A combination of omega-3 and plant sterols regulate glucose and lipid metabolism in individuals with impaired glucose regulation: a randomized and controlled clinical trial.

Journal: Lipids In Health And Disease
Treatment Used: Combination Omega-3 and Plant Sterols (PS)
Number of Patients: 200
MediFind Summary

Overview: This study clarified whether the combination of plant sterols (PS) and omega-3 fatty acids yields any synergistic effect that enhances the prevention and treatment of impaired glucose regulation (IGR).

Conclusion: Plant sterols, omega-3 fatty acids, or the combination thereof significantly improved inflammation, insulin resistance, as well as glucose and lipid metabolism in impaired glucose regulation individuals. These findings may provide a scientific basis for the development of nutritional products incorporating plant sterols and omega-3 fatty acids, and also for the development of nutritional supplement strategies aimed at preventing the development of disease in the impaired glucose regulation population.

Abstract

Background: Lipid metabolism imbalance has been recognized as one of the major drivers of impaired glucose metabolism in the context of type 2 diabetes mellitus (T2DM), the rates of which are steadily increasing worldwide. Impaired glucose regulation (IGR) plays a vital role in the prevention and treatment of T2DM. The goal of this study was to further clarify whether the combination of plant sterols (PS) and omega-3 fatty acids yields any synergistic effect that enhances the prevention and treatment of IGR.

Methods: A total of 200 participants were randomized to receive PS and omega-3 fatty acids (n = 50), PS alone (n = 50), omega-3 fatty acids alone (n = 50), or placebo soy bean powder plus placebo capsules (n = 50) for 12 weeks. Patient characteristics including body composition, blood pressure, glucose metabolism (Fasting plasma glucose (FPG), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR)), lipid metabolism (TG, TC, HDL-C, LDL-C) and inflammatory factors (Hs-CRP, IL-6) were all monitored in these IGR individuals.

Results: Compared to the placebo group, the group receiving the combined intervention exhibited significantly decreased TG, HDL-C, FBG, HOMA-IR and HbA1c. Omega-3 fatty acids alone were associated with significant reductions in waistline, TG, FBG, HOMA-IR and Hs-CRP. PS alone was only associated with decreased TG and Hs-CRP. No interventions produced significant changes in body weight, BMI, blood pressure, FINS, body fat percentage, visceral fat rating, TC, LDL-C or IL-6.

Conclusions: In summary, this study has demonstrated for the first time that PS, omega-3 fatty acids or the combination thereof significantly improved inflammation, insulin resistance, as well as glucose and lipid metabolism in IGR individuals. These findings may provide a scientific basis for the development of nutritional products incorporating PS and omega-3 fatty acids, and also for the development of nutritional supplement strategies aimed at preventing the development of disease in the IGR population.

Authors
Ji-fang Wang, Hai-ming Zhang, Yan-yan Li, Song Xia, Yin Wei, Ling Yang, Dong Wang, Jing-jing Ye, Hao-xiang Li, Jing Yuan, Rui-rong Pan
Relevant Conditions

Type 2 Diabetes (T2D)

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