A Randomized Phase III Study of the Addition of Venetoclax to Ibrutinib and Obinutuzumab Versus Ibrutinib and Obinutuzumab in Untreated Younger Patients With Chronic Lymphocytic Leukemia (CLL)

Who is this study for? Adult patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: Active, not recruiting
Location: See all (874) locations...
Intervention Type: Other, Procedure, Drug, Biological
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This phase III trial studies how well ibrutinib and obinutuzumab with or without venetoclax work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Obinutuzumab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Giving ibrutinib, obinutuzumab, and venetoclax may work better than giving ibrutinib and obinutuzumab in treating patients with chronic lymphocytic leukemia.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 69
Healthy Volunteers: No
View:

• Diagnosis of CLL according to the National Cancer Institute (NCI)/International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria or small lymphocytic lymphoma (SLL) according to the World Health Organization (WHO) criteria. This includes previous documentation of:

• Biopsy-proven small lymphocytic lymphoma OR

• Diagnosis of CLL according to the NCI/IWCLL criteria as evidenced by all of the following:

• Peripheral blood lymphocyte count of greater than 5 x10^9/L

• Immunophenotype consistent with CLL defined as:

• The predominant population of lymphocytes share both B-cell antigens (CD19, CD20 [typically dim expression], or CD23) as well as CD5 in the absence of other pan-T-cell markers (CD3, CD2, etc).

• Clonality as evidenced by kappa or lambda light chain restriction (typically dim immunoglobulin expression)

• Negative fluorescent in situ hybridization (FISH) analysis for t(11;14)(IgH/CCND1) on peripheral blood or tissue biopsy (e.g. marrow aspirate) or negative immunohistochemical stains for cyclin D1 staining on involved tissue biopsy (e.g. marrow aspirate or lymph node biopsy)

• No prior chemotherapy, BTK inhibitor therapy, venetoclax, small molecule signaling inhibitor, or monoclonal anti-body therapy for treatment of CLL or SLL

• Has met at least one of the following indications for treatment:

• Evidence of progressive marrow failure as manifested by the development of worsening anemia (hemoglobin [Hg] < 11 g/dl) and/or thrombocytopenia (platelets < 100 x 10^9/L)

• Symptomatic or progressive lymphadenopathy, splenomegaly, or hepatomegaly

• One or more of the following disease-related symptoms:

• Weight loss >= 10% within the previous 6 months

• Grade 2 or 3 fatigue attributed to CLL

• Fevers > 100.5 degree Fahrenheit (F) for 2 weeks without evidence of infection

• Clinically significant night sweats without evidence of infection

• Progressive lymphocytosis (not due to the effects of corticosteroids) with an increase of > 50% over a two-month period or an anticipated doubling time of less than six months

• Eastern Cooperative Oncology Group (ECOG) performance status between 0-2

• Life expectancy of >= 12 months

• No deletion of 17p13 on cytogenetic analysis by FISH

• Glomerular filtration rate (GFR) > 40 mL/minute as calculated by the Cockcroft-Gault Formula (obtained =< 14 days prior to registration)

• Total bilirubin =< 1.5 x upper limit of normal (ULN) unless due to Gilbert's disease. For those with a total bilirubin > 1.5 x ULN, a direct bilirubin should be performed and must be < 1.5 mg/dL for Gilbert's to be diagnosed (obtained =< 14 days prior to registration)

• Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST])/serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 3.0 x the institutional ULN (obtained =< 14 days prior to registration)

• NOTE: If value is higher due to hepatic involvement by CLL, patient is eligible

• Prothrombin time (PT)/international normalized ratio (INR) < 1.5 ULN and partial thromboplastin time (PTT) (activated partial thromboplastin time [aPTT]) < 1.5 x ULN (obtained =< 14 days prior to registration)

• No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment. Patients who have a positive Coombs test but no evidence of hemolysis are NOT excluded from participation

• No current use of corticosteroids. EXCEPTION: Low doses of steroids (< 10 mg of prednisone or equivalent dose of other steroid; inhaled steroids) used for treatment of non-hematologic medical condition (e.g. chronic adrenal insufficiency) is permitted

• No previous autoimmune complications (e.g. autoimmune hemolytic anemia or immune thrombocytopenia) that have developed since the initial diagnosis of CLL and have required treatment with high dose corticosteroids (e.g. equivalent of > 20 mg/day of prednisone), monoclonal antibody based therapy, or chemotherapy. Prior use of corticosteroids for reasons other than treatment of autoimmune complications is allowed

• No other active primary malignancy (other than non-melanomatous skin cancer or carcinoma in situ of the cervix) requiring treatment or limiting expected survival to =< 2 years

• NOTE: If there is a history of prior malignancy, the patient must not currently be receiving other specific treatment (other than hormonal therapy for their cancer)

• Able to adhere to the study visit schedule and other protocol requirements

• No major surgery within 4 weeks (28 days) of first dose of study drug or minor surgery within 3 days of first dose of study drug

• No radiation therapy =< 4 weeks prior to registration to Step 1

• Patients who are human immunodeficiency virus positive (HIV+) with undetectable HIV viral load are eligible provided they meet all other protocol criteria for participation and are not being treated with protease inhibitors or any non-nucleoside reverse transcriptase inhibitors (NNRTI) that are CYP3A4 inducers; if being treated for HIV, patients should be receiving an alternative antiretroviral therapy (ART) that is not a CYP3A inhibitor

• Women of childbearing potential and sexually active males must be strongly advised to use accepted and highly effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for:

• 18 months after the last dose of obinutuzumab

• 90 days after the last dose of ibrutinib, and

• 30 days after the last dose of venetoclax Male subjects must also agree to refrain from sperm donation until 90 days after the last dose of protocol treatment

• Patient must be able to swallow capsules and not have the following conditions:

• Disease significantly affecting gastrointestinal function

• Resection of the stomach or small bowel

• Symptomatic inflammatory bowel disease

• Ulcerative colitis

• Partial or complete bowel obstruction

• Patient must undergo assessment with Timed Up and Go (TUG) test and comorbidity index

• Patient must be able to receive xanthine oxidase inhibitor or rasburicase for tumor lysis syndrome (TLS) prophylaxis

