Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors

Status: Recruiting
Location: See all (11) locations...
Study Type: Observational [Patient Registry]
SUMMARY

First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). Second, the investigators plan to co-register patients to institutional banks in order to prospectively collect MPNST samples for analysis. These patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: No
View:

• Any patient diagnosed with an MPNST is eligible for enrollment to this registry provided s/he consents to participate (or consent form his/her parent or legal guardian is obtained).

Locations
United States
Florida
Moffitt Cancer Center
Recruiting
Tampa
Massachusetts
Dana Farber Cancer Institute
Recruiting
Boston
Maryland
Johns Hopkins
Recruiting
Baltimore
National Institutes of Health (NIH)
Not yet recruiting
Bethesda
Minnesota
University of Minnesota
Withdrawn
Minneapolis
Missouri
Washington University School of Medicine
Recruiting
Saint Louis
New York
Memorial Sloan Kettering Cancer Center
Not yet recruiting
New York
Rhode Island
Lifespan
Recruiting
Providence
Other Locations
Canada
Mount Sinai
Recruiting
Toronto
India
Global Gene Corporation
Recruiting
Mumbai
United Kingdom
Royal National Orthopedic Hospital
Recruiting
London
Contact Information
Primary
Angela Hirbe, M.D., Ph.D.
hirbea@wustl.edu
(314) 362-8965
Time Frame
Start Date: April 28, 2017
Estimated Completion Date: April 28, 2027
Participants
Target number of participants: 2000
Authors
David Gutmann, Sonika Dahiya, Peter Oppelt, Christine Pratilas, Angela Hirbe, Jesse Hart, David Miller, Ping Chi, Brian Van Tine, Joanne McDonald, Neeta Sarkar Roy, Xia Wang, Jay Wunder, Jack F Shern, Christopher Moertel
Sponsors
Collaborators: Boston's Children Hospital
Leads: Washington University School of Medicine

This content was sourced from clinicaltrials.gov

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