A Clinical Trial Evaluating the Safety, Tolerability, and Preliminary Anti-tumor Activity of IL-22BP/LNP Compound in Refractory Malignant Solid Tumors
This study aims to investigate the safety and efficacy of the IL-22BP/LNP compound in patients with refractory malignant solid tumors, such as advanced soft tissue sarcoma, advanced head and neck squamous cell carcinoma, and malignant melanoma, who have failed second-line treatment, have advanced recurrence or metastatic malignant solid tumors.
• Male or female patients: aged ≥ 18 years old and ≤ 70 years old;
• Patients with histopathologically confirmed, refractory to second-line treatment, advanced recurrent/metastatic malignant solid tumors and without standard clinical treatment regimens (such as patients with advanced soft tissue sarcoma, advanced head and neck squamous cell carcinoma, malignant melanoma, etc.);
• Eastern Cooperative Oncology Group (ECOG) performance status score: 0 - 1;
• Expected survival time ≥ 3 months;
• More than 28 days since the last chemotherapy/radiotherapy/surgery;
• More than 6 weeks since the last use of nitrosoureas or mitomycin C;
• Main organ functions are in good condition;
• Sign a written informed consent form.