Locations
United States
Alaska
Alaska Breast Care and Surgery LLC
Anchorage
Alaska Oncology and Hematology LLC
Anchorage
Alaska Women's Cancer Care
Anchorage
Anchorage Associates in Radiation Medicine
Anchorage
Anchorage Oncology Centre
Anchorage
Anchorage Radiation Therapy Center
Anchorage
Katmai Oncology Group
Anchorage
Providence Alaska Medical Center
Anchorage
Fairbanks Memorial Hospital
Fairbanks
Alabama
University of Alabama at Birmingham Cancer Center
Birmingham
Arkansas
Mercy Hospital Fort Smith
Fort Smith
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs
Arizona
Kingman Regional Medical Center
Kingman
Cancer Center at Saint Joseph's
Phoenix
Mayo Clinic Hospital in Arizona
Phoenix
Mayo Clinic in Arizona
Scottsdale
Banner University Medical Center - Tucson
Tucson
University of Arizona Cancer Center-North Campus
Tucson
University of Arizona Cancer Center-Orange Grove Campus
Tucson
California
Kaiser Permanente-Anaheim
Anaheim
Kaiser Permanente-Deer Valley Medical Center
Antioch
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande
PCR Oncology
Arroyo Grande
Kaiser Permanente-Baldwin Park
Baldwin Park
Kaiser Permanente-Bellflower
Bellflower
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank
UC Irvine Health Cancer Center-Newport
Costa Mesa
City of Hope Comprehensive Cancer Center
Duarte
Kaiser Permanente Dublin
Dublin
Kaiser Permanente-Fontana
Fontana
Kaiser Permanente-Fremont
Fremont
Fresno Cancer Center
Fresno
Kaiser Permanente-Fresno
Fresno
Kaiser Permanente - Harbor City
Harbor City
Kaiser Permanente-Irvine
Irvine
Tibor Rubin VA Medical Center
Long Beach
Kaiser Permanente Los Angeles Medical Center
Los Angeles
Kaiser Permanente West Los Angeles
Los Angeles
Kaiser Permanente-Modesto
Modesto
Kaiser Permanente Oakland-Broadway
Oakland
Kaiser Permanente-Oakland
Oakland
Kaiser Permanente-Ontario
Ontario
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange
Desert Regional Medical Center
Palm Springs
Stanford Cancer Institute Palo Alto
Palo Alto
VA Palo Alto Health Care System
Palo Alto
Kaiser Permanente - Panorama City
Panorama City
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova
Kaiser Permanente-Redwood City
Redwood City
Kaiser Permanente-Richmond
Richmond
Kaiser Permanente-Riverside
Riverside
Rohnert Park Cancer Center
Rohnert Park
Kaiser Permanente-Roseville
Roseville
The Permanente Medical Group-Roseville Radiation Oncology
Roseville
Kaiser Permanente - Sacramento
Sacramento
Kaiser Permanente Downtown Commons
Sacramento
Kaiser Permanente-South Sacramento
Sacramento
South Sacramento Cancer Center
Sacramento
Kaiser Permanente-San Diego Mission
San Diego
Kaiser Permanente-San Diego Zion
San Diego
Kaiser Permanente-San Francisco
San Francisco
Kaiser Permanente-Santa Teresa-San Jose
San Jose
Kaiser Permanente San Leandro
San Leandro
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo
Kaiser Permanente-San Marcos
San Marcos
Kaiser Permanente-San Rafael
San Rafael
Kaiser San Rafael-Gallinas
San Rafael
Kaiser Permanente Medical Center - Santa Clara
Santa Clara
Mission Hope Medical Oncology - Santa Maria
Santa Maria
Kaiser Permanente-Santa Rosa
Santa Rosa
Kaiser Permanente Cancer Treatment Center
South San Francisco
Kaiser Permanente-South San Francisco
South San Francisco
Kaiser Permanente-Stockton
Stockton
Kaiser Permanente Medical Center-Vacaville
Vacaville
Kaiser Permanente-Vallejo
Vallejo
Kaiser Permanente-Walnut Creek
Walnut Creek
Kaiser Permanente-Woodland Hills
Woodland Hills
Colorado
Rocky Mountain Cancer Centers-Aurora
Aurora
Rocky Mountain Regional VA Medical Center
Aurora
The Medical Center of Aurora
Aurora
Boulder Community Foothills Hospital
Boulder
Boulder Community Hospital
Boulder
Rocky Mountain Cancer Centers-Boulder
Boulder
Rocky Mountain Cancer Centers - Centennial
Centennial
Penrose-Saint Francis Healthcare
Colorado Springs
Rocky Mountain Cancer Centers-Penrose
Colorado Springs
Cancer Center of Colorado at Sloan's Lake
Denver
Colorado Blood Cancer Institute
Denver
Denver Health Medical Center
Denver
Kaiser Permanente-Franklin
Denver
National Jewish Health-Main Campus
Denver
Porter Adventist Hospital
Denver
Presbyterian - Saint Lukes Medical Center - Health One
Denver
Rocky Mountain Cancer Centers-Midtown
Denver
Rocky Mountain Cancer Centers-Rose
Denver
Rose Medical Center
Denver
SCL Health Saint Joseph Hospital
Denver
The Women's Imaging Center
Denver
Western Surgical Care
Denver
Mercy Medical Center
Durango
Southwest Oncology PC
Durango
Mountain Blue Cancer Care Center - Swedish
Englewood
Swedish Medical Center
Englewood
Mountain Blue Cancer Care Center
Golden
National Jewish Health-Western Hematology Oncology
Golden
Grand Valley Oncology
Grand Junction
Saint Mary's Hospital and Regional Medical Center
Grand Junction
North Colorado Medical Center
Greeley
Good Samaritan Medical Center
Lafayette
Kaiser Permanente-Rock Creek
Lafayette
Rocky Mountain Cancer Centers-Lakewood
Lakewood
Saint Anthony Hospital
Lakewood
Littleton Adventist Hospital
Littleton
Rocky Mountain Cancer Centers-Littleton
Littleton
Kaiser Permanente-Lone Tree
Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree
Sky Ridge Medical Center
Lone Tree
Longmont United Hospital
Longmont
Rocky Mountain Cancer Centers-Longmont
Longmont
McKee Medical Center
Loveland
Parker Adventist Hospital
Parker
Rocky Mountain Cancer Centers-Parker
Parker
Rocky Mountain Cancer Centers - Pueblo
Pueblo
Saint Mary Corwin Medical Center
Pueblo
National Jewish Health-Northern Hematology Oncology
Thornton
Rocky Mountain Cancer Centers-Thornton
Thornton
SCL Health Lutheran Medical Center
Wheat Ridge
Connecticut
Smilow Cancer Hospital-Derby Care Center
Derby
Smilow Cancer Hospital Care Center-Fairfield
Fairfield
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury
Smilow Cancer Hospital Care Center - Guiford
Guilford
Smilow Cancer Hospital Care Center at Saint Francis
Hartford
Yale University
New Haven
Yale-New Haven Hospital North Haven Medical Center
North Haven
Smilow Cancer Hospital-Orange Care Center
