurable disease per RECIST 1.1 criteria; all sites of disease must be evaluated within 4 weeks prior to randomization

• Patients may have had prior systemic therapy in the adjuvant setting (e.g. interferon, BRAF, or MEK agents). Patients may have had prior anti-CTLA-4 in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment. Patients may have had any prior programmed cell death (PD)-1/PD-ligand (PD-L)1 agent in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment

• Patients must have discontinued chemotherapy, immunotherapy or other investigational agents used in the adjuvant setting >= 4 weeks prior to randomization and recovered from adverse events due to those agents; mitomycin and nitrosoureas must have been discontinued at least 6 weeks prior to entering the study; patients must have discontinued radiation therapy >= 2 weeks prior to entering the study and recovered from any adverse events associated with treatment; prior surgery must be >= 4 weeks from randomization and patients must be fully recovered from post-surgical complications

• White blood count >= 3,000/uL (obtained within 4 weeks prior to randomization)

• Absolute neutrophil count (ANC) >= 1,500/uL (obtained within 4 weeks prior to randomization)

• Platelet count >= 100,000/uL (obtained within 4 weeks prior to randomization)

• Hemoglobin >= 9 g/dL (obtained within 4 weeks prior to randomization)

• Serum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/min (obtained within 4 weeks prior to randomization)

• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases) (obtained within 4 weeks prior to randomization)

• Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) (obtained within 4 weeks prior to randomization)

• Total bilirubin =< 1.5 x ULN except subjects with normal direct bilirubin or those with known Gilbert's syndrome (obtained within 4 weeks prior to randomization)

• Serum lactate dehydrogenase (LDH) =< 10 X ULN (obtained within 4 weeks prior to randomization)

• Patients with autoimmune hypothyroid disease or type I diabetes on replacement treatment are eligible

Locations
United States
Alabama
University of Alabama at Birmingham Cancer Center
Recruiting
Birmingham
Arkansas
John L McClellan Memorial Veterans Hospital
Active, not recruiting
Little Rock
Arizona
Kingman Regional Medical Center
Recruiting
Kingman
California
Kaiser Permanente-Anaheim
Recruiting
Anaheim
PCR Oncology
Recruiting
Arroyo Grande
Sutter Auburn Faith Hospital
Recruiting
Auburn
Sutter Cancer Centers Radiation Oncology Services-Auburn
Recruiting
Auburn
Kaiser Permanente-Baldwin Park
Recruiting
Baldwin Park
Kaiser Permanente-Bellflower
Recruiting
Bellflower
Alta Bates Summit Medical Center-Herrick Campus
Recruiting
Berkeley
Mills-Peninsula Medical Center
Recruiting
Burlingame
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Recruiting
Cameron Park
Eden Hospital Medical Center
Recruiting
Castro Valley
Sutter Davis Hospital
Recruiting
Davis
City of Hope Comprehensive Cancer Center
Active, not recruiting
Duarte
Kaiser Permanente Dublin
Recruiting
Dublin
Kaiser Permanente-Fontana
Recruiting
Fontana
Palo Alto Medical Foundation-Fremont
Recruiting
Fremont
Kaiser Permanente-Fresno
Recruiting
Fresno
Kaiser Permanente - Harbor City
Recruiting
Harbor City
Kaiser Permanente-Irvine
Recruiting
Irvine
Kaiser Permanente Los Angeles Medical Center
Recruiting
Los Angeles
Kaiser Permanente West Los Angeles
Recruiting
Los Angeles
Kaiser Permanente-Modesto
Recruiting
Modesto
Memorial Medical Center
Recruiting
Modesto
Palo Alto Medical Foundation-Camino Division
Recruiting
Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology
Recruiting
Mountain View
Sutter Cancer Research Consortium
Recruiting
Novato
Kaiser Permanente-Oakland
Recruiting
Oakland
Kaiser Permanente-Ontario
Recruiting
Ontario
Saint Joseph Hospital - Orange
Suspended
Orange
UC Irvine Health/Chao Family Comprehensive Cancer Center
Recruiting
Orange
Palo Alto Medical Foundation Health Care
Recruiting
Palo Alto
Stanford Cancer Institute Palo Alto
Recruiting
Palo Alto
Kaiser Permanente - Panorama City
