A Retrospective Study to Compare the Effects of Methylprednisolone and Dexamethasone in 35 Patients with Anaphylactic Shock Due to Iodinated Contrast Media During Cardiac Catheterization.

Journal: Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
Treatment Used: Methylprednisolone vs. Dexamethasone
Number of Patients: 35
MediFind Summary

Overview: This study compared the effects of methylprednisolone versus dexamethasone in patients with anaphylactic shock due to iodinated contrast media (ICM) during cardiac catheterization.

Conclusion: In patients with anaphylactic shock due to iodinated contrast media during cardiac catheterization, treatment with methylprednisolone or dexamethasone had similar effects.

Abstract

BACKGROUND This retrospective study aimed to compare the effects of methylprednisolone and dexamethasone in 35 patients with anaphylactic shock due to iodinated contrast media (ICM) during cardiac catheterization. MATERIAL AND METHODS Thirty-five patients diagnosed with ICM-related anaphylactic shock were enrolled. Nineteen patients received methylprednisolone, while 16 patients received dexamethasone. RESULTS The mean age of patients was 59.8 years in the methylprednisolone group and 57.2 years in the dexamethasone group (P=0.502). Most patients were male (82.9% [26/35]). The groups were matched for cardiac function, kidney function, comorbidities, prior contrast, previous radiocontrast media reactions, and allergic tendencies (all P>0.05). The severity of coronary artery disease, assessed using the SYNTAX II score, was similar between groups (P=0.620). Six patients died from ICM-induced anaphylactic shock. There was no significant difference in mortality between the 2 groups (P=1.000). CONCLUSIONS There was no significant difference in patient mortality from anaphylactic shock associated with ICM during cardiac catheterization between the methylprednisolone and dexamethasone groups.

Authors
Zhiwei Huang, Fenghuan Hu, Haibo Liu, Man Wang

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