Kidney tissue engineering in preclinical models of renal failure: a systematic review and meta-analysis.
Aim: This study aims to compare the efficacy of tissue engineering for kidney reconstruction. Materials &
Methods: We searched MEDLINE, EMBASE (May 2021), and reference lists of review articles.
Results: 19 articles matched our inclusion criteria. A range of natural, synthetic and hybrid scaffolds with or without incorporating cells/growth factors was investigated in 937 animals. More favorable results were observed with a combination of two or more biomaterials, addition of bioactive moieties, and cell seeding. Creatinine concentration, PAX2, collagen type-1, α-SMA, vimentin, IL-1, IL-6 and TNF-α gene expressions were significantly increased compared with native control.
Conclusion: Tissue engineering can improve renal function and regeneration; however, further research could benefit from using hybrid scaffolds, stem cells and large animal models.