Recruiting
Panorama City
Kaiser Permanente-Richmond
Recruiting
Richmond
Kaiser Permanente-Riverside
Recruiting
Riverside
Kaiser Permanente-Roseville
Recruiting
Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Recruiting
Roseville
Sutter Roseville Medical Center
Recruiting
Roseville
Kaiser Permanente - Sacramento
Recruiting
Sacramento
Kaiser Permanente Downtown Commons
Recruiting
Sacramento
Kaiser Permanente-South Sacramento
Recruiting
Sacramento
Sutter Medical Center Sacramento
Recruiting
Sacramento
Kaiser Permanente-San Diego Mission
Recruiting
San Diego
Kaiser Permanente-San Diego Zion
Recruiting
San Diego
Naval Medical Center -San Diego
Active, not recruiting
San Diego
California Pacific Medical Center-Pacific Campus
Recruiting
San Francisco
Kaiser Permanente-Santa Teresa-San Jose
Recruiting
San Jose
Kaiser Permanente San Leandro
Recruiting
San Leandro
Kaiser Permanente-San Marcos
Recruiting
San Marcos
Mills Health Center
Recruiting
San Mateo
Kaiser Permanente-San Rafael
Recruiting
San Rafael
Kaiser San Rafael-Gallinas
Recruiting
San Rafael
Kaiser Permanente Medical Center - Santa Clara
Recruiting
Santa Clara
Palo Alto Medical Foundation-Santa Cruz
Recruiting
Santa Cruz
Sutter Pacific Medical Foundation
Recruiting
Santa Rosa
Kaiser Permanente-Stockton
Recruiting
Stockton
Palo Alto Medical Foundation-Sunnyvale
Recruiting
Sunnyvale
City of Hope Upland
Active, not recruiting
Upland
Kaiser Permanente Medical Center-Vacaville
Recruiting
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Recruiting
Vacaville
Kaiser Permanente-Vallejo
Recruiting
Vallejo
Sutter Solano Medical Center/Cancer Center
Recruiting
Vallejo
Kaiser Permanente-Walnut Creek
Recruiting
Walnut Creek
Kaiser Permanente-Woodland Hills
Recruiting
Woodland Hills
Colorado
The Medical Center of Aurora
Suspended
Aurora
Boulder Community Hospital
Suspended
Boulder
Penrose-Saint Francis Healthcare
Suspended
Colorado Springs
Kaiser Permanente-Franklin
Recruiting
Denver
Porter Adventist Hospital
Suspended
Denver
Presbyterian - Saint Lukes Medical Center - Health One
Suspended
Denver
Rose Medical Center
Suspended
Denver
SCL Health Saint Joseph Hospital
Suspended
Denver
Mercy Medical Center
Suspended
Durango
Southwest Oncology PC
Suspended
Durango
Mountain Blue Cancer Care Center - Swedish
Recruiting
Englewood
Rocky Mountain Cancer Centers - Swedish
Recruiting
Englewood
Swedish Medical Center
Recruiting
Englewood
The Melanoma and Skin Cancer Institute
Recruiting
Englewood
North Colorado Medical Center
Recruiting
Greeley
Kaiser Permanente-Rock Creek
Recruiting
Lafayette
Saint Anthony Hospital
Suspended
Lakewood
Kaiser Permanente-Lone Tree
Recruiting
Lone Tree
Sky Ridge Medical Center
Suspended
Lone Tree
Longmont United Hospital
Suspended
Longmont
McKee Medical Center
Recruiting
Loveland
Saint Mary Corwin Medical Center
Suspended
Pueblo
SCL Health Lutheran Medical Center
Suspended
Wheat Ridge
Connecticut
Smilow Cancer Hospital Care Center - Guiford
Recruiting
Guilford
Smilow Cancer Hospital Care Center at Saint Francis
Recruiting
Hartford
Yale University
Recruiting
New Haven
Washington, D.c.
MedStar Georgetown University Hospital
Recruiting
Washington
MedStar Washington Hospital Center
Recruiting
Washington
Florida
UM Sylvester Comprehensive Cancer Center at Aventura
Recruiting
Aventura
UM Sylvester Comprehensive Cancer Center at Coral Gables
Recruiting
Coral Gables
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Recruiting
Deerfield Beach
Holy Cross Hospital
Recruiting
Fort Lauderdale
UM Sylvester Comprehensive Cancer Center at Kendall
Recruiting
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Active, not recruiting
Miami
UM Sylvester Comprehensive Cancer Center at Plantation
Recruiting
Plantation
Moffitt Cancer Center
Recruiting
Tampa
Moffitt Cancer Center - McKinley Campus
Recruiting
Tampa
Moffitt Cancer Center-International Plaza
Recruiting
Tampa
Georgia
University Cancer and Blood Center LLC
Recruiting
Athens
Emory University Hospital/Winship Cancer Institute
Recruiting
Atlanta
Northside Hospital
Recruiting
Atlanta
Augusta University Medical Center
