Safety, Biodistribution and Radiation Dosimetry of [18F]PARPi
The purpose of this study is to test the safety of a study drug called PARPi-FL. This drug has been tested in animals but not yet in people. The purpose of this study is to test if a PARPi-FL scan can be used to take pictures of head and neck cancer. The usual approach to imaging this cancer includes several different imaging scans, including x-rays, CT (computed tomography), MRI (magnetic resonance imaging), and PET (positron emission tomography). These tests take pictures of the cancer.
• Age ≥18 years
• ECOG performance status 0 or 1
• Biopsy (histologically or cytologically) proven Squamos Cell Carcinoma
• Oral cavity, oropharynx, or nasopharynx primary site
• At least one tumor lesion on standard of care imaging with a minimum diameter of at least 1.5 cm
• Scheduled to undergo treatment at MSKCC
• Willingness to sign informed consent