Real-Time Flash Glucose Monitoring Had Better Effects on Daily Glycemic Control Compared With Retrospective Flash Glucose Monitoring in Patients With Type 2 Diabetes on Premix Insulin Therapy.

Journal: Frontiers In Endocrinology
Treatment Used: Real-Time Flash Glucose Monitoring (FGM)
Number of Patients: 172
MediFind Summary

Overview: This study evaluated the effects of real-time flash glucose monitoring (FGM) in patients with type 2 diabetes on premix insulin therapy.

Conclusion: In patients with type 2 diabetes on premix insulin therapy, real-time flash glucose monitoring provided improvements.

Abstract

Background and

Aims: To compare the effects of real-time and retrospective flash glucose monitoring (FGM) on daily glycemic control and lifestyle in patients with type 2 diabetes on premix insulin therapy. Methods and

Results: A total of 172 patients using premix insulin, with HbA1c ≥ 7.0% (56 mmol/mol), or the time below the target (TBR) ≥ 4%, or the coefficient of variation (CV) ≥36% during the screening period, were randomly assigned to retrospective FGM (n = 89) or real-time FGM group (n = 83). Another two retrospective or real-time 14-day FGMs were performed respectively, 1 month apart. Both groups received educations and medication adjustment after each FGM. Time in range (3.9~10.0 mmol/l, TIR) increased significantly after 3 months in the real-time FGM group (6.5%) compared with the retrospective FGM group (-1.1%) (p = 0.014). HbA1c decreased in both groups (both p < 0.01). Real-time FGMs increased daily exercise time compared with the retrospective group (p = 0.002).

Conclusions: Real-time FGM with visible blood glucose improves daily glycemic control and diabetes self-care behaviors better than retrospective FGM in patients with type 2 diabetes on premix insulin therapy. Clinical trial registration: https://clinicaltrials.gov/NCT04847219.

Authors
Reng-na Yan, Ting-ting Cai, Lan-lan Jiang, Ting Jing, Ling Cai, Xiao-jing Xie, Xiao-fei Su, Lan Xu, Ke He, Liang Cheng, Cheng, Bing-li Liu, Yun Hu, Jian-hua Ma

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