Recruiting
Augusta
Northside Hospital-Forsyth
Active, not recruiting
Cumming
Dekalb Medical Center
Active, not recruiting
Decatur
Northside Hospital - Duluth
Recruiting
Duluth
Northside Hospital - Gwinnett
Recruiting
Lawrenceville
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Recruiting
Savannah
Summit Cancer Care-Candler
Suspended
Savannah
Hawaii
Hawaii Cancer Care - Savio
Recruiting
'aiea
Pali Momi Medical Center
Recruiting
'aiea
Queen's Cancer Center - Pearlridge
Recruiting
'aiea
Straub Pearlridge Clinic
Recruiting
'aiea
The Cancer Center of Hawaii-Pali Momi
Recruiting
'aiea
The Queen's Medical Center - West Oahu
Recruiting
'ewa Beach
Hawaii Cancer Care Inc - Waterfront Plaza
Recruiting
Honolulu
Hawaii Cancer Care Inc-Liliha
Recruiting
Honolulu
Hawaii Diagnostic Radiology Services LLC
Recruiting
Honolulu
Island Urology
Suspended
Honolulu
Kaiser Permanente Moanalua Medical Center
Recruiting
Honolulu
Kapiolani Medical Center for Women and Children
Recruiting
Honolulu
Kuakini Medical Center
Recruiting
Honolulu
Queen's Cancer Cenrer - POB I
Recruiting
Honolulu
Queen's Cancer Center - Kuakini
Recruiting
Honolulu
Queen's Medical Center
Recruiting
Honolulu
Straub Clinic and Hospital
Recruiting
Honolulu
The Cancer Center of Hawaii-Liliha
Recruiting
Honolulu
University of Hawaii Cancer Center
Recruiting
Honolulu
Straub Medical Center - Kahului Clinic
Recruiting
Kahului
Castle Medical Center
Recruiting
Kailua
Wilcox Memorial Hospital and Kauai Medical Clinic
Recruiting
Lihue
Iowa
Mary Greeley Medical Center
Recruiting
Ames
McFarland Clinic PC - Ames
Recruiting
Ames
McFarland Clinic PC-Boone
Recruiting
Boone
McFarland Clinic PC-Trinity Cancer Center
Recruiting
Fort Dodge
McFarland Clinic PC-Jefferson
Recruiting
Jefferson
McFarland Clinic PC-Marshalltown
Recruiting
Marshalltown
Siouxland Regional Cancer Center
Recruiting
Sioux City
Idaho
Saint Alphonsus Cancer Care Center-Boise
Recruiting
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Recruiting
Caldwell
Kootenai Health - Coeur d'Alene
Recruiting
Coeur D'alene
Walter Knox Memorial Hospital
Recruiting
Emmett
Idaho Urologic Institute-Meridian
Recruiting
Meridian
Saint Alphonsus Medical Center-Nampa
Recruiting
Nampa
Kootenai Clinic Cancer Services - Post Falls
Recruiting
Post Falls
Kootenai Cancer Clinic
Recruiting
Sandpoint
Illinois
Rush - Copley Medical Center
Recruiting
Aurora
Illinois CancerCare-Bloomington
Recruiting
Bloomington
Saint Joseph Medical Center
Active, not recruiting
Bloomington
Illinois CancerCare-Canton
Recruiting
Canton
Memorial Hospital of Carbondale
Recruiting
Carbondale
SIH Cancer Institute
Recruiting
Carterville
Illinois CancerCare-Carthage
Recruiting
Carthage
Centralia Oncology Clinic
Recruiting
Centralia
Northwestern University
Recruiting
Chicago
Carle on Vermilion
Recruiting
Danville
Cancer Care Specialists of Illinois - Decatur
Recruiting
Decatur
Decatur Memorial Hospital
Recruiting
Decatur
Illinois CancerCare-Dixon
Recruiting
Dixon
Carle Physician Group-Effingham
Recruiting
Effingham
Crossroads Cancer Center
Recruiting
Effingham
Illinois CancerCare-Eureka
Recruiting
Eureka
NorthShore University HealthSystem-Evanston Hospital
Recruiting
Evanston
Illinois CancerCare-Galesburg
Recruiting
Galesburg
Western Illinois Cancer Treatment Center
Recruiting
Galesburg
NorthShore University HealthSystem-Glenbrook Hospital
Recruiting
Glenview
NorthShore University HealthSystem-Highland Park Hospital
Recruiting
Highland Park
Illinois CancerCare-Kewanee Clinic
Recruiting
Kewanee
Illinois CancerCare-Macomb
Recruiting
Macomb
Carle Physician Group-Mattoon/Charleston
Recruiting
Mattoon
Cancer Care Center of O'Fallon
Recruiting
O'fallon
Illinois CancerCare-Ottawa Clinic
Recruiting
Ottawa
Illinois CancerCare-Pekin
Recruiting
Pekin
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Recruiting
Pekin
Illinois CancerCare-Peoria
Recruiting
Peoria
Methodist Medical Center of Illinois
Recruiting
Peoria
OSF Saint Francis Medical Center
Recruiting
Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Recruiting
Peoria
Illinois CancerCare-Peru
Recruiting
Peru
