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Age-Related Macular Degeneration Clinical Trials

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          Last Updated : 05/19/2022

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          Found 231 clinical trials
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            An Observational Prospective Natural History Study of Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4

            Status: Recruiting
            Start Date: May 3, 2022
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            Summary: Background:~STDG3 is an inherited eye disease. Currently there is no treatment for STDG3. Past studies of STDG3 have largely looked at members of large families at a single time point. Researchers want to learn more about the disease at an individual level.~Objective:~To understand the natural history of changes in the retina that occur in people with STDG3.~Eligibility:~People ages 10 and older w...

            Suprachoroidal Triamcinolone Acetonide Injection in Two Chorioretinal Diseases: One Year Results

            Status: Recruiting
            Start Date: April 14, 2022
            Intervention Type: Drug
            Study Drugs: Kenalog, Hexacetonide
            Phase: Phase 2/Phase 3
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            Summary: Suprachoroidal injection is a safe way for intraocular drug delivery. It was used to treat various retinal conditions.

            A Phase1/2a, Open-Label Study to Evaluate the Safety and Tolerability of RPESC-derived RPE Transplantation as Therapy for Dry Age-related Macular Degeneration (AMD)

            Status: Recruiting
            Start Date: April 2022
            Intervention Type: Biological
            Phase: Phase 1/Phase 2
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            Summary: The main objective of the study is evaluation of the safety and tolerability of RPESC-RPE-4W as therapy for dry AMD.

            Assessing the Impact of Using Autonomous Artificial Intelligence (AI) for Pre-screening of Diabetic Retinopathy (DR) and Diabetic Macular Edema on Physician Productivity in Bangladesh

            Status: Recruiting
            Start Date: March 20, 2022
            Intervention Type: Diagnostic Test
            Phase: Not Applicable
            View Trial
            Summary: The purpose of this study is to assess the impact of using autonomous artificial intelligence (AI) system for identification of diabetic retinopathy (DR) and diabetic macular edema on productivity of retina specialists in Bangladesh.~Globally, the number of people with diabetes mellitus is increasing. Diabetic retinopathy is a chronic, progressive complication of diabetes mellitus that affects the...

            A Phase IV, Multicenter, Open-Label, Single-Arm Study to Investigate Faricimab (RO6867461) Treatment Response in Treatment-Naive, Underrepresented Patients With Diabetic Macular Edema

            Status: Recruiting
            Start Date: February 28, 2022
            Intervention Type: Drug
            Phase: Phase 4
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            Summary: This Phase 4 study is designed to investigate treatment response in treatment-naïve underrepresented patients with diabetic macular edema (DME) who are treated with faricimab. The study population will consist of participants ≥18 years of age who self-identify as Black/African American, Hispanic/Latino American, or Native American/Alaska Native/Native Hawaiian or other Pacific Islander.

            Phase III Clinical Study of the Efficacy and Safety of 9MW0813 and Aflibercept (EYLEA®) in Patients With Diabetic Macular Edema (DME) in a Multicenter, Randomized, Double-blind, Parallel Active-controlled Study

            Status: Recruiting
            Start Date: February 28, 2022
            Intervention Type: Drug
            Study Drugs: Aflibercept
            Phase: Phase 3
            View Trial
            Summary: Phase III clinical study of the efficacy and safety of 9MW0813 and aflibercept (EYLEA®) in patients with diabetic macular edema (DME) in a multicenter, randomized, double-blind, parallel active-controlled study.

            A Randomized, Participant and Investigator Masked, Placebo-controlled, Multicenter, Proof-of-concept Study to Assess the Safety and Efficacy of LNP023 (Iptacopan) in Patients With Early and Intermediate Age-related Macular Degeneration

            Status: Recruiting
            Start Date: February 17, 2022
            Intervention Type: Drug
            Phase: Phase 2
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            Summary: The purpose of this study is to assess the effect of Iptacopan to prevent conversion of early or intermediate age-related macular degeneration (AMD) eyes to new incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) or late AMD.

            Changes Noted After Suprachoroidal Triamcinolone Acetonide Injection.

            Status: Recruiting
            Start Date: February 15, 2022
            Intervention Type: Drug
            Study Drugs: Kenalog, Hexacetonide
            Phase: Not Applicable
            View Trial
            Summary: Changes after suprachoroidal injection are analyzed for statistical analysis.

            Mechanisms of Retinal Revascularization and Clinical Indicators of Neovascular AMD Relapse

            Status: Recruiting
            Start Date: February 8, 2022
            Intervention Type: Drug
            Study Drugs: Ranibizumab, Aflibercept
            View Trial
            Summary: Age-related macular degeneration (AMD) is a chronic and progressive eye disease and is one of the leading causes of vision impairment globally. AMD is referred to as either the dry or the wet type, where the wet type (also called neovascular-AMD or nAMD) is a later stage of the disease with neovascularization and retinal edema being the main attributes. This will usually cause subacute distortion ...

            Long-Term Analysis of DImethyl Fumarate, to Slow the Growth of Areas of Geographic Atrophy

            Status: Recruiting
            Start Date: February 7, 2022
            Intervention Type: Drug, Other
            Study Drugs: Dimethyl-fumarate
            Phase: Phase 2
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            Summary: The primary objectives of the study are to assess the safety, tolerability and evidence of activity of 12 months oral treatment with TEFIDERA® in subjects with Geographic Atrophy associated with Age-Related Macular Degeneration (AMD).

            Remapping the Visual Field to Aid Reading With Central Scotomas

            Status: Recruiting
            Start Date: February 1, 2022
            Intervention Type: Behavioral
            Phase: Not Applicable
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            Summary: Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.

            Impact of Regular Consumption of Grapes on Eye Health in Singapore Older Adults

            Status: Recruiting
            Start Date: January 28, 2022
            Intervention Type: Dietary Supplement
            Phase: Not Applicable
            View Trial
            Summary: Aging epidemics in Singapore are rapidly increasing and Age-related macular degeneration (AMD) prevalence is significantly associated with older age. This study aims to understand the effect of consuming freeze-dried table grape powder on AMD in an older population.
            Showing 1-12 of 231

            Last Updated : 05/19/2022

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