Orange
Smilow Cancer Hospital Care Center-Trumbull
Trumbull
Smilow Cancer Hospital-Waterbury Care Center
Waterbury
Smilow Cancer Hospital Care Center - Waterford
Waterford
Veterans Affairs Connecticut Healthcare System-West Haven Campus
West Haven
Delaware
Beebe South Coastal Health Campus
Frankford
Beebe Medical Center
Lewes
Christiana Care Health System-Christiana Hospital
Newark
Delaware Clinical and Laboratory Physicians PA
Newark
Helen F Graham Cancer Center
Newark
Medical Oncology Hematology Consultants PA
Newark
Beebe Health Campus
Rehoboth Beach
TidalHealth Nanticoke / Allen Cancer Center
Seaford
Christiana Care Health System-Wilmington Hospital
Wilmington
Florida
Broward Health Medical Center
Fort Lauderdale
Holy Cross Hospital
Fort Lauderdale
Mayo Clinic in Florida
Jacksonville
Georgia
University Cancer and Blood Center LLC
Athens
Emory Saint Joseph's Hospital
Atlanta
Emory University Hospital Midtown
Atlanta
Emory University Hospital/Winship Cancer Institute
Atlanta
Augusta University Medical Center
Augusta
Atlanta VA Medical Center
Decatur
Hawaii
Hawaii Cancer Care - Savio
'aiea
Pali Momi Medical Center
'aiea
Queen's Cancer Center - Pearlridge
'aiea
The Cancer Center of Hawaii-Pali Momi
'aiea
Island Urology-Hilo
Hilo
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu
Hawaii Cancer Care Inc-Liliha
Honolulu
Island Urology
Honolulu
Kaiser Permanente Moanalua Medical Center
Honolulu
Kapiolani Medical Center for Women and Children
Honolulu
Kuakini Medical Center
Honolulu
Queen's Cancer Cenrer - POB I
Honolulu
Queen's Cancer Center - Kuakini
Honolulu
Queen's Medical Center
Honolulu
Straub Clinic and Hospital
Honolulu
The Cancer Center of Hawaii-Liliha
Honolulu
University of Hawaii Cancer Center
Honolulu
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue
Iowa
Mary Greeley Medical Center
Ames
McFarland Clinic PC - Ames
Ames
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf
McFarland Clinic PC-Boone
Boone
Mercy Hospital
Cedar Rapids
Oncology Associates at Mercy Medical Center
Cedar Rapids
Physicians' Clinic of Iowa PC
Cedar Rapids
Medical Oncology and Hematology Associates-West Des Moines
Clive
Mercy Cancer Center-West Lakes
Clive
Alegent Health Mercy Hospital
Council Bluffs
Greater Regional Medical Center
Creston
Blank Children's Hospital
Des Moines
Broadlawns Medical Center
Des Moines
Iowa Lutheran Hospital
Des Moines
Iowa Methodist Medical Center
Des Moines
Medical Oncology and Hematology Associates-Des Moines
Des Moines
Mercy Medical Center - Des Moines
Des Moines
Mission Cancer and Blood - Laurel
Des Moines
McFarland Clinic PC-Trinity Cancer Center
Fort Dodge
Trinity Regional Medical Center
Fort Dodge
University of Iowa/Holden Comprehensive Cancer Center
Iowa City
McFarland Clinic PC-Jefferson
Jefferson
McFarland Clinic PC-Marshalltown
Marshalltown
Siouxland Regional Cancer Center
Sioux City
MercyOne Waterloo Cancer Center
Waterloo
Mercy Medical Center-West Lakes
West Des Moines
Methodist West Hospital
West Des Moines
Idaho
Saint Alphonsus Cancer Care Center-Boise
Boise
Saint Luke's Cancer Institute - Boise
Boise
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell
Kootenai Health - Coeur d'Alene
Coeur D'alene
Walter Knox Memorial Hospital
Emmett
Saint Luke's Cancer Institute - Fruitland
Fruitland
Idaho Urologic Institute-Meridian
Meridian
Saint Luke's Cancer Institute - Meridian
Meridian
Saint Alphonsus Medical Center-Nampa
Nampa
Saint Luke's Cancer Institute - Nampa
Nampa
Kootenai Clinic Cancer Services - Post Falls
Post Falls
Kootenai Cancer Clinic
Sandpoint
Saint Luke's Cancer Institute - Twin Falls
Twin Falls
Illinois
Rush - Copley Medical Center
Aurora
Illinois CancerCare-Bloomington
Bloomington
Loyola Center for Health at Burr Ridge
Burr Ridge
Illinois CancerCare-Canton
Canton
Memorial Hospital of Carbondale
Carbondale
SIH Cancer Institute
Carterville
Illinois CancerCare-Carthage
Carthage
Centralia Oncology Clinic
Centralia
Northwestern University
Chicago
Rush University Medical Center
Chicago
University of Chicago Comprehensive Cancer Center
Chicago
Carle on Vermilion
Danville
Cancer Care Specialists of Illinois - Decatur
Decatur
Decatur Memorial Hospital
Decatur
Northwestern Medicine Cancer Center Kishwaukee
Dekalb
Illinois CancerCare-Dixon
Dixon
Carle Physician Group-Effingham
Effingham
Crossroads Cancer Center
Effingham
Illinois CancerCare-Eureka
Eureka
NorthShore University HealthSystem-Evanston Hospital
Evanston
Illinois CancerCare-Galesburg
Galesburg
Western Illinois Cancer Treatment Center
Galesburg
Northwestern Medicine Cancer Center Delnor
Geneva
NorthShore University HealthSystem-Glenbrook Hospital
Glenview
Ingalls Memorial Hospital
Harvey
NorthShore University HealthSystem-Highland Park Hospital
Highland Park
Loyola Medicine Homer Glen
Homer Glen
Illinois CancerCare-Kewanee Clinic
Kewanee
Northwestern Medicine Lake Forest Hospital
Lake Forest
Illinois CancerCare-Macomb
Macomb
Carle Physician Group-Mattoon/Charleston
Mattoon
Loyola University Medical Center
Maywood
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park
Good Samaritan Regional Health Center
Mount Vernon
UC Comprehensive Cancer Center at Silver Cross
New Lenox
Cancer Care Center of O'Fallon
O'fallon
University of Chicago Medicine-Orland Park
Orland Park
Illinois CancerCare-Ottawa Clinic
Ottawa
Illinois CancerCare-Pekin
Pekin
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin
Illinois CancerCare-Peoria
Peoria
Methodist Medical Center of Illinois
Peoria
OSF Saint Francis Medical Center
Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria
Illinois CancerCare-Peru
Peru
Valley Radiation Oncology
Peru
Illinois CancerCare-Princeton
Princeton
SwedishAmerican Regional Cancer Center/ACT
Rockford
North Shore Medical Center
Skokie
Memorial Medical Center
Springfield
Southern Illinois University School of Medicine
Springfield
Springfield Clinic
Springfield
Southwest Illinois Health Services LLP
Swansea
Carle Cancer Center
Urbana
The Carle Foundation Hospital
Urbana