Valley Radiation Oncology
Recruiting
Peru
Illinois CancerCare-Princeton
Recruiting
Princeton
Memorial Medical Center
Recruiting
Springfield
Southern Illinois University School of Medicine
Recruiting
Springfield
Springfield Clinic
Recruiting
Springfield
Southwest Illinois Health Services LLP
Suspended
Swansea
Carle Cancer Center
Recruiting
Urbana
The Carle Foundation Hospital
Recruiting
Urbana
Illinois CancerCare - Washington
Recruiting
Washington
Rush-Copley Healthcare Center
Recruiting
Yorkville
Indiana
Deaconess Clinic Downtown
Recruiting
Evansville
Franciscan Health Indianapolis
Recruiting
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
Recruiting
Indianapolis
Franciscan Saint Anthony Health-Michigan City
Suspended
Michigan City
Woodland Cancer Care Center
Suspended
Michigan City
Franciscan Health Mooresville
Recruiting
Mooresville
Chancellor Center for Oncology
Recruiting
Newburgh
Reid Health
Recruiting
Richmond
Kansas
Cancer Center of Kansas - Chanute
Recruiting
Chanute
Cancer Center of Kansas - Dodge City
Recruiting
Dodge City
Cancer Center of Kansas - El Dorado
Recruiting
El Dorado
Cancer Center of Kansas - Fort Scott
Suspended
Fort Scott
Cancer Center of Kansas-Independence
Recruiting
Independence
Cancer Center of Kansas-Kingman
Recruiting
Kingman
Lawrence Memorial Hospital
Suspended
Lawrence
Cancer Center of Kansas-Liberal
Recruiting
Liberal
Cancer Center of Kansas-Manhattan
Recruiting
Manhattan
Cancer Center of Kansas - McPherson
Recruiting
Mcpherson
Cancer Center of Kansas - Newton
Recruiting
Newton
Cancer Center of Kansas - Parsons
Recruiting
Parsons
Cancer Center of Kansas - Pratt
Recruiting
Pratt
Cancer Center of Kansas - Salina
Recruiting
Salina
Cotton O'Neil Cancer Center / Stormont Vail Health
Recruiting
Topeka
Cancer Center of Kansas - Wellington
Recruiting
Wellington
Ascension Via Christi Hospitals Wichita
Recruiting
Wichita
Associates In Womens Health
Suspended
Wichita
Cancer Center of Kansas - Wichita
Recruiting
Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower
Recruiting
Wichita
Cancer Center of Kansas - Winfield
Recruiting
Winfield
Kentucky
Oncology Hematology Care Inc-Crestview
Suspended
Crestview Hills
The James Graham Brown Cancer Center at University of Louisville
Active, not recruiting
Louisville
Louisiana
Louisiana Hematology Oncology Associates LLC
Active, not recruiting
Baton Rouge
LSU Health Baton Rouge-North Clinic
Recruiting
Baton Rouge
Mary Bird Perkins Cancer Center
Active, not recruiting
Baton Rouge
Medical Center of Baton Rouge
Active, not recruiting
Baton Rouge
Ochsner Health Center-Summa
Active, not recruiting
Baton Rouge
Ochsner High Grove
Active, not recruiting
Baton Rouge
Our Lady of The Lake
Recruiting
Baton Rouge
Our Lady of the Lake Physicians Group - Medical Oncology
Recruiting
Baton Rouge
Mary Bird Perkins Cancer Center - Covington
Suspended
Covington
Northshore Oncology Associates-Covington
Active, not recruiting
Covington
Mary Bird Perkins Cancer Center - Houma
Suspended
Houma
Oncology Center of The South Incorporated
Suspended
Houma
Ochsner Medical Center Kenner
Active, not recruiting
Kenner
Ochsner LSU Health Monroe Medical Center
Recruiting
Monroe
Louisiana State University Health Science Center
Active, not recruiting
New Orleans
Ochsner Medical Center Jefferson
Active, not recruiting
New Orleans
University Medical Center New Orleans
Active, not recruiting
New Orleans
CHRISTUS Highland Medical Center
Active, not recruiting
Shreveport
LSU Health Sciences Center at Shreveport
Recruiting
Shreveport
Massachusetts
Beth Israel Deaconess Medical Center
Recruiting
Boston
Dana-Farber Cancer Institute
Recruiting
Boston
Massachusetts General Hospital Cancer Center
Recruiting
Boston
Baystate Medical Center
Recruiting
Springfield
UMass Memorial Medical Center - University Campus
Active, not recruiting
Worcester
Maryland
Greater Baltimore Medical Center
Recruiting
Baltimore
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Recruiting
Baltimore
Saint Agnes Hospital
Recruiting
Baltimore
Sinai Hospital of Baltimore
Active, not recruiting
Baltimore
UPMC Western Maryland
