Molecular Biology of Familial Myeloproliferative Disorders

Status: Completed
Location: See all (6) locations...
Study Type: Observational
SUMMARY

Myeloproliferative disorders occur in families, thus giving rise to the theory that it is a genetic disease that may be caused by an abnormal gene in the DNA that can be passed from one generation of family members to another. DNA can be gathered from family members through blood samples and the investigators will investigate (through DNA testing) to see if there are abnormal genes that may be responsible for causing the MPDs. Understanding which genes are responsible for causing MPDs can help develop ways to identify people who may be at risk for developing an MPD, allow for the development of better treatments, possibly a cure, or even prevent the development of MPDs.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 7
Healthy Volunteers: No
View:

• Families with 2 or more members diagnosed with polycythemia vera (PV), essential thrombocythemia (ET), PV and ET related myelofibrosis (PV-MF and ET-MF), idiopathic myelofibrosis (IM) or chronic myelogenous leukemia (CML).

• Healthy family members of subjects diagnosed with a myeloproliferative neoplasm (MPN).

• Participating subjects must be 7 years of age or older

• A written assent, parental permission or consent must be obtained prior to any study procedures being performed.

Locations
United States
Washington, D.c.
Georgetown University
Washington, D.c.
Illinois
University of Illinois at Chicago
Chicago
New York
Mount Sinai School of Medicine
New York
Weill Cornell
New York
Utah
University of Utah
Salt Lake City
Other Locations
Italy
University of Florence
Florence
Time Frame
Start Date: March 2008
Completion Date: June 20, 2015
Participants
Target number of participants: 17
Authors
Sponsors
Collaborators: Myeloproliferative Disorders-Research Consortium, National Cancer Institute (NCI)
Leads: Icahn School of Medicine at Mount Sinai

This content was sourced from clinicaltrials.gov

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