Northwestern Medicine Cancer Center Warrenville
Warrenville
Rush-Copley Healthcare Center
Yorkville
Indiana
Parkview Regional Medical Center
Fort Wayne
Community Cancer Center East
Indianapolis
Community Cancer Center North
Indianapolis
Community Cancer Center South
Indianapolis
Franciscan Health Indianapolis
Indianapolis
Community Howard Regional Health
Kokomo
Franciscan Health Mooresville
Mooresville
Reid Health
Richmond
Union Hospital
Terre Haute
Kansas
Coffeyville Regional Medical Center
Coffeyville
Central Care Cancer Center - Garden City
Garden City
Central Care Cancer Center - Great Bend
Great Bend
HaysMed University of Kansas Health System
Hays
Cancer Center of Kansas-Independence
Independence
University of Kansas Cancer Center
Kansas City
University of Kansas Cancer Center-West
Kansas City
Lawrence Memorial Hospital
Lawrence
Olathe Health Cancer Center
Olathe
University of Kansas Cancer Center-Overland Park
Overland Park
Ascension Via Christi - Pittsburg
Pittsburg
Salina Regional Health Center
Salina
University of Kansas Health System Saint Francis Campus
Topeka
University of Kansas Hospital-Westwood Cancer Center
Westwood
Ascension Via Christi Hospitals Wichita
Wichita
Cancer Center of Kansas - Wichita
Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita
Wesley Medical Center
Wichita
Kentucky
Flaget Memorial Hospital
Bardstown
Commonwealth Cancer Center-Corbin
Corbin
Saint Joseph Hospital East
Lexington
Saint Joseph Radiation Oncology Resource Center
Lexington
Saint Joseph London
London
Jewish Hospital
Louisville
Saints Mary and Elizabeth Hospital
Louisville
UofL Health Medical Center Northeast
Louisville
Jewish Hospital Medical Center South
Shepherdsville
Louisiana
Medical Center of Baton Rouge
Baton Rouge
Ochsner High Grove
Baton Rouge
Ochsner Medical Center Jefferson
New Orleans
Massachusetts
Tufts Medical Center
Boston
Lahey Hospital and Medical Center
Burlington
Lowell General Hospital
Lowell
Mercy Medical Center
Springfield
Maryland
UPMC Western Maryland
Cumberland
Maine
Harold Alfond Center for Cancer Care
Augusta
Waldo County General Hospital
Belfast
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Biddeford
Stephens Memorial Hospital
Norway
Penobscot Bay Medical Center
Rockport
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Sanford
Maine Medical Partners - South Portland
South Portland
Michigan
Hickman Cancer Center
Adrian
Saint Joseph Mercy Hospital
Ann Arbor
Saint Joseph Mercy Brighton
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton
Henry Ford Cancer Institute-Downriver
Brownstown
Saint Joseph Mercy Canton
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton
Caro Cancer Center
Caro
Saint Joseph Mercy Chelsea
Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea
Hematology Oncology Consultants-Clarkston
Clarkston
Newland Medical Associates-Clarkston
Clarkston
Henry Ford Macomb Hospital-Clinton Township
Clinton Township
Beaumont Hospital - Dearborn
Dearborn
Henry Ford Medical Center-Fairlane
Dearborn
Ascension Saint John Hospital
Detroit
Henry Ford Hospital
Detroit
Wayne State University/Karmanos Cancer Institute
Detroit
Great Lakes Cancer Management Specialists-Doctors Park
East China Township
Green Bay Oncology - Escanaba
Escanaba
Beaumont Hospital - Farmington Hills
Farmington Hills
Weisberg Cancer Treatment Center
Farmington Hills
Genesee Cancer and Blood Disease Treatment Center
Flint
Genesee Hematology Oncology PC
Flint
Genesys Hurley Cancer Institute
Flint
Hurley Medical Center
Flint
Academic Hematology Oncology Specialists
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods
Michigan Breast Specialists-Grosse Pointe Woods
Grosse Pointe Woods
Allegiance Health
Jackson
Sparrow Hospital
Lansing
Hope Cancer Clinic
Livonia
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb
Michigan Breast Specialists-Macomb Township
Macomb
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette
Toledo Clinic Cancer Centers-Monroe
Monroe
Henry Ford Medical Center-Columbus
Novi
21st Century Oncology-Pontiac
Pontiac
Hope Cancer Center
Pontiac
Newland Medical Associates-Pontiac
Pontiac
Saint Joseph Mercy Oakland
Pontiac
Huron Medical Center PC
Port Huron
Lake Huron Medical Center
Port Huron
Great Lakes Cancer Management Specialists-Rochester Hills
Rochester Hills
Cancer Care Associates PC
Royal Oak
Comprehensive Medical Center PLLC
Royal Oak
Hematology Oncology Consultants PC
Royal Oak
Oakland Colon Rectal Associates
Royal Oak
Oakland Medical Group
Royal Oak
William Beaumont Hospital-Royal Oak
Royal Oak
Ascension Saint Mary's Hospital
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Saginaw
Henry Ford Macomb Health Center - Shelby Township
Shelby
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights
Premier Hematology Oncology Care
Sterling Heights
Ascension Saint Joseph Hospital
Tawas City
Hematology Oncology Consultants PC-Troy
Troy
Michigan Institute of Urology-Town Center
Troy
William Beaumont Hospital - Troy
Troy
Advanced Breast Care Center PLLC
Warren
Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren
Macomb Hematology Oncology PC
Warren
Michigan Breast Specialists-Warren
Warren
Saint John Macomb-Oakland Hospital
Warren
Henry Ford West Bloomfield Hospital
West Bloomfield
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch
Huron Gastroenterology PC
Ypsilanti
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti
Minnesota
Riverwood Healthcare Center
Aitkin
Sanford Joe Lueken Cancer Center
Bemidji
Essentia Health Saint Joseph's Medical Center
Brainerd
Fairview Ridges Hospital
Burnsville
Minnesota Oncology - Burnsville
Burnsville
Cambridge Medical Center
Cambridge
Mercy Hospital
Coon Rapids
Essentia Health - Deer River Clinic
Deer River
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes
Essentia Health Cancer Center
Duluth
Essentia Health Saint Mary's Medical Center
Duluth
Miller-Dwan Hospital
Duluth
Fairview Southdale Hospital
Edina
Lake Region Healthcare Corporation-Cancer Care
Fergus Falls
Essentia Health - Fosston
Fosston
Unity Hospital
Fridley