Active, not recruiting
Cumberland
Northwest Hospital Center
Active, not recruiting
Randallstown
Maine
Eastern Maine Medical Center
Recruiting
Bangor
Lafayette Family Cancer Center-EMMC
Suspended
Brewer
Maine Center for Cancer Medicine-Kennebunk
Suspended
Kennebunk
Maine Center for Cancer Medicine-Scarborough
Suspended
Scarborough
Michigan
Hickman Cancer Center
Active, not recruiting
Adrian
Saint Joseph Mercy Hospital
Recruiting
Ann Arbor
Bronson Battle Creek
Suspended
Battle Creek
Saint Joseph Mercy Brighton
Recruiting
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Recruiting
Brighton
Saint Joseph Mercy Canton
Recruiting
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Recruiting
Canton
Caro Cancer Center
Recruiting
Caro
Saint Joseph Mercy Chelsea
Recruiting
Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Recruiting
Chelsea
Hematology Oncology Consultants-Clarkston
Recruiting
Clarkston
Newland Medical Associates-Clarkston
Recruiting
Clarkston
Beaumont Hospital - Dearborn
Active, not recruiting
Dearborn
Ascension Saint John Hospital
Recruiting
Detroit
Great Lakes Cancer Management Specialists-Doctors Park
Recruiting
East China Township
Genesee Cancer and Blood Disease Treatment Center
Recruiting
Flint
Genesee Hematology Oncology PC
Recruiting
Flint
Genesys Hurley Cancer Institute
Recruiting
Flint
Hurley Medical Center
Recruiting
Flint
Mercy Health Saint Mary's
Recruiting
Grand Rapids
Spectrum Health at Butterworth Campus
Recruiting
Grand Rapids
Academic Hematology Oncology Specialists
Recruiting
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Recruiting
Grosse Pointe Woods
Michigan Breast Specialists-Grosse Pointe Woods
Recruiting
Grosse Pointe Woods
Allegiance Health
Suspended
Jackson
Ascension Borgess Cancer Center
Recruiting
Kalamazoo
Borgess Medical Center
Recruiting
Kalamazoo
Bronson Methodist Hospital
Recruiting
Kalamazoo
West Michigan Cancer Center
Recruiting
Kalamazoo
Sparrow Hospital
Recruiting
Lansing
Hope Cancer Clinic
Suspended
Livonia
Trinity Health Saint Mary Mercy Livonia Hospital
Recruiting
Livonia
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Recruiting
Macomb
Michigan Breast Specialists-Macomb Township
Recruiting
Macomb
Saint Mary's Oncology/Hematology Associates of Marlette
Recruiting
Marlette
Toledo Clinic Cancer Centers-Monroe
Active, not recruiting
Monroe
Mercy Health Mercy Campus
Recruiting
Muskegon
Cancer and Hematology Centers of Western Michigan - Norton Shores
Recruiting
Norton Shores
21st Century Oncology-Pontiac
Recruiting
Pontiac
Hope Cancer Center
Recruiting
Pontiac
Newland Medical Associates-Pontiac
Recruiting
Pontiac
Saint Joseph Mercy Oakland
Recruiting
Pontiac
Spectrum Health Reed City Hospital
Suspended
Reed City
Great Lakes Cancer Management Specialists-Rochester Hills
Suspended
Rochester Hills
William Beaumont Hospital-Royal Oak
Active, not recruiting
Royal Oak
Ascension Saint Mary's Hospital
Recruiting
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Recruiting
Saginaw
Ascension Providence Hospitals - Southfield
Recruiting
Southfield
Bhadresh Nayak MD PC-Sterling Heights
Recruiting
Sterling Heights
Ascension Saint Joseph Hospital
Recruiting
Tawas City
Munson Medical Center
Suspended
Traverse City
William Beaumont Hospital - Troy
Active, not recruiting
Troy
Advanced Breast Care Center PLLC
Recruiting
Warren
Great Lakes Cancer Management Specialists-Macomb Professional Building
Recruiting
Warren
Macomb Hematology Oncology PC
Recruiting
Warren
Michigan Breast Specialists-Warren
Recruiting
Warren
Saint John Macomb-Oakland Hospital
Recruiting
Warren
Saint Mary's Oncology/Hematology Associates of West Branch
Recruiting
West Branch
Metro Health Hospital
Suspended
Wyoming
Huron Gastroenterology PC
Recruiting
Ypsilanti
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Recruiting
Ypsilanti
Minnesota
Riverwood Healthcare Center
Recruiting
Aitkin
Essentia Health - Baxter Clinic
Recruiting
Baxter
Sanford Joe Lueken Cancer Center
Recruiting
Bemidji
Essentia Health Saint Joseph's Medical Center
Recruiting
Brainerd
Fairview Ridges Hospital
Recruiting
Burnsville
