Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Who is this study for? Patients who develop new-onset post-operative atrial fibrillation after isolated coronary artery bypass graft surgery
Status: Recruiting
Location: See all (74) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying POAF event, who decline randomization, will be offered the option of enrollment in a parallel registry that captures their baseline risk profile and their treatment strategy in terms of anticoagulants or antiplatelets received. These patients will also be asked to fill out a brief decliner survey.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Patients of age ≥18 years who undergo isolated CABG for coronary artery disease

• POAF that persists for >60 minutes or is recurrent (more than one episode) within 7 days after the index CABG surgery

Locations
United States
Arkansas
CHI St. Vincent, Arkansas
Recruiting
Little Rock
California
Cedars-Sinai Medical Center
Recruiting
Los Angeles
University of Southern California
Recruiting
Los Angeles
Stanford University
Recruiting
Stanford
Colorado
Medical Center of Aurora
Recruiting
Aurora
Connecticut
Western Connecticut Hospital Systems
Active, not recruiting
Danbury
Yale New Haven
Recruiting
New Haven
Washington, D.c.
MedStar Washington Hospital Center
Recruiting
Washington
Georgia
Emory University
Recruiting
Atlanta
Piedmont Healthcare Inc.
Recruiting
Atlanta
Indiana
Lutheran Medical Center
Recruiting
Fort Wayne
Ascension St. Vincent
Recruiting
Indianapolis
Indiana University
Recruiting
Indianapolis
Louisiana
Ochsner Clinic
Recruiting
New Orleans
Massachusetts
Boston Medical Center
Recruiting
Boston
Brigham and Women's Hospital
Recruiting
Boston
Massachusetts General Hospital
Recruiting
Boston
Baystate Health
Recruiting
Springfield
Maryland
Johns Hopkins
Recruiting
Baltimore
University of Maryland
Recruiting
Baltimore
Suburban Hospital
Recruiting
Bethesda
Maine
Maine Medical Center
Recruiting
Portland
Michigan
University of Michigan
Recruiting
Ann Arbor
Minnesota
Mayo Clinic
Not yet recruiting
Rochester
Missouri
Mid America Health Institute
Recruiting
Kansas City
North Carolina
Duke University
Recruiting
Durham
East Carolina University
Recruiting
Greenville
WakeMed
Not yet recruiting
Raleigh
New Hampshire
Dartmouth-Hitchcock Medical Center
Recruiting
Lebanon
New York
Montefiore Medical Center
Recruiting
Bronx
Northwell Health System
Recruiting
Great Neck
Columbia University Medical Center
Recruiting
New York
The Mount Sinai Hospital
Not yet recruiting
New York
Ohio
Cleveland Clinic Foundation
Recruiting
Cleveland
Ohio State University Medical Center
Recruiting
Columbus
Oklahoma
Ascension St. John
Recruiting
Tulsa
Pennsylvania
University of Pittsburgh Medical Center
Not yet recruiting
Hermitage
University of Pennsylvania
Recruiting
Philadelphia
Allegheny Health Network
Recruiting
Pittsburgh
Texas
Baylor College of Medicine
Recruiting
Houston
Baylor Research Institute
Recruiting
Plano
Utah
Intermountain CV Research
Recruiting
Murray
University of Utah
Recruiting
Salt Lake City
Virginia
University of Virginia Health System
Recruiting
Charlottesville
Inova Health
Recruiting
Falls Church
Vermont
University of Vermont
Recruiting
Burlington
Wisconsin
University of Wisconsin
Recruiting
Madison
West Virginia
West Virginia University
Recruiting
Morgantown
Other Locations
Canada
University of Alberta Hospital
Recruiting
Edmonton
London Health Sciences Centre
Recruiting
London
Centre Hospitalier de l'Université de Montréal
Recruiting
Montreal
Hôpital du Sacré-Cœur de Montréal
Not yet recruiting
Montreal
Montreal Heart Institute
Recruiting
Montreal
University of Ottawa Heart Institute
Not yet recruiting
Ottawa
Hôpital Laval
Recruiting
Quebec
Sunnybrook Hospital
Recruiting
Toronto
Toronto General Hospital
Not yet recruiting
Toronto
Germany
Clinic Bad Neustadt - Medical Center for Heart and Vascular Diseases
Not yet recruiting
Bad Neustadt An Der Saale
HDZ-NRW Bad Oeynhausen
Not yet recruiting
Bad Oeynhausen
Charité Berlin - Benjamin Franklin Campus
Not yet recruiting
Berlin
Charité Berlin - Rudolf Virchow Campus
Not yet recruiting
Berlin
German Heart Center Berlin
Not yet recruiting
Berlin
Heart Center Leipzig
Not yet recruiting
Berlin
University Heart Center Hamburg
Not yet recruiting
Berlin
Medical Center Braunschweig
Not yet recruiting
Braunschweig
University Medical Center Frankfurt
Not yet recruiting
Frankfurt
Heart Center, University of Freiburg
Not yet recruiting
Freiburg
University Medical Center Göttingen
Not yet recruiting
Göttingen
University Medical Center Heidelberg
Not yet recruiting
Heidelberg
University Medical Center Jena
Not yet recruiting
Jena
University Medical Center Schleswig-Holstein Kiel
Not yet recruiting
Kiel
University Medical Center Schleswig-Holstein Lübeck
Not yet recruiting
Lübeck
German Heart Center Munich
Not yet recruiting
Munich
Medical Center of the Ludwig-Maximilians-University Munich
Not yet recruiting
Munich
Contact Information
Primary
Ellen Moquete, RN
ellen.moquete@mountsinai.org
212-659-9651
Time Frame
Start Date: December 13, 2019
Estimated Completion Date: December 1, 2025
Participants
Target number of participants: 3200
Treatments
Active Comparator: Antiplatelet Therapy
Antiplatelet-only strategy
Active Comparator: Oral Anticoagulant
OAC-based strategy
Sponsors
Collaborators: National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center
Leads: Icahn School of Medicine at Mount Sinai

This content was sourced from clinicaltrials.gov

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