Determining the Optimal Treatment Strategy for Patients Who Have Chronic Migraine With Medication Overuse

Status: Completed
Location: See all (29) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

There are two commonly used treatment strategies for treating patients who have chronic migraine with medication overuse. This study will compare the outcomes amongst patients randomized to one of the two treatment strategies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Healthy Volunteers: No
View:

• Adults, at least 21 years of age

• Chronic Migraine - diagnosed according to ICHD3beta criteria

• Medication Overuse - diagnosed according to ICHD3beta criteria

• Willingness to be randomized to either of the two treatment arms

• Willingness to maintain a headache diary

• Plan for follow-up care with the clinician

• No changes to migraine prophylactic therapy within the 4 weeks prior to randomization.

Locations
United States
Arizona
Northern Arizona Healthcare Medical Group
Flagstaff
Mayo Clinic in Arizona Headache Center
Phoenix
Mayo Clinic in Arizona Neurology Center
Phoenix
Honor Health Neurology
Scottsdale
Mayo Clinic Thunderbird
Scottsdale
California
Keck Medical Center of USC
Los Angeles
Colorado
University of Colorado Denver Headache Center
Aurora
University of Colorado Denver Primary Center
Denver
Blue Sky Neurology
Greenwood Village
Florida
Memorial Healthcare
Hollywood
University of Miami Miller School of Medicine
Miami
Kentucky
Norton Neurology
Louisville
Massachusetts
Brigham Women's Hospital Headache Clinic
Boston
Brigham Women's Hospital Neurology Clinic
Boston
Michigan
Henry Ford Allegiance Health
Jackson
Minnesota
Mayo Clinic Headache Center
Rochester
Missouri
Clinvest Research
Springfield
Mississippi
The Headache Center
Ridgeland
Ohio
University of Cincinnati Neurology
Cincinnati
Cleveland Clinic
Cleveland
University of Cincinnati Headache Center
Dayton
Toledo Clinic Adult Neurology
Toledo
Pennsylvania
Thomas Jefferson University Hospital Headache Center
Philadelphia
Preferred Headache Center
Pittsburgh
Utah
University of Utah General Neurology
Salt Lake City
University of Utah Headache Center
Salt Lake City
University of Utah Primary Care
Salt Lake City
Washington
University of Washington
Seattle
West Virginia
West Virginia University Neurology
Morgantown
Time Frame
Start Date: January 9, 2017
Completion Date: March 31, 2021
Participants
Target number of participants: 720
Treatments
Active Comparator: Discontinuation
Migraine prophylactic therapy will be initiated or optimized with the immediate discontinuation of the overused medication(s)
Active Comparator: Preventive Therapy Only
Migraine prophylactic therapy will be initiated or optimized without the early discontinuation of the overused medication(s)
Related Therapeutic Areas
Sponsors
Leads: Mayo Clinic
Collaborators: Patient-Centered Outcomes Research Institute

This content was sourced from clinicaltrials.gov

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