Minnesota Oncology - Burnsville
Recruiting
Burnsville
Cambridge Medical Center
Recruiting
Cambridge
Mercy Hospital
Recruiting
Coon Rapids
Essentia Health - Deer River Clinic
Recruiting
Deer River
Essentia Health Saint Mary's - Detroit Lakes Clinic
Recruiting
Detroit Lakes
Essentia Health Cancer Center
Recruiting
Duluth
Essentia Health Saint Mary's Medical Center
Recruiting
Duluth
Miller-Dwan Hospital
Recruiting
Duluth
Fairview Southdale Hospital
Recruiting
Edina
Essentia Health - Ely Clinic
Recruiting
Ely
Lake Region Healthcare Corporation-Cancer Care
Suspended
Fergus Falls
Essentia Health - Fosston
Recruiting
Fosston
Unity Hospital
Recruiting
Fridley
Essentia Health Hibbing Clinic
Recruiting
Hibbing
Essentia Health - International Falls Clinic
Recruiting
International Falls
Fairview Clinics and Surgery Center Maple Grove
Recruiting
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Recruiting
Maplewood
Saint John's Hospital - Healtheast
Recruiting
Maplewood
Abbott-Northwestern Hospital
Recruiting
Minneapolis
Health Partners Inc
Recruiting
Minneapolis
Hennepin County Medical Center
Recruiting
Minneapolis
Monticello Cancer Center
Recruiting
Monticello
Essentia Health - Moose Lake Clinic
Recruiting
Moose Lake
New Ulm Medical Center
Recruiting
New Ulm
Essentia Health - Park Rapids
Recruiting
Park Rapids
Fairview Northland Medical Center
Recruiting
Princeton
North Memorial Medical Health Center
Recruiting
Robbinsdale
Park Nicollet Clinic - Saint Louis Park
Recruiting
Saint Louis Park
Regions Hospital
Recruiting
Saint Paul
United Hospital
Recruiting
Saint Paul
Essentia Health Sandstone
Recruiting
Sandstone
Saint Francis Regional Medical Center
Recruiting
Shakopee
Lakeview Hospital
Recruiting
Stillwater
Sanford Thief River Falls Medical Center
Recruiting
Thief River Falls
Essentia Health Virginia Clinic
Recruiting
Virginia
Ridgeview Medical Center
Recruiting
Waconia
Rice Memorial Hospital
Recruiting
Willmar
Minnesota Oncology Hematology PA-Woodbury
Recruiting
Woodbury
Sanford Cancer Center Worthington
Recruiting
Worthington
Fairview Lakes Medical Center
Recruiting
Wyoming
Missouri
Parkland Health Center-Bonne Terre
Suspended
Bonne Terre
Saint Francis Medical Center
Recruiting
Cape Girardeau
Southeast Cancer Center
Recruiting
Cape Girardeau
Saint Luke's Hospital
Recruiting
Chesterfield
Parkland Health Center - Farmington
Recruiting
Farmington
Capital Region Southwest Campus
Recruiting
Jefferson City
Heartland Regional Medical Center
Suspended
Saint Joseph
Missouri Baptist Medical Center
Recruiting
Saint Louis
Sainte Genevieve County Memorial Hospital
Recruiting
Sainte Genevieve
CoxHealth South Hospital
Recruiting
Springfield
Mercy Hospital Springfield
Recruiting
Springfield
Missouri Baptist Sullivan Hospital
Recruiting
Sullivan
Missouri Baptist Outpatient Center-Sunset Hills
Recruiting
Sunset Hills
Montana
Community Hospital of Anaconda
Recruiting
Anaconda
Billings Clinic Cancer Center
Suspended
Billings
Bozeman Deaconess Hospital
Recruiting
Bozeman
Saint James Community Hospital and Cancer Treatment Center
Suspended
Butte
Benefis Healthcare- Sletten Cancer Institute
Recruiting
Great Falls
Saint Peter's Community Hospital
Suspended
Helena
Kalispell Regional Medical Center
Suspended
Kalispell
North Carolina
AdventHealth Infusion Center Asheville
Active, not recruiting
Asheville
Southeastern Medical Oncology Center-Clinton
Recruiting
Clinton
Southeastern Medical Oncology Center-Goldsboro
Recruiting
Goldsboro
Wayne Memorial Hospital
Active, not recruiting
Goldsboro
Hendersonville Hematology and Oncology at Pardee
Recruiting
Hendersonville
Margaret R Pardee Memorial Hospital
Recruiting
Hendersonville
Onslow Memorial Hospital
Active, not recruiting
Jacksonville
Southeastern Medical Oncology Center-Jacksonville
Recruiting
Jacksonville
Vidant Oncology-Kenansville
Recruiting
Kenansville
Vidant Oncology-Kinston
Recruiting
Kinston
Vidant Oncology-Richlands
Recruiting
Richlands
North Dakota
Sanford Bismarck Medical Center
Recruiting
Bismarck
Essentia Health Cancer Center-South University Clinic
Recruiting
Fargo
Sanford Broadway Medical Center