Essentia Health Hibbing Clinic
Hibbing
Mayo Clinic Health Systems-Mankato
Mankato
Fairview Clinics and Surgery Center Maple Grove
Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Maplewood
Saint John's Hospital - Healtheast
Maplewood
Abbott-Northwestern Hospital
Minneapolis
Health Partners Inc
Minneapolis
Hennepin County Medical Center
Minneapolis
Minneapolis VA Medical Center
Minneapolis
Monticello Cancer Center
Monticello
New Ulm Medical Center
New Ulm
Essentia Health - Park Rapids
Park Rapids
Fairview Northland Medical Center
Princeton
North Memorial Medical Health Center
Robbinsdale
Mayo Clinic in Rochester
Rochester
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park
Regions Hospital
Saint Paul
United Hospital
Saint Paul
Essentia Health Sandstone
Sandstone
Saint Francis Regional Medical Center
Shakopee
Lakeview Hospital
Stillwater
Sanford Thief River Falls Medical Center
Thief River Falls
Essentia Health Virginia Clinic
Virginia
Ridgeview Medical Center
Waconia
Rice Memorial Hospital
Willmar
Minnesota Oncology Hematology PA-Woodbury
Woodbury
Sanford Cancer Center Worthington
Worthington
Fairview Lakes Medical Center
Wyoming
Missouri
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin
Central Care Cancer Center - Bolivar
Bolivar
Parkland Health Center-Bonne Terre
Bonne Terre
Cox Cancer Center Branson
Branson
Saint Francis Medical Center
Cape Girardeau
Southeast Cancer Center
Cape Girardeau
Saint Luke's Hospital
Chesterfield
University of Missouri - Ellis Fischel
Columbia
Siteman Cancer Center at West County Hospital
Creve Coeur
Parkland Health Center - Farmington
Farmington
Capital Region Southwest Campus
Jefferson City
Freeman Health System
Joplin
Mercy Hospital Joplin
Joplin
The University of Kansas Cancer Center-South
Kansas City
Truman Medical Centers
Kansas City
University of Kansas Cancer Center - North
Kansas City
University of Kansas Cancer Center - Lee's Summit
Lee's Summit
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City
Delbert Day Cancer Institute at PCRMC
Rolla
Mercy Clinic-Rolla-Cancer and Hematology
Rolla
Heartland Regional Medical Center
Saint Joseph
Mercy Hospital Saint Louis
Saint Louis
Mercy Hospital South
Saint Louis
Missouri Baptist Medical Center
Saint Louis
Saint Louis Cancer and Breast Institute-South City
Saint Louis
Siteman Cancer Center at Christian Hospital
Saint Louis
Siteman Cancer Center-South County
Saint Louis
Washington University School of Medicine
Saint Louis
Siteman Cancer Center at Saint Peters Hospital
Saint Peters
Sainte Genevieve County Memorial Hospital
Sainte Genevieve
CoxHealth South Hospital
Springfield
Mercy Hospital Springfield
Springfield
Missouri Baptist Sullivan Hospital
Sullivan
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills
Mercy Hospital Washington
Washington
Mississippi
Forrest General Hospital / Cancer Center
Hattiesburg
Hattiesburg Clinic - Hematology/Oncology Clinic
Hattiesburg
Montana
Community Hospital of Anaconda
Anaconda
Billings Clinic Cancer Center
Billings
Saint Vincent Frontier Cancer Center
Billings
Saint Vincent Healthcare
Billings
Bozeman Deaconess Hospital
Bozeman
Saint James Community Hospital and Cancer Treatment Center
Butte
Benefis Healthcare- Sletten Cancer Institute
Great Falls
Great Falls Clinic
Great Falls
Saint Peter's Community Hospital
Helena
Kalispell Regional Medical Center
Kalispell
Community Medical Hospital
Missoula
Saint Patrick Hospital - Community Hospital
Missoula
North Carolina
Messino Cancer Centers
Asheville
Mission Hospital
Asheville
Waverly Hematology Oncology
Cary
UNC Lineberger Comprehensive Cancer Center
Chapel Hill
Southeastern Medical Oncology Center-Clinton
Clinton
Duke University Medical Center
Durham
Southeastern Medical Oncology Center-Goldsboro
Goldsboro
Wayne Memorial Hospital
Goldsboro
Margaret R Pardee Memorial Hospital
Hendersonville
Onslow Memorial Hospital
Jacksonville
Southeastern Medical Oncology Center-Jacksonville
Jacksonville
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst
North Dakota
Sanford Bismarck Medical Center
Bismarck
Essentia Health Cancer Center-South University Clinic
Fargo
Sanford Broadway Medical Center
Fargo
Sanford Medical Center Fargo
Fargo
Sanford Roger Maris Cancer Center
Fargo
Sanford South University Medical Center
Fargo
Essentia Health - Jamestown Clinic
Jamestown
Trinity Cancer Care Center
Minot
Nebraska
CHI Health Saint Francis
Grand Island
CHI Health Good Samaritan
Kearney
Heartland Hematology and Oncology
Kearney
Saint Elizabeth Regional Medical Center
Lincoln
Alegent Health Bergan Mercy Medical Center
Omaha
Alegent Health Immanuel Medical Center
Omaha
Alegent Health Lakeside Hospital
Omaha
Creighton University Medical Center
Omaha
Hematology and Oncology Consultants PC
Omaha
Midlands Community Hospital
Papillion
New Hampshire
New Hampshire Oncology Hematology PA-Concord
Concord
Elliot Hospital
Manchester
Solinsky Center for Cancer Care
Manchester
New Jersey
Ocean University Medical Center
Brick
Monmouth Medical Center Southern Campus
Lakewood
Monmouth Medical Center
Long Branch
Southern Ocean County Medical Center
Manahawkin
Morristown Medical Center
Morristown
Jersey Shore Medical Center
Neptune
Rutgers Cancer Institute of New Jersey
New Brunswick
Riverview Medical Center/Booker Cancer Center
Red Bank
Overlook Hospital
Summit
New Mexico
University of New Mexico Cancer Center
Albuquerque
Memorial Medical Center - Las Cruces
Las Cruces
Nevada
Carson Tahoe Regional Medical Center
Carson City
Cancer and Blood Specialists-Henderson
Henderson
Comprehensive Cancer Centers of Nevada - Henderson
Henderson
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson
GenesisCare USA - Henderson
Henderson
Las Vegas Cancer Center-Henderson
Henderson
Las Vegas Urology - Green Valley
Henderson
Las Vegas Urology - Pebble
Henderson
OptumCare Cancer Care at Seven Hills
Henderson
Urology Specialists of Nevada - Green Valley
Henderson
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas
Ann M Wierman MD LTD
Las Vegas
