Proton Radiation for Low Grade Gliomas

Status: Completed
Location: See location...
Intervention Type: Other, Radiation, Procedure
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY

RATIONALE: Specialized radiation therapy, such as proton beam radiation therapy, that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase I/II trial is studying the best way to give proton beam radiation therapy and to see how well it works in treating patients with low grade gliomas.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Patients with histologically confirmed diagnosis of low grade glioma of the CNS

• Patients with WHO grade II; may be symptomatic; including patients who are being followed and have radiographic expression

• Patients must have a Karnofsky Performance Status of >= 60

• Patients must be able to provide informed consent

• Patients must have adequate bone marrow function:

• WBC >= 4000/mm^3

• platelets >= 100,000 mm^3

• Women of child-bearing potential as long as she agrees to use a recognized method of birth control (e.g. oral contraceptive, IUD, condoms or other barrier methods etc); Hysterectomy or menopause must be clinically documented

Locations
United States
Pennsylvania
Abramson Cancer Center of The University of Pennsylvania
Philadelphia
Time Frame
Start Date: December 17, 2009
Completion Date: February 2014
Participants
Target number of participants: 23
Treatments
Experimental: Arm I
Patients undergo proton beam radiation therapy for 6 weeks in the absence of disease progression or unacceptable toxicity.
Sponsors
Leads: Abramson Cancer Center of the University of Pennsylvania

This content was sourced from clinicaltrials.gov

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