Recruiting
Fargo
Sanford Clinic North-Fargo
Suspended
Fargo
Sanford Roger Maris Cancer Center
Recruiting
Fargo
Sanford South University Medical Center
Recruiting
Fargo
Essentia Health - Jamestown Clinic
Recruiting
Jamestown
Nebraska
Great Plains Health Callahan Cancer Center
Active, not recruiting
North Platte
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Recruiting
Omaha
Nebraska Methodist Hospital
Recruiting
Omaha
Oncology Associates PC
Recruiting
Omaha
New Hampshire
Dartmouth Hitchcock Medical Center
Recruiting
Lebanon
New Jersey
Memorial Sloan Kettering Basking Ridge
Recruiting
Basking Ridge
Hackensack University Medical Center
Recruiting
Hackensack
New Mexico
Lovelace Medical Center-Saint Joseph Square
Recruiting
Albuquerque
New Mexico Oncology Hematology Consultants
Active, not recruiting
Albuquerque
Presbyterian Kaseman Hospital
Recruiting
Albuquerque
University of New Mexico Cancer Center
Recruiting
Albuquerque
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Recruiting
Rio Rancho
Christus Saint Vincent Regional Cancer Center
Active, not recruiting
Santa Fe
Nevada
Carson Tahoe Regional Medical Center
Recruiting
Carson City
Cancer and Blood Specialists-Henderson
Recruiting
Henderson
Comprehensive Cancer Centers of Nevada - Henderson
Recruiting
Henderson
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Recruiting
Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Recruiting
Henderson
GenesisCare USA - Henderson
Recruiting
Henderson
Las Vegas Cancer Center-Henderson
Recruiting
Henderson
Las Vegas Urology - Green Valley
Recruiting
Henderson
Las Vegas Urology - Pebble
Recruiting
Henderson
OptumCare Cancer Care at Seven Hills
Recruiting
Henderson
Urology Specialists of Nevada - Green Valley
Recruiting
Henderson
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Recruiting
Las Vegas
Ann M Wierman MD LTD
Recruiting
Las Vegas
Cancer and Blood Specialists-Shadow
Suspended
Las Vegas
Cancer and Blood Specialists-Tenaya
Suspended
Las Vegas
Comprehensive Cancer Centers of Nevada
Recruiting
Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley
Recruiting
Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest
Recruiting
Las Vegas
Comprehensive Cancer Centers of Nevada - Town Center
Recruiting
Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin
Recruiting
Las Vegas
Desert West Surgery
Suspended
Las Vegas
GenesisCare USA - Fort Apache
Recruiting
Las Vegas
GenesisCare USA - Las Vegas
Recruiting
Las Vegas
GenesisCare USA - Vegas Tenaya
Recruiting
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Suspended
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Suspended
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Suspended
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Suspended
Las Vegas
Hope Cancer Care of Nevada
Recruiting
Las Vegas
Las Vegas Cancer Center-Medical Center
Recruiting
Las Vegas
Las Vegas Prostate Cancer Center
Recruiting
Las Vegas
Las Vegas Urology - Cathedral Rock
Recruiting
Las Vegas
Las Vegas Urology - Pecos
Recruiting
Las Vegas
Las Vegas Urology - Smoke Ranch
Recruiting
Las Vegas
Las Vegas Urology - Sunset
Recruiting
Las Vegas
OptumCare Cancer Care at Charleston
Recruiting
Las Vegas
OptumCare Cancer Care at Fort Apache
Recruiting
Las Vegas
OptumCare Cancer Care at MountainView
Recruiting
Las Vegas
Radiation Oncology Centers of Nevada Central
Recruiting
Las Vegas
Radiation Oncology Centers of Nevada Southeast
Recruiting
Las Vegas
Summerlin Hospital Medical Center
Recruiting
Las Vegas
Sunrise Hospital and Medical Center
Recruiting
Las Vegas
University Cancer Center
Recruiting
Las Vegas
University Medical Center of Southern Nevada
Recruiting
Las Vegas
Urology Specialists of Nevada - Central
Recruiting
Las Vegas
Urology Specialists of Nevada - Northwest
Recruiting
Las Vegas
Urology Specialists of Nevada - Southwest
Recruiting
Las Vegas
Hope Cancer Care of Nevada-Pahrump
Recruiting
Pahrump
Radiation Oncology Associates
Recruiting
Reno
Renown Regional Medical Center
Recruiting
Reno
Saint Mary's Regional Medical Center
Recruiting
Reno
New York
Roswell Park Cancer Institute