Cancer and Blood Specialists-Shadow
Las Vegas
Cancer and Blood Specialists-Tenaya
Las Vegas
Comprehensive Cancer Centers of Nevada
Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas
Desert West Surgery
Las Vegas
GenesisCare USA - Fort Apache
Las Vegas
GenesisCare USA - Las Vegas
Las Vegas
GenesisCare USA - Vegas Tenaya
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas
Hope Cancer Care of Nevada
Las Vegas
Las Vegas Cancer Center-Medical Center
Las Vegas
Las Vegas Prostate Cancer Center
Las Vegas
Las Vegas Urology - Cathedral Rock
Las Vegas
Las Vegas Urology - Pecos
Las Vegas
Las Vegas Urology - Smoke Ranch
Las Vegas
Las Vegas Urology - Sunset
Las Vegas
OptumCare Cancer Care at Charleston
Las Vegas
OptumCare Cancer Care at Fort Apache
Las Vegas
OptumCare Cancer Care at MountainView
Las Vegas
Radiation Oncology Centers of Nevada Central
Las Vegas
Radiation Oncology Centers of Nevada Southeast
Las Vegas
Summerlin Hospital Medical Center
Las Vegas
Sunrise Hospital and Medical Center
Las Vegas
University Cancer Center
Las Vegas
University Medical Center of Southern Nevada
Las Vegas
Urology Specialists of Nevada - Central
Las Vegas
Urology Specialists of Nevada - Northwest
Las Vegas
Urology Specialists of Nevada - Southwest
Las Vegas
Hope Cancer Care of Nevada-Pahrump
Pahrump
Radiation Oncology Associates
Reno
Renown Regional Medical Center
Reno
Saint Mary's Regional Medical Center
Reno
New York
Hematology Oncology Associates of Central New York-Auburn
Auburn
Roswell Park Cancer Institute
Buffalo
Cancer Institute at Saint Francis Hospital
East Hills
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse
Glens Falls Hospital
Glens Falls
NYU Winthrop Hospital
Mineola
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York
NYP/Weill Cornell Medical Center
New York
University of Rochester
Rochester
Hematology Oncology Associates of Central New York-Onondaga Hill
Syracuse
State University of New York Upstate Medical University
Syracuse
Good Samaritan Hospital Medical Center
West Islip
Ohio
Indu and Raj Soin Medical Center
Beavercreek
Strecker Cancer Center-Belpre
Belpre
Saint Elizabeth Boardman Hospital
Boardman
Cleveland Clinic Mercy Hospital
Canton
Mercy Hematology and Oncology Associates Inc
Canton
Dayton Physicians LLC-Miami Valley South
Centerville
Miami Valley Hospital South
Centerville
Adena Regional Medical Center
Chillicothe
Bethesda North Hospital
Cincinnati
Good Samaritan Hospital - Cincinnati
Cincinnati
Oncology Hematology Care Inc-Kenwood
Cincinnati
TriHealth Cancer Institute-Anderson
Cincinnati
TriHealth Cancer Institute-Westside
Cincinnati
MetroHealth Medical Center
Cleveland
Columbus Oncology and Hematology Associates Inc
Columbus
Doctors Hospital
Columbus
Grant Medical Center
Columbus
Mount Carmel East Hospital
Columbus
Mount Carmel Health Center West
Columbus
Ohio State University Comprehensive Cancer Center
Columbus
Riverside Methodist Hospital
Columbus
The Mark H Zangmeister Center
Columbus
Dayton Physician LLC-Miami Valley Hospital North
Dayton
Good Samaritan Hospital - Dayton
Dayton
Miami Valley Hospital
Dayton
Miami Valley Hospital North
Dayton
Delaware Health Center-Grady Cancer Center
Delaware
Grady Memorial Hospital
Delaware
Dublin Methodist Hospital
Dublin
Armes Family Cancer Center
Findlay
Blanchard Valley Hospital
Findlay
Orion Cancer Care
Findlay
Atrium Medical Center-Middletown Regional Hospital
Franklin
Dayton Physicians LLC-Atrium
Franklin
Central Ohio Breast and Endocrine Surgery
Gahanna
Dayton Physicians LLC-Wayne
Greenville
Wayne Hospital
Greenville
Mount Carmel Grove City Hospital
Grove City
First Dayton Cancer Care
Kettering
Greater Dayton Cancer Center
Kettering
Kettering Medical Center
Kettering
Fairfield Medical Center
Lancaster
OhioHealth Mansfield Hospital
Mansfield
Marietta Memorial Hospital
Marietta
OhioHealth Marion General Hospital
Marion
Knox Community Hospital
Mount Vernon
Licking Memorial Hospital
Newark
Newark Radiation Oncology
Newark
Mercy Health Perrysburg Cancer Center
Perrysburg
Southern Ohio Medical Center
Portsmouth
Springfield Regional Cancer Center
Springfield
Springfield Regional Medical Center
Springfield
ProMedica Flower Hospital
Sylvania
Mercy Health - Saint Anne Hospital
Toledo
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo
Toledo Clinic Cancer Centers-Toledo
Toledo
Dayton Physicians LLC-Upper Valley
Troy
Upper Valley Medical Center
Troy
Saint Joseph Warren Hospital
Warren
Saint Ann's Hospital
Westerville
Wright-Patterson Medical Center
Wright-patterson Air Force Base
Saint Elizabeth Youngstown Hospital
Youngstown
Genesis Healthcare System Cancer Care Center
Zanesville
Oklahoma
Cancer Centers of Southwest Oklahoma Research
Lawton
Mercy Hospital Oklahoma City
Oklahoma City
University of Oklahoma Health Sciences Center
Oklahoma City
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa
Oregon
Saint Alphonsus Medical Center-Baker City
Baker City
Saint Charles Health System
Bend
Clackamas Radiation Oncology Center
Clackamas
Providence Cancer Institute Clackamas Clinic
Clackamas
Bay Area Hospital
Coos Bay
Providence Newberg Medical Center
Newberg
Saint Alphonsus Medical Center-Ontario
Ontario
Kaiser Permanente Northwest
Portland
Oregon Health and Science University
Portland
Providence Portland Medical Center
Portland
Providence Saint Vincent Medical Center
Portland
Saint Charles Health System-Redmond
Redmond
Salem Hospital
Salem
Pennsylvania
Lehigh Valley Hospital-Cedar Crest
Allentown
Lehigh Valley Hospital - Muhlenberg
Bethlehem
Bryn Mawr Hospital
Bryn Mawr
Christiana Care Health System-Concord Health Center
Chadds Ford
Chambersburg Hospital
Chambersburg
Main Line Health Center-Collegeville
Collegeville
Geisinger Medical Center
Danville
Pocono Medical Center
East Stroudsburg
Ephrata Cancer Center
Ephrata
Ephrata Community Hospital
Ephrata
Main Line Health Center-Exton
Exton
Adams Cancer Center
Gettysburg
Cherry Tree Cancer Center
Hanover
Geisinger Medical Center-Cancer Center Hazleton
Hazleton
Lehigh Valley Hospital-Hazleton
Hazleton
