The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis in Cirrhotic Patients Infected With Chronic Hepatitis C Virus

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Previous data have suggested that vitamin D levels may influence cancer development. In particular, several single nucleotide polymorphisms have been described in the Vitamin D receptor( VDR gene), and some polymorphisms are associated with tumor occurrence. For instance, VDR polymorphisms have been related to cancers of the breast, prostate, skin, colon-rectum, bladder and kidney, although with conflicting observations . VDR polymorphisms have also been investigated in the context of some chronic liver diseases, such as chronic hepatitis B, primary biliary cirrhosis and autoimmune hepatitis . In a recent published study, VDR polymorphism may be used as a molecular marker to predict the risk and to evaluate the disease severity of HCC in patients with chronic hepatitis B. A significant association of VDR (ApaI) polymorphism with the development of HCC in chronic HCV infection may help to identify those who are at high risk of developing HCC.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: Accepts Healthy Volunteers
View:

• Hcv cirrhotic patient with and without Hcc

Locations
Other Locations
Egypt
Tanta university - faculty of medicine
Recruiting
Tanta
Contact Information
Primary
Sherief Abd-elsalam, lecturer
Sheriefabdelsalam@yahoo.com
00201095159522
Backup
Sherief Abd-elsalam, lecturer
sherif_tropical@yahoo.com
00201095159522
Time Frame
Start Date: February 2015
Estimated Completion Date: December 2022
Participants
Target number of participants: 50
Treatments
Other: Hepatocellular carcinoma (HCC)
The VDR genotype in 20 HCV cirrhotic patient with HCC
Other: Liver cirrhosis
The VDR genotype in 20 HCV cirrhotic patient without HCC
Other: Control group
The The VDR genotype in 10 healthy individuals as control
Authors
Fathia Asal
Sponsors
Leads: Sherief Abd-Elsalam
Collaborators: Tanta University

This content was sourced from clinicaltrials.gov

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