Active, not recruiting
Buffalo
Memorial Sloan Kettering Commack
Recruiting
Commack
Mary Imogene Bassett Hospital
Recruiting
Cooperstown
Memorial Sloan Kettering Westchester
Recruiting
Harrison
Memorial Sloan Kettering Cancer Center
Recruiting
New York
University of Rochester
Recruiting
Rochester
Ohio
UHHS-Chagrin Highlands Medical Center
Recruiting
Beachwood
Indu and Raj Soin Medical Center
Recruiting
Beavercreek
Strecker Cancer Center-Belpre
Recruiting
Belpre
Saint Elizabeth Boardman Hospital
Recruiting
Boardman
Dayton Physicians LLC-Miami Valley South
Recruiting
Centerville
Miami Valley Hospital South
Recruiting
Centerville
Adena Regional Medical Center
Recruiting
Chillicothe
Oncology Hematology Care Inc-Anderson
Suspended
Cincinnati
Oncology Hematology Care Inc-Blue Ash
Suspended
Cincinnati
Oncology Hematology Care Inc-Eden Park
Suspended
Cincinnati
Oncology Hematology Care Inc-Kenwood
Recruiting
Cincinnati
Oncology Hematology Care Inc-Mercy West
Suspended
Cincinnati
University of Cincinnati Cancer Center-UC Medical Center
Recruiting
Cincinnati
Case Western Reserve University
Recruiting
Cleveland
MetroHealth Medical Center
Recruiting
Cleveland
Columbus Oncology and Hematology Associates Inc
Recruiting
Columbus
Doctors Hospital
Recruiting
Columbus
Grant Medical Center
Recruiting
Columbus
Mount Carmel East Hospital
Recruiting
Columbus
Mount Carmel Health Center West
Recruiting
Columbus
Riverside Methodist Hospital
Recruiting
Columbus
The Mark H Zangmeister Center
Recruiting
Columbus
Dayton Physician LLC-Miami Valley Hospital North
Recruiting
Dayton
Good Samaritan Hospital - Dayton
Suspended
Dayton
Miami Valley Hospital
Recruiting
Dayton
Miami Valley Hospital North
Recruiting
Dayton
Delaware Health Center-Grady Cancer Center
Recruiting
Delaware
Grady Memorial Hospital
Recruiting
Delaware
Columbus Oncology and Hematology Associates
Recruiting
Dublin
Oncology Hematology Care Inc-Healthplex
Suspended
Fairfield
Armes Family Cancer Center
Recruiting
Findlay
Blanchard Valley Hospital
Recruiting
Findlay
Orion Cancer Care
Recruiting
Findlay
Atrium Medical Center-Middletown Regional Hospital
Recruiting
Franklin
Dayton Physicians LLC-Atrium
Recruiting
Franklin
Dayton Physicians LLC-Wayne
Recruiting
Greenville
Wayne Hospital
Recruiting
Greenville
Mount Carmel Grove City Hospital
Recruiting
Grove City
Greater Dayton Cancer Center
Recruiting
Kettering
Kettering Medical Center
Recruiting
Kettering
Fairfield Medical Center
Recruiting
Lancaster
Saint Rita's Medical Center
Recruiting
Lima
OhioHealth Mansfield Hospital
Recruiting
Mansfield
Marietta Memorial Hospital
Recruiting
Marietta
OhioHealth Marion General Hospital
Recruiting
Marion
Toledo Clinic Cancer Centers-Maumee
Active, not recruiting
Maumee
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Active, not recruiting
Maumee
UH Seidman Cancer Center at Lake Health Mentor Campus
Recruiting
Mentor
Dayton Physicians LLC-Signal Point
Active, not recruiting
Middletown
Knox Community Hospital
Recruiting
Mount Vernon
Licking Memorial Hospital
Recruiting
Newark
Newark Radiation Oncology
Recruiting
Newark
Saint Charles Hospital
Active, not recruiting
Oregon
Mercy Health Perrysburg Cancer Center
Recruiting
Perrysburg
Southern Ohio Medical Center
Recruiting
Portsmouth
UH Seidman Cancer Center at Firelands Regional Medical Center
Recruiting
Sandusky
Dayton Physicians LLC-Wilson
Active, not recruiting
Sidney
Springfield Regional Cancer Center
Recruiting
Springfield
Springfield Regional Medical Center
Recruiting
Springfield
ProMedica Flower Hospital
Active, not recruiting
Sylvania
Mercy Health - Saint Anne Hospital
Suspended
Toledo
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Active, not recruiting
Toledo
Saint Vincent Mercy Medical Center
Recruiting
Toledo
Toledo Clinic Cancer Centers-Toledo
Active, not recruiting
Toledo
Dayton Physicians LLC-Upper Valley
Recruiting
Troy
Upper Valley Medical Center
Recruiting
Troy
Saint Joseph Warren Hospital
Recruiting
Warren
University of Cincinnati Cancer Center-West Chester
Recruiting
West Chester
Saint Ann's Hospital
Recruiting
Westerville