Penn State Milton S Hershey Medical Center
Hershey
Sechler Family Cancer Center
Lebanon
Geisinger Medical Oncology-Lewisburg
Lewisburg
Lewistown Hospital
Lewistown
Riddle Memorial Hospital
Media
Paoli Memorial Hospital
Paoli
Thomas Jefferson University Hospital
Philadelphia
Pottstown Hospital
Pottstown
Geisinger Cancer Services-Pottsville
Pottsville
Community Medical Center
Scranton
Geisinger Medical Oncology-Selinsgrove
Selinsgrove
Geisinger Medical Group
State College
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-barre
Asplundh Cancer Pavilion
Willow Grove
Lankenau Medical Center
Wynnewood
WellSpan Health-York Cancer Center
York
WellSpan Health-York Hospital
York
Rhode Island
Smilow Cancer Hospital Care Center - Westerly
Westerly
South Carolina
Prisma Health Cancer Institute - Spartanburg
Boiling Springs
Medical University of South Carolina
Charleston
Prisma Health Cancer Institute - Laurens
Clinton
Prisma Health Cancer Institute - Easley
Easley
Gibbs Cancer Center-Gaffney
Gaffney
BI-LO Charities Children's Cancer Center
Greenville
Prisma Health Cancer Institute - Butternut
Greenville
Prisma Health Cancer Institute - Eastside
Greenville
Prisma Health Cancer Institute - Faris
Greenville
Prisma Health Greenville Memorial Hospital
Greenville
Saint Francis Cancer Center
Greenville
Saint Francis Hospital
Greenville
Self Regional Healthcare
Greenwood
Gibbs Cancer Center-Pelham
Greer
Prisma Health Cancer Institute - Greer
Greer
Prisma Health Cancer Institute - Seneca
Seneca
Spartanburg Medical Center
Spartanburg
MGC Hematology Oncology-Union
Union
South Dakota
Avera Cancer Institute-Aberdeen
Aberdeen
Avera Cancer Institute at Pierre
Pierre
Avera Cancer Institute
Sioux Falls
Sanford Cancer Center Oncology Clinic
Sioux Falls
Sanford USD Medical Center - Sioux Falls
Sioux Falls
Tennessee
Memorial Hospital
Chattanooga
Pulmonary Medicine Center of Chattanooga-Hixson
Hixson
Memorial GYN Plus
Ooltewah
Texas
The Don and Sybil Harrington Cancer Center
Amarillo
Saint Joseph Regional Cancer Center
Bryan
Dallas VA Medical Center
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Dallas
UT Southwestern Clinical Center at Richardson/Plano
Richardson
Utah
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork
Sandra L Maxwell Cancer Center
Cedar City
Logan Regional Hospital
Logan
Intermountain Medical Center
Murray
McKay-Dee Hospital Center
Ogden
Utah Valley Regional Medical Center
Provo
Riverton Hospital
Riverton
Saint George Regional Medical Center
Saint George
Huntsman Cancer Institute/University of Utah
Salt Lake City
LDS Hospital
Salt Lake City
Utah Cancer Specialists-Salt Lake City
Salt Lake City
Virginia
University of Virginia Cancer Center
Charlottesville
Inova Schar Cancer Institute
Fairfax
Inova Fairfax Hospital
Falls Church
Centra Lynchburg Hematology-Oncology Clinic Inc
Lynchburg
Virginia Cancer Institute
Richmond
Virginia Commonwealth University/Massey Cancer Center
Richmond
VCU Community Memorial Health Center
South Hill
Washington
Providence Regional Cancer System-Aberdeen
Aberdeen
MultiCare Auburn Medical Center
Auburn
Virginia Mason Bainbridge Island Medical Center
Bainbridge Island
Overlake Medical Center
Bellevue
PeaceHealth Saint Joseph Medical Center
Bellingham
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton
Harrison Medical Center
Bremerton
Highline Medical Center-Main Campus
Burien
Providence Regional Cancer System-Centralia
Centralia
Swedish Cancer Institute-Edmonds
Edmonds
Saint Elizabeth Hospital
Enumclaw
Providence Regional Cancer Partnership
Everett
Saint Francis Hospital
Federal Way
Virginia Mason Federal Way Medical Center
Federal Way
MultiCare Gig Harbor Medical Park
Gig Harbor
Tacoma/Valley Radiation Oncology Centers-Gig Harbor
Gig Harbor
Swedish Cancer Institute-Issaquah
Issaquah
Kadlec Clinic Hematology and Oncology
Kennewick
Northwest Cancer Clinic
Kennewick
Providence Regional Cancer System-Lacey
Lacey
Saint Clare Hospital
Lakewood
PeaceHealth Saint John Medical Center
Longview
Virginia Mason Lynnwood Medical Center
Lynnwood
Jefferson Healthcare
Port Townsend
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo
MultiCare Good Samaritan Hospital
Puyallup
Tacoma/Valley Radiation Oncology Centers-Puyallup
Puyallup
Valley Medical Center
Renton
FHCC at Northwest Hospital
Seattle
FHCC South Lake Union
Seattle
Fred Hutchinson Cancer Research Center
Seattle
Kaiser Permanente Washington
Seattle
Pacific Gynecology Specialists
Seattle
Swedish Medical Center-Ballard Campus
Seattle
Swedish Medical Center-Cherry Hill
Seattle
Swedish Medical Center-First Hill
Seattle
University of Washington Medical Center - Montlake
Seattle
Virginia Mason Medical Center
Seattle
PeaceHealth United General Medical Center
Sedro-woolley
Providence Regional Cancer System-Shelton
Shelton
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - North
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
Spokane Valley
Franciscan Research Center-Northwest Medical Plaza
Tacoma
Mary Bridge Children's Hospital and Health Center
Tacoma
MultiCare Tacoma General Hospital
Tacoma
Northwest Medical Specialties PLLC
Tacoma
Tacoma/Valley Radiation Oncology Centers-Jackson Hall
Tacoma
Tacoma/Valley Radiation Oncology Centers-Saint Joe's
Tacoma
PeaceHealth Southwest Medical Center
Vancouver
Providence Saint Mary Regional Cancer Center
Walla Walla
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima
Providence Regional Cancer System-Yelm
Yelm
Wisconsin
Langlade Hospital and Cancer Center
Antigo
ThedaCare Regional Cancer Center
Appleton
Duluth Clinic Ashland
Ashland
Northwest Wisconsin Cancer Center
Ashland
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield
Aurora Cancer Care-Southern Lakes VLCC
Burlington
Marshfield Clinic-Chippewa Center
Chippewa Falls
Aurora Saint Luke's South Shore
Cudahy
HSHS Sacred Heart Hospital
Eau Claire
Marshfield Medical Center-EC Cancer Center
Eau Claire
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire
Aurora Health Center-Fond du Lac
Fond Du Lac
Ascension Saint Francis - Reiman Cancer Center
