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Exploring the Benefits of Eccentric Training for Aging Adults With Knee Osteoarthritis

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods. The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail. The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 70
Healthy Volunteers: t
View:

• Aged 40-70 years

• Radiographically confirmed knee OA (Kellgren-Lawrence \[KL\] Grade 2 or 3)

• Able to walk independently (assistive devices permitted)

• Aged 40-70 years

• No radiographic evidence of knee OA (KL Grade 0 or 1)

• No frequent knee pain

• No history of:

• Knee surgery (e.g., ACL reconstruction, meniscectomy, patellar realignment)

• Significant knee injury (e.g., ligament tears, fractures, dislocations)

• Diagnosed knee conditions (e.g., patellofemoral pain syndrome, bursitis)

Locations
United States
Colorado
University of Colorado, Denver
RECRUITING
Aurora
Contact Information
Primary
Katie Boncella, MS
katie.boncella@cuanschutz.edu
7207241786
Backup
Michael Harris-Love, PT, MPT, DSc, FGSA, FAPTA
michael.harris-love@cuanschutz.edu
303-724-0687
Time Frame
Start Date: 2025-08-20
Estimated Completion Date: 2029-05-31
Participants
Target number of participants: 60
Treatments
Experimental: Initial-Exercise'
The initial exercise group will participate in an 8-week eccentric overload exercise intervention using a kBox, with two sessions per week. Participants will then cease the intervention for 8 weeks to enter a detraining period.
Experimental: Delayed-Exercise
The 'Delayed-Exercise' group will maintain their normal activity, without intervention, for the first 8 weeks of the study. In the second half of the study, they will begin the same 8-week kBox training completed by the 'Initial-Exercise' group.
Related Therapeutic Areas
Sponsors
Collaborators: NIH/NCATS Colorado CTSA Grant Number T32TR004367
Leads: University of Colorado, Denver

This content was sourced from clinicaltrials.gov