Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: A Prospective Cohort Study From the Type 1 Diabetes in Acute Pancreatitis Consortium.

Journal: Pancreas
Published:
Abstract

Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

Authors
Phil Hart, Georgios Papachristou, Walter Park, Anne-marie Dyer, Vernon Chinchilli, Elham Afghani, Venkata Akshintala, Dana Andersen, James Buxbaum, Darwin Conwell, Kathleen Dungan, Jeffrey Easler, Evan Fogel, Carla Greenbaum, Rita Kalyani, Murray Korc, Richard Kozarek, Maren Laughlin, Peter Lee, Jennifer Maranki, Stephen Pandol, Anna Phillips, Jose Serrano, Vikesh Singh, Cate Speake, Temel Tirkes, Frederico G Toledo, Guru Trikudanathan, Santhi Vege, Ming Wang, Cemal Yazici, Atif Zaheer, Christopher Forsmark, Melena Bellin, Dhiraj Yadav