Franklin
Aurora Health Care Germantown Health Center
Germantown
Aurora Cancer Care-Grafton
Grafton
Aurora BayCare Medical Center
Green Bay
Bellin Memorial Hospital
Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay
Saint Vincent Hospital Cancer Center Green Bay
Green Bay
Aurora Cancer Care-Kenosha South
Kenosha
Gundersen Lutheran Medical Center
La Crosse
Mayo Clinic Health System-Franciscan Healthcare
La Crosse
Marshfield Clinic - Ladysmith Center
Ladysmith
Dean Hematology and Oncology Clinic
Madison
University of Wisconsin Carbone Cancer Center
Madison
Holy Family Memorial Hospital
Manitowoc
Aurora Bay Area Medical Group-Marinette
Marinette
Saint Vincent Hospital Cancer Center at Marinette
Marinette
Marshfield Medical Center-Marshfield
Marshfield
Aspirus Medford Hospital
Medford
Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon
Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee
Aurora Cancer Care-Milwaukee
Milwaukee
Aurora Saint Luke's Medical Center
Milwaukee
Aurora Sinai Medical Center
Milwaukee
Medical College of Wisconsin
Milwaukee
Marshfield Clinic-Minocqua Center
Minocqua
ProHealth D N Greenwald Center
Mukwonago
Cancer Center of Western Wisconsin
New Richmond
ProHealth Oconomowoc Memorial Hospital
Oconomowoc
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh
Ascension All Saints Hospital
Racine
Aurora Cancer Care-Racine
Racine
Marshfield Medical Center-Rice Lake
Rice Lake
HSHS Saint Nicholas Hospital
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan
Marshfield Medical Center-River Region at Stevens Point
Stevens Point
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay
Aurora Medical Center in Summit
Summit
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers
ProHealth Waukesha Memorial Hospital
Waukesha
UW Cancer Center at ProHealth Care
Waukesha
Aspirus Regional Cancer Center
Wausau
Marshfield Clinic-Wausau Center
Wausau
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa
Aurora Cancer Care-Milwaukee West
Wauwatosa
Aurora West Allis Medical Center
West Allis
Marshfield Medical Center - Weston
Weston
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids
West Virginia
West Virginia University Charleston Division
Charleston
Wyoming
Cheyenne Regional Medical Center-West
Cheyenne
Billings Clinic-Cody
Cody
Welch Cancer Center
Sheridan
Other Locations
Israel
Shaare Zedek Medical Center
Jerusalem
Time Frame
Start Date: January 3, 2019
Estimated Completion Date: May 7, 2028
Participants
Target number of participants: 720
Treatments
Experimental: Arm A (ibrutinib, obinutuzumab, venetoclax)
Patients receive ibrutinib PO daily on days 1-28 and obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 1-28 of cycles 3-14. Treatment repeats every 28 days for up to 19 cycles in the absence of disease progression or unacceptable toxicity.
Active Comparator: Arm B (ibrutinib, obinutuzumab)
Patients receive ibrutinib PO and obinutuzumab as in arm A. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Authors
Irl B. Greenwell, Leonard J. Seigel, Deborah W. Wilbur, Carter T. Davis, Charles S. Kuzma, Jennifer Slim, Craig A. Portell, Mary L. Mayer, Jonathan S. Treisman, Scott Huntington, Jeffrey P. Letzer, Robert J. Behrens, Hassan I. Tahsildar, Seth D. Cohen, Danielle A. Shafer, Michael C. Marte, Jonathan E. Dowell, Hagen F. Kennecke, Bryan A. Faller, Jennifer A. Woyach, Abderrahim Khomani, Janelle M. Meyer, Preston D. Steen, Rex B. Mowat, Wei Song, Blanche H. Mavromatis, Danielle M. Brander, Bruce J. Averbook, Howard M. Gross, Jay W. Carlson, Jeffrey L. Berenberg, Joseph Sokhn, Steven J. Jubelirer, Jeffrey J. Kirshner, Andreas K. Klein, Alexey V. Danilov, Amitkumar N. Mehta, Marc S. Hoffmann, Cameron B. Harkness, Timothy R. Wassenaar, Priyank P. Patel, James E. Radford, Samer S. Kasbari, Donald J. Jurgens, Robert M. Eisner, Victor Y. Yazbeck, Lara N. Durna, Farrukh T. Awan, Timothy D. Moore, Mark L. Graham, Paul M. Barr, John M. Schallenkamp, Ding Wang, Amit Sanyal, Stephen E. Spurgeon, Natasha C. Edwin, Albert S. DeNittis, Abdul H. Mansoor, Gregory A. Masters, Tareq Al Baghdadi, Neil E. Kay, Erlene K. Seymour, David F. Claxton, Keren Sturtz, Nagesh H. Jayaram, Michael J. Thirman, Ali W. Bseiso, Pankaj Gupta, Tanya Siddiqi, Locke J. Bryan, Mohamad Khawandanah, David B. Duggan, Jeffrey Crawford, Mazyar Shadman, Madhu Unnikrishnan, Brad S. Kahl, Tait Shanafelt, Ryan F. Porter, Kurt Oettel, Alexander Menter, Donald F. Busiek, Neil D. Palmisiano, Julie E. Chang, Brian L. Burnette, Lynn J. Howie, Alison K. Conlin, Shuo Ma, Robert D. Siegel, Nicholas DiBella, Harish G. Ahuja, Donald B. Wender, Taylor M. Ortiz, Ellice Y. Wong, Ki Y. Chung, Ranveer Nand, Charles M. Farber, Debra M. Prow, Grerk Sutamtewagul, Shannon B. Keating, John N. Allan, Leslie A. Andritsos, Johnson M. Liu, Shaker R. Dakhil, Sharon D. Luikart, Douglas J. Weckstein, Craig S. Boddy, Jonathan D. King, Joseph J. Vadakara, Russell A. Baur, Faye Yin, Brian Dietrich, Ashraf R. Aziz, Catherine C. Coombs, Jessica D. McDermott, Donald C. Doll, Mayur Narkhede, Hande H. Tuncer, Rajat Bannerji, Tatjana Kolevska, Abhijeet Kumar, Benjamin T. Marchello, Harvey E. Einhorn, Bret E. Friday, David L. Grinblatt, Susan M. O'Brien, Bruce G. Raphael, Suchitra Sundaram, Dan Sotirescu, Mukund Nadipuram, Anita Ravipati, Richard L. Deming, Jay Yang, Mark F. Kozloff, Jatin Desani, Florin D. Andreca, David M. King, Steven E. Coutre, Irene M. Hutchins, William P. Fusselman, Christopher R. Mason, Satyanarayan K. Reddy, Leonard T. Heffner, Roberto A. Ferro, Feng Jiang, Deborah M. Stephens, Jacob M. Rowe, Mitchell Haut, Albert T. Quiery, Mohammed T. Masri, Kathleen W. Phelan, Christopher H. Chay, Ishmael A. Jaiyesimi, Seo-Hyun Kim, John A. Ellerton, Abdul Hai Mansoor, John A. Keech, Shamsuddin Virani, William Tse, Francisco J. Hernandez-ILizaliturri, Matthew C. Foster, Guru Subramanian Guru Murthy
Sponsors
Leads: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov

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